Cited by 227Phytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative StressFood Science and Nutritional Studies

The DOI matches its Crossref record; 146 of the 147 references it cites were found in a registry or an index.

Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging

Ferrari, Carlos K. B.·2004·Biogerontology

DOI 10.1007/s10522-004-2566-z

Open this paper in CoChat — free account

Abstract

Aging is associated with mitochondrial dysfunctions, which trigger membrane leakage, release of reactive species from oxygen and nitrogen and subsequent induction of peroxidative reactions that result in biomolecules' damaging and releasing of metals with amplification of free radicals discharge. Free radicals induce neuronal cell death increasing tissue loss, which could be associated with memory detriment. These pathological events are involved in cardiovascular, neurodegenerative and carcinogenic processes. Dietary bioactive compounds from different functional foods, herbs and nutraceuticals (ginseng, ginkgo, nuts, grains, tomato, soy phytoestrogens, curcumin, melatonin, polyphenols, antioxidant vitamins, carnitine, carnosine, ubiquinone, etc.) can ameliorate or even prevent diseases. Protection from chronic diseases of aging involves antioxidant activities, mitochondrial stabilizing functions, metal chelating activities, inhibition of apoptosis of vital cells, and induction of cancer cell apoptosis. Functional foods and nutraceuticals constitute a great promise to improve health and prevent aging-related chronic diseases.

Integrity signals

Registry

Crossref · 10.1007/s10522-004-2566-z

Cites

146 of 146 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
The Bcl-2 Protein Family: Arbiters of Cell Survival
Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,334
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Yang, J., Liu, X., Bhalla, K. N., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P., & Wang, X. (1997) · Science · doi:10.1126/science.275.5303.1129 · Cited by 4,913
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
Kluck, R. M., Bossy‐Wetzel, E., Green, D. R., & Newmeyer, D. D. (1997) · Science · doi:10.1126/science.275.5303.1132 · Cited by 4,715
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Neurodegenerative diseases and oxidative stress
Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683 · cited 4×
“Polyphenols are natural iron chelators with high antioxidant activity (quercetin, rutin, catechins, sesamol, caffeic, ferulic and tannic acids) (Chen and Ann 1998; Lopes et al. 1999; Barnham et al. 2004 ) that could decrease AD risk.”
BackgroundInfluential
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species
Kane, D. J., Sarafian, T. A., Anton, R., Hahn, H., Gralla, E. B., Valentine, J. S., Örd, T., & Bredesen, D. E. (1993) · Science · doi:10.1126/science.8235659 · Cited by 1,671
A Matter of Life and Cell Death
Evan, G. I., & Littlewood, T. D. (1998) · Science · doi:10.1126/science.281.5381.1317 · Cited by 1,528
Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells
Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., & Murphy, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009093200 · Cited by 1,091
Oxidative stress in Alzheimer’s disease
Smith, M. A., Rottkamp, C. A., Nunomura, A., Raina, A. K., & Perry, G. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(00)00040-5 · Cited by 895

Show all 147 references

Research works printed but not linked: 10

Castro AJ, Merchut MP, Neafsey EJ and Wurster RD (2000) nuerotransmitter. In: Neurosciences: an Outline Approach. Chapter 7, pp.74?83 Mosby Inc., St.Louis.
Couture E (2002) Le ginseng.Qu�bec Pharmacie 49:J106?108
Duthie GG (1993) Lipid peroxidation.Eur J Clin Nutr 47:759?764
Ferrari CKB (2000a) Free radicals, lipid peroxidation and antioxidants in apoptosis:implications in cancer,cardiovascular and neurological diseases.Biologia 55:581?590
Ferrari CKB (2000b) Apoptose:import�ncia da maquinaria de morte celular no controle e na patog�nese das doen�as.Rev Ci�nc Med 9:21?31
Ferrari CKB (2001) Oxidative stress pathophysiology:search-ing for an effective antioxidant protection.Int Med J8:175?184
Gann PH, Ma J, Giovannucci E, Willett W, Sacks FM, Hennekens CH and Stampfer MJ (1999) Lower prostate cancer risk in men with elevated plasma lycopene levels:re-sults from a prospective analysis.Cane Res 59:1225?1230
Kimoto T, Aga M, Hino K, Koya S, Yamamoto Y, Hanaya T, Arai S, Ikeda M and Kurimoto M (1998) Apoptosis of hu-man leukemia cell lines induced by artellipin C extracted from Brazilian propolis.Biotherapy 12:1135?1142
Krishnaswamy K (1999) Turmeric-a source of phytochemicals in Indian diets.Proc Nutr Soc India 46:73?76
Rattan SIS (2003) Biology of aging and possibilities of geron-tomodulation.Proc Indian Nat Sci Acad B69:157?164

Sorted by citations

CURCUMIN: THE INDIAN SOLID GOLD
Aggarwal, B. B., Sundaram, C., Malani, N., & Ichikawa, H. (2007) · Springer eBooks · doi:10.1007/978-0-387-46401-5_1 · Cited by 1,740
New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?
Fardet, A. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000041 · Cited by 1,030
Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
Hormesis in aging
Rattan, S. I. S. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.03.002 · Cited by 498
Sirtuins, a promising target in slowing down the ageing process
Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017) · Biogerontology · doi:10.1007/s10522-017-9685-9 · Cited by 470
Anticancer Drugs from Marine Flora: An Overview
Boopathy, N. S., & Kathiresan, K. (2010) · Journal of Oncology · doi:10.1155/2010/214186 · Cited by 415
Dietary Sources and Bioactivities of Melatonin
Meng, X., Li, Y., Li, S., Zhou, Y., Gan, R.-Y., Xu, D.-P., & Li, H.-B. (2017) · Nutrients · doi:10.3390/nu9040367 · Cited by 362
Estresse oxidativo: conceito, implicações e fatores modulatórios
Barbosa, K. B. F., Costa, N. M. B., Alfenas, R. D. C. G., de Paula, S. O., Minim, V. P. R., & Bressan, J. (2010) · Revista de Nutrição · doi:10.1590/s1415-52732010000400013 · Cited by 357
Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease
Maczurek, A. E., Häger, K., Kenklies, M., Sharman, M. J., Martins, R. N., Engel, J., Carlson, D. A., & Münch, G. W. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.04.015 · Cited by 353
Total Antioxidant Capacity: a biomarker in biomedical and nutritional studies
Kusano, C., & Ferrari, B. (2008) · Journal of cell & molecular biology · Cited by 304
Measurement of anthocyanins and other phytochemicals in purple wheat
Hosseinian, F. S., Li, W., & Trust Beta (2008) · Food Chemistry · doi:10.1016/j.foodchem.2007.12.083 · Cited by 303
Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms
Hardeland, R. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12090 · Cited by 290
Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease
Berretta, A. A., Silveira, M. A. D., Capcha, J. M. C., & JONG, D. D. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110622 · Cited by 288
Nutrition, Brain Aging, and Neurodegeneration: Table 1.
Joseph, J., Cole, G., Head, E., & Ingram, D. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3520-09.2009 · Cited by 264
Mitochondrial oxidative stress, aging and caloric restriction: The protein and methionine connection
Pamplona, R., & Barja, G. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.01.009 · Cited by 256
Is the Mitochondrial Free Radical Theory of Aging Intact?
Sanz, A., Pamplona, R., & Barja, G. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.582 · Cited by 245
Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits
Wang, Q., Sun, A. Y., Simonyi, Á., Jensen, M. D., Shelat, P. B., Rottinghaus, G. E., MacDonald, R. S., Miller, D. K., Lubahn, D. E., Weisman, G. A., et al. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20610 · Cited by 233
Green Tea: Nature's Defense against Malignancies
Butt, M. S., & Sultan, M. T. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390802145310 · Cited by 219
Functional Foods and Nutraceuticals in the Primary Prevention of Cardiovascular Diseases
Alissa, E. M., & Ferns, G. A. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/569486 · Cited by 221
Olive tree ( Olea europaea L.) leaf as a waste by‐product of table olive and olive oil industry: a review
Şahin, S., & Bilgin, M. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8619 · Cited by 205
Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension
Roghani, F., & Kamkhah, A. F. (2008) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2008.00607.x · Cited by 199
Neuroprotective Herbs and Foods from Different Traditional Medicines and Diets
Iriti, M., Vitalini, S., Fico, G., & Faoro, F. (2010) · Molecules · doi:10.3390/molecules15053517 · Cited by 191
HPLC Determination of Phenolic Acids, Flavonoids and Juglone in Walnut Leaves
Nour, V., Trandafir, I., & Cosmulescu, S. N. (2012) · Journal of Chromatographic Science · doi:10.1093/chromsci/bms180 · Cited by 178
Nutrition, Well-Being and Health
(2012) · doi:10.5772/1864 · Cited by 178
Natural polyphenols in cancer therapy
Asensi, M., Ortega, A., Mena, S., Feddi, F., & Estrela, J. M. (2011) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2011.631268 · Cited by 174
Sirtuins and their Biological Relevance in Aging and Age-Related Diseases
Zhao, L., Cao, J., Hu, K., He, X., Dou, Y., Tong, T., & Han, L. (2020) · Aging and Disease · doi:10.14336/ad.2019.0820 · Cited by 178
Nigella sativa: Reduces the Risk of Various Maladies
Butt, M. S., & Sultan, M. T. (2010) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390902768797 · Cited by 153
Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases
Baig, M. H., Ahmad, K., Saeed, M., Alharbi, A. M., Barreto, G. E., Ashraf, G. M., & Choi, I. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.025 · Cited by 154
Jerte Valley Cherry-Enriched Diets Improve Nocturnal Rest and Increase 6-Sulfatoxymelatonin and Total Antioxidant Capacity in the Urine of Middle-Aged and Elderly Humans
Garrido, M., Paredes, S. D., Juánez, J. C., Lozano, M., Toribio-Delgado, A. F., Munoz, J. L., Reiter, R. J., Barriga, C., & Rodríguez, A. B. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq099 · Cited by 140
Melatonin, Aging, and Age-Related Diseases: Perspectives for Prevention, Intervention, and Therapy
Pöeggeler, B. (2005) · Endocrine · doi:10.1385/endo:27:2:201 · Cited by 137
Curcumin induces heme oxygenase‐1 in normal human skin fibroblasts through redox signaling: Relevance for anti‐aging intervention
Lima, C. F., Pereira‐Wilson, C., & Rattan, S. I. S. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000221 · Cited by 136
Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial
Azimi, P., Ghiasvand, R., Feizi, A., Hosseinzadeh‐Attar, M. J., Bahreynian, M., Hariri, M., & Khosravi‐Boroujeni, H. (2016) · Blood Pressure · doi:10.3109/08037051.2015.1111020 · Cited by 135
Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration
Legette, L. L., Ma, L., Reed, R. L., Miranda, C. L., Christensen, J. M., Rodriguez‐Proteau, R., & Stevens, J. F. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100554 · Cited by 122
Mitochondria as a Target in the Therapeutic Properties of Curcumin
Trujillo, J., Granados‐Castro, L. F., Zazueta, C., Andérica‐Romero, A. C., Chirino, Y. I., & Pedraza‐Chaverrí, J. (2014) · Archiv der Pharmazie · doi:10.1002/ardp.201400266 · Cited by 121
Effects of berberine on lipid profile in subjects with low cardiovascular risk
Derosa, G., D'Angelo, A., Bonaventura, A., Bianchi, L., Romano, D., & Maffioli, P. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.776037 · Cited by 112
Curcumin and aging
Shen, L., Parnell, L. D., Ordovás, J. M., & Lai, C. (2013) · BioFactors · doi:10.1002/biof.1086 · Cited by 112
Flavonoid-rich foods (FRF): A promising nutraceutical approach against lifespan-shortening diseases.
Janabi, A. H. W., Kamboh, A. A., Saeed, M., Lu, X., Bibi, J., Majeed, F., Naveed, M., Jameel, M., Korejo, N. A., Kamboh, R., et al. (2020) · PubMed Central · doi:10.22038/ijbms.2019.35125.8353 · Cited by 112
Characteristics and consumer acceptance of healthier meat and meat product formulations—a review
Swapna, H. C., Rai, A. K., Modi, V. K., & Narayan, B. (2011) · Journal of Food Science and Technology · doi:10.1007/s13197-011-0476-z · Cited by 106
Pressurized Hot Ethanol Extraction of Carotenoids from Carrot By-Products
Mustafa, A., Mijangos, L., & Turner, C. (2012) · Molecules · doi:10.3390/molecules17021809 · Cited by 104
Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats
Legette, L. L., Luna, A. Y. M., Reed, R. L., Miranda, C. L., Bobe, G., Rodriguez‐Proteau, R., & Stevens, J. F. (2012) · Phytochemistry · doi:10.1016/j.phytochem.2012.04.018 · Cited by 100
Some Biological Properties of Curcumin: A Review
Ali, B. H., Marrif, H. I., Noureldayem, S. A., Bakheit, A. O., & Blunden, G. (2006) · Natural Product Communications · doi:10.1177/1934578x0600100613 · Cited by 96
Inhibitory effect of soy protein coating formulations on walnut (Juglans regia L.) kernels against lipid oxidation
Kang, H.-J., Kim, S.-J., You, Y.-S., Lacroix, M., & Han, J. (2012) · LWT · doi:10.1016/j.lwt.2012.10.019 · Cited by 94
Chemopreventative effects of tetrahydrocurcumin on human diseases
Wu, J.-C., Tsai, M.-L., Lai, C., Wang, Y., Ho, C., & Pan, M. (2013) · Food & Function · doi:10.1039/c3fo60370a · Cited by 92
Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans
Oliveras‐López, M., Muros, J. J., Mir, M. V., Rey, E. F., Martín, F., & de la Serrana, H. L.-G. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2013.04.002 · Cited by 95
Could the 3D Printing Technology be a Useful Strategy to Obtain Customized Nutrition?
Severini, C., & Derossi, A. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000705 · Cited by 87
Nutrition and other lifestyle influences on arterial aging
LaRocca, T. J., Martens, C. R., & Seals, D. R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.002 · Cited by 83
Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function: Streptopelia Risoria as a Model
Paredes, S. D., Barriga, C., Reiter, R. J., & Rodríguez, A. B. (2009) · International Journal of Tryptophan Research · doi:10.4137/ijtr.s1129 · Cited by 79
Biological and pharmacological effects of hexahydrocurcumin, a metabolite of curcumin
Huang, Y., Cao, S., Zhang, Q., Zhang, H., Fan, Y., Qiu, F., & Kang, N. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.03.030 · Cited by 79
Enhancement of mitochondrial biogenesis with polyphenols: combined effects of resveratrol and equol in human endothelial cells
Davinelli, S., Sapere, N., Visentin, M., Zella, D., & Scapagnini, G. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-28 · Cited by 76
Metabolismo mitocondrial, radicais livres e envelhecimento
da Silva, W. J. M., & Ferrari, C. K. B. (2011) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/s1809-98232011000300005 · Cited by 74
Functional foods and physical activities in health promotion of aging people
Ferrari, C. K. B. (2007) · Maturitas · doi:10.1016/j.maturitas.2007.09.011 · Cited by 77
Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells
Mendonça, L. M., dos Santos, G. C., Antonucci, G. A., dos Santos, A. C., Bianchi, M. D. L. P., & Antunes, L. M. G. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2009.02.003 · Cited by 71
Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate
Pamplona, R., Portero‐Otín, M., Sanz, A., Ayala, V., Vasileva, E., & Barja, G. (2005) · AGE · doi:10.1007/s11357-005-4562-x · Cited by 70
L-carnitine reduces doxorubicin-induced apoptosis through a prostacyclin-mediated pathway in neonatal rat cardiomyocytes
Chao, H.-H., Liu, J., Hong, H.-J., Lin, J., Chen, C., & Cheng, T. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.06.010 · Cited by 67
Optimal extraction and fingerprinting of carotenoids by accelerated solvent extraction and liquid chromatography with tandem mass spectrometry
Saha, S., Walia, S., Kundu, A., Sharma, K., & Paul, R. K. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.01.039 · Cited by 63
Urinary 6-sulfatoxymelatonin and total antioxidant capacity increase after the intake of a grape juice cv. Tempranillo stabilized with HHP
González, D., Gamero, E., Garrido, M., Ramírez, R., Moreno, D., Delgado, J., Valdés, M. E., Barriga, C., Rodríguez, A. B., & Paredes, S. D. (2011) · Food & Function · doi:10.1039/c1fo10146c · Cited by 63
Protein methionine content and MDA-lysine adducts are inversely related to maximum life span in the heart of mammals
Ruiz, M. C., Ayala, V., Portero‐Otín, M., Requena, J. R., Barja, G., & Pamplona, R. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.04.005 · Cited by 61
Oxidative stress—implications, source and its prevention
Kaur, R., Kaur, J., Mahajan, J., Kumar, R., & Arora, S. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-2251-3 · Cited by 59
Administration of carnosine in the treatment of acute spinal cord injury
Paola, R. D., Impellizzeri, D., Salinaro, A. T., Mazzon, E., Bellia, F., Cavallaro, M., Cornelius, C., Vecchio, G., Calabrese, V., Rizzarelli, E., et al. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.074 · Cited by 59
Anti-aging potential of tree nuts with a focus on the phytochemical composition, molecular mechanisms and thermal stability of major bioactive compounds
Rusu, M. E., Gheldiu, A.-M., Mocan, A., Vlase, L., & Popa, D. (2018) · Food & Function · doi:10.1039/c7fo01967j · Cited by 59
Should Patients Undergoing Chemotherapy and Radiotherapy Be Prescribed Antioxidants?
Moss, R. W. (2006) · Integrative Cancer Therapies · doi:10.1177/1534735405285882 · Cited by 59
Functional foods and cardiometabolic diseases
Assmann, G., Buono, P., Daniele, A., Valle, E. D., Farinaro, E., Ferns, G. A., Krogh, V., Kromhout, D., Masana, L., Merino, J., et al. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.10.010 · Cited by 59
Carnosine derivatives: new multifunctional drug-like molecules
Bellia, F., Vecchio, G., & Rizzarelli, E. (2011) · Amino Acids · doi:10.1007/s00726-011-1178-6 · Cited by 57
Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in older men: a randomised, placebo‐controlled trial
Harris, E., Macpherson, H., Vitetta, L., Kirk, J., Sali, A., & Pipingas, A. (2012) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2236 · Cited by 55
Slowing Down Ageing: The Role of Nutrients and Microbiota in Modulation of the Epigenome
Gadecka, A., & Bielak-Żmijewska, A. (2019) · Nutrients · doi:10.3390/nu11061251 · Cited by 56
Ultrasonication-assisted extraction and preconcentration of medicinal products from herb by ionic liquids
Bi, W., Tian, M., & Row, K. H. (2011) · Talanta · doi:10.1016/j.talanta.2011.04.054 · Cited by 52
Benefits of tree nut consumption on aging and age-related diseases: Mechanisms of actions
Rusu, M. E., Simedrea, R., Gheldiu, A.-M., Mocan, A., Vlase, L., Popa, D., & Ferreira, I. C. F. R. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.03.006 · Cited by 53
Fertilizing Crops to Improve Human Health: A Scientific Review
Bruulsema, T. W., Heffer, P., Welch, R. M., Çakmak, İ., & Moran, K. (2012) · Cited by 50
Healthy efficacy of Nostoc commune Vaucher
Li, Z., & Guo, M. (2017) · Oncotarget · doi:10.18632/oncotarget.23620 · Cited by 52
Understanding and Modulating Ageing
Rattan, S. I. S., & Clark, B. F. C. (2005) · IUBMB Life · doi:10.1080/15216540500092195 · Cited by 62
A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases
Chen, B., Zhang, W., Lin, C., & Zhang, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911569 · Cited by 51
Nutraceuticals and Antioxidants in Prevention of Diseases
Jain, N., & Ramawat, K. G. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_70 · Cited by 48
Chitosan/PLGA Particles for Controlled Release of α-Tocopherol in The GI Tract Via Oral Administration
Murugeshu, A., Astete, C. E., Leonardi, C., Morgan, T. W., & Sabliov, C. M. (2011) · Nanomedicine · doi:10.2217/nnm.11.44 · Cited by 48
Extraction and concentration of tanshinones in Salvia miltiorrhiza Bunge by task-specific non-ionic surfactant assistance
Bi, W., Tian, M., & Row, K. H. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.12.059 · Cited by 47
Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats
Chen, Y.-P., Sivalingam, K., Shibu, M. A., Rajendran, P., Day, C. H., Shen, C.-Y., Lai, C., Chen, R., Viswanadha, V. P., Chen, Y., et al. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.09.179 · Cited by 47
New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: Synthesis and characterization of their copper(II) complexes
Lanza, V., Bellia, F., D’Agata, R., Grasso, G., Rizzarelli, E., & Vecchio, G. (2010) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2010.10.014 · Cited by 46
Extraction of β-carotene from organic phase using ammonium based ionic liquids aqueous solution
Rajabi, M. S., Moniruzzaman, M., Mahmood, H., Sivapragasam, M., & Bustam, M. A. (2016) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2016.12.008 · Cited by 46
Development of functional beverages from blends of Hibiscus sabdariffa extract and selected fruit juices for optimal antioxidant properties
Ogundele, O. M. A., Awolu, O. O., Badejo, A. A., Nwachukwu, I. D., & Fagbemi, T. N. (2016) · Food Science & Nutrition · doi:10.1002/fsn3.331 · Cited by 45
Healthy endothelium: The scientific basis for cardiovascular health promotion and chronic disease prevention
Mensah, G. A. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.10.013 · Cited by 46
Antioxidative Effects of Plant Polyphenols
Jefremov, V., Zilmer, M., Zilmer, K., Bogdanović, N., & Karelson, E. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1397.048 · Cited by 44
The Science of Healthy Aging
Rattan, S. I. S. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.044 · Cited by 42
The Biochemical and Cellular Basis for Nutraceutical Strategies to Attenuate Neurodegeneration in Parkinson’s Disease
MAZZIO, E. A., Close, F. T., & Soliman, K. F. A. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12010506 · Cited by 41
Polyphenolic content and antioxidant activity of some wild Saudi Arabian asteraceae plants
Shahat, A. A., Ibrahim, A. Y., & Elsaid, M. S. (2014) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(14)60091-2 · Cited by 38
The effects of soy extract on spatial learning and memory damage induced by global ischemia in ovariectomised rats.
Vafaee, F., Hosseini, M., Sadeghnia, H. R., Hadjzadeh, M. A.-R., Soukhtanloo, M., & Rahimi, M. (2014) · PubMed Central · Cited by 37
Effects on oral fat load of a nutraceutical combination of fermented red rice, sterol esters and stanols, curcumin, and olive polyphenols: A randomized, placebo controlled trial
Derosa, G., Catena, G., Raddino, R., Gaudio, G. V., Maggi, A., D’Angelo, A., & Maffioli, P. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.01.014 · Cited by 34
Protein engineering of toluene monooxygenases for synthesis of hydroxytyrosol
Brouk, M., & Fishman, A. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.02.020 · Cited by 32
Olive Leaf Extract Supplementation to Old Wistar Rats Attenuates Aging-Induced Sarcopenia and Increases Insulin Sensitivity in Adipose Tissue and Skeletal Muscle
González‐Hedström, D., Priego, T., Amor, S., de la Fuente‐Fernández, M., Martı́n, A. I., López‐Calderón, A., Inarejos-García, A. M., Garcı́a-Villalón, Á. L., & Granado, M. (2021) · Antioxidants · doi:10.3390/antiox10050737 · Cited by 32
Rescue of ER oxidoreductase function through polyphenolic phytochemical intervention: Implications for subcellular traffic and neurodegenerative disorders
Pal, R., Cristan, E. A., Schnittker, K., & Narayan, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.01.071 · Cited by 31
Encapsulation and controlled release of antioxidants and vitamins
Sabliov, C. M., & Astete, C. E. (2008) · Elsevier eBooks · doi:10.1533/9781845694210.3.297 · Cited by 31
Application of alkyl polyglycoside surfactant in ultrasonic-assisted extraction followed by macroporous resin enrichment for the separation of vitexin-2″- O -rhamnoside and vitexin from Crataegus pinnatifida leaves
Han, F., Guo, Y., Gu, H., Li, F., Bao-zhong, H., & Yang, L. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.01.017 · Cited by 31
Synergistic Effect of L-Carnosine and EGCG in the Prevention of Physiological Brain Aging
Davinelli, S., Marco, R. D., Bracale, R., Quattrone, A., Zella, D., & Scapagnini, G. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319150007 · Cited by 30
Evaluation of antioxidant enzyme activity and antioxidant capacity in patients with newly diagnosed pemphigus vulgaris
Javanbakht, M. H., Djalali, M., Daneshpazhooh, M., Zarei, M., Eshraghian, M. R., Derakhshanian, H., & Chams‐Davatchi, C. (2015) · Clinical and Experimental Dermatology · doi:10.1111/ced.12489 · Cited by 29
Hawthorn fruit increases the antioxidant capacity and reduces lipid peroxidation in senescence-accelerated mice
Wang, H., Zhang, Z., Guo, Y., Sun, P., Lv, X., & Zuo, Y. (2011) · European Food Research and Technology · doi:10.1007/s00217-011-1435-7 · Cited by 30
Microencapsulation of the natural urucum pigment with chitosan by spray drying in different solvents
Parize, A. L., Cristina, T., de Souza, R., Brighente, I. M. C., Fávere, V. T., Laranjeira, M. C. M., Spinelli, A., & Longo, E. (2008) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.4314/ajb.v7i17.59236 · Cited by 30
Phytochemical Profile of Erythrina variegata by Using High-Performance Liquid Chromatography and Gas Chromatography-Mass Spectroscopy Analyses
Muthukrishnan͙͙, S., Palanisamy, S., Subramanian, S., Selvaraj, S., Mari, K. R., & Kuppulingam, R. (2016) · Journal of Acupuncture and Meridian Studies · doi:10.1016/j.jams.2016.06.001 · Cited by 30
Coenzyme Q homeostasis in aging: Response to non-genetic interventions
López‐Lluch, G. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.01.024 · Cited by 29
A preliminary study on the effects of star fruit consumption on antioxidant and lipid status in elderly Thai individuals
Leelarungrayub, J., Yankai, A., Pinkaew, D., Puntumetakul, R., Laskin, J., & Bloomer, R. J. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s110718 · Cited by 25
Hormesis for Healthy Aging
Rattan, S. I. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814253-0.00018-8 · Cited by 25
Noncovalent Interaction-Driven Stereoselectivity of Copper(II) Complexes with Cyclodextrin Derivatives of l - and d -Carnosine
Grasso, G. I., Bellia, F., Arena, G., Vecchio, G., & Rizzarelli, E. (2011) · Inorganic Chemistry · doi:10.1021/ic200132a · Cited by 24
Cinnamomum zeylanicum extract on the radiolabelling of blood constituents and the morphometry of red blood cells: In vitro assay
Benarroz, M. D. O., da Fonseca, A. D. S., Rocha, G. S., Frydman, J. N. G., da Rocha, V. C., Pereira, M. O., & Bernardo-Filho, M. (2007) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2007.08.004 · Cited by 22

Authors: Ferrari, C. K. B.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: Ferrari, Carlos K. B.
ORCID: Ferrari, Carlos K. B.
Venue: Biogerontology
Publisher: Springer Science and Business Media LLC
Published: 2004-10
Volume: 5
Issue: 5
Pages: 275-290
ISSN: 1389-5729 (ISSN-L)
1573-6768
DOI: 10.1007/s10522-004-2566-z
OpenAlex: W2025236117
Cited by: 227
References: 147
Citations by year: 2026: 3 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 9 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 10 · 2017: 7 · 2016: 17 · 2015: 6 · 2014: 11 · 2013: 17 · 2012: 10
FWCI: 1.14
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Biogerontology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Nursing › Nutrition and Dietetics › Food Science and Nutritional Studies
Keywords: healthy aging, functional foods, nutraceuticals, herbs, mitochondrial dysfunction, free radicals, oxidative stress, neurodegeneration, cardiovascular disease, cancer prevention, bioactive compounds, antioxidants, polyphenols, melatonin, curcumin, soy phytoestrogens, ginseng, Ginkgo biloba, metal chelation, apoptosis, memory impairment
MeSH terms: Aging, Antioxidants, Chelating Agents, Food, Heart Diseases, Homocysteine, Humans, Lipoproteins, LDL, Oxidative Stress, Mitochondrial Diseases, Herbal Medicine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks