Cited by 227Phytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative StressFood Science and Nutritional Studies

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Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging

Ferrari, Carlos K. B.·2004·Biogerontology

DOI 10.1007/s10522-004-2566-z

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Abstract

Aging is associated with mitochondrial dysfunctions, which trigger membrane leakage, release of reactive species from oxygen and nitrogen and subsequent induction of peroxidative reactions that result in biomolecules' damaging and releasing of metals with amplification of free radicals discharge. Free radicals induce neuronal cell death increasing tissue loss, which could be associated with memory detriment. These pathological events are involved in cardiovascular, neurodegenerative and carcinogenic processes. Dietary bioactive compounds from different functional foods, herbs and nutraceuticals (ginseng, ginkgo, nuts, grains, tomato, soy phytoestrogens, curcumin, melatonin, polyphenols, antioxidant vitamins, carnitine, carnosine, ubiquinone, etc.) can ameliorate or even prevent diseases. Protection from chronic diseases of aging involves antioxidant activities, mitochondrial stabilizing functions, metal chelating activities, inhibition of apoptosis of vital cells, and induction of cancer cell apoptosis. Functional foods and nutraceuticals constitute a great promise to improve health and prevent aging-related chronic diseases.

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Authors: Ferrari, C. K. B.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: Ferrari, Carlos K. B.
ORCID: Ferrari, Carlos K. B.
Venue: Biogerontology
Publisher: Springer Science and Business Media LLC
Published: 2004-10
Volume: 5
Issue: 5
Pages: 275-290
ISSN: 1389-5729 (ISSN-L)
1573-6768
DOI: 10.1007/s10522-004-2566-z
OpenAlex: W2025236117
Cited by: 227
References: 147
Citations by year: 2026: 3 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 9 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 10 · 2017: 7 · 2016: 17 · 2015: 6 · 2014: 11 · 2013: 17 · 2012: 10
FWCI: 1.14
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Biogerontology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Nursing › Nutrition and Dietetics › Food Science and Nutritional Studies
Keywords: healthy aging, functional foods, nutraceuticals, herbs, mitochondrial dysfunction, free radicals, oxidative stress, neurodegeneration, cardiovascular disease, cancer prevention, bioactive compounds, antioxidants, polyphenols, melatonin, curcumin, soy phytoestrogens, ginseng, Ginkgo biloba, metal chelation, apoptosis, memory impairment
MeSH terms: Aging, Antioxidants, Chelating Agents, Food, Heart Diseases, Homocysteine, Humans, Lipoproteins, LDL, Oxidative Stress, Mitochondrial Diseases, Herbal Medicine

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Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging

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