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Cited by 11Genetics, Aging, and Longevity in Model OrganismsDietary Effects on HealthSirtuins and Resveratrol in Medicine

RETRACTED ARTICLE: Carbohydrate-restricted diet promotes skin senescence in senescence-accelerated prone mice

Wu, Qiming, E, Shuang, Yamamoto, Kazushi, Tsuduki, Tsuyoshi·2019·Biogerontology
DOI 10.1007/s10522-018-9777-1
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Abstract

This study used senescence-accelerated prone mice (SAMP8) to examine the effects of a carbohydrate-restricted diet on aging and skin senescence, to determine how long-term carbohydrate restriction affects the aging process. Three-week-old male SAMP8 mice were divided into three groups after 1 week of preliminary feeding: one was given a controlled diet, the other was given a high-fat diet, and the third was given a carbohydrate-restricted diet. Ad libitum feeding was administered until the mice reached 50 weeks of age. Before the end of the test period, a grading test was used to evaluate visible aging in the mice. After the test period, serum and skin samples in mice were obtained and submitted for analysis. As a result, the grading test demonstrated that there was significant progression of visible aging in the carbohydrate-restricted group, as well as a decreased survival rate. Histological examination of the skin revealed that the epidermis and dermis in the carbohydrate-restricted group had become thinner. Analysis of the mechanisms involved demonstrated an increase in serum interleukin-6, aggravated skin senescence, inhibition of skin autophagy and activation of skin mTOR. Therefore, this study proved that a carbohydrate-restricted diet promoted skin senescence in senescence-accelerated mice.

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Crossref · 10.1007/s10522-018-9777-1This paper is marked retracted.

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56 of 56 references verified0 citation errors · 0 not checkable

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  • When mice were fed with carbohydrate-controlled diets for 50 weeks, the epidermis and dermis were significantly thinned, autophagy was inhibited, and inflammation was exacerbated.

    “When the mice were fed with carbohydrate-controlled diets for 50 weeks, the epidermis and dermis were significantly thinned, autophagy was inhibited, and inflammation was exacerbated.”

    From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [96]

  • Long-term intake of carbohydrates in mice promotes skin aging by activating mTOR.

    “Mechanistically, long-term intake of carbohydrates in mice promotes skin aging by activating the mammalian target of rapamycin (mTOR) [96].”

    From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [96]

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Authors
Wu, Q., E, S., Yamamoto, K., & Tsuduki, T.
Affiliations
Tohoku University (JP)
Corresponding author
Tsuduki, Tsuyoshi
ORCID
Venue
Biogerontology
Publisher
Springer Science and Business Media LLC
Published
2018-10-03
Volume
20
Issue
1
Pages
71-82
ISSN
  • 1389-5729 (ISSN-L)
  • 1573-6768
DOI
10.1007/s10522-018-9777-1
OpenAlex
W2894975274
Cited by
11
References
56
Citations by year
2023: 1 · 2021: 1 · 2020: 3 · 2019: 6
FWCI
0.99
Type
journal article
Language
en
Status
Retracted
Update notices
Open access
closed
Licence
Locations
  • Biogerontology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Society for the Promotion of Science (18J13328)
  • Bio-oriented Technology Research Advancement Institution
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords
low-carbohydrate diet, skin aging, SAMP8 mice, aging, high-fat diet, skin histology, interleukin-6, mTOR signaling, survival rate
MeSH terms
Animals, Autophagy, Skin, Skin Aging, Interleukin-6, Cellular Senescence, Aging, Premature, Models, Animal, Diet, Carbohydrate-Restricted, Mice, TOR Serine-Threonine Kinases, Diet, High-Fat

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