Effects of zinc status on age-related T cell dysfunction and chronic inflammation
Open accessAbstract
Age-related T cell dysfunction contributes to immunosenescence and chronic inflammation. Aging is also associated with a progressive decline in zinc status. Zinc is an essential micronutrient critical for immune function. A significant portion of the older populations are at risk for marginal zinc deficiency. The combined impact of dietary zinc deficiency and age on immune dysfunction has not been well explored despite the common occurrence together in the elderly population. We hypothesize that age-related zinc loss contributes to T cell dysfunction and chronic inflammation in the elderly and is exacerbated by inadequate dietary intake and improved with zinc supplementation. Using an aging mouse model, the effects of marginal zinc deficiency and zinc supplementation on Th1/Th17/proinflammatory cytokine profiles and CD4+ T cell naïve/memory phenotypes were examined. In the first study, young (2 months) and old (24 months) C57BL/6 mice were fed a zinc adequate (ZA) or marginally zinc deficient (MZD) diets for 6 weeks. In the second study, mice were fed a ZA or zinc supplemented (ZS) diet for 6 weeks. MZD old mice had significant increase in LPS-induced IL6 compared to ZA old mice. In contrast, ZS old mice had significantly reduced plasma MCP1 levels, reduced T cell activation-induced IFNγ, IL17, and TNFα response, as well as increased naïve CD4+ T-cell subset compared to ZA old mice. Our data suggest that zinc deficiency is an important contributing factor in immune aging, and improving zinc status can in part reverse immune dysfunction and reduce chronic inflammation associated with aging.
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Supplementation of minerals, such as zinc, can increase the naive T cell subgroup and improve the homeostasis of Th1 and Th2 cells.
“The supplementation of minerals, such as zinc, can increase the naive T cell subgroup328 and improve the homeostasis of Th1 and Th2 cells.329”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [328]
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Of Mice and Not Men: Differences between Mouse and Human Immunology
Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822 · see citing works
Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
Fulop, T., Larbi, A., Dupuis, G., Le Page, A., Frost, E. H., Cohen, A. A., Witkowski, J. M., & Franceschi, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01960 · Cited by 1,364 · see citing works
Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. P., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.002 · Cited by 1,322 · see citing works
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267 · see citing works
Biomarkers of Nutrition for Development—Folate Review
Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., et al. (2015) · Journal of Nutrition · doi:10.3945/jn.114.206599 · Cited by 1,147 · see citing works
Wessells, K. R., & Brown, K. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050568 · Cited by 1,109 · see citing works
Zinc in Infection and Inflammation
Gammoh, N. Z., & Rink, L. (2017) · Nutrients · doi:10.3390/nu9060624 · Cited by 829 · see citing works
Biomarkers of Nutrition for Development (BOND)—Zinc Review
King, J. C., Brown, K. H., Gibson, R. S., Krebs, N. F., Lowe, N. M., Siekmann, J. H., & Raiten, D. J. (2016) · Journal of Nutrition · doi:10.3945/jn.115.220079 · Cited by 581 · see citing works
Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance
Wu, D., Lewis, E. D., Pae, M., & Meydani, S. N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03160 · Cited by 494 · see citing works
ZINC AND THE RISK FOR INFECTIOUS DISEASE
Walker, C. L. F., & Black, R. E. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073054 · Cited by 490 · see citing works
Reprogramming of the immune system during zinc deficiency
Fraker, P. J., & King, L. E. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132454 · Cited by 470 · see citing works
Nutritional considerations for healthy aging and reduction in age-related chronic disease
Shlisky, J., Bloom, D. E., Beaudreault, A. R., Tucker, K. L., Keller, H. H., Freund-Levi, Y., Fielding, R. A., Cheng, F. W., Jensen, G. L., Wu, D., et al. (2017) · Advances in Nutrition · doi:10.3945/an.116.013474 · Cited by 462 · see citing works
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
Thomas, R., Wang, W., & Su, D.-M. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-0173-8 · Cited by 442 · see citing works
The gut microbiota and healthy aging: A mini-review
Kim, S., & Jazwinski, S. M. (2018) · Gerontology · doi:10.1159/000490615 · Cited by 427 · see citing works
Successful and Maladaptive T Cell Aging
Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362 · see citing works
Dixon, L. B., Winkleby, M. A., & Radimer, K. L. (2001) · Journal of Nutrition · doi:10.1093/jn/131.4.1232 · Cited by 340 · see citing works
The immune system and the impact of zinc during aging
Haase, H., & Rink, L. (2009) · Immunity & Ageing · doi:10.1186/1742-4933-6-9 · Cited by 334 · see citing works
Elyahu, Y., Hekselman, I., Eizenberg-Magar, I., Berner, O., Strominger, I., Schiller, M., Mittal, K., Nemirovsky, A., Eremenko, E., Vital, A., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw8330 · Cited by 324 · see citing works
Girodon, F. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.7.748 · Cited by 290 · see citing works
Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories
Nikolich-Žugich, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401174 · Cited by 259 · see citing works
Zinc Deficiency Affects DNA Damage, Oxidative Stress, Antioxidant Defenses, and DNA Repair in Rats
Song, Y., Leonard, S. W., Traber, M. G., & Ho, E. (2009) · Journal of Nutrition · doi:10.3945/jn.109.106369 · Cited by 251 · see citing works
Self-citationLipopolysaccharide-induced lethality and cytokine production in aged mice
Tateda, K., Matsumoto, T., Miyazaki, S., & Yamaguchi, K. (1996) · Infection and Immunity · doi:10.1128/iai.64.3.769-774.1996 · Cited by 235 · see citing works
The Role of Nutrients in Reducing the Risk for Noncommunicable Diseases during Aging
Bruins, M. J., Dael, P. V., & Eggersdorfer, M. L. (2019) · Nutrients · doi:10.3390/nu11010085 · Cited by 231 · see citing works
T-cell immunosenescence: lessons learned from mouse models of aging
Maue, A. C., Yager, E. J., Swain, S. L., Woodland, D. L., Blackman, M. A., & Haynes, L. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.04.007 · Cited by 182 · see citing works
Wong, C. P., Rinaldi, N. A., & Ho, E. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400761 · Cited by 174 · see citing works
Self-citationThe role of nutrition in enhancing immunity in aging.
Pae, M., Meydani, S. N., & Wu, D. (2012) · Europe PMC (PubMed Central) · Cited by 173 · see citing works
Stable Isotope Studies of Zinc Absorption and Retention in Young and Elderly Men
Turnlund, J. R., Durkin, N., Costa, F., & Margen, S. (1986) · Journal of Nutrition · doi:10.1093/jn/116.7.1239 · Cited by 167 · see citing works
The Effect of Zinc and Vitamin A Supplementation on Immune Response in an Older Population
Fortes, C., Forastiere, F., Agabiti, N., Fano, V., Pacifici, R., Virgili, F., Piras, G., Guidi, L., Bartoloni, C., Tricerri, A., et al. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb01008.x · Cited by 164 · see citing works
Correlation between zinc status and immune function in the elderly
Haase, H., Mocchegiani, E., & Rink, L. (2006) · Biogerontology · doi:10.1007/s10522-006-9057-3 · Cited by 162 · see citing works
Serum zinc and pneumonia in nursing home elderly
Meydani, S. N., Barnett, J. B., Dallal, G. E., Fine, B. C., Jacques, P. F., Leka, L. S., & Hamer, D. H. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.4.1167 · Cited by 155 · see citing works
Ervin, R. B., & Kennedy‐Stephenson, J. (2002) · Journal of Nutrition · doi:10.1093/jn/132.11.3422 · Cited by 138 · see citing works
Girodon, F., Lombard, M., Galan, P., Brunet-Lecomte, P., Monget, A. L., Arnaud, J., Preziosi, P., & Herçberg, S. (1997) · Annals of Nutrition and Metabolism · doi:10.1159/000177984 · Cited by 134 · see citing works
Coder, B., Wang, H., Ruan, L., & Su, D. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500082 · Cited by 128 · see citing works
Nutritional strategies to boost immunity and prevent infection in elderly individuals
High, K. P. (2001) · Clinical Infectious Diseases · doi:10.1086/324509 · Cited by 122 · see citing works
August, D., Janghorbani, M., & Young, V. R. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.6.1457 · Cited by 109 · see citing works
Pinchuk, L. M., & Filipov, N. M. (2008) · Immunity & Ageing · doi:10.1186/1742-4933-5-1 · Cited by 108 · see citing works
Aging and serum MCP-1 are associated with gut microbiome composition in a murine model
Conley, M. N., Wong, C. P., Duyck, K. M., Hord, N. G., Ho, E., & Sharpton, T. J. (2016) · PeerJ · doi:10.7717/peerj.1854 · Cited by 108 · see citing works
Self-citationHomeostasis and the age-associated defect of CD4 T cells
Swain, S. L., Clise-Dwyer, K., & Haynes, L. (2005) · Seminars in Immunology · doi:10.1016/j.smim.2005.05.007 · Cited by 107 · see citing works
Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months
Bogden, J. D., Oleske, J. M., Lavenhar, M., Munves, E. M., Kemp, F., Bruening, K. S., Holding, K. J., Denny, T. N., Guarino, M. A., & Krieger, L. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.3.655 · Cited by 106 · see citing works
Tsukamoto, H., Senju, S., Matsumura, K., Swain, S. L., & Nishimura, Y. (2015) · Nature Communications · doi:10.1038/ncomms7702 · Cited by 104 · see citing works
Wong, C. P., Magnusson, K. R., & Ho, E. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.07.005 · Cited by 98 · see citing works
Self-citationInadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005–2016 NHANES
Reider, C. A., Chung, R.-Y., Devarshi, P. P., Grant, R. W., & Mitmesser, S. H. (2020) · Nutrients · doi:10.3390/nu12061735 · Cited by 98 · see citing works
Wang, H., Fu, H., Zhu, R., Wu, X., Ji, X., Li, X., Jiang, H., Lin, Z., Tang, X., Sun, S., et al. (2020) · Aging · doi:10.18632/aging.103200 · Cited by 96 · see citing works
Provinciali, M., MONTENOVO, A., Stefano, G. D., Colombo, M. M., Daghetta, L., Cairati, M., VERONI, C., Cassino, R., TORRE, F. D., & Fabris, N. (1998) · Age and Ageing · doi:10.1093/ageing/27.6.715 · Cited by 81 · see citing works
Nutritional modulation of age-related changes in the immune system and risk of infection
Pae, M., & Wu, D. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.02.001 · Cited by 80 · see citing works
Restoration of the Thymus in Aging Mice by in Vivo Zinc Supplementation
Dardenne, M., Boukaïba, N., Gagnerault, M. C., Homo‐Delarche, F., Chappuis, P., Lemonnier, D., & Savino, W. (1993) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1993.1016 · Cited by 78 · see citing works
Tibbs, T., Lopez, L. R., & Arthur, J. C. (2019) · Microbial Cell · doi:10.15698/mic2019.08.685 · Cited by 70 · see citing works
Zinc Supplementation Increases Zinc Status and Thymopoiesis in Aged Mice ,
Wong, C. P., Song, Y., Elias, V. D., Magnusson, K. R., & Ho, E. (2009) · Journal of Nutrition · doi:10.3945/jn.109.106021 · Cited by 59 · see citing works
Self-citationHodkinson, C., Kelly, M. T., Alexander, H. D., Bradbury, I., Robson, P. J., Bonham, M. P., O’Connor, J. M., Coudray, C., Strain, J. J., & Wallace, J. M. W. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.6.598 · Cited by 55 · see citing works
Rodríguez‐Caballero, A., García‐Montero, A. C., Bueno, C., Almeida, J., Varro, R., Chen, R., Pandiella, A., & Órfão, A. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700162 · Cited by 38 · see citing works
Interventions to restore appropriate immune function in the elderly
Aspinall, R., & Lang, P. O. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0111-6 · Cited by 38 · see citing works
Wong, C. P., Dashner-Titus, E. J., Alvarez, S. C., Chase, T. T., Hudson, L. G., & Ho, E. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-1631-z · Cited by 36 · see citing works
Self-citationSchuerwegh, A. J., Clerck, L. S. D., Bridts, C. H., & Stevens, W. J. (2003) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.10041 · Cited by 35 · see citing works
Genetic Variations as Modifying Factors to Dietary Zinc Requirements—A Systematic Review
Day, K., Adamski, M. M., Dordevic, A. L., & Murgia, C. (2017) · Nutrients · doi:10.3390/nu9020148 · Cited by 33 · see citing works
Differential sensitivity to endotoxin exposure in young and middle-age mice
Kohman, R. A., Crowell, B., & Kusnecov, A. W. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.12.004 · Cited by 26 · see citing works
Harpaz, I., Bhattacharya, U., Elyahu, Y., Strominger, I., & Monsonego, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00283 · Cited by 22 · see citing works
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Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works
Natural Compounds and Products from an Anti-Aging Perspective
Bjørklund, G., Shanaida, M., Lysiuk, R., Butnariu, M., Peana, M., Sărac, I., Strus, O., Smetanina, K., & Chirumbolo, S. (2022) · Molecules · doi:10.3390/molecules27207084 · Cited by 231 · see citing works
Luís, C., Maduro, A. I., Pereira, P. M. D. C. C., Mendes, J. J., Soares, R. A., & Ramalho, R. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.958563 · Cited by 64 · see citing works
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Sun, R., Wang, J., Feng, J., & Cao, B. (2022) · Biomolecules · doi:10.3390/biom12071000 · Cited by 61 · see citing works
Dabravolski, S. A., Sadykhov, N. K., Kartuesov, A. G., Borisov, E. E., Sukhorukov, V. N., & Orekhov, A. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136890 · Cited by 52 · see citing works
Liu, Q., Li, J., Sun, X., Lin, J., Yu, Z., Xiao, Y., Li, D., Sun, B., Bao, H., & Liu, Y. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01735-w · Cited by 54 · see citing works
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Schulz, M., & Rink, L. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00511-1 · Cited by 42 · see citing works
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Ho, E., Wong, C. P., & King, J. C. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.12.256 · Cited by 39 · see citing works
Self-citationRebalancing the unbalanced aged immune system – A special focus on zinc
Baarz, B. R., & Rink, L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101541 · Cited by 35 · see citing works
Eggersdorfer, M. L., Berger, M. M., Calder, P. C., Gombart, A. F., Ho, E., Laviano, A., & Meydani, S. N. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac058 · Cited by 31 · see citing works
Self-citationSharma, R., Diwan, B., Sharma, A., & Witkowski, J. M. (2022) · Biogerontology · doi:10.1007/s10522-022-09995-6 · Cited by 29 · see citing works
Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?
Hieber, C., Grabbe, S., & Bros, M. (2023) · Biomolecules · doi:10.3390/biom13071085 · Cited by 28 · see citing works
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Kepp, K. P. (2021) · ChemBioChem · doi:10.1002/cbic.202100554 · Cited by 21 · see citing works
Li, R., Zhan, W., Huang, X., Zhang, L., Sun, Y., Zhang, Z., Bao, W., & Ma, Y. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s330300 · Cited by 17 · see citing works
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Samuelson, D. R., Smith, D. R., Cunningham, K. C., Wyatt, T. A., Hall, S. C., Murry, D. J., Chhonker, Y. S., & Knoell, D. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031022 · Cited by 14 · see citing works
Davis, E. W., Wong, C. P., Arnold, H. K., Kasschau, K. D., Gaulke, C. A., Sharpton, T. J., & Ho, E. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275352 · Cited by 12 · see citing works
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Ding, F., Yu, Y., Zhang, Y., Wei, S., Han, J. H., Li, Z., Jiang, H., Ryu, D., Park, W., Ha, K., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1579266 · Cited by 10 · see citing works
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Duan, H., Guo, Y., Ren, C., Wei, R., & Yan, W. (2024) · Journal of Future Foods · doi:10.1016/j.jfutfo.2024.07.001 · Cited by 7 · see citing works
Yang, Q., Cai, X., Zhu, Y., Hu, Z., Wei, Y., Dang, Q., Zhang, Y., Zhao, X., Jiang, X., & Yu, H. (2023) · Food & Function · doi:10.1039/d3fo00429e · Cited by 7 · see citing works
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Socha‐Banasiak, A., Sputa-Grzegrzółka, P., Grzegrzółka, J., Pacześ, K., Dzięgiel, P., Sordyl, B., Romanowicz, H., & Czkwianianc, E. (2021) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2021/6665697 · Cited by 6 · see citing works
Nikoonezhad, M., Hosseini, A. Z., Kadkhoda, D., Parkhideh, S., Jahankhani, K., Shakiba, Y., Hajifathali, A., Shadnoush, M., & Zahedi, H. (2025) · BMC Immunology · doi:10.1186/s12865-025-00760-1 · Cited by 3 · see citing works
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Nikoonezhad, M., Hosseini, A. Z., Hajifathali, A., Parkhideh, S., Shadnoush, M., Shakiba, Y., & Zahedi, H. (2022) · Research Square · doi:10.21203/rs.3.rs-2408471/v1
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Panagiotidou, E., Gioran, A., & Chondrogianni, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-19247-0.00007-2
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Sahoo, P., Vyas, M., & Sahu, S. K. (2024) · Current Bioactive Compounds · doi:10.2174/0115734072313321240604104711
Kundu, S., Kumar, V., Arora, S., Prasad, S., Singh, C., & Singh, A. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00026-9
Mukherjee, B., Chakraborty, A., Paul, P., Bhattacharya, S., & Das, L. (2025) · Springer eBooks · doi:10.1007/978-981-97-9936-7_22-1
Mukherjee, B., Chakraborty, A., Paul, P., Bhattacharya, S., & Das, L. (2025) · Springer eBooks · doi:10.1007/978-981-96-8622-3_22
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Başaran, A. (2026) · Uluslararası Sağlık Bilimlerinde Disiplinler Arası Etkileşim Dergisi · doi:10.65349/nxpt1964
Zarlashat, Y., Shah, S. S., Seerat-Uz-Zahra, Lorenzo, R. D., & Picca, A. (2026) · Biomolecules · doi:10.3390/biom16101487
- Authors
- Wong, C. P., Magnusson, K. R., Sharpton, T. J., & Ho, E.
- Affiliations
- Oregon State University (US)
- Corresponding author
- Ho, Emily
- Venue
- BioMetals
- Published
- 2021-01-03
- Volume
- 34
- Issue
- 2
- Pages
- 291-301
- ISSN
- 0966-0844 (ISSN-L)
- 1572-8773
- PMC
- PMC8559905
- OpenAlex
- W3120909992
- Cited by
- 46
- References
- 56
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 7 · 2023: 7 · 2022: 12 · 2021: 5
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- BioMetals (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Food and Agriculture (NIFA-2018-67017-27358)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- zinc deficiency, zinc supplementation, immunosenescence, T cell dysfunction, chronic inflammation, aging, Th1/Th17 cytokines, CD4+ T cell subsets, naive T cells, memory T cells, MCP-1, interleukin-6, interferon-gamma, IL-17, TNF-α, zinc intake, older adults
- MeSH terms
- Aging, Animals, Chronic Disease, Inflammation, Lipopolysaccharides, Male, Mice, Inbred C57BL, T-Lymphocytes, Zinc, Cytokines, Dietary Supplements, Mice
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