Nutritional considerations for healthy aging and reduction in age-related chronic disease
Open accessAbstract
A projected doubling in the global population of people aged ≥60 y by the year 2050 has major health and economic implications, especially in developing regions. Burdens of unhealthy aging associated with chronic noncommunicable and other age-related diseases may be largely preventable with lifestyle modification, including diet. However, as adults age they become at risk of "nutritional frailty," which can compromise their ability to meet nutritional requirements at a time when specific nutrient needs may be high. This review highlights the role of nutrition science in promoting healthy aging and in improving the prognosis in cases of age-related diseases. It serves to identify key knowledge gaps and implementation challenges to support adequate nutrition for healthy aging, including applicability of metrics used in body-composition and diet adequacy for older adults and mechanisms to reduce nutritional frailty and to promote diet resilience. This review also discusses management recommendations for several leading chronic conditions common in aging populations, including cognitive decline and dementia, sarcopenia, and compromised immunity to infectious disease. The role of health systems in incorporating nutrition care routinely for those aged ≥60 y and living independently and current actions to address nutritional status before hospitalization and the development of disease are discussed.
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Undernutrition makes older people unable to trigger an efficient immune response to newly encountered pathogens.
“This makes older people enable to trigger an efficient immune response to newly encountered pathogens.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [99]
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Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works
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Zhang, Y., Gu, Z., Xu, Y., He, M., Gerber, B. S., Wang, Z., Liu, F., & Peng, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2023.e23405 · Cited by 26 · see citing works
- Authors
- Shlisky, J., Bloom, D. E., Beaudreault, A. R., Tucker, K. L., Keller, H. H., Freund-Levi, Y., Fielding, R. A., Cheng, F. W., Jensen, G. L., Wu, D., & Meydani, S. N.
- Affiliations
- New York Academy of Sciences (US)
- Harvard University (US)
- University of California, Davis (US)
- University of Massachusetts Lowell (US)
- University of Waterloo (CA)
- Pennsylvania State University (US)
- University of Vermont (US)
- Tufts University (US)
- Corresponding author
- Shlisky, Julie
- ORCID
- Venue
- Advances in Nutrition
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 8
- Issue
- 1
- Pages
- 17-26
- ISSN
- 2156-5376 (ISSN-L)
- 2161-8313
- PMC
- PMC5227979
- OpenAlex
- W2573624341
- Cited by
- 462
- References
- 116
- Citations by year
- 2026: 34 · 2025: 54 · 2024: 63 · 2023: 60 · 2022: 60 · 2021: 72 · 2020: 49 · 2019: 34 · 2018: 27 · 2017: 8 · 2015: 1
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Advances in Nutrition (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- healthy aging, older adults, age-related chronic diseases, non-communicable diseases, diet and lifestyle modification, body composition, diet adequacy, cognitive decline, dementia, sarcopenia, immune function, population aging
- MeSH terms
- Aging, Alzheimer Disease, Chronic Disease, Communicable Diseases, Diet, Humans, Life Style, Nutritional Requirements, Prognosis, Health Behavior, Nutrition Assessment, Randomized Controlled Trials as Topic, Sarcopenia, Observational Studies as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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