Nutritional strategies to boost immunity and prevent infection in elderly individuals

High, Kevin P.

doi:10.1086/324509

Cited by 122Nutrition and Health in AgingNutrition and Health StudiesTrace Elements in Health

Nutritional strategies to boost immunity and prevent infection in elderly individuals

High, Kevin P.·2001·Clinical Infectious Diseases

DOI 10.1086/324509

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Abstract

Older adults are at risk for malnutrition, which may contribute to their increased risk of infection. Nutritional supplementation strategies can reduce this risk and reverse some of the immune dysfunction associated with advanced age. This review discusses nutritional interventions that have been examined in clinical trials of older adults. The data support use of a daily multivitamin or trace-mineral supplement that includes zinc (elemental zinc, >20 mg/day) and selenium (100 microg/day), with additional vitamin E, to achieve a daily dosage of 200 mg/day. Specific syndromes may also be addressed by nutritional interventions (for example, cranberry juice consumption to reduce urinary tract infections) and may reduce antibiotic use in older adults, particularly those living in long-term care facilities. Drug-nutrient interactions are common in elderly individuals, and care providers should be aware of these interactions. Future research should evaluate important clinical end points rather than merely surrogate markers of immunity.

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An insufficient intake of micronutrients in older people has been reported both in the community (vitamins A, B12, D and zinc) and at a higher prevalence in long-term care facilities (vitamins A, D, and E), while lower food intake has been associated with lower intakes of calcium, iron, zinc, B vitamins and vitamin E in older people.
“An insufficient intake of micronutrients in older people has been reported both in the community (vitamins A, B12, D and zinc) and at a higher prevalence in long-term care facilities (vitamins A, D, and E) [101], while lower food intake has been associated with lower intakes of calcium, iron, zinc, B vitamins and vitamin E in older people [100].”
From Immune function and micronutrient requirements change over the life course (2018) · cites this paper as [101]

1 retracted

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Authors: High, K. P.
Affiliations: Wake Forest University Health Sciences (US)
Corresponding author: High, Kevin P.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2001-12
Volume: 33
Issue: 11
Pages: 1892-1900
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1086/324509
OpenAlex: W2100398420
Cited by: 122
References: 98
Citations by year: 2026: 3 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 12 · 2020: 20 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 7 · 2014: 4 · 2013: 5 · 2012: 7
FWCI: 0.88
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r01ai042022-01a1)
National Institute of Allergy and Infectious Diseases (R01 AI 42022)
Topics: Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: older adults, malnutrition, immune dysfunction, infection control, dietary supplementation, multivitamins, zinc supplementation, selenium supplementation, vitamin E, cranberry juice, urinary tract infection, antibiotic use, long-term care facilities, drug-nutrient interactions, dietary intervention
MeSH terms: Aged, Aging, Humans, Infections, Nutrition Disorders, Risk Factors, Randomized Controlled Trials as Topic, Food-Drug Interactions, Appetite Stimulants, Dietary Supplements

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Nutritional strategies to boost immunity and prevent infection in elderly individuals

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