New approaches to selectively target cancer-associated matrix metalloproteinase activity

New functions for the matrix metalloproteinases in cancer progression

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Matrix Metalloproteinases

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The growing impact of click chemistry on drug discovery

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To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

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Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

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International Journal of Nanomedicine

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Dynamic Covalent Chemistry

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Chemistry and biochemistry of dietary polyphenols

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International Journal of Oncology

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Drug Resistance and the Solid Tumor Microenvironment

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Metastatic potential correlates with enzymatic degradation of basement membrane collagen

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Strategies for MMP inhibition in cancer: innovations for the post-trial era

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Matrix Metalloproteinases As Novel Biomarker s and Potential Therapeutic Targets in Human Cancer

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Emerging roles of proteases in tumour suppression

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Protease degradomics: A new challenge for proteomics

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Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

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Determination of protease cleavage site motifs using mixture-based oriented peptide libraries

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Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics

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Green Tea Catechins and Cardiovascular Health: An Update

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Metalloproteinases and their natural inhibitors in inflammation and immunity

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Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint responsePreprint

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MT1‐MMP: A potent modifier of pericellular microenvironment

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Activity-based probes for the proteomic profiling of metalloproteases

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Matrix metalloproteinase inhibition by green tea catechins

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Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

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In search of partners: linking extracellular proteases to substrates

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Peptides and Peptide Hormones for Molecular Imaging and Disease Diagnosis

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Journal of the American Chemical Society

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Anticancer potential of silymarin: from bench to bed side.

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Crystal structures of matrilysin-inhibitor complexes

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Matrix Metalloproteinases as Valid Clinical Target

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Macrophage Metalloelastase Degrades Matrix and Myelin Proteins and Processes a Tumour Necrosis Factor-α Fusion Protein

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Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1

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Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways

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Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC δ signal transduction

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Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members

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Paclitaxel: biosynthesis, production and future prospects

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PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy

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Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages

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Green tea polyphenol (−)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells

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Imaging matrix metalloproteinases in cancer

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New approaches for dissecting protease functions to improve probe development and drug discovery

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Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

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Quantitative imaging of disease signatures through radioactive decay signal conversion

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Development of Novel Tumor‐Targeted Theranostic Nanoparticles Activated by Membrane‐Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy

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New Beginnings for Matrix Metalloproteinase Inhibitors: Identification of High-Affinity Zinc-Binding Groups

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Ageladine A: An Antiangiogenic Matrixmetalloproteinase Inhibitor from the Marine Sponge Agelas nakamurai

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Cysteine Array Matrix Metalloproteinase (CA-MMP)/MMP-23 Is a Type II Transmembrane Matrix Metalloproteinase Regulated by a Single Cleavage for Both Secretion and Activation

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Crystal Structures of MMP-9 Complexes with Five Inhibitors: Contribution of the Flexible Arg424 Side-chain to Selectivity

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Curcumin Inhibits SK-Hep-1 Hepatocellular Carcinoma Cell Invasion in vitro and Suppresses Matrix Metalloproteinase-9 Secretion

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Enhancing cellular uptake of activable cell-penetrating peptide–doxorubicin conjugate by enzymatic cleavage

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MT1-MMP Is Required for Myeloid Cell Fusion via Regulation of Rac1 Signaling

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Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials

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Anti-Invasive Gene Expression Profile of Curcumin in Lung Adenocarcinoma Based on a High Throughput Microarray Analysis

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Enzyme-Directed Assembly of Nanoparticles in Tumors Monitored by in Vivo Whole Animal Imaging and ex Vivo Super-Resolution Fluorescence Imaging

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In Situ “Click” Assembly of Small Molecule Matrix Metalloprotease Inhibitors Containing Zinc-Chelating Groups

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Membrane-Type Matrix Metalloproteinases (MT-MMPs) in Cell Invasion

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Trastuzumab Emtansine (T-DM1): A Novel Agent for Targeting HER2+ Breast Cancer

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Bioluminescent nanosensors for protease detection based upon gold nanoparticle–luciferase conjugates

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Bevacizumab: overview of the literature

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Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro

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Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism‐based selective gelatinase inhibitor

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Anti-angiogenic activity of resveratrol, a natural compound from medicinal plants

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Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors

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Optical Imaging of Matrix Metalloproteinase-7 Activity in Vivo Using a Proteolytic Nanobeacon

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Evaluation of shark cartilage in patients with advanced cancer

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Third generation of matrix metalloprotease inhibitors: Gain in selectivity by targeting the depth of the S1′ cavity

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The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90βPreprint

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Natural Bio-Drugs as Matrix Metalloproteinase Inhibitors: New Perspectives on the Horizon?

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Detection of MMP-2 and MMP-9 Activity in Vivo with a Triple-Helical Peptide Optical Probe

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Effect of curcumin on gelatinase A (MMP-2) activity in B16F10 melanoma cells

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(−)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis

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Selective matrix metalloproteinase (MMP) inhibitors in cancer therapy: Ready for prime time?

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Trial Watch

Vacchelli, E., Aranda, F., Eggermont, A. M. M., Galon, J., Sautès‐Fridman, C., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2014) · OncoImmunology · doi:10.4161/onci.27048 · Cited by 81 · see citing works

Anti‐neovascular therapy by liposomal drug targeted to membrane type‐1 matrix metalloproteinase

Kondo, M., Asai, T., Katanasaka, Y., Sadzuka, Y., Tsukada, H., Ogino, K., Taki, T., Baba, K., & Oku, N. (2003) · International Journal of Cancer · doi:10.1002/ijc.11526 · Cited by 79 · see citing works

Heterocyclic zinc-binding groups for use in next-generation matrix metalloproteinase inhibitors: potency, toxicity, and reactivity

Puerta, D. T., Griffin, M. O., Lewis, J. A., Romero‐Perez, D., Garcia, R. A., Villarreal, F. J., & Cohen, S. M. (2005) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-005-0053-x · Cited by 78 · see citing works

The Citrus Flavonoid, Nobiletin, Inhibits Peritoneal Dissemination of Human Gastric Carcinoma in SCID Mice

Minagawa, A., Otani, Y., Kubota, T., Wada, N., Furukawa, T., Kumai, K., Kameyama, K., Okada, Y., Fujii, M., Yano, M., et al. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb02156.x · Cited by 77 · see citing works

X-ray Absorption Studies of Human Matrix Metalloproteinase-2 (MMP-2) Bound to a Highly Selective Mechanism-based Inhibitor

Kleifeld, O., Kotra, L. P., Gervasi, D. C., Brown, S., Bernardo, M. M., Fridman, R. A., Mobashery, S., & Sagi, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011604200 · Cited by 73 · see citing works

Chemoradiotherapy With or Without AE-941 in Stage III Non–Small Cell Lung Cancer: A Randomized Phase III Trial

Lu, C. S., Lee, J. J., Komaki, R. U., Herbst, R. S., Feng, L., Evans, W. K., Choy, H., Desjardins, P., Esparaz, B. T., Truong, M. T., et al. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq179 · Cited by 71 · see citing works

Clinical Pharmacology: Advances and Applications

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Depolymerized Products of λ-Carrageenan as a Potent Angiogenesis Inhibitor

Chen, H., Yan, X., Lin, J., Wang, F., & Xu, W. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070183+ · Cited by 60 · see citing works

Inhibition of host extracellular matrix destructive enzyme production and activity by a high‐molecular‐weight cranberry fraction

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Intelligently Targeted Drug Delivery and Enhanced Antitumor Effect by Gelatinase-Responsive Nanoparticles

Li, R., Wu, W., Liu, Q., Wu, P., Li, X., Zhu, Z., Yang, M., Qian, X., Ding, Y., Yu, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069643 · Cited by 56 · see citing works

Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin.

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Genistein inhibits both constitutive and EGF-stimulated invasion in ER-negative human breast carcinoma cell lines.

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Citrus auraptene targets translation of MMP‐7 (matrilysin) via ERK1/2‐dependent and mTOR‐independent mechanism

Kawabata, K., Murakami, A., & Ohigashi, H. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.08.072 · Cited by 53 · see citing works

Activation of protein kinase C βII/ε-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin

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Using tetracyclines to treat osteoporotic/osteopenic bone loss: From the basic science laboratory to the clinic

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Biphenyl Sulfonylamino Methyl Bisphosphonic Acids as Inhibitors of Matrix Metalloproteinases and Bone Resorption

Rubino, M. T., Agamennone, M., Campestre, C., Campiglia, P., Cremasco, V., Faccio, R., Laghezza, A., Loiodice, F., Maggi, D., Panza, E., et al. (2011) · ChemMedChem · doi:10.1002/cmdc.201000540 · Cited by 48 · see citing works

A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1–MMP

Shiryaev, S. A., Remacle, A. G., Golubkov, V. S., Ingvarsen, S., Porse, A., Behrendt, N., Cieplak, P., & Strongin, A. Y. (2013) · Oncogenesis · doi:10.1038/oncsis.2013.44 · Cited by 45 · see citing works

An Osteoblast-Derived Proteinase Controls Tumor Cell Survival via TGF-beta Activation in the Bone Microenvironment

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Distinct chemical factors in hydrolytic reactions catalyzed by metalloenzymes and metal complexes

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Abiotic Mimic of Matrix Metalloproteinase-9 Inhibitor against Advanced Metastatic Cancer

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Toad skin extract cinobufatini inhibits migration of human breast carcinoma MDA-MB-231 cells into a model stromal tissue

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Nanoparticle-based Probes to Enable Noninvasive Imaging of Proteolytic Activity for Cancer Diagnosis

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Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II

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SPARC Negatively Correlates With Prognosis After Transarterial Chemoembolization and Facilitates Proliferation and Metastasis of Hepatocellular Carcinoma via ERK/MMP Signaling Pathways

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A Hyaluronan and Proteoglycan Link Protein 1 Matrikine: Role of Matrix Metalloproteinase 2 in Multiple Myeloma NF-κB Activation and Drug Resistance

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The multiple roles of actin-binding proteins at invadopodia

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The effect of porosity and stiffness of glutaraldehyde cross-linked egg white scaffold simulating aged extracellular matrix on distribution and aggregation of ovarian cancer cells

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Employing comparative QSAR techniques for the recognition of dibenzofuran and dibenzothiophene derivatives toward MMP-12 inhibition

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Constructing and Validating 3D-pharmacophore Models to a Set of MMP-9 Inhibitors for Designing Novel Anti-melanoma Agents

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Matrix Metalloproteinases (MMPs) in Targeted Drug Delivery: Synthesis of a Potent and Highly Selective Inhibitor against Matrix Metalloproteinase-7

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Matrix Metalloproteinase 13 Inhibitors for Modulation of Osteoclastogenesis: Enhancement of Solubility and Stability

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An aqueous extract from toad skin prevents gelatinase activities derived from fetal serum albumin and serum-free culture medium of human breast carcinoma MDA-MB-231 cells

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Collagenolytic Matrix Metalloproteinases in Chronic Obstructive Lung Disease and Cancer

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Discovery of a d-pro-lys peptidomimetic inhibitor of MMP9: Addressing the gelatinase selectivity beyond S1′ subsite

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Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases

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Quantum Dot-Based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases

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C-peptide exhibits a late induction effect on matrix metallopeptidase-9 in high glucose-stimulated rat mesangial cells

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Cancer stem cells, their origin and niche: A search for the therapeutic target

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Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy

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Antitumor Effects of Sesamin via the LincRNA-p21/STAT3 Axis in Human Bladder Cancer: Inhibition of Metastatic Progression and Enhanced Chemosensitivity

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Naringin, a natural flavonone glycoside attenuates N-nitrosodiethylamine- induced hepatocellular carcinoma in sprague-dawley rats

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Metalloprotein-Based Nanomedicines: Design Strategies, Functional Mechanisms, and Biomedical Applications

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Matrix metalloproteases

Trabocchi, A., & Lenci, E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823974-2.00033-4 · Cited by 3 · see citing works

Effect of Octopine on Oxidative Stress Indices and Serum Levels of Lipids and Trace Elements in Mice with Breast Cancer

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The effect of opine on matrix metalloproteinase expression in mice with breast cancer

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Matrix Metalloproteinase-Responsive Superparamagnetic Iron Oxide Nanoparticles (SPIONs) to Distinguish Between Aggressive and Indolent Cancer

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Tissue Infiltration of Tumor-Associated Macrophages: Towards the Identification of Therapeutic Targets

Sanchez, T., Lagarrigue, F., & Cabec, V. L. (2021) · Internal Medicine Research – Open Journal · doi:10.31038/imroj.2021611 · Cited by 1 · see citing works

Aplicação de modelagem molecular e de formalismo do CAMD (Computer-Aided Molecular Design) na elucidação do mecanismo de ação de inibidores de metalopropteinases de matriz

Turra, K. M. (2017) · doi:10.11606/t.9.2017.tde-18022016-105120

The cutting edge of platelets

Andrews, R. K., & Gardiner, E. E. (2017) · Platelets · doi:10.1080/09537104.2017.1338397

BindingDB Entry 50013169: Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II.

BindingDB (2022) · UC San Diego · doi:10.7270/q2ww7nf0

BindingDB Entry 50001045: Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases.

BindingDB (2020) · UC San Diego · doi:10.7270/q2ms3w8m

BindingDB Entry 50011338: TBA

BindingDB (2022) · UC San Diego · doi:10.7270/q2474ff0

MMPs

Fingleton, B. (2014) · Springer eBooks · doi:10.1007/978-1-4614-6613-0_21-3

Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes

Winer, A., Adams, S., & Mignatti, P. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0646 · Cited by 659 · see citing works

Moving targets: Emerging roles for MMPs in cancer progression and metastasis

Shay, G., Lynch, C. C., & Fingleton, B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.01.019 · Cited by 424 · see citing works

Matrix metalloproteinase inhibitors (MMPIs) as attractive therapeutic targets: Recent progress and current challenges

Shi, Y., Ma, X., Ge, F., Tian, X., & Ge, C. (2021) · NanoImpact · doi:10.1016/j.impact.2021.100293 · Cited by 44 · see citing works

Inhibitors of matrix metalloproteinases in clinical trials

Jamialahmadi, K., & Noruzi, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26635-5.00056-0