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Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

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Tarantini, Stefano, Tran, Cam Ha T., Gordon, Grant R., Ungvari, Zoltan, Csiszar, Anna·2017·Experimental Gerontology
DOI 10.1016/j.exger.2016.11.004PMC PMC5429210
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Abstract

The importance of (micro)vascular contributions to cognitive impairment and dementia (VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age-related cerebromicrovascular pathologies are a subject of intensive research. In particular, aging impairs the increase in cerebral blood flow triggered by neural activation (termed neurovascular coupling or functional hyperemia), a critical mechanism that matches oxygen and nutrient delivery with the increased demands in active brain regions. From epidemiological, clinical and experimental studies the picture emerges of a complex functional impairment of cerebral microvessels and astrocytes, which likely contribute to neurovascular dysfunction and cognitive decline in aging and in age-related neurodegenerative diseases. This overview discusses age-related alterations in neurovascular coupling responses responsible for impaired functional hyperemia. The mechanisms and consequences of astrocyte dysfunction (including potential alteration of astrocytic endfeet calcium signaling, dysregulation of eicosanoid gliotransmitters and astrocyte energetics) and functional impairment of the microvascular endothelium are explored. Age-related mechanisms (cellular oxidative stress, senescence, circulating IGF-1 deficiency) impairing the function of cells of the neurovascular unit are discussed and the evidence for the causal role of neurovascular uncoupling in cognitive decline is critically examined.

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  • Aging-induced dysregulation of microvascular endothelial function and phenotype critically contributes to the pathogenesis of both vascular cognitive impairment (VCI) and Alzheimer's disease (AD).

    “There is strong evidence that aging-induced dysregulation of microvascular endothelial function and phenotype critically contributes to the pathogenesis of both vascular cognitive impairment (VCI) and Alzheimer ' s disease (AD)”

    From Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain (2020) · cites this paper as Tarantini et al. 2017a

    The Introduction section on oxidative stress and endothelial dysfunction says age-related endothelial dysfunction contributes significantly to neurovascular uncoupling, and the section on Alzheimer’s disease describes growing evidence for a causal role of microvascular alterations in AD. The paper does not establish that aging-induced changes in endothelial function and phenotype critically cause the pathogenesis of both VCI and AD; it presents a narrower, partly qualified account of neurovascular dysfunction and cognitive decline. Page numbers are not available in our copy. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Tarantini, S., Tran, C. H. T., Gordon, G. R., Ungvari, Z., & Csiszar, A.
Affiliations
  • University of Oklahoma Health Sciences Center (US)
  • University of Calgary (CA)
ORCID
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2017-08
Volume
94
Pages
52-58
ISSN
0531-5565 (ISSN-L)
DOI
10.1016/j.exger.2016.11.004
PMC
PMC5429210
OpenAlex
W2552241218
Cited by
411
References
10
Citations by year
2026: 37 · 2025: 34 · 2024: 42 · 2023: 58 · 2022: 56 · 2021: 52 · 2020: 40 · 2019: 44 · 2018: 27 · 2017: 21
FWCI
2.69
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Heart Association
  • National Center for Complementary and Alternative Medicine (R01-AT006526)
  • National Institute on Aging (R01-AG047879, R01-AG038747, 3P30AG050911-02S1)
  • National Institute of Neurological Disorders and Stroke (R01-NS056218)
  • Arkansas Medical Center (P30 AG028718)
  • Oklahoma Center for the Advancement of Science and Technology
  • Reynolds Foundation
  • Canadian Institutes of Health Research
  • Canada Research Chair
  • Alberta Innovates Health Solutions
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
neurovascular coupling, functional hyperemia, aging, Alzheimer's disease, vascular cognitive impairment and dementia, astrocyte dysfunction, endothelial dysfunction, cerebral microvasculature, astrocyte calcium signaling, oxidative stress, cellular senescence, IGF-1 deficiency, neurovascular unit, cognitive decline
MeSH terms
Cognitive Aging, Neurovascular Coupling, Age Factors, Alzheimer Disease, Animals, Astrocytes, Cerebrovascular Circulation, Cognition, Cognition Disorders, Endothelium, Vascular, Humans, Insulin-Like Growth Factor I, Microcirculation, Cellular Senescence, Oxidative Stress, Calcium Signaling

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