The DOI matches its Crossref record; 472 of the 472 references it cites were found in a registry or an index.
Dopamine: Functions, Signaling, and Association with Neurological Diseases
Open accessAbstract
The dopaminergic system plays important roles in neuromodulation, such as motor control, motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a neurotransmitter, synthesized in both central nervous system and the periphery, that exerts its actions upon binding to G protein-coupled receptors. Dopamine receptors are widely expressed in the body and function in both the peripheral and the central nervous systems. Dopaminergic signaling pathways are crucial to the maintenance of physiological processes and an unbalanced activity may lead to dysfunctions that are related to neurodegenerative diseases. Unveiling the neurobiology and the molecular mechanisms that underlie these illnesses may contribute to the development of new therapies that could promote a better quality of life for patients worldwide. In this review, we summarize the aspects of dopamine as a catecholaminergic neurotransmitter and discuss dopamine signaling pathways elicited through dopamine receptor activation in normal brain function. Furthermore, we describe the potential involvement of these signaling pathways in evoking the onset and progression of some diseases in the nervous system, such as Parkinson's, Schizophrenia, Huntington's, Attention Deficit and Hyperactivity Disorder, and Addiction. A brief description of new dopaminergic drugs recently approved and under development treatments for these ailments is also provided.
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“An extensive literature implicates shared alterations in the reward circuitry in MDD, neurodegenerative disorders, and obesity261-263.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [263]
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From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [16]
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From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [16]
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Teleanu, R. I., Niculescu, A.-G., Roza, E., Vladâcenco, O. A., Grumezescu, A. M., & Teleanu, D. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115954 · Cited by 659
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Dopamine in Parkinson's disease
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Metadata
- Authors
- Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G.
- Affiliations
- Universidade de São Paulo (BR)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Bittencourt, Jackson C.
- Correa, Ricardo G.
- ORCID
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2018-11-16
- Volume
- 39
- Issue
- 1
- Pages
- 31-59
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC11469830
- OpenAlex
- W2901208536
- Cited by
- 1,073
- References
- 472
- Citations by year
- 2026: 141 · 2025: 174 · 2024: 214 · 2023: 199 · 2022: 148 · 2021: 105 · 2020: 64 · 2019: 27
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine, dopaminergic signaling, dopamine receptors, G protein-coupled receptors, catecholamine neurotransmitters, neuromodulation, neurodegenerative diseases, Parkinson's disease, schizophrenia, Huntington's disease, attention deficit hyperactivity disorder, addiction, dopaminergic therapy, reward and motivation
- MeSH terms
- Animals, Brain, Dopamine, Humans, Models, Biological, Nervous System Diseases, Signal Transduction
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