Cited by 1,073Neurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 472 of the 472 references it cites were found in a registry or an index.

Dopamine: Functions, Signaling, and Association with Neurological Diseases

Open access

Klein, Marianne O., Battagello, Daniella S., Cardoso, Ariel R., Hauser, David N., Bittencourt, Jackson C., Correa, Ricardo G.·2019·Cellular and Molecular Neurobiology

DOI 10.1007/s10571-018-0632-3PMC PMC11469830

Open this paper in CoChat — free account

Abstract

The dopaminergic system plays important roles in neuromodulation, such as motor control, motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a neurotransmitter, synthesized in both central nervous system and the periphery, that exerts its actions upon binding to G protein-coupled receptors. Dopamine receptors are widely expressed in the body and function in both the peripheral and the central nervous systems. Dopaminergic signaling pathways are crucial to the maintenance of physiological processes and an unbalanced activity may lead to dysfunctions that are related to neurodegenerative diseases. Unveiling the neurobiology and the molecular mechanisms that underlie these illnesses may contribute to the development of new therapies that could promote a better quality of life for patients worldwide. In this review, we summarize the aspects of dopamine as a catecholaminergic neurotransmitter and discuss dopamine signaling pathways elicited through dopamine receptor activation in normal brain function. Furthermore, we describe the potential involvement of these signaling pathways in evoking the onset and progression of some diseases in the nervous system, such as Parkinson's, Schizophrenia, Huntington's, Attention Deficit and Hyperactivity Disorder, and Addiction. A brief description of new dopaminergic drugs recently approved and under development treatments for these ailments is also provided.

Integrity signals

Registry

Crossref · 10.1007/s10571-018-0632-3

Cites

472 of 472 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Principles of neural science
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,150
α-Synuclein in Lewy bodies
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366
MDS clinical diagnostic criteria for Parkinson’s disease
Postuma, R. B., Berg, D., Stern, M., Poewe, W., Olanow, C. W., Oertel, W., Obeso, J., Marek, K., Litvan, I., Lang, A. E., et al. (2015) · Movement Disorders · doi:10.1002/mds.26424 · Cited by 7,653
Parkinson's disease
Kalia, L. V., & Lang, A. E. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61393-3 · Cited by 6,184
Parkinson's Disease
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
The worldwide prevalence of ADHD: a systematic review and metaregression analysis
Polanczyk, G., de Lima, M. S., Horta, B. L., Biederman, J., & Rohde, L. A. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.6.942 · Cited by 5,346
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
Multiple receptors for dopamine
Kebabian, J. W., & Calne, D. B. (1979) · Nature · doi:10.1038/277093a0 · Cited by 3,756
Glutamate receptor ion channels
Mayer, M. L. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.004 · Cited by 3,655
Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY
FEARNLEY, J. M., & LEES, A. J. (1991) · Brain · doi:10.1093/brain/114.5.2283 · Cited by 3,529
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
Gibb, W. R., & Lees, A. J. (1988) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.6.745 · Cited by 3,481
Stress and disorders of the stress system
Chrousos, G. P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.106 · Cited by 3,215
Targeting the phosphoinositide 3-kinase pathway in cancer
Liu, P., Cheng, H.-L. M., Roberts, T. M., & Zhao, J. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2926 · Cited by 2,785
The physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763
Seven-transmembrane receptors
Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,712
Huntington's disease
Walker, F. O. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60111-1 · Cited by 2,691
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
Pathological roles of MAPK signaling pathways in human diseases
Kim, E. K., & Choi, E.-J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.12.009 · Cited by 2,472
Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357
Tyrosine Hydroxylase
Nagatsu, T., Levitt, M., & Udenfriend, S. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93832-9 · Cited by 2,067
Neurobiology of the structure of personality: Dopamine, facilitation of incentive motivation, and extraversion
Depue, R. A., & Collins, P. F. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002046 · Cited by 2,046
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
Tol, H. H. M. V., Bunzow, J. R., Guan, H., Sunahara, R. K., Seeman, P. M., Niznik, H. B., & Civelli, O. (1991) · Nature · doi:10.1038/350610a0 · Cited by 2,015
Principles of Neural Science
Zăgrean, L. (2014) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2014.529 · Cited by 1,922
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885
Schizophrenia
Owen, M. J., Sawa, A., & Mortensen, P. B. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01121-6 · Cited by 1,870
Brain dopamine and obesity
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864
Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831
Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes
Castellanos, F. X., & Tannock, R. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn896 · Cited by 1,827
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling
Ferguson, S. S. G. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01478-9 · Cited by 1,827
Primate anterior cingulate cortex: Where motor control, drive and cognition interface
Paus, T. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077500 · Cited by 1,722
Modulation of Striatal Projection Systems by Dopamine
Gerfen, C. R., & Surmeier, D. J. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113641 · Cited by 1,700
Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis
Simon, V., Czobor, P., Bálint, S., Mészáros, Á., & Bitter, I. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.107.048827 · Cited by 1,601
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,505
The primate basal ganglia: Parallel and integrative networks
Haber, S. N. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2003.10.003 · Cited by 1,479
Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477
MAPK cascade signalling and synaptic plasticity
Thomas, G. M., & Huganir, R. L. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1346 · Cited by 1,454
The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450
The mysterious motivational functions of mesolimbic dopamine
Salamone, J. D., & Correa, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.021 · Cited by 1,418
β-Arrestins and Cell Signaling
DeWire, S. M., Ahn, S., Lefkowitz, R. J., & Shenoy, S. K. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.022405.154749 · Cited by 1,397
G PROTEIN–COUPLED RECEPTOR KINASES
Pitcher, J. A., Freedman, N. J., & Lefkowitz, R. J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.653 · Cited by 1,370
Attention-Deficit/Hyperactivity Disorder: A Selective Overview
Biederman, J. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.020 · Cited by 1,343
Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons
Watabe‐Uchida, M., Zhu, L., Ogawa, S. K., Vamanrao, A., & Uchida, N. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.017 · Cited by 1,277
General hospital psychiatry: the Italian experience.
Faraone, S. V., Sergeant, J. A., Gillberg, C., & Biederman, J. (2003) · Europe PMC (PubMed Central) · Cited by 1,277
3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists
Carlsson, A., Lindqvist, M., & Magnusson, T. (1957) · Nature · doi:10.1038/1801200a0 · Cited by 1,272
Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers
Reitz, C., & Mayeux, R. P. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.024 · Cited by 1,271
Affective neuroscience of pleasure: reward in humans and animals
Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254
β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
Lohse, M. J., Benovic, J., Codina, J., Caron, M. G., & Lefkowitz, R. J. (1990) · Science · doi:10.1126/science.2163110 · Cited by 1,222
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203
PI3K/AKT signaling pathway and cancer: an updated review
Martini, M., Santis, M. C. D., Braccini, L., Gulluni, F., & Hirsch, E. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.912836 · Cited by 1,195
Neurobehavioural mechanisms of reward and motivation
Robbins, T. W., & Everitt, B. J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80077-8 · Cited by 1,187
Schizophrenia
Kahn, R. S., Sommer, I. E., Murray, R. M., Meyer‐Lindenberg, A., Weinberger, D. R., Cannon, T. D., O’Donovan, M. C., Correll, C. U., Kane, J. M., van Os, J., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.67 · Cited by 1,163
Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring
Stephan, K. E., Friston, K. J., & Frith, C. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn176 · Cited by 1,134
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
Luttrell, L. M., & Lefkowitz, R. J. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.3.455 · Cited by 1,123
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
Chang, D., Nalls, M. A., Hallgrímsdóttir, I. B., Hunkapiller, J., van der Brug, M., Cai, F., International Parkinson's Disease Genomics Consortium, 23andMe Research Team, Kerchner, G. A., Ayalon, G., et al. (2017) · Nature Genetics · doi:10.1038/ng.3955 · Cited by 1,112
Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106
Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease
Carlsson, M. L., & Carlsson, A. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90108-m · Cited by 1,086
Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine
Eisenhofer, G., Kopin, I. J., & Goldstein, D. S. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.1 · Cited by 1,072
The basal ganglia
Graybiel, A. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00593-5 · Cited by 1,051
Huntington's disease: a clinical review
Roos, R. A. C. (2010) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-5-40 · Cited by 1,049
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034
Neuroscience of addiction
Koob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026
Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the “dopamine receptor”
Kebabian, J. W., Petzold, G. L., & Greengard, P. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.8.2145 · Cited by 1,025
Central mechanisms of motor skill learning
Hikosaka, O., Nakamura, K., Sakai, K., & Nakahara, H. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00307-0 · Cited by 1,023
Candidate gene studies of ADHD: a meta-analytic review
Gizer, I. R., Ficks, C., & Waldman, I. D. (2009) · Human Genetics · doi:10.1007/s00439-009-0694-x · Cited by 1,020
Clinical progression in Parkinson disease and the neurobiology of axons
Cheng, H., Ulane, C. M., & Burke, R. E. (2010) · Annals of Neurology · doi:10.1002/ana.21995 · Cited by 1,012
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
Beaulieu, J., Sotnikova, T. D., Marion, S., Lefkowitz, R. J., Gainetdinov, R. R., & Caron, M. G. (2005) · Cell · doi:10.1016/j.cell.2005.05.012 · Cited by 1,005
Imaging dopamine's role in drug abuse and addiction
Volkow, N. D., Fowler, J. S., Wang, G. J., Baler, R., & Telang, F. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.022 · Cited by 988
Dopamine as a Prolactin (PRL) Inhibitor
Ben-Jonathan, N., & Hnasko, R. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.6.0451 · Cited by 983
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
Horvitz, J. C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00019-1 · Cited by 967
Impulsive choice induced in rats by lesions of the nucleus accumbens core
Cardinal, R. N., Pennicott, D. R., Lakmali, C., Sugathapala, Robbins, T. W., & Everitt, B. J. (2001) · Science · doi:10.1126/science.1060818 · Cited by 923
Trace amines: Identification of a family of mammalian G protein-coupled receptors
Borowsky, B., Adham, N., JONES, K. A., Raddatz, R., Artymyshyn, R. P., Ogozalek, K. L., Durkin, M. M., Lakhlani, P. P., Bonini, J. A., Pathirana, S. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151105198 · Cited by 912
Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway
Dolmetsch, R. E., Pajvani, U., Fife, K., Spotts, J. M., & Greenberg, M. E. (2001) · Science · doi:10.1126/science.1063395 · Cited by 900
Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans
Werhahn, K. J., Kunesch, E., Noachtar, S., Benecke, R., & Classen, J. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0591t.x · Cited by 887
Role of Serotonin in the Paradoxical Calming Effect of Psychostimulants on Hyperactivity
Gainetdinov, R. R., Wetsel, W. C., Jones, S. R., Levin, E. D., Jaber, M., & Caron, M. G. (1999) · Science · doi:10.1126/science.283.5400.397 · Cited by 885
The Neurobiology of Slow Synaptic Transmission
Greengard, P. (2001) · Science · doi:10.1126/science.294.5544.1024 · Cited by 865
Über humorale übertragbarkeit der Herznervenwirkung
Loewi, O. (1921) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf01738910 · Cited by 864
Structure and function of dopamine receptors
Vallone, D., Picetti, R., & Borrelli, E. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00063-9 · Cited by 857
Nonvesicular release of neurotransmitter
Attwell, D., Barbour, B., & Szatkowski, M. S. (1993) · Neuron · doi:10.1016/0896-6273(93)90145-h · Cited by 840
Direct and indirect pathways of basal ganglia: a critical reappraisal
Calabresi, P., Picconi, B., Tozzi, A., Ghiglieri, V., & Filippo, M. D. (2014) · Nature Neuroscience · doi:10.1038/nn.3743 · Cited by 820
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
Beaulieu, J., Sotnikova, T. D., Yao, W., Kockeritz, L. K., Woodgett, J. R., Gainetdinov, R. R., & Caron, M. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307921101 · Cited by 815
BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.
Spector, S., Sjoerdsma, A., & Udenfriend, S. (1965) · PubMed · Cited by 812
Inositol trisphosphate and calcium signalling mechanisms
Berridge, M. J. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.10.005 · Cited by 797
Recent Advances in the Molecular Biology of Dopamine Receptors
Gingrich, J. A., & Caron, M. G. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.001503 · Cited by 795
Non‐motor symptoms in Parkinson’s disease
Poewe, W. H. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02056.x · Cited by 790
The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease
Berridge, M. J. (2016) · Physiological Reviews · doi:10.1152/physrev.00006.2016 · Cited by 779
Role of Transmitter Uptake Mechanisms in Synaptic Neurotransmission
Iversen, L. L. (1971) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1971.tb07066.x · Cited by 776
The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes
Bilder, R. M., Volavka, J., Lachman, H. M., & Grace, A. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300542 · Cited by 769
Dopaminergic modulation of synaptic transmission in cortex and striatum
Tritsch, N. X., & Sabatini, B. L. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.023 · Cited by 756
Tyrosine, Phenylalanine, and Catecholamine Synthesis and Function in the Brain2
Fernstrom, J. D., & Fernstrom, M. H. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.6.1539s · Cited by 755
Parkinson disease: from pathology to molecular disease mechanisms
Dexter, D. T., & Jenner, P. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.018 · Cited by 751
DARPP-32: An Integrator of Neurotransmission
Svenningsson, P., Nishi, A., Fisone, G., Girault, J., Nairn, A. C., & Greengard, P. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121415 · Cited by 737
Blood–brain barrier dysfunction in parkinsonian midbrain in vivo
Kortekaas, R., Leenders, K. L., van Oostrom, J. C. H., Vaalburg, W., Bart, J., Willemsen, A. T. M., & Hendrikse, N. H. (2005) · Annals of Neurology · doi:10.1002/ana.20369 · Cited by 733
Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling
Hollinger, S., & Hepler, J. R. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.527 · Cited by 731
Neurobiology of Schizophrenia
Ross, C. A., Margolis, R. L., Reading, S. A. J., Pletnikov, M. V., & Coyle, J. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.015 · Cited by 719
LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β
Peineau, S., Taghibiglou, C., Bradley, C. A., Wong, T. P., Liu, L., Lu, J., Lo, E., Wu, D., Saule, E., Bouschet, T., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.029 · Cited by 709
Brain receptors for antipsychotic drugs and dopamine: direct binding assays.
Seeman, P. M., Chau-Wong, M., Tedesco, J., & Wong, K. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.11.4376 · Cited by 702
Alternative splicing directs the expression of two D2 dopamine receptor isoforms
Giros, B., Sokoloff, P., Martres, M., Riou, J., Emorine, L. J., & Schwartz, J.-C. (1989) · Nature · doi:10.1038/342923a0 · Cited by 698
The dopamine theory of addiction: 40 years of highs and lows
Nutt, D., Lingford-Hughes, A. R., Erritzøe, D., & Stokes, P. R. A. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3939 · Cited by 696
Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines
Morón, J. A., Brockington, A., Wise, R. A., Rocha, B. A., & Hope, B. T. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00389.2002 · Cited by 681
Precursor control of neurotransmitter synthesis.
Wurtman, R. J., Hefti, F. F., & Melamed, E. (1980) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06841-3 · Cited by 674
Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin.
Lévesque, D., Díaz, J., Pilon, C., Martres, M., Bruno Giros, A., Souil, E., Schott, D., Morgat, J. L., Schwartz, J., & Sokoloff, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8155 · Cited by 674
Psychobiology of novelty seeking and drug seeking behavior
Bardo, M. T., Donohew, R. L., & Harrington, N. G. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00203-0 · Cited by 667
Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors
Fambrough, D. M., Drachman, D. B., & Satya‐Murti, S. (1973) · Science · doi:10.1126/science.182.4109.293 · Cited by 641
The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia
Howes, O. D., McCutcheon, R. A., Owen, M. J., & Murray, R. M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.07.014 · Cited by 640
PKB/AKT: functional insights from genetic models
Scheid, M. P., & Woodgett, J. R. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096067 · Cited by 614
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum
Valjent, E., Pascoli, V., Svenningsson, P., Paul, S., Enslen, H., Corvol, J.-C., Stipanovich, A., Caboche, J., Lombroso, P. J., Nairn, A. C., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408305102 · Cited by 614
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1
Hemmings, H. C., Greengard, P., Tung, H. Y. L., & Cohen, P. (1984) · Nature · doi:10.1038/310503a0 · Cited by 613
Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD)
Li, D., Sham, P. C., Owen, M. J., & He, L. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl152 · Cited by 602
The dopamine D2 receptor: two molecular forms generated by alternative splicing.
Toso, R. D., Sommer, B., Ewert, M., Herb, A., Pritchett, D. B., Bach, A., Shivers, B. D., & SEEBURG, P. H. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08585.x · Cited by 600
Dopaminergic Network Differences in Human Impulsivity
Buckholtz, J. W., Treadway, M. T., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Shelby, E. S., Smith, C. E., et al. (2010) · Science · doi:10.1126/science.1185778 · Cited by 600
The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors
Lee, S., Hjerling-Leffler, J., Zagha, E., Fishell, G., & Rudy, B. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1869-10.2010 · Cited by 600
Schizophrenia
Freedman, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035458 · Cited by 598
Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function
Angers, S., Salahpour, A., & Bouvier, M. (2002) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.091701.082314 · Cited by 587
Involvement of the Extracellular Signal-Regulated Kinase Cascade for Cocaine-Rewarding Properties
Valjent, E., Corvol, J., Pagès, C., Besson, M., Maldonado, R. J., & Caboche, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08701.2000 · Cited by 571
PRESYNAPTIC IONOTROPIC RECEPTORS AND THE CONTROL OF TRANSMITTER RELEASE
MacDermott, A. B., Role, L. W., & Siegelbaum, S. A. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.443 · Cited by 570
Intercellular communication in the brain: Wiring versus volume transmission
Agnati, L. F., Zoli, M., Strömberg, I., & Fuxé, K. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00308-6 · Cited by 569
Dopamine Signaling in reward-related behaviors
Baik, J. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00152 · Cited by 568
Dopamine receptors – IUPHAR R eview 13
Beaulieu, J., Espinoza, S., & Gainetdinov, R. R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12906 · Cited by 561
Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis
Carlezon, W. A., & Thomas, M. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.075 · Cited by 561
Dissociation in Effects of Lesions of the Nucleus Accumbens Core and Shell on Appetitive Pavlovian Approach Behavior and the Potentiation of Conditioned Reinforcement and Locomotor Activity byd-Amphetamine
Parkinson, J. A., Olmstead, M. C., Burns, L. H., Robbins, T. W., & Everitt, B. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02401.1999 · Cited by 555
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
Bibb, J. A., Snyder, G. L., Nishi, A., Yan, Z., Meijer, L., Fienberg, A. A., Tsai, L., Kwon, Y. T., Girault, J., Czernik, A. J., et al. (1999) · Nature · doi:10.1038/45251 · Cited by 553
Dopamine: 50 years in perspective
Iversen, S. D., & Iversen, L. L. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.002 · Cited by 540
Akt/GSK3 Signaling in the Action of Psychotropic Drugs
Beaulieu, J., Gainetdinov, R. R., & Caron, M. G. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145634 · Cited by 536
Provocative tests with psychostimulant drugs in schizophrenia
Lieberman, J. A., Kane, J. M., & Alvir, J. (1987) · Psychopharmacology · doi:10.1007/bf00216006 · Cited by 535
Protein kinases that phosphorylate activated G protein‐coupled receptors
Premont, R. T., Inglese, J., & Lefkowitz, R. J. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7781920 · Cited by 533
Cell Membrane Resealing by a Vesicular Mechanism Similar to Neurotransmitter Release
Steinhardt, R. A., Bi, G., & Alderton, J. M. (1994) · Science · doi:10.1126/science.7904084 · Cited by 530
Protective and toxic roles of dopamine in Parkinson's disease
Segura‐Aguilar, J., Paris, I. B., Muñoz, P., Ferrari, E., Zecca, L., & Zucca, F. A. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12686 · Cited by 517
A Specific Sympathomimetic Ergone in Adrenergic Nerve Fibres (Sympathin) and its Relations to Adrenaline and Nor‐Adrenaline
von Euler, U. S. (1946) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1946.tb00368.x · Cited by 512
Physiological Roles of G Protein–Coupled Receptor Kinases and Arrestins
Premont, R. T., & Gainetdinov, R. R. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.022405.154731 · Cited by 511
GSK-3: Functional Insights from Cell Biology and Animal Models
Kaidanovich‐Beilin, O., & Woodgett, J. R. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00040 · Cited by 505
Roles for nigrostriatal—not just mesocorticolimbic—dopamine in reward and addiction
Wise, R. A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.06.004 · Cited by 500
DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
Fienberg, A. A., Hiroi, N., Mermelstein, P. G., Song, W., Snyder, G. L., Nishi, A., Chéramy, A., O'Callaghan, J. P., Miller, D. B., Cole, D. G., et al. (1998) · Science · doi:10.1126/science.281.5378.838 · Cited by 496
D1–D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of G q /11 in the striatum
Rashid, A. J., So, C. H., Kong, M. M. C., Furtak, T., El-Ghundi, M., Cheng, R., O’Dowd, B. F., & George, S. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604049104 · Cited by 492
Mammalian RGS Proteins: Barbarians at the Gate
Berman, D. M., & Gilman, A. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1269 · Cited by 490
Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism
Hauser, D. N., & Hastings, T. G. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.10.011 · Cited by 487
Self-citation
Nicotinic acetylcholine binding sites in Alzheimer's disease
Whitehouse, P. J., Martino, A. M., Antuono, P., Lowenstein, P. R., Coyle, J. T., Price, D. L., & Kellar, K. J. (1986) · Brain Research · doi:10.1016/0006-8993(86)90819-x · Cited by 485
Über humorale Übertragbarkeit der Herznervenwirkung
Loewi, O., & Navratil, E. (1924) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf01722757 · Cited by 480
Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens
Pijnenburg, A. J. J., & van Rossum, J. M. (1973) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1973.tb09995.x · Cited by 480
Mechanism of Transport and Storage of Neurotransmitter
Kanner, B. I., & Schuldiner, S. (1987) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238709082546 · Cited by 477
Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain
Garris, P. A., Ciolkowski, E. L., Pastore, P., & Wightman, R. M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-06084.1994 · Cited by 475
Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas.
Pedersen, C. A., Caldwell, J. D., Walker, C., Ayers, G., & Mason, G. A. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.6.1163 · Cited by 475
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
Gurevich, V. V., & Gurevich, E. V. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.09.008 · Cited by 473
Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal
Lee, S. P., So, C. H., Rashid, A. J., Varghese, G. K., Cheng, R., Lança, A. J., O’Dowd, B. F., & George, S. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401923200 · Cited by 468
Restless legs syndrome: Revisiting the dopamine hypothesis from the spinal cord perspective
Clemens, S., Rye, D., & Hochman, S. (2006) · Neurology · doi:10.1212/01.wnl.0000223316.53428.c9 · Cited by 465
Genetics in Parkinson disease: Mendelian versus non‐Mendelian inheritance
Hernandez, D. G., Reed, X., & Singleton, A. B. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13593 · Cited by 448
The history of attention deficit hyperactivity disorder
Lange, K. W., Reichl, S., Lange, K. M., Tucha, L., & Tucha, O. (2010) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-010-0045-8 · Cited by 446
D2Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca2+Currents and Excitability via a Novel PLCβ1–IP3–Calcineurin-Signaling Cascade
Hernández-López, S., Tkatch, T., Perez-Garci, E., Galarraga, E., Bargas, J., Hamm, H., & Surmeier, D. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-08987.2000 · Cited by 443
Addiction and Brain Reward and Antireward Pathways
Gardner, E. L. (2011) · Advances in psychosomatic medicine · doi:10.1159/000324065 · Cited by 441
The action of adrenalin
Elliott, T. R. (1905) · The Journal of Physiology · doi:10.1113/jphysiol.1905.sp001093 · Cited by 438
The neurodevelopmental basis of sex differences in schizophrenia
Castle, D. J., & Murray, R. M. (1991) · Psychological Medicine · doi:10.1017/s0033291700022194 · Cited by 437
Attention-deficit/hyperactivity disorder and adverse health outcomes
Nigg, J. T. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.11.005 · Cited by 436
Direct protein–protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors
Liu, F., Wan, Q., Pristupa, Z. B., Yu, X., Wang, Y. T., & Niznik, H. B. (2000) · Nature · doi:10.1038/35002014 · Cited by 433
Dopamine-Sensitive Adenyl Cyclase: Possible Role in Synaptic Transmission
Kebabian, J. W., & Greengard, P. (1971) · Science · doi:10.1126/science.174.4016.1346 · Cited by 425
Bidirectional Regulation of DARPP-32 Phosphorylation by Dopamine
Nishi, A., Snyder, G. L., & Greengard, P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08147.1997 · Cited by 420
Selective Brain Dopamine Depletion in Developing Rats: An Experimental Model of Minimal Brain Dysfunction
Shaywitz, B. A., Yager, R. D., & Klopper, J. H. (1976) · Science · doi:10.1126/science.942800 · Cited by 405
GPCR desensitization: Acute and prolonged phases
Rajagopal, S., & Shenoy, S. K. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.01.024 · Cited by 401
Exercise as a novel treatment for drug addiction: A neurobiological and stage-dependent hypothesis
Lynch, W. J., Peterson, A. B., Sánchez, V., Abel, J. M., & Smith, M. A. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.011 · Cited by 399
Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat
Champagne, F. A., Chretien, P., Stevenson, C. W., Zhang, T. Y., Gratton, A., & Meaney, M. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5322-03.2004 · Cited by 398
The Dopamine Transporter and Attention-Deficit/Hyperactivity Disorder
Madras, B. K., Miller, G. M., & Fischman, A. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.011 · Cited by 393
Common cellular and molecular mechanisms in obesity and drug addiction
Kenny, P. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3105 · Cited by 382
Dopamine transporters and neuronal injury
Miller, G. W., Gainetdinov, R. R., Levey, A. I., & Caron, M. G. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01379-6 · Cited by 377
Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator
Maeda, K., Sugino, H., Akazawa, H., Amada, N., Shimada, J., Futamura, T., Yamashita, H., Ito, N., McQuade, R. D., Mørk, A., et al. (2014) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.213793 · Cited by 372
Sexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: Comparison with novelty and locomotion.
Damsma, G., Pfaus, J. G., Wenkstern, D., Phillips, A. G., & al, E. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.1.181 · Cited by 370
Sexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: comparison with novelty and locomotion
Damsma, G., Pfaus, J. G., Wenkstern, D., Phillips, A. G., & Fibiger, H. C. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.1.181 · Cited by 370
Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist–Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile
Kiss, B., Horváth, A., Némethy, Z., Schmidt, E. M., Laszlovszky, I., Bugovics, G., Fazekas, K., Hornok, K., Orosz, S., Gyertyán, I., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.160432 · Cited by 368
TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity
Revel, F. G., Moreau, J., Gainetdinov, R. R., Bradaïa, A., Sotnikova, T. D., Mory, R., Durkin, S., Zbinden, K. G., Norcross, R. D., Meyer, C. A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103029108 · Cited by 366
Methylphenidate improves prefrontal cortical cognitive function through α2 adrenoceptor and dopamine D1 receptor actions: Relevance to therapeutic effects in Attention Deficit Hyperactivity Disorder
Arnsten, A. F., & Dudley, A. G. (2005) · Behavioral and Brain Functions · doi:10.1186/1744-9081-1-2 · Cited by 363
The basal ganglia in Parkinson's disease: Current concepts and unexplained observations
Obeso, J. A., Marin, C., Rodriguez-Oroz, C., Blesa, J., Benitez-Temiño, B., Mena-Segovia, J., Rodríguez, M., & Olanow, C. W. (2009) · Annals of Neurology · doi:10.1002/ana.21481 · Cited by 359
Dopaminergic Modulation of Arousal in Drosophila
Waldowski, R. A., van Swinderen, B., & Greenspan, R. J. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.025 · Cited by 359
Motivational systems and the neural circuitry of maternal behavior in the rat
Numan, M. (2007) · Developmental Psychobiology · doi:10.1002/dev.20198 · Cited by 358
Preparation and properties of a homogeneous aromatic l-amino acid decarboxylase from hog kidney
Christenson, J. G., Dairman, W. M., & Udenfriend, S. (1970) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(70)90144-x · Cited by 357
Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices
Halpain, S., Girault, J.-A., & Greengard, P. (1990) · Nature · doi:10.1038/343369a0 · Cited by 357
Dopaminergic modulation of gap junction permeability between amacrine cells in mammalian retina
Hampson, E. C. G. M., Vaney, D., & Weiler, R. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04911.1992 · Cited by 356
Dopamine supersensitivity correlates with D2 High states, implying many paths to psychosis
Seeman, P. M., Weinshenker, D., Quirion, R., Srivastava, L. K., Bhardwaj, S. K., Grandy, D. K., Premont, R. T., Sotnikova, T. D., Boksa, P., El-Ghundi, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409766102 · Cited by 353
Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity
Lindemann, L., Meyer, C. A., Jeanneau, K., Bradaïa, A., Ozmen, L., Bluethmann, H., Bettler, B., Wettstein, J. G., Borroni, E., Moreau, J., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.132647 · Cited by 351
The basal ganglia and cognitive pattern generators
Graybiel, A. M. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.3.459 · Cited by 351
A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions
Walaas, S. I., Aswad, D. W., & Greengard, P. (1983) · Nature · doi:10.1038/301069a0 · Cited by 348
The Yin and Yang of dopamine release: a new perspective
GOTO, Y., OTANI, S., & GRACE, A. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.007 · Cited by 342
A Comparison of the Vascular Dopamine Receptor with Other Dopamine Receptors
Goldberg, L. I., Volkman, P. H., & Kohli, J. D. (1978) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.18.040178.000421 · Cited by 337
Dopamine, a neurotransmitter, influences the immune system
Basu, S., & Dasgupta, P. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00176-9 · Cited by 335
G protein‐coupled receptor hetero‐dimerization: contribution to pharmacology and function
Milligan, G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00169.x · Cited by 335
Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson’s Disease: Dawn of a New Era
Barker, R. A., Parmar, M., Studer, L., & Takahashi, J. B. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.09.014 · Cited by 334
Pharmacology and Nerve-endings (Walter Ernest Dixon Memorial Lecture): (Section of Therapeutics and Pharmacology).
Dale, H. H. (1935) · PubMed · Cited by 330
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling
Paul, S., Nairn, A. C., Wang, P., & Lombroso, P. J. (2002) · Nature Neuroscience · doi:10.1038/nn989 · Cited by 324
Proportional Release of Norepinephrine and Dopamine-β-Hydroxylase from Sympathetic Nerves
Weinshilboum, R. M., Thoa, N. B., Johnson, D. G., Kopin, I. J., & Axelrod, J. (1971) · Science · doi:10.1126/science.174.4016.1349 · Cited by 323
Negative Symptoms and the Failure to Represent the Expected Reward Value of Actions
Gold, J. M. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1269 · Cited by 319
Autoradiographic localization of D1 dopamine receptors in the rat brain with [3H]SCH 23390
Savasta, M., Dubois, A., & Scatton, B. (1986) · Brain Research · doi:10.1016/0006-8993(86)90749-3 · Cited by 318
Trace amine-associated receptors and their ligands
Zucchi, R., Chiellini, G., Scanlan, T. S., & Grandy, D. K. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706948 · Cited by 314
Calcium/calmodulin-dependent protein kinase II and synaptic plasticity
Colbran, R. J., & Brown, A. M. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.05.008 · Cited by 311
Differential Regulation of the Dopamine D2and D3 Receptors by G Protein-coupled Receptor Kinases and β-Arrestins
Kim, K., Valenzano, K. J., Robinson, S. W., Yao, W.-D., Barak, L. S., & Caron, M. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106728200 · Cited by 306
Origin of the dopaminergic innervation of the central extended amygdala and accumbens shell: A combined retrograde tracing and immunohistochemical study in the rat
Hasue, R. H., & Shammah‐Lagnado, S. J. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10420 · Cited by 306
Evidence of an incerto-hypothalamic dopamine neurone system in the rat
Björklund, A., Lindvall, O., & Nobin, A. (1975) · Brain Research · doi:10.1016/0006-8993(75)90131-6 · Cited by 301
G-protein-coupled receptors: turn-ons and turn-offs
Carman, C. V., & Benovic, J. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80058-5 · Cited by 299
An integrative perspective on the role of dopamine in schizophrenia
Maia, T. V., & Frank, M. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.021 · Cited by 293

Flagged first, then by citations

Research works printed but not linked: 4

Dale H (1935) Pharmacology and nerve-endings: Walter Ernest Dixon Memorial Lecture. Proc R Soc Med 28:319–332
Faraone SV, Sergeant J, Gillberg C, Biederman J (2003) The worldwide prevalence of ADHD: is it an American condition? World Psychiatry 2:104
Hohman LB (1922) Post-encephalitic behavior disorders in children. Johns Hopkins Hospt Bull 33:372–375
Stryker S (1925) Encephalitis lethargica—the behavior residuals. Train Sch Bull (Vinel) 22:152–157

Sorted by citations

Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System
Teleanu, R. I., Niculescu, A.-G., Roza, E., Vladâcenco, O. A., Grumezescu, A. M., & Teleanu, D. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115954 · Cited by 659
Next-generation GRAB sensors for monitoring dopaminergic activity in vivo
Sun, F., Zhou, J., Dai, B., Qian, T., Zeng, J., Li, X., Zhuo, Y., Zhang, Y., Wang, Y., Cheng, Q., et al. (2020) · Nature Methods · doi:10.1038/s41592-020-00981-9 · Cited by 483
Dopamine in Parkinson's disease
Latif, S., Jahangeer, M., Razia, D. E. M., Ashiq, M., Ghaffar, A., Akram, M., Allam, A. E., Bouyahya, A., Garipova, L., Shariati, M. A., et al. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.08.009 · Cited by 374
Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management
Berk, M., Köhler‐Forsberg, O., Turner, M., Penninx, B. W. J. H., Wrobel, A., Firth, J., Loughman, A., Reavley, N. J., McGrath, J. J., Momen, N. C., et al. (2023) · World Psychiatry · doi:10.1002/wps.21110 · Cited by 336
Electrochemical Biosensing of Dopamine Neurotransmitter: A Review
Lakard, S., Pavel, I., & Lakard, B. (2021) · Biosensors · doi:10.3390/bios11060179 · Cited by 245

See all 1,073

Authors: Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G.
Affiliations: Universidade de São Paulo (BR)
Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Bittencourt, Jackson C.
Correa, Ricardo G.
ORCID: Klein, Marianne O.
Battagello, Daniella S.
Cardoso, Ariel R.
Hauser, David N.
Bittencourt, Jackson C.
Correa, Ricardo G.
Venue: Cellular and Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2018-11-16
Volume: 39
Issue: 1
Pages: 31-59
ISSN: 0272-4340 (ISSN-L)
1573-6830
DOI: 10.1007/s10571-018-0632-3
PMC: PMC11469830
OpenAlex: W2901208536
Cited by: 1,073
References: 472
Citations by year: 2026: 141 · 2025: 174 · 2024: 214 · 2023: 199 · 2022: 148 · 2021: 105 · 2020: 64 · 2019: 27
FWCI: 6.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Neurobiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine, dopaminergic signaling, dopamine receptors, G protein-coupled receptors, catecholamine neurotransmitters, neuromodulation, neurodegenerative diseases, Parkinson's disease, schizophrenia, Huntington's disease, attention deficit hyperactivity disorder, addiction, dopaminergic therapy, reward and motivation
MeSH terms: Animals, Brain, Dopamine, Humans, Models, Biological, Nervous System Diseases, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dopamine: Functions, Signaling, and Association with Neurological Diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks