Cited by 1,073Neurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 472 of the 472 references it cites were found in a registry or an index.

Dopamine: Functions, Signaling, and Association with Neurological Diseases

Open access

Klein, Marianne O., Battagello, Daniella S., Cardoso, Ariel R., Hauser, David N., Bittencourt, Jackson C., Correa, Ricardo G.·2019·Cellular and Molecular Neurobiology

DOI 10.1007/s10571-018-0632-3PMC PMC11469830

Open this paper in CoChat — free account

Abstract

The dopaminergic system plays important roles in neuromodulation, such as motor control, motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a neurotransmitter, synthesized in both central nervous system and the periphery, that exerts its actions upon binding to G protein-coupled receptors. Dopamine receptors are widely expressed in the body and function in both the peripheral and the central nervous systems. Dopaminergic signaling pathways are crucial to the maintenance of physiological processes and an unbalanced activity may lead to dysfunctions that are related to neurodegenerative diseases. Unveiling the neurobiology and the molecular mechanisms that underlie these illnesses may contribute to the development of new therapies that could promote a better quality of life for patients worldwide. In this review, we summarize the aspects of dopamine as a catecholaminergic neurotransmitter and discuss dopamine signaling pathways elicited through dopamine receptor activation in normal brain function. Furthermore, we describe the potential involvement of these signaling pathways in evoking the onset and progression of some diseases in the nervous system, such as Parkinson's, Schizophrenia, Huntington's, Attention Deficit and Hyperactivity Disorder, and Addiction. A brief description of new dopaminergic drugs recently approved and under development treatments for these ailments is also provided.

Integrity signals

Registry

Crossref · 10.1007/s10571-018-0632-3

Cites

472 of 472 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Principles of neural science
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,150
α-Synuclein in Lewy bodies
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366
MDS clinical diagnostic criteria for Parkinson’s disease
Postuma, R. B., Berg, D., Stern, M., Poewe, W., Olanow, C. W., Oertel, W., Obeso, J., Marek, K., Litvan, I., Lang, A. E., et al. (2015) · Movement Disorders · doi:10.1002/mds.26424 · Cited by 7,653
Parkinson's disease
Kalia, L. V., & Lang, A. E. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61393-3 · Cited by 6,184
Parkinson's Disease
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
The worldwide prevalence of ADHD: a systematic review and metaregression analysis
Polanczyk, G., de Lima, M. S., Horta, B. L., Biederman, J., & Rohde, L. A. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.6.942 · Cited by 5,346
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564

Show all 472 references

Research works printed but not linked: 4

Dale H (1935) Pharmacology and nerve-endings: Walter Ernest Dixon Memorial Lecture. Proc R Soc Med 28:319–332
Faraone SV, Sergeant J, Gillberg C, Biederman J (2003) The worldwide prevalence of ADHD: is it an American condition? World Psychiatry 2:104
Hohman LB (1922) Post-encephalitic behavior disorders in children. Johns Hopkins Hospt Bull 33:372–375
Stryker S (1925) Encephalitis lethargica—the behavior residuals. Train Sch Bull (Vinel) 22:152–157

Sorted by citations

Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System
Teleanu, R. I., Niculescu, A.-G., Roza, E., Vladâcenco, O. A., Grumezescu, A. M., & Teleanu, D. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115954 · Cited by 659
Next-generation GRAB sensors for monitoring dopaminergic activity in vivo
Sun, F., Zhou, J., Dai, B., Qian, T., Zeng, J., Li, X., Zhuo, Y., Zhang, Y., Wang, Y., Cheng, Q., et al. (2020) · Nature Methods · doi:10.1038/s41592-020-00981-9 · Cited by 483
Dopamine in Parkinson's disease
Latif, S., Jahangeer, M., Razia, D. E. M., Ashiq, M., Ghaffar, A., Akram, M., Allam, A. E., Bouyahya, A., Garipova, L., Shariati, M. A., et al. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.08.009 · Cited by 374
Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management
Berk, M., Köhler‐Forsberg, O., Turner, M., Penninx, B. W. J. H., Wrobel, A., Firth, J., Loughman, A., Reavley, N. J., McGrath, J. J., Momen, N. C., et al. (2023) · World Psychiatry · doi:10.1002/wps.21110 · Cited by 336
Electrochemical Biosensing of Dopamine Neurotransmitter: A Review
Lakard, S., Pavel, I., & Lakard, B. (2021) · Biosensors · doi:10.3390/bios11060179 · Cited by 245
Emerging porous organic polymers for biomedical applications
Zhu, Y., Xu, P., Zhang, X., & Wu, D. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00871d · Cited by 238
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208
An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H2S Upregulation in Mice
Chen, Z., Mu, X., Han, Z., Yang, S., Zhang, C., Guo, Z., Bai, Y., & He, W. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b09181 · Cited by 204
Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression
Huang, F., & Wu, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.649103 · Cited by 193
A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)
Kumar, A., Sreedharan, S., Kashyap, A. K., Singh, P., & Ramchiary, N. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08669 · Cited by 161
Neurotransmitter and Intestinal Interactions: Focus on the Microbiota-Gut-Brain Axis in Irritable Bowel Syndrome
Chen, M., Ruan, G., Chen, L., Ying, S., Li, G., Xu, F., Xiao, Z., Tian, Y., Lv, L., Ping, Y., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.817100 · Cited by 167
The correlation between gut microbiota and both neurotransmitters and mental disorders: A narrative review
Mhanna, A., Martini, N., Hmaydoosh, G., Hamwi, G., Jarjanazi, M., Zaifah, G., Kazzazo, R., Mohamad, A. H., & Alshehabi, Z. (2024) · Medicine · doi:10.1097/md.0000000000037114 · Cited by 144
Monoamine Oxidase Inhibitors: A Review of Their Anti-Inflammatory Therapeutic Potential and Mechanisms of Action
Ostadkarampour, M., & Putnins, E. E. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.676239 · Cited by 138
Neurotransmitters in Prevention and Treatment of Alzheimer’s Disease
Yang, Z., Zou, Y., & Wang, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043841 · Cited by 138
Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction
Pignalosa, F. C., Desiderio, A., Mirra, P., Nigro, C., Perruolo, G., Ulianich, L., Formisano, P., Bèguinot, F., Miele, C., Napoli, R., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212366 · Cited by 130
Fluorescent Biosensors for Neurotransmission and Neuromodulation: Engineering and Applications
Leopold, A. V., Shcherbakova, D. M., & Verkhusha, V. V. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00474 · Cited by 125
The receptor hypothesis and the pathogenesis of depression: Genetic bases and biological correlates
Wang, H., Wang, Z., & Chen, N. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105542 · Cited by 122
Dopamine: an immune transmitter
Broome, S. T., Louangaphay, K., Keay, K. A., Leggio, G. M., Musumeci, G., & Castorina, A. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.284976 · Cited by 109
Functional catalytic nanoparticles (nanozymes) for sensing
Ouyang, Y., O’Hagan, M., & Willner, I. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114768 · Cited by 109
Bidirectional Association between Physical Activity and Dopamine Across Adulthood—A Systematic Review
Marques, A., Marconcin, P., Werneck, A. O., Ferrari, G., Gouveia, É. R., Kliegel, M., Peralta, M., & Ihle, A. (2021) · Brain Sciences · doi:10.3390/brainsci11070829 · Cited by 127
A critical review on the bio-mediated green synthesis and multiple applications of magnesium oxide nanoparticles
Nguyen, N. T. T., Nguyen, L. M., Nguyen, T. T. T., Tran, U. P. N., Nguyen, D. T. C., & Tran, T. V. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.137301 · Cited by 108
Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways
Rębas, E., Rzajew, J., Radzik, T., & Żylińska, L. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200106155127 · Cited by 112
Disrupted sleep and circadian rhythms in schizophrenia and their interaction with dopamine signaling
Ashton, A., & Jagannath, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00636 · Cited by 106
The Microbiota–Gut–Brain Axis: Psychoneuroimmunological Insights
Marano, G., Mazza, M., Lisci, F. M., Ciliberto, M., Traversi, G., Kotzalidis, G. D., Berardis, D. D., Laterza, L., Sani, G., Gasbarrini, A., et al. (2023) · Nutrients · doi:10.3390/nu15061496 · Cited by 116
Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders
Williams, O. O. F., Coppolino, M., George, S. R., & Perreault, M. L. (2021) · Brain Sciences · doi:10.3390/brainsci11091199 · Cited by 106
Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation
Bueno-Carrasco, M. T., Cuéllar, J., Flydal, M. I., Santiago, C. A., Kråkenes, T.-A., Kleppe, R., López‐Blanco, J. R., Marcilla, M., Teigen, K., Alvira, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27657-y · Cited by 102
The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models
MacDonald, H. J., Kleppe, R., Szigetvari, P. D., & Haavik, J. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1492126 · Cited by 124
Role of Descending Dopaminergic Pathways in Pain Modulation
Li, C., Liu, S., Lu, X., & Tao, F. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190430102531 · Cited by 103
Cerebellar Contributions to the Basal Ganglia Influence Motor Coordination, Reward Processing, and Movement Vigor
Yoshida, J., Oñate, M., Khatami, L., Vera, J. R., Nadim, F., & Khodakhah, K. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1535-22.2022 · Cited by 102
The interplay of dopamine metabolism abnormalities and mitochondrial defects in the pathogenesis of schizophrenia
Xu, H., & Yang, F. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02233-0 · Cited by 114
Come Fly with Me: An overview of dopamine receptors in Drosophila melanogaster
Karam, C. S., Jones, S. K., & Javitch, J. A. (2019) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13277 · Cited by 90
Gut–Brain–Skin Axis in Psoriasis: A Review
Chen, G., Zai-ming, C., Fan, X., Jin, Y., Li, X., Wu, S.-R., Ge, W., Lv, C.-H., Wang, Y.-K., & Chen, J. (2020) · Dermatology and Therapy · doi:10.1007/s13555-020-00466-9 · Cited by 95
The influence of polyphenols on metabolic disorders caused by compounds released from plastics - Review
Żwierełło, W., Maruszewska, A., Skórka-Majewicz, M., Goschorska, M., Baranowska‐Bosiacka, I., Dec, K., Styburski, D., Nowakowska, A., & Gutowska, I. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124901 · Cited by 89
The modulatory role of dopamine receptors in brain neuroinflammation
Xia, Q.-P., Cheng, Z.-Y., & He, L. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105908 · Cited by 87
The Promise of the Zebrafish Model for Parkinson’s Disease: Today’s Science and Tomorrow’s Treatment
Razali, K., Othman, N., Nasir, M. H. M., Doolaanea, A. A., Kumar, J., Ibrahim, W. N., Ibrahim, N. M., & Mohamed, W. M. Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.655550 · Cited by 86
Early-life exposure to the organophosphorus flame-retardant tris (1,3-dichloro-2-propyl) phosphate induces delayed neurotoxicity associated with DNA methylation in adult zebrafish
Li, R., Guo, W., Lei, L., Zhang, L., Liu, Y., Han, J. Z., Chen, L., & Zhou, B. (2019) · Environment International · doi:10.1016/j.envint.2019.105293 · Cited by 84
The neurodevelopmental role of dopaminergic signaling in neurological disorders
Cai, Y., Xing, L., Yang, T., Chai, R., Wang, J., Bao, J., Shen, W., Ding, S., & Chen, G. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135540 · Cited by 84
Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis
Bruno, A., Dolcetti, E., Rizzo, F. R., Fresegna, D., Musella, A., Gentile, A., Vito, F. D., Caioli, S., Guadalupi, L., Bullitta, S., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00169 · Cited by 87
A gut-secreted peptide suppresses arousability from sleep
Titos, I., Juginović, A., Vaccaro, A., Nambara, K., Gorelik, P., Mazor, O., & Rogulja, D. (2023) · Cell · doi:10.1016/j.cell.2023.02.022 · Cited by 95
Interaction of neurotransmitters and neurochemicals with lymphocytes
Kerage, D., Sloan, E. K., Mattarollo, S. R., & McCombe, P. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.04.006 · Cited by 82
Nanozyme-based strategies for efficient theranostics of brain diseases
Xu, R., Zhang, S., Wang, P., Zhang, R., Lin, P., Wang, Y., Gao, L., Wei, H., Zhang, X., Ling, D., et al. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215519 · Cited by 77
A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways
Matrone, G. M., van Doremaele, E. R. W., Surendran, A., Laswick, Z., Griggs, S., Ye, G., McCulloch, I. A., Santoro, F., Rivnay, J., & van de Burgt, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-47226-3 · Cited by 90
Targeting the Labile Iron Pool with Engineered DFO Nanosheets to Inhibit Ferroptosis for Parkinson's Disease Therapy
Li, L., Yuan, J., Dai, Z., Song, X., Tu, Q., Cui, X., Zhai, S., Chen, X., He, Z., Fang, B., et al. (2024) · Advanced Materials · doi:10.1002/adma.202409329 · Cited by 86
Ultrasensitive dopamine detection with graphene aptasensor multitransistor arrays
Abrantes, M., Rodrigues, D., Domingues, T., Nemala, S. S., Monteiro, P., Borme, J., Alpuim, P., & Jacinto, L. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01695-0 · Cited by 77
The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders
Abramova, O. V., Zorkina, Y., Ushakova, V. M., Zubkov, E. A., Morozova, A. Y., & Chekhonin, V. P. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102079 · Cited by 75
The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases
Possemato, E., Barbera, L. L., Nobili, A., Krashia, P., & D’Amelio, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101907 · Cited by 76
Electrochemical Micropyramid Array-Based Sensor for In Situ Monitoring of Dopamine Released from Neuroblastoma Cells
Şenel, M., Dervisevic, M., Alhassen, S., Alachkar, A., & Voelcker, N. H. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00835 · Cited by 71
Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review
Quintero, J., Gutiérrez-Casares, J. R., & Álamo, C. (2022) · Neurology and Therapy · doi:10.1007/s40120-022-00392-2 · Cited by 70
“the diagnosis and treatment of this disorder is the lack of complete understanding of the underlying molecular pathology [16].”
Background
Vein-Like Ni-BTC@Ni3S4 with Sulfur Vacancy and Ni3+ Fabricated In Situ Etching Vulcanization Strategy for an Electrochemical Sensor of Dopamine
Niu, B., Liu, M., Li, X., Guo, H., & Chen, Z. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c22586 · Cited by 70
3D printed electrochemical devices for bio-chemical sensing: A review
Sharma, A., Faber, H., Khosla, A., & Anthopoulos, T. (2023) · Materials science & engineering. R, Reports · doi:10.1016/j.mser.2023.100754 · Cited by 55
Nicotine’s effect on cognition, a friend or foe?
Wang, Q., Du, W., Wang, H., Geng, P., Sun, Y., Zhang, J., Wang, W., & Jin, X. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110723 · Cited by 70
The Formation and Function of the VTA Dopamine System
Hou, G., Hao, M., Duan, J., & Han, M.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073875 · Cited by 65
Tributyltin enhanced anxiety of adult male zebrafish through elevating cortisol level and disruption in serotonin, dopamine and gamma-aminobutyric acid neurotransmitter pathways
Tu, X., Li, Y., Chen, Q.-L., Shen, Y., & Liu, Z. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111014 · Cited by 65
The mutually reinforcing dynamics between pain and stress: mechanisms, impacts and management strategies
Aboushaar, N., & Serrano, N. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1445280 · Cited by 78
A Potential Role for Neuroinflammation in ADHD
Vázquez-González, D., Carreón-Trujillo, S., Álvarez‐Arellano, L., Abarca-Merlin, D. M., Domínguez-López, P., Salazar–García, M., & Corona, J. C. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_15 · Cited by 65
Structure of the human dopamine transporter and mechanisms of inhibition
Srivastava, D. K., Navratna, V., Tosh, D. K., Chinn, A., Sk, M. F., Tajkhorshid, E., Jacobson, K. A., & Gouaux, E. (2024) · Nature · doi:10.1038/s41586-024-07739-9 · Cited by 61
Glutamatergic neurotransmission: A potential pharmacotherapeutic target for the treatment of cognitive disorders
Chakraborty, P., Dey, A., Gopalakrishnan, A. V., Swati, K., Ojha, S. K., Prakash, A., Kumar, D., Ambasta, R. K., Jha, N. K., Jha, S. K., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101838 · Cited by 59
Nanocomposite Materials based on Metal Nanoparticles for the Electrochemical Sensing of Neurotransmitters
Leau, S.-A., Lete, C., & Lupu, S. (2023) · Chemosensors · doi:10.3390/chemosensors11030179 · Cited by 60
The Green Synthesis of Carbon Quantum Dots through One-step Hydrothermal Approach by Orange Juice for Rapid, and Accurate Detection of Dopamine
Gholipour, A., & Rahmani, S. (2023) · Journal of Fluorescence · doi:10.1007/s10895-023-03483-x · Cited by 58
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
Huber, N., Korhonen, S., Hoffmann, D. B., Leskelä, S., Rostalski, H., Remes, A. M., Honkakoski, P., Solje, E., & Haapasalo, A. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01384-8 · Cited by 58
Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies
Fan, S., Lin, W., Huang, Y., Xia, J., Xu, J., Zhang, J., & Pi, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.829712 · Cited by 56
Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?
Zhao, F., Cheng, Z., Piao, J., Cui, R., & Li, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.947785 · Cited by 64
Mechanisms and Potential Benefits of Neuroprotective Agents in Neurological Health
Pekdemir, B., Raposo, A., Saraiva, A., Lima, M. J., Alsharari, Z. D., BinMowyna, M. N., & Karav, S. (2024) · Nutrients · doi:10.3390/nu16244368 · Cited by 64
Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease
Roostalu, U., Salinas, C. B. G., Thorbek, D. D., Skytte, J. L., Fabricius, K., Barkholt, P., John, L. M., Jurtz, V. I., Knudsen, L. B., Jelsing, J., et al. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.042200 · Cited by 60
Dopamine activates NF-κB and primes the NLRP3 inflammasome in primary human macrophages
Nolan, R. A., Reeb, K. L., Rong, Y., Matt, S. M., Johnson, H. S., Runner, K., & Gaskill, P. J. (2019) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2019.100030 · Cited by 54
Central Insulin Modulates Dopamine Signaling in the Human Striatum
Kullmann, S., Blum, D., Jaghutriz, B. A., Gassenmaier, C., Bender, B., Häring, H., Reischl, G., Preissl, H. T., la Fougère, C., Fritsche, A., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab410 · Cited by 61
Advanced functional materials for electrochemical dopamine sensors
Burns, G., Ali, M. Y., & Howlader, M. M. R. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117367 · Cited by 52
The Impact of Neurotransmitters on the Neurobiology of Neurodegenerative Diseases
Davis, S. E., Cirincione, A. B., Jiménez-Torres, A. C., & Zhu, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015340 · Cited by 55
Recent advances with 5‐HT3 modulators for neuropsychiatric and gastrointestinal disorders
Jůza, R., Vlček, P., Mezeiová, E., Musílek, K., Soukup, O., & Korábečný, J. (2020) · Medicinal Research Reviews · doi:10.1002/med.21666 · Cited by 55
Nonenzymatic electrochemical sensor based on metal oxide, MO (M= Cu, Ni, Zn, and Fe) nanomaterials for neurotransmitters: An abridged review
Ratnam, K. V., Manjunatha, H., Janardan, S., Naidu, K. C. B., & Ramesh, S. (2020) · Sensors International · doi:10.1016/j.sintl.2020.100047 · Cited by 51
Dopamine Imaging in Living Cells and Retina by Surface-Enhanced Raman Scattering Based on Functionalized Gold Nanoparticles
Ren, X., Zhang, Q., Yang, J., Zhang, X., Zhang, X., Zhang, Y., Huang, L., Xu, C., Ge, Y., Chen, H., et al. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c01108 · Cited by 50
The Development of the Mesoprefrontal Dopaminergic System in Health and Disease
Islam, K. U. S., Meli, N., & Blaess, S. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.746582 · Cited by 55
Perfluorooctane sulfonates induces neurobehavioral changes and increases dopamine neurotransmitter levels in zebrafish larvae
Wu, L.-Y., Dang, Y., Liang, L.-X., Gong, Y.-C., Zeeshan, M., Qian, Z. M., Geiger, S. D., Vaughn, M. G., Zhou, Y., Li, Q., et al. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.134234 · Cited by 50
Phytochemicals Modulate Biosynthesis and Function of Serotonin, Dopamine, and Norepinephrine for Treatment of Monoamine Neurotransmission-Related Psychiatric Diseases
Naoi, M., Wu, Y., Maruyama, W., & Shamoto‐Nagai, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072916 · Cited by 55
Imidacloprid and thiamethoxam affect synaptic transmission in zebrafish
Zhang, J., Ma, D.-D., Xiong, Q., Qiu, S., Huang, G., Shi, W., & Ying, G. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112917 · Cited by 49
ADHD co-morbidities: A review of implication of gene × environment effects with dopamine-related genes
Kanarik, M., Grimm, O., Mota, N. R., Reif, A., & Harro, J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104757 · Cited by 53
Dopamine Receptors in Cancer: Are They Valid Therapeutic Targets?
Rosas-Cruz, A., Salinas-Jazmín, N., & Velasco-Velázquez, M. A. (2021) · Technology in Cancer Research & Treatment · doi:10.1177/15330338211027913 · Cited by 49
The Role of Dopamine in Neurological, Psychiatric, and Metabolic Disorders and Cancer: A Complex Web of Interactions
Speranza, L., Miniaci, M. C., & Volpicelli, F. (2025) · Biomedicines · doi:10.3390/biomedicines13020492 · Cited by 46
Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders
Masuda, K., Han, X., Kato, H., Sato, H., Zhang, Y., Sun, X., Hirofuji, Y., Yamaza, H., Yamada, A., & Fukumoto, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052269 · Cited by 49
Maternal exposure to air pollution during pregnancy and child's cognitive, language, and motor function: ECLIPSES study
Iglesias‐Vázquez, L., Binter, A.-C., Canals, J., Hernández‐Martínez, C., Voltas, N., Ambrós, A., Fernández‐Barrés, S., Pérez‐Crespo, L., Guxens, M., & Arija, V. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113501 · Cited by 47
Purkinje cell dopaminergic inputs to astrocytes regulate cerebellar-dependent behavior
Li, C., Saliba, N. B., Martin, H., Losurdo, N. A., Kolahdouzan, K., Siddiqui, R., Medeiros, D., & Li, W. (2023) · Nature Communications · doi:10.1038/s41467-023-37319-w · Cited by 46
Behavioral effects of early-life exposure to perfluorooctanoic acid might synthetically link to multiple aspects of dopaminergic neuron development and dopamine functions in zebrafish larvae
Yu, T., Zhou, G., Cai, Z., Liang, W., Du, Y., & Wang, W. (2021) · Aquatic Toxicology · doi:10.1016/j.aquatox.2021.105926 · Cited by 44
Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition
Papa, A., Pasquini, S., Contri, C., Gemma, S., Campiani, G., Butini, S., Varani, K., & Vincenzi, F. (2022) · Cells · doi:10.3390/cells11030471 · Cited by 49
Getting more out of the zebrafish light dark transition test
Haigis, A.-C., Ottermanns, R., Schiwy, A., Hollert, H., & Legradi, J. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133863 · Cited by 44
β‐Hydroxybutyric acid attenuates heat stress‐induced neuroinflammation via inhibiting TLR4/p38 MAPK and NF‐κB pathways in the hippocampus
Huang, J., Chai, X., Wu, Y., Hou, Y., Li, C., Xue, Y., Pan, J., Zhao, Y., Su, A., Zhu, X., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101469rr · Cited by 46
Butyrate emerges as a crucial effector of Zhi-Zi-Chi decoctions to ameliorate depression via multiple pathways of brain-gut axis
Liu, J., Fang, Y., Cui, L.-X., Wang, Z., Luo, Y., Gao, C., Ge, W., Huang, T., Wen, J., & Zhou, T. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112861 · Cited by 47
Apathy and Motivation: Biological Basis and Drug Treatment
Costello, H., Husain, M., & Roiser, J. P. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-022423-014645 · Cited by 51
Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance
Humińska‐Lisowska, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111602 · Cited by 52
Sex and strain differences in dynamic and static properties of the mesolimbic dopamine system
Rivera-Garcia, M. T., McCane, A. M., Chowdhury, T. G., Wallin-Miller, K. G., & Moghaddam, B. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0765-1 · Cited by 43
Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms linking mood, metabolism and medicines
Gangopadhyay, A., Ibrahim, R., Theberge, K., May, M. A., & Houseknecht, K. L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1042442 · Cited by 50
Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD)
Govindula, A., Ranadive, N., Nampoothiri, M., Rao, C. M., Arora, D. S., & Mudgal, J. (2023) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-023-10064-z · Cited by 47
Dopamine in the Regulation of Glucose Homeostasis, Pathogenesis of Type 2 Diabetes, and Chronic Conditions of Impaired Dopamine Activity/Metabolism: Implication for Pathophysiological and Therapeutic Purposes
Lisco, G., Tullio, A. D., Iovino, M., Disoteo, O., Guastamacchia, E., Giagulli, V. A., & Triggiani, V. (2023) · Biomedicines · doi:10.3390/biomedicines11112993 · Cited by 51
The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus
Puri, N. M., Romano, G. R., Lin, T., Quynh, N., & Irannejad, R. (2022) · eLife · doi:10.7554/elife.75468 · Cited by 42
Dopamine transporter silencing in the rat: systems-level alterations in striato-cerebellar and prefrontal-midbrain circuits
Reinwald, J., Gass, N., Mallien, A. S., Sartorius, A., Becker, R., Sack, M., Falfán-Melgoza, C., von Hohenberg, C. C., Leo, D., Pfeiffer, N., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01471-4 · Cited by 43
Peroxidase-like Fe3O4 Nanoparticle/Few-Layered Graphene Composite for Electrochemical Detection of Dopamine, Ascorbic Acid, and Uric Acid
Maseed, H., Reddy, Y. V. M., Devarakonda, S. S., Petnikota, S., Madhavi, G., & Srikanth, V. V. S. S. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c04018 · Cited by 42
Cell-type diversity in the bed nucleus of the stria terminalis to regulate motivated behaviors
Ortiz-Juza, M. M., Alghorazi, R., & Rodríguez-Romaguera, J. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113401 · Cited by 43
Surface-Enhanced Raman Scattering Nanosensing and Imaging in Neuroscience
Boudries, R., Williams, H., Paquereau--Gaboreau, S., Bashir, S., Jodaylami, M. H., Chisanga, M., Trudeau, L., & Masson, J. (2024) · ACS Nano · doi:10.1021/acsnano.4c05200 · Cited by 43
Electrochemical Properties of Screen-Printed Carbon Nano-Onion Electrodes
Cumba, L. R., Camisasca, A., Giordani, S., & Forster, R. J. (2020) · Molecules · doi:10.3390/molecules25173884 · Cited by 41
Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions
Lai, Y., Lu, X., Liao, Y., Ouyang, P., Wang, H., Zhang, X., Huang, G., Qi, S., & Li, Y. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.05.025 · Cited by 41
The dopaminergic system and Alzheimer’s disease
Zhang, Y., Liang, Y., & Gu, Y. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00230 · Cited by 47

Authors: Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G.
Affiliations: Universidade de São Paulo (BR)
Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Bittencourt, Jackson C.
Correa, Ricardo G.
ORCID: Klein, Marianne O.
Battagello, Daniella S.
Cardoso, Ariel R.
Hauser, David N.
Bittencourt, Jackson C.
Correa, Ricardo G.
Venue: Cellular and Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2018-11-16
Volume: 39
Issue: 1
Pages: 31-59
ISSN: 0272-4340 (ISSN-L)
1573-6830
DOI: 10.1007/s10571-018-0632-3
PMC: PMC11469830
OpenAlex: W2901208536
Cited by: 1,073
References: 472
Citations by year: 2026: 141 · 2025: 174 · 2024: 214 · 2023: 199 · 2022: 148 · 2021: 105 · 2020: 64 · 2019: 27
FWCI: 6.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Neurobiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine, dopaminergic signaling, dopamine receptors, G protein-coupled receptors, catecholamine neurotransmitters, neuromodulation, neurodegenerative diseases, Parkinson's disease, schizophrenia, Huntington's disease, attention deficit hyperactivity disorder, addiction, dopaminergic therapy, reward and motivation
MeSH terms: Animals, Brain, Dopamine, Humans, Models, Biological, Nervous System Diseases, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dopamine: Functions, Signaling, and Association with Neurological Diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks