Connectivity dynamics in typical development and its relationship to autistic traits and autism spectrum disorder
Open accessAbstract
Recent advances in neuroimaging techniques have provided significant insights into developmental trajectories of human brain function. Characterizations of typical neurodevelopment provide a framework for understanding altered neurodevelopment, including differences in brain function related to developmental disorders and psychopathology. Historically, most functional connectivity studies of typical and atypical development operate under the assumption that connectivity remains static over time. We hypothesized that relaxing stationarity assumptions would reveal novel features of both typical brain development related to children on the autism spectrum. We employed a "chronnectomic" (recurring, time-varying patterns of connectivity) approach to evaluate transient states of connectivity using resting-state functional MRI in a population-based sample of 774 6- to 10-year-old children. Dynamic connectivity was evaluated using a sliding-window approach, and revealed four transient states. Internetwork connectivity increased with age in modularized dynamic states, illustrating an important pattern of connectivity in the developing brain. Furthermore, we demonstrated that higher levels of autistic traits and ASD diagnosis were associated with longer dwell times in a globally disconnected state. These results provide a roadmap to the chronnectomic organization of the developing brain and suggest that characteristics of functional brain connectivity are related to children on the autism spectrum.
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In a very large sample of 774 6- to 10-year-old children from the Generation R Study, higher levels of autistic traits and ASD diagnosis were associated with longer dwell times in a functional connectivity state characterized by global disconnection.
“In a very large sample including 774 6–10 year-old children from the Generation R Study (122), higher levels of autistic traits and ASD diagnosis were associated with longer dwell times in a functional connectivity state characterized by global disconnection (123).”
From Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder (2021) · cites this paper as [123]
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- Allen EA, Damaraju E, Plis SM, Erhardt EB, Eichele T, Calhoun VD (2014) Tracking whole-brain connectivity dynamics in the resting state. Cereb Cortex, 24: 663– 76. 23146964 PMC3920766
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- Authors
- Rashid, B., Blanken, L. M. E., Muetzel, R. L., Miller, R., Damaraju, E., Arbabshirani, M. R., Erhardt, E. B., Verhulst, F. C., van der Lugt, A., Jaddoe, V. W. V., Tiemeier, H., White, T., & Calhoun, V.
- Affiliations
- Harvard University (US)
- Erasmus MC (NL)
- Mind Research Network (US)
- Geisinger Health System (US)
- University of New Mexico (US)
- Department of Radiology Erasmus MC Rotterdam The Netherlands
- Corresponding author
- White, Tonya
- Calhoun, Vince
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2018-03-30
- Volume
- 39
- Issue
- 8
- Pages
- 3127-3142
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6045960
- OpenAlex
- W2794826046
- Cited by
- 120
- References
- 57
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 16 · 2020: 24 · 2019: 18 · 2018: 4
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Simons Foundation (307280)
- Netherlands Organisation for Health Research and Development (91211021)
- National Institutes of Health (P20GM103472, R01EB005846, R01EB020407, NSF 1539067)
- EC Seventh Framework Programm (FP7/2008‐2013, 212652)
- Erasmus Medisch Centrum
- Erasmus University Rotterdam
- Netherlands Organisation for Scientific Research
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- dynamic functional connectivity, autism spectrum disorder, autistic traits, children, resting-state fMRI, sliding window analysis, developmental trajectories, dwell time
- MeSH terms
- Autism Spectrum Disorder, Brain, Child, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Rest, Connectome
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