Cited by 51Cardiac Ischemia and ReperfusionThyroid Disorders and TreatmentsCardiac Fibrosis and Remodeling

Cardioprotection and thyroid hormones

Pingitore, Alessandro, Nicolini, Giuseppina, Kusmic, Claudia, Iervasi, Giorgio, Grigolini, Paolo, Forini, Francesca·2016·Heart Failure Reviews

Abstract

The evolution of cardiac disease after an acute ischemic event depends on a complex and dynamic network of mechanisms alternating from ischemic damage due to acute coronary occlusion to reperfusion injury due to the adverse effects of coronary revascularization till post-ischemic remodeling. Cardioprotection is a new purpose of the therapeutic interventions in cardiology with the goal to reduce infarct size and thus prevent the progression toward heart failure after an acute ischemic event. In a complex biological system such as the human one, an effective cardioprotective strategy should diachronically target the network of cross-talking pathways underlying the disease progression. Thyroid system is strictly interconnected with heart homeostasis, and recent studies highlighted its role in cardioprotection, in particular through the preservation of mitochondrial function and morphology, the antifibrotic and proangiogenetic effect and also to the potential induction of cell regeneration and growth. The objective of this review was to highlight the cardioprotective role of triiodothyronine in the complexity of post-ischemic disease evolution.

Integrity signals

Registry

Crossref · 10.1007/s10741-016-9545-8

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79 of 79 references verified0 citation errors · 0 not checkable

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  • Cardioprotection is an emerging therapeutic target in acute myocardial infarction to limit irreversible ischemic damage and promote functional recovery of ischemic myocardium.

    “Cardioprotection is an emerging target of therapeutic intervention in AMI to minimize irreversible ischemic damage and favor functional recovery of the ischemic-damaged myocardium (20).”

    From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [20]

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Authors
Pingitore, A., Nicolini, G., Kusmic, C., Iervasi, G., Grigolini, P., & Forini, F.
Affiliations
Istituto di Fisiologia Clinica (IT)
Corresponding author
Pingitore, Alessandro
Venue
Heart Failure Reviews
Published
2016-03-24
Volume
21
Issue
4
Pages
391-399
ISSN
  • 1382-4147 (ISSN-L)
  • 1573-7322
OpenAlex
W2310093262
Cited by
51
References
79
Citations by year
2026: 1 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 13 · 2019: 9 · 2018: 8 · 2017: 2 · 2016: 4
FWCI
6.92
Type
journal article
Language
en
Open access
closed
Locations
  • Heart Failure Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
cardioprotection, thyroid hormones, triiodothyronine, myocardial ischemia, ischemia-reperfusion injury, infarct size, mitochondrial function, myocardial fibrosis, angiogenesis, cell regeneration, heart failure
MeSH terms
Animals, Cardiotonic Agents, Disease Models, Animal, Heart, Humans, Mitochondria, Heart, Regeneration, Thyroid Hormones, Myocardial Ischemia, Hormone Replacement Therapy, Rats

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