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Cited by 12Circadian rhythm and melatoninRheumatoid Arthritis Research and TherapiesNatural Compounds in Disease Treatment

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Biological Clock Perspective in Rheumatoid Arthritis

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Liu, Qingxue, Zhang, Yihao·2024·Inflammation
DOI 10.1007/s10753-024-02120-4
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Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic polyarticular pain, and its main pathological features include inflammatory cell infiltration, synovial fibroblast proliferation, and cartilage erosion. Immune cells, synovial cells and neuroendocrine factors play pivotal roles in the pathophysiological mechanism underlying rheumatoid arthritis. Biological clock genes regulate immune cell functions, which is linked to rhythmic changes in arthritis pathology. Additionally, the interaction between biological clock genes and neuroendocrine factors is also involved in rhythmic changes in rheumatoid arthritis. This review provides an overview of the contributions of circadian rhythm genes to RA pathology, including their interaction with the immune system and their involvement in regulating the secretion and function of neuroendocrine factors. A molecular understanding of the role of the circadian rhythm in RA may offer insights for effective disease management.

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Metadata

Authors
Liu, Q., & Zhang, Y.
Affiliations
  • Clinical College of Anhui Medical University (CN)
  • Anhui Medical University (CN)
Corresponding author
Zhang, Yihao
ORCID
Venue
Inflammation
Publisher
Springer Science and Business Media LLC
Published
2024-08-10
Volume
48
Issue
3
Pages
1028-1041
ISSN
  • 0360-3997 (ISSN-L)
  • 1573-2576
DOI
10.1007/s10753-024-02120-4
OpenAlex
W4401484419
Cited by
12
References
7
Citations by year
2026: 6 · 2025: 4 · 2024: 2
FWCI
0.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Inflammation (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (82102533)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords
rheumatoid arthritis, circadian rhythm, clock genes, neuroendocrine factors, immune cell function, synovial fibroblasts, cartilage erosion, autoimmune disease pathophysiology
MeSH terms
Animals, Arthritis, Rheumatoid, Biological Clocks, Circadian Rhythm, Humans, Circadian Clocks

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