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Cited by 449Circadian rhythm and melatoninStress Responses and CortisolAdrenal Hormones and Disorders

Interactions of the circadian CLOCK system and the HPA-axis

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Nader, Nancy, Chrousos, George P., Kino, Tomoshige·2010·Trends in Endocrinology & Metabolism
DOI 10.1016/j.tem.2009.12.011PMC PMC2862789
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Abstract

Organisms have developed concurrent behavioral and physiological adaptations to the strong influence of day/night cycles, as well as to unforeseen, random stress stimuli. These circadian and stress-related responses are achieved by two highly conserved and interrelated regulatory networks, the circadian CLOCK and stress systems, which respectively consist of oscillating molecular pacemakers, the Clock/Bmal1 transcription factors, and the hypothalamic-pituitary-adrenal (HPA) axis and its end-effector, the glucocorticoid receptor. These systems communicate with one another at different signaling levels and dysregulation of either system can lead to development of pathologic conditions. In this review, we summarize the mutual physiologic interactions between the circadian CLOCK system and the HPA axis, and discuss their clinical implications.

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  • The ultradian pattern is caused by intrinsic dynamics of the HPA axis itself.

    “It is generally believed that the circadian pattern is modulated by exogenous factors such as daylight, temperature, psychological as well as physical stress, but that the ultradian pattern is caused by intrinsic dynamics of the HPA axis itself [13, 19, 32, 36, 54].”

    From Patient specific modeling of the HPA axis related to clinical diagnosis of depression (2017) · cites this paper as [36]

    The section “The stress HPA axis” describes a negative-feedback loop, and “Regulation of the HPA axis by the circadian CLOCK system” discusses circadian glucocorticoid rhythms. Neither identifies an ultradian pattern or says that intrinsic HPA-axis dynamics cause it; searches for “ultradian” and pulsatile HPA oscillations found no such passage in our copy. (LLM, conf=0.75)

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Authors
Nader, N., Chrousos, G. P., & Kino, T.
Affiliations
  • National Institutes of Health (US)
  • National and Kapodistrian University of Athens (GR)
Corresponding author
Kino, Tomoshige
ORCID
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2010-05
Volume
21
Issue
5
Pages
277-286
ISSN
1043-2760 (ISSN-L)
DOI
10.1016/j.tem.2009.12.011
PMC
PMC2862789
OpenAlex
W2005229523
Cited by
449
References
7
Citations by year
2026: 19 · 2025: 28 · 2024: 18 · 2023: 40 · 2022: 33 · 2021: 32 · 2020: 34 · 2019: 19 · 2018: 36 · 2017: 32 · 2016: 26 · 2015: 26 · 2014: 32 · 2013: 19 · 2012: 20
FWCI
2.41
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZIAHD008732)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
circadian clock, hypothalamic-pituitary-adrenal axis, stress response, glucocorticoid receptor, circadian rhythm
MeSH terms
Animals, Biological Clocks, Blood Glucose, Circadian Rhythm, Cushing Syndrome, Diabetes Mellitus, Type 2, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Receptors, Glucocorticoid, Stress, Physiological

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