Preparation and identification of antioxidant peptides from protein hydrolysate of marine alga Gracilariopsis lemaneiformis

Zhang, Xiaoqian; Cao, Dequn; Sun, Xue; Sun, Siqi; Xu, Nianjun

doi:10.1007/s10811-019-1746-9

Cited by 79Protein Hydrolysis and Bioactive PeptidesSeaweed-derived Bioactive CompoundsFood and Agricultural Sciences

Preparation and identification of antioxidant peptides from protein hydrolysate of marine alga Gracilariopsis lemaneiformis

Zhang, Xiaoqian, Cao, Dequn, Sun, Xue, Sun, Siqi, Xu, Nianjun·2019·Journal of Applied Phycology

DOI 10.1007/s10811-019-1746-9

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Gracilariopsis lemaneiformis peptides have good antioxidant potential.
“For example, Gracilariopsis lemaneiformis peptides have good antioxidant potential [100].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [100]

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“lemaneiformis Antioxidant In vitro DPPH• scavenging activity [285]”
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Background
Novel marine bioactives: application in functional foods, nutraceuticals, and pharmaceuticals
Shahidi, F., & Santhiravel, S. (2022) · Journal of Food Bioactives · doi:10.31665/jfb.2022.18316 · Cited by 15 · see citing works
HPLC purification of antioxidant and antibacterial peptides from a lichen “Parmotrema perlatum (Huds.) M. Choisy”: Identification by LC‐MS/MS peptide mass fingerprinting
Radhakrishnan, D. P., Kanakaraja, A., Krishnan, N., Sakthivelu, M., Gopinath, S. C. B., & Pachaiappan, R. (2024) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2563 · Cited by 14 · see citing works
“31 The purified fractions were analyzed for antioxidant activity by using assays such as FRAP, DPPH, ABTS, and NOS.”
Method
Unlocking the potential: Exploring the application of bioactive peptides in aquaculture
Chen, S., Ding, T., Wang, J., Liang, X., Wang, H., Wang, J., & Xue, M. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.03.017 · Cited by 14 · see citing works
“Therefore, for the optimization of enzymatic hydrolysis conditions, researchers used to apply response surface designs such as central composite design (CCD) and Box-Behnken design (BBD) (Chandrasekaran and Gonzalez de Mejia, 2022; Zhang et al., 2019; Zhuang and Sun, 2011).”
Marine Antimicrobial Peptides: Advances in Discovery, Multifunctional Mechanisms, and Therapeutic Translation Challenges
Gao, B., Yang, N., Teng, D., Hao, Y., Wang, J., & Mao, R. (2025) · Marine Drugs · doi:10.3390/md23120463 · Cited by 12 · see citing works
“Reactive oxygen species (ROS) and free radicals participate in diverse metabolic processes and are implicated in the onset and progression of cancer, cardiovascular, neurological, respiratory, renal, ophthalmic, and autoimmune diseases [155].”
Separation, characterization, AI screening, and bioactivities of marine bioactive peptides: A review
Cui, Y., Li, X., Sun, Y., Liu, Y., Zhang, W., Jiang, Y., Zhou, Y., Liu, J., Gong, B., Wu, Y., et al. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.146312 · Cited by 11 · see citing works
Peptides From Animal and Fishery Byproducts: Uplifting the Functionality of Fifth Quarter
Verma, A. K., Umaraw, P., Kumar, P., Mehta, N. R., Sharma, N., Kumar, D., Sazili, A. Q., & Lee, S. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70140 · Cited by 11 · see citing works
“Zhang, Tong, et al. (2019), Zhang, Cao, et al. (2019), Zhang, Ma, (2019) identified three peptides WVNEEDHL (Octa-), NSLEGEFKG (nona-), and KDLFDPVIQD (deca) with molecular weights ranging from 1 to 5 kDa, having umami and kokumi enhancing effects from chicken protein hydrolysate by ultrafiltration…”
Advances in analytical techniques coupled to in vitro bioassays in the search for new peptides with functional activity in effect-directed analysis
Guerra-Fajardo, L. D., Pavón-Pérez, J., Vallejos‐Almirall, A., & Jorquera-Pereira, D. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.133784 · Cited by 11 · see citing works
Hydrolysate protein from brown macroalgae ( Sargassum ilicifolium ): Antioxidant, antitumor, antibacterial, and ACE inhibitory activities
Mousaie, M., Khodadadi, M., & Tadayoni, M. (2022) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.17020 · Cited by 10 · see citing works
Impact of High-Speed Homogenisation Followed by pH Treatment of Arthrospira platensis on Protein Accessibility and In Vitro Protein Digestibility
Irvani, N., Leong, S. Y., Carne, A., Agyei, D., & Oey, I. (2023) · Food and Bioprocess Technology · doi:10.1007/s11947-023-03269-w · Cited by 10 · see citing works
Unlocking the Therapeutic Potential of a Manila Clam-Derived Antioxidant Peptide: Insights into Mechanisms of Action and Cytoprotective Effects against Oxidative Stress
Jin, H., Zhao, H., Shi, R., Fan, F., & Cheng, W. (2024) · Foods · doi:10.3390/foods13081160 · Cited by 9 · see citing works
Bioactive peptide production and determination of functional properties using crude water extracts of Ulva lactuca (Chlorophyta) and Sargassum crassifolium (Phaeophyceae) collected from Sri Lanka
Hamit, C. S., Nam, K., & Abeyrathne, E. D. N. S. (2022) · Applied Phycology · doi:10.1080/26388081.2022.2063758 · Cited by 9 · see citing works
Identification and Characterization of a Novel Protein ASP-3 Purified from Arca subcrenata and Its Antitumor Mechanism
Guo, Z., Shi, H. R., Li, C., Luo, Y., Bi, S., Yu, R., Wang, H., Liu, W., Zhu, J., Huang, W., et al. (2019) · Marine Drugs · doi:10.3390/md17090528 · Cited by 9 · see citing works
“Marine proteins are mainly isolated from marine organisms such as sponges [8], sea squirts [9], mollusks [10], algae [11], marine fungi [12], and marine strain [13].”
Background
Functional properties of the bioactive peptides derived from Sargassum angustifolium algae
Jafarirad, S., Nateghi, L., Moslemi, M., & Afshari, K. P. (2023) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-023-02161-7 · Cited by 8 · see citing works
Current status and future prospects of Chlorella as raw materials in cosmeceuticals: cultivation, extraction, and commercial applications
Hidhayati, N., Purba, L. D. A., Firman, N., Admirasari, R., Rahman, D. Y., Agustini, N. W. S., Maryati, L., Anam, K., & Prayitno, J. (2024) · Journal of Applied Phycology · doi:10.1007/s10811-024-03372-1 · Cited by 9 · see citing works
“Amino acids containing hydrophobic amino acids (for instance Ala, Val, Trp, Phe, Tyr, Leu) play significant roles in antioxidant properties as they allow peptides to penetrate membrane lipid bilayers through hydrophobic interactions (Zhang et al. 2019a, b).”
LC-QTOF-MS/MS for Tentative Identification of Antioxidant Peptides in Defatted Spirulina platensis Cakes Obtained by Supercritical CO2 Extraction
Cuesta-Ramos, L., Sánchez-Moreno, N., Salgado-Ramos, M., Castagnini, J. M., Martí-Quijal, F. J., Ferrer, E., Barba, F. J., & Pallarés, N. (2026) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-025-06073-x · Cited by 7 · see citing works
“In addition, acidic or basic amino acids (Glu, Asp, and Lys) could act as metal ion chelators, while aromatic amino acids (Tyr, Trp, and Phe) could quench free radicals by electron transfer [31, 32].”
Algal proteins and bioactive peptides: Sustainable nutrition for human health
Meng, T., Wen, J., Liu, H., Guo, Y., Tong, A., Chu, Y., Du, B., He, X., & Zhao, C. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140760 · Cited by 7 · see citing works
1-Aminocyclopropane-1-carboxylic acid mitigates copper stress by decreasing copper transport and inducing jasmonic acid synthesis in Gracilariopsis lemaneiformis
Tang, Y., Chen, X., Zhang, H., Sun, X. K., & Xu, N. (2023) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2023.105237 · Cited by 7 · see citing works
Self-citation
Analysis and Characterization of Novel Bioactive Peptides Derived from Red Macroalgae Protein Hydrolysis Using Peptidomics and Bioinformatics Approaches
Dhaouafi, J., Romdhani, M., Deracinois, B., Flahaut, C., Balti, R., & Nedjar, N. (2024) · Waste and Biomass Valorization · doi:10.1007/s12649-024-02715-w · Cited by 6 · see citing works
“Indeed, an antioxidant peptide was purified and identified as ELWKTF from Grateloupia lemaneiformis proteins hydrolyzed by α-chymotrypsin [16].”
Antioxidant and antidiabetic properties of bioactive peptides from soursop (Annona muricata) leaf biomass
Lee, C. H., Hamdan, N., Ling, L. I., Wong, S. L., Nyakuma, B. B., Khoo, S. C., Ramachandran, H., Jamaluddin, H., Wong, K. Y., & Lee, T. H. (2023) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-023-03993-5 · Cited by 6 · see citing works
The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways
Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., & Zhang, Y. L. (2024) · Marine Drugs · doi:10.3390/md22030100 · Cited by 6 · see citing works
Functional food candidate from Indonesian green algae Caulerpa racemosa (Försskal) J. Agardh by two extraction methods: Metabolite profile, antioxidant activity, and cytotoxic properties
Taslim, N. A., Hardinsyah, H., Radu, S., Mayulu, N., Tsopmo, A., Kurniawan, R., Tallei, T. E., Herlina, T., Maksum, I. P., & Nurkolis, F. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101513 · Cited by 5 · see citing works
Algal Proteins and Peptides: Current Trends and Future Prospects
Ganesan, A. R., Munisamy, S., Bhat, R., Seedevi, P., Mohan, K., & Matsukawa, S. (2021) · Wiley eBooks · doi:10.1002/9781119542650.ch14 · Cited by 5 · see citing works
Navigating the potential of algal peptides: health effects, market applications, and scientific challenges
Khaliq, M., Noor, Z., Moazzam, M., Saeed, F., Tul-Zohra, K., Tariq, E., Muhammad Shahbaz, H., & Khaliq, K. (2026) · Annals of Medicine · doi:10.1080/07853890.2026.2637282 · Cited by 4 · see citing works
“For example, Gracilariopsis lemaneiformis peptides have good antioxidant potential [100].”
Marine Bioactives
Tahergorabi, R., & Abdollahi, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-57469-7_6 · Cited by 3 · see citing works
Extraction and purification of protein from algae (microalgae and seaweeds)
Naz, S., & Mukherjee, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21674-9.00002-7 · Cited by 3 · see citing works
Algal-derived oligopeptides: overcoming extraction, and purification barriers for sustainable nutraceuticals innovation
Perumal, P. K., Dubey, S., Wani, H. M. U. D., Singhania, R. R., Bhatia, S. K., & Patel, A. K. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2617462 · Cited by 2 · see citing works
“…scavenging (EC 50 : 1.514 mg/mL), while enzymatic digestion of Dunaliella salina yields peptides (e.g., Ile-Leu-Thr-Lys-Ala-Ala) with demonstrated antioxidant activity, highlighting algae as a renewable and promising source for health-promoting applications (Wang et al. 2010; Zhang et al. 2019b).”
Influential
Algal proteins, peptides and amino acids
Flórez-Fernández, N., Ravindran, R., Balboa, E. M., Torres, M. D., & Falqué, E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-98819-3.00001-8 · Cited by 2 · see citing works
Production and characterisation of dual-function antioxidant and anti-inflammatory peptides from edible bird’s nest (EBN) protein hydrolysates
Lee, C. H., Hamdan, N., Nyakuma, B. B., Wong, S. L., Wong, K. Y., Tan, H., Jamaluddin, H., & Lee, T. H. (2024) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-024-03015-6 · Cited by 2 · see citing works
“Beyond the threshold (above 55 °C), a slightly reduced antioxidant rate was observed due to thermal denaturation of the enzyme, which decreased its activity [37].”
Influential
Marine algal carbohydrate and peptide antioxidants
Mishra, P. K., Chatterjee, S., Gautam, R. K., Kakatkar, A. S., & Kumar, V. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95086-2.00008-4 · Cited by 2 · see citing works
Antioxidant compounds from fermentation and microbial sources
Alfaia, C. M., Patarata, L., & Fraqueza, M. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15386-0.00008-4 · Cited by 1 · see citing works
Seaweed-Based Proteins and Peptides: Processing and Development of Innovative Products
Mirzapour‐Kouhdasht, A., Shaghaghian, S., & García‐Vaquero, M. (2025) · Springer eBooks · doi:10.1007/978-981-96-0519-4_9 · Cited by 1 · see citing works
Biological Properties of Red Macroalgal Protein Hydrolysates and Their Uses as Biopreservatives
Dhaouafi, J., Romdhani, M., Outman, A., Nedjar, N., & Balti, R. (2025) · Journal of Food Processing and Preservation · doi:10.1155/jfpp/3852135 · Cited by 1 · see citing works
Antioxidant and Anti‐Inflammatory Activities of Enzymatic Hydrolysates From Gracilaria tenuistipitata Phycobiliproteins
Khan, A. M., Munna, M. M. R., Shoyshob, T. Z., Haque, M. R., & Hannan, M. A. (2026) · Journal of Food Biochemistry · doi:10.1155/jfbc/9116317 · Cited by 1 · see citing works
Bioactive peptides released from seaweeds during gastrointestinal digestion
Fraga‐Corral, M., Silva, A., Echave, J., Cassani, L., Xiao, J., Simal‐Gándara, J., & Prieto, M. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19141-1.00013-3 · Cited by 1 · see citing works
Algal cell factories as a source of marine antioxidants
Singh, R. P., Rehmanji, M., Nesamma, A. A., & Jutur, P. P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95086-2.00035-7
Pharmacological Importance of Gracilariopsis Lemaniformis Seaweed
Alam, M. M. (2023) · Oceanography & Fisheries Open access Journal · doi:10.19080/ofoaj.2023.16.555927
Bioactivity and Biofunctionality Characterization of Algal Biomass
Echave, J., Barciela, P., Perez-Vazquez, A., Seyyedi-Mansour, S., Donn, P., Cassani, L., Prieto, M. A., Simal‐Gándara, J., Otero, P., & Fraga‐Corral, M. (2024) · Environmental science and engineering · doi:10.1007/978-981-97-2371-3_23
An integrated, eco-friendly analytical platform for exploratory assessment of biomass composition and antioxidant potential in Euglena gracilis (Euglenophyceae)
Leal, V. L., Rathke, C. R., Ortolan, S. A., Ferrão, M. F., Schneider, R. D. C. D. S., & Corbellini, V. A. (2025) · Algal Research · doi:10.1016/j.algal.2025.104435
Antioxidant peptide from Synechococcus marine microalgae with therapeutic potential against human colon adenocarcinoma
Saisavoey, T., Boonserm, P., Sangtanoo, P., Srimongkol, P., & Karnchanatat, A. (2025) · Future Foods · doi:10.1016/j.fufo.2025.100895
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Algal and Cyanobacterial Hydrolysates as Serum-Reducing Supplements Across Mammalian, Avian and Fish Cells with Identification of Bioactive Chromopeptides
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Mollusk-Derived Peptides at the Food-Pharma Interface: Bioactivities, Preclinical Evidence, and Development Prospects
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Preparation, purification, and identification of novel antioxidant peptides derived from Gracilariopsis lemaneiformis protein hydrolysates
Hu, X., Liu, J., Li, J., Song, Y., Chen, S., Zhou, S., & Yang, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.971419 · Cited by 35 · see citing works
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Purification and identification of antioxidant peptides from grass carp muscle hydrolysates by consecutive chromatography and electrospray ionization-mass spectrometry
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Optimization for enzymatic hydrolysis of Gracilaria lemaneiformis protein and antioxidant activity of its hydrolysate
Yu, H., Liu, H., Li, M., Shi-qi, L., Fei-long, W., & Guo, H. (2017) · 食品工业科技 · doi:10.13386/j.issn1002-0306.2017.12.029

Authors: Zhang, X., Cao, D., Sun, X., Sun, S., & Xu, N.
Affiliations: Ningbo University (CN)
Corresponding author: Xu, Nianjun
ORCID: Zhang, Xiaoqian
Sun, Xue
Sun, Siqi
Xu, Nianjun
Venue: Journal of Applied Phycology
Publisher: Springer Science and Business Media LLC
Published: 2019-02-13
Volume: 31
Issue: 4
Pages: 2585-2596
ISSN: 0921-8971 (ISSN-L)
1573-5176
DOI: 10.1007/s10811-019-1746-9
OpenAlex: W2912276438
Cited by: 79
References: 44
Citations by year: 2026: 6 · 2025: 16 · 2024: 21 · 2023: 12 · 2022: 11 · 2021: 7 · 2020: 2 · 2019: 4
FWCI: 1.99
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Applied Phycology (publishedVersion)
Funders: Sciences and Technology program in Ningbo (2017D10019)
Chung-Shan Institute of Science and Technology (2016C10034)
National Natural Science Foundation of China (31672674)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
Keywords: antioxidant peptides, Gracilaria lemaneiformis, marine algae, protein hydrolysates, hydrolysis condition optimization, peptide purification, DPPH radical scavenging, natural antioxidants, peptide sequences

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Preparation and identification of antioxidant peptides from protein hydrolysate of marine alga Gracilariopsis lemaneiformis

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