Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

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Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival

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BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

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Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels

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BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for Apoptosis

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Structural and functional features and significance of the physical linkage between ER and mitochondria

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x L , but not Bcl-2, until displaced by BH3-only proteinsPreprint

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Ca 2+ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

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The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

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Control of mitochondrial apoptosis by the Bcl-2 family

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Dimers of mitochondrial ATP synthase form the permeability transition pore

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MAM: more than just a housekeeper

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The role of mitochondria in apoptosis

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Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

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Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

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Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

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The Endoplasmic Reticulum: Folding, Calcium Homeostasis, Signaling, and Redox Control

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Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiationPreprint

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Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery

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Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

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Ca2+ transfer from the ER to mitochondria: When, how and why

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Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells

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Regulation of apoptosis by Bcl‐2 family proteins

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Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria

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Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival

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BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

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Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

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The endoplasmic reticulum gateway to apoptosis by Bcl-XL modulation of the InsP3R

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Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate

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Bcl-x Promotes the Open Configuration of the Voltage-dependent Anion Channel and Metabolite Passage through the Outer Mitochondrial Membrane

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Gene expression during ER stress–induced apoptosis in neurons

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Bcl-2 proteins and mitochondria—Specificity in membrane targeting for death

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Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane

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Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c

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VDAC regulation by the Bcl-2 family of proteins

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Identification of a major polypeptide of the nuclear pore complex.

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The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

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Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2

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VDAC closure increases calcium ion flux

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The Type III Inositol 1,4,5-Trisphosphate Receptor Preferentially Transmits Apoptotic Ca2+ Signals into Mitochondria

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Calpain and Mitochondria in Ischemia/Reperfusion Injury

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Capacitative Calcium Entry

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Cytosolic Phosphorylation of Calnexin Controls Intracellular Ca2+ Oscillations via an Interaction with Serca2b

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Characteristics and possible functions of mitochondrial Ca2+ transport mechanisms

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Bcl-2-dependent modulation of Ca2+ homeostasis and store-operated channels in prostate cancer cells

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Oligomeric Bax Is a Component of the Putative Cytochrome c Release Channel MAC, Mitochondrial Apoptosis-induced Channel

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Ionomycin-activated Calpain Triggers Apoptosis

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Differential Modulation of SERCA2 Isoforms by Calreticulin

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Calcineurin-Mediated BAD Dephosphorylation Activates the Caspase-3 Apoptotic Cascade in Traumatic Spinal Cord Injury

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Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins

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Bid, but Not Bax, Regulates VDAC Channels

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Depletion of calcium from the lumen of endoplasmic reticulum reversibly inhibits passive diffusion and signal-mediated transport into the nucleus.

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Calreticulin Differentially Modulates Calcium Uptake and Release in the Endoplasmic Reticulum and Mitochondria

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Apoptosis Protection by Mcl-1 and Bcl-2 Modulation of Inositol 1,4,5-Trisphosphate Receptor-dependent Ca2+ Signaling

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MCU encodes the pore conducting mitochondrial calcium currents

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Transient Expression of Wild-type or Mitochondrially Targeted Bcl-2 Induces Apoptosis, whereas Transient Expression of Endoplasmic Reticulum-targeted Bcl-2 Is Protective against Bax-induced Cell Death

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BH3-only BIK Regulates BAX,BAK-dependent Release of Ca2+ from Endoplasmic Reticulum Stores and Mitochondrial Apoptosis during Stress-induced Cell Death

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Old players in a new role: mitochondria-associated membranes, VDAC, and ryanodine receptors as contributors to calcium signal propagation from endoplasmic reticulum to the mitochondria

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A novel protein, RTN-xS, interacts with both Bcl-xL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity

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14-3-3 Inhibits Bad-Induced Cell Death through Interaction with Serine-136

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Electron microscopic tomography of rat‐liver mitochondria and their interactions with the endoplasmic reticulum

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Capacitative calcium entry

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Bcl‐xL sequesters its C‐terminal membrane anchor in soluble, cytosolic homodimers

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BAK and BAX deletion using zinc‐finger nucleases yields apoptosis‐resistant CHO cells

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Apoptosis regulation by Bcl-x L modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating

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Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor κB

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Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members

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BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

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Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy

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Endoplasmic reticulum–mitochondria crosstalk in NIX-mediated murine cell death

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Bad Targets the Permeability Transition Pore Independent of Bax or Bak to Switch between Ca2+-Dependent Cell Survival and Death

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Mitochondria and Endoplasmic Reticulum: The Lethal Interorganelle Cross-Talk

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High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling

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Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption

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Chiral compounds from bacterial polyesters: Sugars to plastics to fine chemicals

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Molecular and Cell Biology of Phosphatidylserine and Phosphatidylethanolamine Metabolism

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Inhibition of Bid-induced Apoptosis by Bcl-2

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Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53

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How calpain is activated by calcium

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BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis: Figure 1.Preprint

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