Anxiety, depression, and opioid misuse among adults with chronic pain: The role of emotion dysregulation
Open accessAbstract
The opioid epidemic is a significant public health concern in the United States, particularly among adults with chronic pain. Considerable research suggests that people with mental health problems, including anxiety and depression, may experience more opioid-related problems in the context of chronic pain. Yet, little work has examined potential mechanisms underyling these relations. Emotion dysregulation is one mechanistic factor that may link anxiety and depression and opioid-related problems among persons with chronic pain. Therefore, the current study examined the explanatory role of emotion dysregulation in the cross-sectional relationship between anxiety and depression problems and current opioid misuse and severity of opioid dependence among 431 adults with chronic pain who reported currently using opioid medications (74% female, M age=38.32 years, SD = 11.11). Results indicated that emotion dysregulation explained, in part, the relationship between anxiety and depression symptoms and opioid-related problems. These findings highlight the need to further consider the role of emotion dysregulation among adults with chronic pain who use prescription opioids and experience symptoms of anxiety or depression. Future prospective research will be needed to further establish emotion dysregulation as a mechanism in anxiety/depression-opioid misuse/dependence processes.
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Anxiety sensitivity, emotion dysregulation, pain-anxiety, distress intolerance, and acceptance are transdiagnostic vulnerability factors for opioid-related and anxiety-related disorders.
“recent research has addressed transdiagnostic vulnerability factors [95], and specifically, anxiety sensitivity [96], emotion dysregulation [97], pain-anxiety [89], distress intolerance [98], and acceptance [39,40,41] as in the present study.”
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“In order to understand the mechanisms underlying the association between opioid-related and anxiety-related disorders, recent research has addressed transdiagnostic vulnerability factors [95], and specifically, anxiety sensitivity [96], emotion dysregulation [97], pain-anxiety [89], distress intolerance [98], and acce…”
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- Authors
- Rogers, A. H., Orr, M. F., Shepherd, J. M., Bakhshaie, J., Ditre, J. W., Buckner, J. D., & Zvolensky, M. J.
- Affiliations
- University of Houston (US)
- Baylor College of Medicine (US)
- Syracuse University (US)
- Louisiana State University (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Zvolensky, Michael J.
- ORCID
- Venue
- Journal of Behavioral Medicine
- Published
- 2020-06-27
- Volume
- 44
- Issue
- 1
- Pages
- 66-73
- ISSN
- 0160-7715 (ISSN-L)
- 1573-3521
- PMC
- PMC11862901
- OpenAlex
- W3037689204
- Cited by
- 25
- References
- 60
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 3
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Civil War Book Review (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH076629)
- National Center for Complementary and Integrative Health (K23AT012364)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- chronic pain, opioid misuse, opioid use disorder, anxiety, depression, emotional dysregulation, prescription opioids, opioid epidemic
- MeSH terms
- Adult, Analgesics, Opioid, Anxiety, Cross-Sectional Studies, Depression, Female, Humans, Male, Opioid-Related Disorders, United States, Chronic Pain
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