Candida bracarensis: Evaluation of Virulence Factors and its Tolerance to Amphotericin B and Fluconazole
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Candida bracarensis is an uncommon Candida species found during an epidemiological study of candidiasis performed in Braga, Portugal. Initially, it was identified as C. glabrata, but recently detailed analyses pointed out their differences. So, little information is still available about C. bracarensis virulence factors and antifungal susceptibilities. Therefore, the main goal of this work is to evaluate the ability of C. bracarensis to form biofilms, to produce hydrolytic enzymes (proteases, phospholipases and hemolysins), as well as its susceptibility to amphotericin B and fluconazole. It was shown, for the first time, that all C. bracarensis strains were able to form biofilms and display proteinase and hemolytic activities. Moreover, although planktonic cells presented antifungal susceptibility, amphotericin B and fluconazole were unable to inhibit biofilm formation and eradicate pre-formed biofilms. Due to the propensity of C. bracarensis to display antifungal resistance and virulence attributes, the control of these emerging pathogens is recommended.
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C. glabrata secretes hydrolytic enzymes (phospholipases, proteases, haemolysins) to destroy host tissues.
“Candida glabrata secretes hydrolytic enzymes (e.g., phospholipases, proteases, and haemolysins) to destroy host tissues [19].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [19]
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- Authors
- Moreira, A., Silva, S., Botelho, C., Sampaio, P., Pais, C., & Henriques, M.
- Affiliations
- University of Minho (PT)
- Corresponding author
- Silva, Sónia
- Venue
- Mycopathologia
- Published
- 2015-07-16
- Volume
- 180
- Issue
- 5-6
- Pages
- 305-315
- ISSN
- 0301-486X (ISSN-L)
- 1573-0832
- OpenAlex
- W859490027
- Cited by
- 10
- References
- 34
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 2 · 2015: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Mycopathologia (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Funders
- Fundação para a Ciência e a Tecnologia (FCOMP-01-0124-FEDER-027462, PTDC/SAU-MIC/119069/2010, FCOMP-01-0124-FEDER, PEst-OE/EQB/LA0023/2013)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida bracarensis, virulence factors, biofilm formation, antifungal susceptibility, amphotericin B, fluconazole, proteolytic enzymes, hemolysin, phospholipase, candidiasis, emerging fungal pathogens, antifungal resistance
- MeSH terms
- Amphotericin B, Antifungal Agents, Candida, Candidiasis, Hemolysis, Humans, Hydrolases, Mycotoxins, Fluconazole, Biofilms, Drug Resistance, Fungal, Virulence Factors
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