Candida Species Exhibit Differential In Vitro Hemolytic Activities
Open accessAbstract
A total of 80 Candida isolates representing 14 species were examined for their respective responses to an in vitro hemolytic test. A modification of a previously described plate assay system where the yeasts are incubated on glucose (3%)-enriched sheep blood agar in a carbon dioxide (5%)-rich environment for 48 h was used to evaluate the hemolytic activity. A group of eight Candida species which included Candida albicans (15 isolates), C. dubliniensis (2), C. kefyr (2), C. krusei (4), C. zeylanoides (1), C. glabrata (34), C. tropicalis (5), and C. lusitaniae (2) demonstrated both alpha and beta hemolysis at 48 h postinoculation. Only alpha hemolysis was detectable in four Candida species, viz., C. famata (3), C. guilliermondii (4), C. rugosa (1), and C. utilis (1), while C. parapsilosis (5) and C. pelliculosa (1) failed to demonstrate any hemolytic activity after incubation for 48 h or longer. This is the first study to demonstrate the variable expression profiles of hemolysins by different Candida species.
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C. glabrata lacks the haem receptor.
“Although C. glabrata exhibits haemolytic activity in vitro and possesses hemolysins, it lacks the haem receptor [121,122,124].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [124]
C. glabrata exhibits haemolytic activity in vitro and possesses hemolysins.
“Although C. glabrata exhibits haemolytic activity in vitro and possesses hemolysins, it lacks the haem receptor [121,122,124].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [124]
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- Authors
- Luo, G., Samaranayake, L. P., & Yau, J. Y. Y.
- Affiliations
- West China Medical Center of Sichuan University (CN)
- University of Hong Kong (HK)
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2001-08
- Volume
- 39
- Issue
- 8
- Pages
- 2971-2974
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC88272
- OpenAlex
- W2115834673
- Cited by
- 282
- References
- 18
- Citations by year
- 2026: 17 · 2025: 12 · 2024: 14 · 2023: 15 · 2022: 11 · 2021: 17 · 2020: 14 · 2019: 21 · 2018: 18 · 2017: 15 · 2016: 9 · 2015: 16 · 2014: 14 · 2013: 16 · 2012: 10
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida, hemolytic activity, hemolysin, alpha-hemolysis, beta-hemolysis, Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, Candida guilliermondii, Candida rugosa, Candida utilis, Debaryomyces hansenii, Candida kefyr, Candida krusei, Candida zeylanoides, Candida lusitaniae, Candida pelliculosa
- MeSH terms
- Animals, Blood, Candida, Candidiasis, Culture Media, Hemolysin Proteins, Hemolysis, Humans, Mycology, Sheep
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