Neuropsychological Contributions to the Early Identification of Alzheimer’s Disease
Open accessAbstract
A wealth of evidence demonstrates that a prodromal period of Alzheimer's disease (AD) exists for some years prior to the appearance of significant cognitive and functional declines required for the clinical diagnosis. This prodromal period of decline is characterized by a number of different neuropsychological and brain changes, and reliable identification of individuals prior to the development of significant clinical symptoms remains a top priority of research. In this review we provide an overview of those neuropsychological changes. In particular, we examine specific domains of cognition that appear to be negatively affected during the prodromal period of AD, and we review newer analytic strategies designed to examine cognitive asymmetries or discrepancies between higher-order cognitive functions versus fundamental skills. Finally, we provide a critical examination of the clinical concept of Mild Cognitive Impairment and offer suggestions for an increased focus on the impact of cerebrovascular disease (CVD) and CVD risk during the prodromal period of AD.
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The percentage of older adults classified as MCI ranges greatly from 11% to 74% depending on the number of tests considered in the diagnosis and the cutoffs used to define objective cognitive impairment.
“Jak and Bondi and colleagues [24, 25] have found that the percentage of older adults classified as MCI ranges greatly from 11% to 74% depending on the number of tests considered in the diagnosis and the cutoffs used to define objective cognitive impairment (see also [26]).”
From Neuropsychological Criteria for Mild Cognitive Impairment Improves Diagnostic Precision, Biomarker Associations, and Progression Rates (2014) · cites this paper as [24]
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- Authors
- Bondi, M. W., Jak, A. J., Delano-Wood, L., Jacobson, M. W., Delis, D. C., & Salmon, D. P.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Bondi, Mark W.
- Venue
- Neuropsychology Review
- Published
- 2008-03
- Volume
- 18
- Issue
- 1
- Pages
- 73-90
- ISSN
- 1040-7308 (ISSN-L)
- 1573-6660
- PMC
- PMC2882236
- OpenAlex
- W1971761527
- Cited by
- 216
- References
- 23
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 6 · 2023: 13 · 2022: 14 · 2021: 13 · 2020: 15 · 2019: 21 · 2018: 11 · 2017: 12 · 2016: 16 · 2015: 9 · 2014: 10 · 2013: 18 · 2012: 12
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychology Review (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P50AG005131, R01AG012674, K24AG026431)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, prodromal Alzheimer's disease, early detection, mild cognitive impairment, cognitive asymmetry, cognitive domain, cerebrovascular disease, cerebrovascular risk, neuropsychological assessment, cognitive decline
- MeSH terms
- Alzheimer Disease, Cognition Disorders, Humans, Neuropsychology, Risk Factors
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