The DOI matches its Crossref record; 226 of the 227 references it cites were found in a registry or an index.
Micellar Nanocarriers: Pharmaceutical Perspectives
Abstract
Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and hydrophilic shell are currently successfully used as pharmaceutical carriers for water-insoluble drugs and demonstrate a series of attractive properties as drug carriers. Among the micelle-forming compounds, amphiphilic copolymers, i.e., polymers consisting of hydrophobic block and hydrophilic block, are gaining an increasing attention. Polymeric micelles possess high stability both in vitro and in vivo and good biocompatibility, and can solubilize a broad variety of poorly soluble pharmaceuticals many of these drug-loaded micelles are currently at different stages of preclinical and clinical trials. Among polymeric micelles, a special group is formed by lipid-core micelles, i.e., micelles formed by conjugates of soluble copolymers with lipids (such as polyethylene glycol-phosphatidyl ethanolamine conjugate, PEG-PE). Polymeric micelles, including lipid-core micelles, carrying various reporter (contrast) groups may become the imaging agents of choice in different imaging modalities. All these micelles can also be used as targeted drug delivery systems. The targeting can be achieved via the enhanced permeability and retention (EPR) effect (into the areas with the compromised vasculature), by making micelles of stimuli-responsive amphiphilic block-copolymers, or by attaching specific targeting ligand molecules to the micelle surface. Immunomicelles prepared by coupling monoclonal antibody molecules to p-nitrophenylcarbonyl groups on the water-exposed termini of the micelle corona-forming blocks demonstrate high binding specificity and targetability. This review will discuss some recent trends in using micelles as pharmaceutical carriers.
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“Surfactant tends to form a supramolecular assembly known also as a colloidal dispersion, which has a small diameter in the range from 5 to 100 nm [29].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [29]
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Metadata
- Authors
- Torchilin, V. P.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Torchilin, V. P.
- ORCID
- Torchilin, V. P.
- Venue
- Pharmaceutical Research
- Published
- 2006-11-16
- Volume
- 24
- Issue
- 1
- Pages
- 1-16
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W2016156919
- Cited by
- 1,910
- References
- 227
- Citations by year
- 2026: 52 · 2025: 80 · 2024: 70 · 2023: 68 · 2022: 88 · 2021: 99 · 2020: 94 · 2019: 68 · 2018: 98 · 2017: 115 · 2016: 144 · 2015: 140 · 2014: 126 · 2013: 142 · 2012: 133
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
- Keywords
- polymeric micelles, amphiphilic block copolymers, poorly water-soluble drugs, drug solubilization, targeted drug delivery, enhanced permeability and retention effect, stimuli-responsive polymers, targeting ligands, monoclonal antibody conjugation, nanocarriers
- MeSH terms
- Animals, Chemistry, Pharmaceutical, Contrast Media, Drug Carriers, Drug Compounding, Humans, Micelles, Polymers, Drug Delivery Systems, Nanoparticles
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