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Cited by 1,910Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsSurfactants and Colloidal Systems

The DOI matches its Crossref record; 226 of the 227 references it cites were found in a registry or an index.

Micellar Nanocarriers: Pharmaceutical Perspectives

Torchilin, V. P.·2006·Pharmaceutical Research
DOI 10.1007/s11095-006-9132-0
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Abstract

Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and hydrophilic shell are currently successfully used as pharmaceutical carriers for water-insoluble drugs and demonstrate a series of attractive properties as drug carriers. Among the micelle-forming compounds, amphiphilic copolymers, i.e., polymers consisting of hydrophobic block and hydrophilic block, are gaining an increasing attention. Polymeric micelles possess high stability both in vitro and in vivo and good biocompatibility, and can solubilize a broad variety of poorly soluble pharmaceuticals many of these drug-loaded micelles are currently at different stages of preclinical and clinical trials. Among polymeric micelles, a special group is formed by lipid-core micelles, i.e., micelles formed by conjugates of soluble copolymers with lipids (such as polyethylene glycol-phosphatidyl ethanolamine conjugate, PEG-PE). Polymeric micelles, including lipid-core micelles, carrying various reporter (contrast) groups may become the imaging agents of choice in different imaging modalities. All these micelles can also be used as targeted drug delivery systems. The targeting can be achieved via the enhanced permeability and retention (EPR) effect (into the areas with the compromised vasculature), by making micelles of stimuli-responsive amphiphilic block-copolymers, or by attaching specific targeting ligand molecules to the micelle surface. Immunomicelles prepared by coupling monoclonal antibody molecules to p-nitrophenylcarbonyl groups on the water-exposed termini of the micelle corona-forming blocks demonstrate high binding specificity and targetability. This review will discuss some recent trends in using micelles as pharmaceutical carriers.

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Crossref · 10.1007/s11095-006-9132-0

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Citations

Cites

Research works printed but not linked: 10

  1. D. D. Lasic and F. J. Martin. Stealth Liposomes, CRC, Boca Raton, Florida, 1995.
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Metadata

Authors
Torchilin, V. P.
Affiliations
Northeastern University (US)
Corresponding author
Torchilin, V. P.
ORCID
Torchilin, V. P.
Venue
Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Published
2006-11-16
Volume
24
Issue
1
Pages
1-16
ISSN
  • 0724-8741 (ISSN-L)
  • 1573-904X
DOI
10.1007/s11095-006-9132-0
OpenAlex
W2016156919
Cited by
1,910
References
227
Citations by year
2026: 52 · 2025: 80 · 2024: 70 · 2023: 68 · 2022: 88 · 2021: 99 · 2020: 94 · 2019: 68 · 2018: 98 · 2017: 115 · 2016: 144 · 2015: 140 · 2014: 126 · 2013: 142 · 2012: 133
FWCI
3.93
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Pharmaceutical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Keywords
polymeric micelles, amphiphilic block copolymers, poorly water-soluble drugs, drug solubilization, targeted drug delivery, enhanced permeability and retention effect, stimuli-responsive polymers, targeting ligands, monoclonal antibody conjugation, nanocarriers
MeSH terms
Animals, Chemistry, Pharmaceutical, Contrast Media, Drug Carriers, Drug Compounding, Humans, Micelles, Polymers, Drug Delivery Systems, Nanoparticles

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