Cited by 1,910Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsSurfactants and Colloidal Systems

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Micellar Nanocarriers: Pharmaceutical Perspectives

Torchilin, V. P.·2006·Pharmaceutical Research

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Abstract

Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and hydrophilic shell are currently successfully used as pharmaceutical carriers for water-insoluble drugs and demonstrate a series of attractive properties as drug carriers. Among the micelle-forming compounds, amphiphilic copolymers, i.e., polymers consisting of hydrophobic block and hydrophilic block, are gaining an increasing attention. Polymeric micelles possess high stability both in vitro and in vivo and good biocompatibility, and can solubilize a broad variety of poorly soluble pharmaceuticals many of these drug-loaded micelles are currently at different stages of preclinical and clinical trials. Among polymeric micelles, a special group is formed by lipid-core micelles, i.e., micelles formed by conjugates of soluble copolymers with lipids (such as polyethylene glycol-phosphatidyl ethanolamine conjugate, PEG-PE). Polymeric micelles, including lipid-core micelles, carrying various reporter (contrast) groups may become the imaging agents of choice in different imaging modalities. All these micelles can also be used as targeted drug delivery systems. The targeting can be achieved via the enhanced permeability and retention (EPR) effect (into the areas with the compromised vasculature), by making micelles of stimuli-responsive amphiphilic block-copolymers, or by attaching specific targeting ligand molecules to the micelle surface. Immunomicelles prepared by coupling monoclonal antibody molecules to p-nitrophenylcarbonyl groups on the water-exposed termini of the micelle corona-forming blocks demonstrate high binding specificity and targetability. This review will discuss some recent trends in using micelles as pharmaceutical carriers.

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Authors: Torchilin, V. P.
Affiliations: Northeastern University (US)
Corresponding author: Torchilin, V. P.
ORCID: Torchilin, V. P.
Venue: Pharmaceutical Research
Publisher: Springer Science and Business Media LLC
Published: 2006-11-16
Volume: 24
Issue: 1
Pages: 1-16
ISSN: 0724-8741 (ISSN-L)
1573-904X
DOI: 10.1007/s11095-006-9132-0
OpenAlex: W2016156919
Cited by: 1,910
References: 227
Citations by year: 2026: 52 · 2025: 80 · 2024: 70 · 2023: 68 · 2022: 88 · 2021: 99 · 2020: 94 · 2019: 68 · 2018: 98 · 2017: 115 · 2016: 144 · 2015: 140 · 2014: 126 · 2013: 142 · 2012: 133
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Pharmaceutical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Keywords: polymeric micelles, amphiphilic block copolymers, poorly water-soluble drugs, drug solubilization, targeted drug delivery, enhanced permeability and retention effect, stimuli-responsive polymers, targeting ligands, monoclonal antibody conjugation, nanocarriers
MeSH terms: Animals, Chemistry, Pharmaceutical, Contrast Media, Drug Carriers, Drug Compounding, Humans, Micelles, Polymers, Drug Delivery Systems, Nanoparticles

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