Cited by 126Mitochondrial Function and PathologyBioactive Compounds and Antitumor AgentsRedox biology and oxidative stress

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Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death

Ralph, Stephen J., Moreno-Sánchez, Rafael, Neuzil, Jiri, Rodríguez-Enríquez, Sara·2011·Pharmaceutical Research

DOI 10.1007/s11095-011-0566-7

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Abstract

Succinate:quinone reductase (SQR) of Complex II occupies a unique central point in the mitochondrial respiratory system as a major source of electrons driving reactive oxygen species (ROS) production. It is an ideal pharmaceutical target for modulating ROS levels in normal cells to prevent oxidative stress-induced damage or alternatively,increase ROS in cancer cells, inducing cell death.The value of drugs like diazoxide to prevent ROS production,protecting normal cells, whereas vitamin E analogues promote ROS in cancer cells to kill them is highlighted. As pharmaceuticals these agents may prevent degenerative disease and their modes of action are presently being fully explored. The evidence that SDH/Complex II is tightly coupled to the NADH/NAD+ ratio in all cells,impacted by the available supplies of Krebs cycle intermediates as essential NAD-linked substrates, and the NAD+-dependent regulation of SDH/Complex II are reviewed, as are links to the NAD+-dependent dehydrogenases, Complex I and the E3 dihiydrolipoamide dehydrogenase to produce ROS. This review collates and discusses diverse sources of information relating to ROS production in different biological systems, focussing on evidence for SQR as the main source of ROS production in mitochondria, particularly its relevance to protection from oxidative stress and to the mitochondrial-targeted anti cancer drugs (mitocans) as novel cancer therapies [corrected].

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Authors: Ralph, S. J., Moreno-Sánchez, R., Neuzil, J., & Rodríguez-Enríquez, S.
Affiliations: Griffith University (AU)
Corresponding author: Ralph, Stephen J.
ORCID: Ralph, Stephen J.
Venue: Pharmaceutical Research
Publisher: Springer Science and Business Media LLC
Published: 2011-08-24
Volume: 28
Issue: 11
Pages: 2695-2730
ISSN: 0724-8741 (ISSN-L)
1573-904X
DOI: 10.1007/s11095-011-0566-7
OpenAlex: W1983521123
Cited by: 126
References: 292
Citations by year: 2026: 2 · 2025: 4 · 2024: 12 · 2023: 12 · 2022: 6 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 5 · 2015: 9 · 2014: 12 · 2013: 6 · 2012: 9
FWCI: 0.78
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Pharmaceutical Research (publishedVersion)
PubMed (publishedVersion)
ASEP (submittedVersion, public-domain)
Griffith Research Online (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: succinate dehydrogenase, mitochondrial reactive oxygen species, oxidative stress, ischemic injury, cancer cell death, diazoxide, vitamin E analogues, NAD+/NADH ratio, Krebs cycle intermediates, NAD-dependent dehydrogenase, mitocans
MeSH terms: Coenzyme A, Fatty Acids, Nonesterified, Humans, Dihydrolipoamide Dehydrogenase, Mitochondria, Neoplasms, Organophosphorus Compounds, Ubiquinone, NAD(P)H Dehydrogenase (Quinone), Cell Death, Reactive Oxygen Species, Succinic Acid, Protective Agents, alpha-Tocopherol

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Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death

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