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Addressing Core Challenges for the Next Generation of Type 2 Translation Research and Systems: The Translation Science to Population Impact (TSci Impact) Framework

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Society for Prevention Research Type 2 Translational Task Force Members and Contributing Authors, Spoth, Richard, Rohrbach, Louise A., Greenberg, Mark, Leaf, Philip, Brown, C. Hendricks, Fagan, Abigail, Catalano, Richard F., Pentz, Mary Ann, Sloboda, Zili, Hawkins, J. David·2013·Prevention Science

DOI 10.1007/s11121-012-0362-6PMC PMC3696461

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Abstract

Evidence-based preventive interventions developed over the past two decades represent great potential for enhancing public health and well-being. Research confirming the limited extent to which these interventions have been broadly and effectively implemented, however, indicates much progress is needed to achieve population-level impact. In part, progress requires Type 2 translation research that investigates the complex processes and systems through which evidence-based interventions are adopted, implemented, and sustained on a large scale, with a strong orientation toward devising empirically-driven strategies for increasing their population impact. In this article, we address two core challenges to the advancement of T2 translation research: (1) building infrastructure and capacity to support systems-oriented scaling up of evidence-based interventions, with well-integrated practice-oriented T2 research, and (2) developing an agenda and improving research methods for advancing T2 translation science. We also summarize a heuristic "Translation Science to Population Impact (TSci Impact) Framework." It articulates key considerations in addressing the core challenges, with three components that represent: (1) four phases of translation functions to be investigated (pre-adoption, adoption, implementation, and sustainability); (2) the multiple contexts in which translation occurs, ranging from community to national levels; and (3) necessary practice and research infrastructure supports. Discussion of the framework addresses the critical roles of practitioner-scientist partnerships and networks, governmental agencies and policies at all levels, plus financing partnerships and structures, all required for both infrastructure development and advances in the science. The article concludes with two sets of recommended action steps that could provide impetus for advancing the next generation of T2 translation science and, in turn, potentially enhance the health and well-being of subsequent generations of youth and families.

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Fig. 1 Addressing core challenges for the next generation of Type 2 translation research and systems: The Translation Science to Population Impact (TSci Impact) framework. Notes: EBIs: evidence-based interventions. Research cycle begins with intervention design guided by epidemiological, etiological, and life course development research. It should include T2 translation research integrated into pilot, efficacy, and effectiveness testing; optimally, interventions are developed to cover the full range of health-compromising behaviors across population segmentsCC BY-NC · PubMed Central

Fig. 2 The two core challenges for Type 2 translation research: summary of primary topics, subtopics, and key issues addressedCC BY-NC · PubMed Central

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Authors: Society for Prevention Research Type 2 Translational Task Force Members and Contributing Authors, Spoth, R., Rohrbach, L. A., Greenberg, M., Leaf, P., Brown, C. H., Fagan, A., Catalano, R. F., Pentz, M. A., Sloboda, Z., & Hawkins, J. D.
Affiliations: Iowa State University (US)
University of Southern California (US)
Pennsylvania State University (US)
Johns Hopkins University (US)
University of Miami (US)
Florida State University (US)
University of Washington (US)
JBS International (United States) (US)
Corresponding author: Spoth, Richard
ORCID: Spoth, Richard
Greenberg, Mark
Brown, C. Hendricks
Fagan, Abigail
Pentz, Mary Ann
Sloboda, Zili
Venue: Prevention Science
Publisher: Springer Science and Business Media LLC
Published: 2013-02-21
Volume: 14
Issue: 4
Pages: 319-351
ISSN: 1389-4986 (ISSN-L)
1573-6695
DOI: 10.1007/s11121-012-0362-6
PMC: PMC3696461
OpenAlex: W2002173750
Cited by: 283
References: 218
Citations by year: 2026: 8 · 2025: 8 · 2024: 7 · 2023: 13 · 2022: 17 · 2021: 23 · 2020: 32 · 2019: 35 · 2018: 29 · 2017: 26 · 2016: 23 · 2015: 36 · 2014: 19 · 2013: 6
FWCI: 50.72
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by-nc/2.0 (unspecified)
Locations: Prevention Science (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: National Institutes of Health (5r13da021047-09)
National Institute on Drug Abuse (P30DA027828, 5R13DA021047-08SI, R01DA013709, 5R13DA021047-09, R13 DA021047)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24HD042828)
Topics: Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
Health Sciences › Health Professions › General Health Professions › Health Sciences Research and Education
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › School Health and Nursing Education
Keywords: scaling up interventions, population effects, implementation research, practice-oriented research, research infrastructure, research networks, health policy
MeSH terms: Evidence-Based Practice, Translational Research, Biomedical

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