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Mechanisms of Dendritic Cell Trafficking Across the Blood–brain Barrier
Open accessAbstract
Although the central nervous system (CNS) is considered to be an immunoprivileged site, it is susceptible to a host of autoimmune as well as neuroinflammatory disorders owing to recruitment of immune cells across the blood-brain barrier into perivascular and parenchymal spaces. Dendritic cells (DCs), which are involved in both primary and secondary immune responses, are the most potent immune cells in terms of antigen uptake and processing as well as presentation to T cells. In light of the emerging importance of DC traficking into the CNS, these cells represent good candidates for targeted immunotherapy against various neuroinflammatory diseases. This review focuses on potential physiological events and receptor interactions between DCs and the microvascular endothelial cells of the brain as they transmigrate into the CNS during degeneration and injury. A clear understanding of the underlying mechanisms involved in DC migration may advance the development of new therapies that manipulate these mechanistic properties via pharmacologic intervention. Furthermore, therapeutic validation should be in concurrence with the molecular imaging techniques that can detect migration of these cells in vivo. Since the use of noninvasive methods to image migration of DCs into CNS has barely been explored, we highlighted potential molecular imaging techniques to achieve this goal. Overall, information provided will bring this important leukocyte population to the forefront as key players in the immune cascade in the light of the emerging contribution of DCs to CNS health and disease.
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Systemic chronic inflammation resulting from immunosenescence and non-neurotropic viral infection compels immune cells in the peripheral blood to penetrate the blood-brain barrier and choroid plexus and enter the brain; immune cells originating from the cranial bone marrow migrate to the meninges, thereby promoting neuroinflammation and neuronal dysfunction while inhibiting neurogenesis, and thisc
“Finally, the systemic chronic inflammation resulting from immunosenescence and non-neurotropic viral infection compels immune cells in the peripheral blood to penetrate the blood-brain barrier (BBB) and choroid plexus and enter the brain,345,346 Additionally, immune cells originating from the cranial bone marrow migrate to the meninges,347 thereby promoting neuroinflammation and neuronal”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [345]
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Metadata
- Authors
- Sagar, D., Foss, C., El Baz, R., Pomper, M. G., Khan, Z. K., & Jain, P.
- Affiliations
- Drexel University (US)
- Johns Hopkins University (US)
- Corresponding author
- Jain, Pooja
- Venue
- Journal of Neuroimmune Pharmacology
- Published
- 2011-08-06
- Volume
- 7
- Issue
- 1
- Pages
- 74-94
- ISSN
- 1557-1890 (ISSN-L)
- 1557-1904
- PMC
- PMC3276728
- OpenAlex
- W2067219175
- Cited by
- 60
- References
- 184
- Citations by year
- 2025: 2 · 2024: 9 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 8 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neuroimmune Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA134675)
- National Institute of Allergy and Infectious Diseases (R01AI077414, R21AI093172)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- dendritic cells, blood-brain barrier, dendritic cell trafficking, neuroinflammation, autoimmune disease, microvascular endothelial cells, dendritic cell migration, receptor interaction, central nervous system injury, targeted immunotherapy
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Dendritic Cells, Humans, Transendothelial and Transepithelial Migration
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