Cited by 146Mitochondrial Function and PathologyAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

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Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus

Abdul-Ghani, Muhammad A., DeFronzo, Ralph A.·2008·Current Diabetes Reports

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Abstract

Insulin resistance is a characteristic feature of type 2 diabetes mellitus, obesity, and the metabolic syndrome. Increased intracellular fat content in skeletal muscle and liver associated with insulin resistance has led to the hypothesis that a mitochondrial defect in substrate oxidation exists in disorders of insulin resistance. In vivo measurements of metabolic fluxes through the tricarboxylic acid and oxidative phosphorylation with magnetic resonance spectroscopy have demonstrated multiple defects in mitochondrial function in skeletal muscle. A decrease in mitochondrial density and mitochondrial copy number has been reported in insulin-resistant individuals. However, these findings have not been a consistent observation in all studies. Similarly, an intrinsic functional defect in mitochondrial adenosine triphosphate production synthesis has been reported in some but not all studies. This review summarizes evidence that implicates a defect in mitochondrial oxidative phosphorylation and its relationship to insulin resistance in common metabolic diseases characterized by impaired insulin action.

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Authors: Abdul-Ghani, M. A., & DeFronzo, R. A.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
ORCID: DeFronzo, Ralph A.
Venue: Current Diabetes Reports
Publisher: Springer Science and Business Media LLC
Published: 2008-06
Volume: 8
Issue: 3
Pages: 173-178
ISSN: 1534-4827 (ISSN-L)
1539-0829
DOI: 10.1007/s11892-008-0030-1
OpenAlex: W2111504946
Semantic Scholar: 40928a1ba7c82d86511874f290fc872cb921a3cb
Cited by: 146
References: 65
Citations by year: 2026: 6 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 10 · 2017: 7 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 8 · 2012: 10
FWCI: 0.98
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Diabetes Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: mitochondrial dysfunction, insulin resistance, type 2 diabetes, oxidative phosphorylation, skeletal muscle, liver, metabolic syndrome, obesity, mitochondrial density, mitochondrial DNA copy number, ATP production, TCA cycle, substrate oxidation
MeSH terms: Animals, Diabetes Mellitus, Type 2, Fatty Acids, Humans, Insulin Resistance, Mitochondria, Muscle, Skeletal

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Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus

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