Neurophysiologic markers of abnormal brain activity in schizophrenia
Open accessAbstract
Cortical electrophysiologic event-related potentials are multidimensional measures of information processing that are well-suited for efficiently parsing automatic and controlled components of cognition that span the range of deficits evidenced in schizophrenia patients. These information processes are key cognitive measures that are recognized as informative and valid targets for understanding the neurobiology of schizophrenia. These measures may be used in concert with the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) neurocognitive measures in the development of novel treatments for schizophrenia and related neuropsychiatric disorders. The employment of novel event-related potential paradigms designed to carefully characterize the early spectrum of perceptual and cognitive information processing allows investigators to identify the neurophysiologic basis of cognitive dysfunction in schizophrenia and to examine the associated clinical and functional impairments.
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Imaging studies have demonstrated relationships between cognitive deficits and structural or functional brain abnormalities.
“imaging studies have demonstrated relationships between cognitive deficits and structural or functional brain abnormalities.9–13”
From Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? (2013) · cites this paper as [13]
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- Authors
- Rissling, A. J., Makeig, S., Braff, D. L., & Light, G. A.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Light, Gregory A.
- Venue
- Current Psychiatry Reports
- Published
- 2010-09-21
- Volume
- 12
- Issue
- 6
- Pages
- 572-578
- ISSN
- 1523-3812 (ISSN-L)
- 1535-1645
- PMC
- PMC2965365
- OpenAlex
- W2125271724
- Cited by
- 58
- References
- 47
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 6 · 2012: 6
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Current Psychiatry Reports (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- Allergan
- National Institute of Mental Health (#MH065571, MH079777, R01MH065554, R01MH065571, R01MH079777)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, event-related potentials, cognitive impairment, cortical processing, automatic and controlled processing, perceptual processing, neuropsychiatric disorders
- MeSH terms
- Brain, Electroencephalography, Evoked Potentials, Humans, Schizophrenia
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