Depression in HIV Infected Patients: a Review
Abstract
Depression is the most common neuropsychiatric complication in HIV-infected patients and may occur in all phases of the infection. Accurately, diagnosing major depressive disorder in the context of HIV is an ongoing challenge to clinicians and researchers, being complicated by the complex biological, psychological, and social factors associated with the HIV illness. Evidences exist to support the importance of improving the identification of depressive symptoms and their adequate treatment. Depression has long been recognized as a predictor of negative clinical outcomes in HIV-infected patients, such as reducing medication adherence, quality of life, and treatment outcome, and possibly worsening the progression of the illness and increasing mortality. By analyzing the most relevant studies (MEDLINE, EMBASE, PsycLit, Cochrane Library), the review discusses the epidemiology and the main clinical features of depression in HIV-infected patients, the causal pathways linking depression and HIV infection, the validity of screening tools, and the efficacy of different treatment approaches, including psychosocial interventions, psychopharmacology as well as HIV-specific health psychology health service models.
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People living with HIV experience a disproportionate burden of mental health problems compared to people living without HIV.
“People living with HIV (PLWH) experience a disproportionate burden of mental health problems compared to people living without HIV.”
From Resilience resources for mental health among people living with HIV: a mixed-method systematic review (2024) · cites this paper as Nanni et al., 2015
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- Authors
- Nanni, M. G., Caruso, R., Mitchell, A. J., Meggiolaro, E., & Grassi, L.
- Affiliations
- University of Ferrara (IT)
- University of Leicester (GB)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Corresponding author
- Nanni, Maria Giulia
- Venue
- Current Psychiatry Reports
- Published
- 2014-11-21
- Volume
- 17
- Issue
- 1
- Pages
- 530-530
- ISSN
- 1523-3812 (ISSN-L)
- 1535-1645
- OpenAlex
- W2169236274
- Cited by
- 511
- References
- 9
- Citations by year
- 2026: 21 · 2025: 35 · 2024: 34 · 2023: 48 · 2022: 69 · 2021: 56 · 2020: 97 · 2019: 61 · 2018: 39 · 2017: 31 · 2016: 14 · 2015: 6
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Psychiatry Reports (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, HIV infection, major depressive disorder, neuropsychiatric complications, medication adherence, quality of life, depression screening tools, psychosocial interventions, psychopharmacology, epidemiology of depression, causal pathways
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Humans, Risk Factors, HIV Infections
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