Role of depression, stress, and trauma in HIV disease progression
Abstract
Despite advances in HIV treatment, there continues to be great variability in the progression of this disease. This paper reviews the evidence that depression, stressful life events, and trauma account for some of the variation in HIV disease course. Longitudinal studies both before and after the advent of highly active antiretroviral therapies (HAART) are reviewed. To ensure a complete review, PubMed was searched for all English language articles from January 1990 to July 2007. We found substantial and consistent evidence that chronic depression, stressful events, and trauma may negatively affect HIV disease progression in terms of decreases in CD4 T lymphocytes, increases in viral load, and greater risk for clinical decline and mortality. More research is warranted to investigate biological and behavioral mediators of these psychoimmune relationships, and the types of interventions that might mitigate the negative health impact of chronic depression and trauma. Given the high rates of depression and past trauma in persons living with HIV/AIDS, it is important for healthcare providers to address these problems as part of standard HIV care.
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Acute life events and chronic difficulties increase risk for a wide variety of mental and physical health problems, including anxiety disorders, depression, autoimmune disorders, cardiovascular disease, certain cancers, and Alzheimer's disease.
“The resulting consensus from this body of work is that acute life events (e.g., getting divorced or fired from a job) and chronic difficulties (e.g., ongoing marital or financial problems) increase risk for a wide variety of mental and physical health problems, including anxiety disorders, depression, autoimmune disorders, cardiovascular disease, certain cancers, and Alzheimer's disease (6–10).”
From Assessing Lifetime Stress Exposure Using the Stress and Adversity Inventory for Adults (Adult STRAIN): An Overview and Initial Validation (2018) · cites this paper as [9]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
DiMatteo, M. R., Lepper, H. S., & Croghan, T. W. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.14.2101 · Cited by 4,177 · see citing works
Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
Paterson, D. L., Swindells, S., Mohr, J. A., Brester, M., Vergis, E. N., Squier, C. L., Wagener, M. M., & Singh, N. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-1-200007040-00004 · Cited by 3,289 · see citing works
Stress and immunity in humans: a meta-analytic review.
Herbert, T. B., & Cohen, S. (1993) · Psychosomatic Medicine · doi:10.1097/00006842-199307000-00004 · Cited by 1,093 · see citing works
Mortality, CD4 Cell Count Decline, and Depressive Symptoms Among HIV-Seropositive Women
Ickovics, J. R., Hamburger, M. E., Vlahov, D., Schoenbaum, E. E., Schuman, P. C., BOLAND, R. J., & Moore, J. (2001) · JAMA · doi:10.1001/jama.285.11.1466 · Cited by 885 · see citing works
Depression and immunity: A meta-analytic review.
Herbert, T. B., & Cohen, S. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.113.3.472 · Cited by 812 · see citing works
Bower, J. E., Kemeny, M. E., Taylor, S. E., & Fahey, J. L. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.66.6.979 · Cited by 458 · see citing works
Leserman, J., Jackson, E. D., Petitto, J. M., Golden, R. N., Silva, S. G., Perkins, D. O., Cai, J., Folds, J. D., & Evans, D. L. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199905000-00021 · Cited by 441 · see citing works
Self-citationEstrogen Replacement Therapy and Ovarian Cancer Mortality in a Large Prospective Study of US Women
Rodríguez, C. (2001) · JAMA · doi:10.1001/jama.285.11.1460 · Cited by 424 · see citing works
Depressive Symptoms and AIDS-Related Mortality Among a Multisite Cohort of HIV-Positive Women
Cook, J. Α., Grey, D. D., Burke-Miller, J. K., Cohen, M. H., Gurtman, A., Richardson, J. L., Wilson, T. E., Young, M., & Hessol, N. A. (2004) · American Journal of Public Health · doi:10.2105/ajph.94.7.1133 · Cited by 396 · see citing works
Depressive Symptoms and CD4 Lymphocyte Decline Among HIV-Infected Men
Burack, J. H. (1993) · JAMA · doi:10.1001/jama.1993.03510210054027 · Cited by 358 · see citing works
Ironson, G. H., O’Cleirigh, C. M., FLETCHER, M. A., Laurenceau, J., Balbin, E., Klimas, N. G., Schneiderman, N., & Solomon, G. F. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000188569.58998.c8 · Cited by 357 · see citing works
Whetten, K., Reif, S., Whetten, R., & Murphy-McMillan, L. K. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31817749dc · Cited by 352 · see citing works
Leserman, J., Petitto, J. M., Golden, R. N., Gaynes, B. N., Gu, H., Perkins, D. O., Silva, S. G., Folds, J. D., & Evans, D. L. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1221 · Cited by 343 · see citing works
Self-citationLESERMAN, J., PETITTO, J. M., GU, H., GAYNES, B. N., BARROSO, J., GOLDEN, R. N., PERKINS, D. O., FOLDS, J. D., & EVANS, D. L. (2002) · Psychological Medicine · doi:10.1017/s0033291702005949 · Cited by 311 · see citing works
Self-citationHIV disease progression: depression, stress, and possible mechanisms
Leserman, J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00323-8 · Cited by 308 · see citing works
Self-citationDepression, the Immune System, and Health and Illness
Stein, M., Miller, A. H., & Trestman, R. L. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810260079012 · Cited by 297 · see citing works
Positive Affect Predicts Lower Risk of AIDS Mortality
Moskowitz, J. T. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000073873.74829.23 · Cited by 291 · see citing works
Lima, V. D., Geller, J., Bangsberg, D. R., Patterson, T. L., Daniel, M., Kerr, T. H., Montaner, J. S. G., & Hogg, R. S. (2007) · AIDS · doi:10.1097/qad.0b013e32811ebf57 · Cited by 274 · see citing works
Depressive Symptoms Increase Risk of HIV Disease Progression and Mortality Among Women in Tanzania
Antelman, G., Kaaya, S., Wei, R., Mbwambo, J., Msamanga, G., Fawzi, W. W., & Fawzi, M. C. S. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31802f1318 · Cited by 274 · see citing works
Depression Is a Risk Factor for Suboptimal Adherence to Highly Active Antiretroviral Therapy
Starace, F., Ammassari, A., Trotta, M. P., Murri, R., Longis, P. D., Izzo, C. M., Scalzini, A., Monforte, A. D., Wu, A. W., & Antinori, A. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200212153-00010 · Cited by 254 · see citing works
Underdiagnosis of depression in HIV
Asch, S. M., Kilbourne, A. M., Gifford, A. L., Burnam, M. A., Turner, B. J., Shapiro, M. F., & Bozzette, S. A. (2003) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2003.20938.x · Cited by 239 · see citing works
Pence, B. W., Miller, W. C., Whetten, K., Eron, J. J., & Gaynes, B. N. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000219773.82055.aa · Cited by 237 · see citing works
Depressive Symptoms as Predictors of Medical Outcomes in HIV Infection
Lyketsos, C. G. (1993) · JAMA · doi:10.1001/jama.1993.03510210049026 · Cited by 236 · see citing works
Changes in depressive symptoms as AIDS develops. The Multicenter AIDS Cohort Study
Lyketsos, C. G., Hoover, D. R., Guccione, M., Dew, M. A., Wesch, J. E., Bing, E. G., & Treisman, G. J. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.11.1430 · Cited by 229 · see citing works
Relation of Lifetime Trauma and Depressive Symptoms to Mortality in HIV
Leserman, J., Pence, B. W., Whetten, K., Mugavero, M. J., Thielman, N. M., Swartz, M. S., & Stangl, D. K. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111775 · Cited by 220 · see citing works
Self-citationLeserman, J. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830150105015 · Cited by 217 · see citing works
Self-citationPence, B. W., Miller, W. C., Gaynes, B. N., & Eron, J. J. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31802c2f51 · Cited by 206 · see citing works
Perry, S. W. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820050060010 · Cited by 195 · see citing works
Depression and immunocompetence: A review of the literature.
Weisse, C. S. (1992) · Psychological Bulletin · doi:10.1037/0033-2909.111.3.475 · Cited by 192 · see citing works
Depressive Affect and Survival Among Gay and Bisexual Men Infected With HIV
Mayne, T. J. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440180095012 · Cited by 192 · see citing works
Leserman, J., Whetten, K., Lowe, K., Stangl, D. K., Swartz, M. S., & Thielman, N. M. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000160459.78182.d9 · Cited by 186 · see citing works
Self-citationSevere life stress as a predictor of early disease progression in HIV infection
Evans, D. L., Leserman, J., Perkins, D. O., Stern, R. A., Murphy, C. V., Zheng, B., Gettes, D. R., Longmate, J., Silva, S. G., van der Horst, C. M., et al. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.5.630 · Cited by 182 · see citing works
Self-citationFarinpour, R., Miller, E. N., Satz, P., Selnes, O. A., Cohen, B. A., Becker, J. T., Skolasky, R. L., & Visscher, B. R. (2003) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.25.5.654.14577 · Cited by 181 · see citing works
the MANIF 2000 Study Group, Bouhnik, A., Préau, M., Vincent, E., Carrieri, P., Gallais, H., Lepeu, G., Gastaut, J., Moatti, J., & Spire, B. (2005) · Antiviral Therapy · doi:10.1177/135965350501000103 · Cited by 180 · see citing works
Do Positive Psychosocial Factors Predict Disease Progression in HIV-1? A Review of the Evidence
Ironson, G., & Hayward, H. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318177216c · Cited by 174 · see citing works
Ironson, G. H., Friedman, A. L., Klimas, N. G., Antoni, M. H., FLETCHER, M. A., LaPerriere, A. R., Simoneau, J., & Schneiderman, N. (1994) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0101_6 · Cited by 168 · see citing works
Katz, M. H., Cunningham, W. E., Fleishman, J. A., Andersen, R. M., Kellogg, T., Bozzette, S. A., & Shapiro, M. F. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-8_part_1-200110160-00006 · Cited by 162 · see citing works
Traumatic Stress in HIV-Infected Women
Kimerling, R. E., Calhoun, K. S., Forehand, R., Armistead, L. P., Morse, E. V., Morse, P., Clark, R., & Clark, L. (1999) · AIDS Education and Prevention · doi:10.1521/aeap.1999.11.4.321 · Cited by 159 · see citing works
Comorbidity and survival in HIV-Infected men in the San Francisco Men's Health Survey
Page, K. A., DeLorenze, G. N., Satariano, W. A., & Winkelstein, W. (1996) · Annals of Epidemiology · doi:10.1016/s1047-2797(96)00064-6 · Cited by 157 · see citing works
Whetten, K., Leserman, J., Lowe, K., Stangl, D. K., Thielman, N. M., Swartz, M. S., Hanisch, L. J., & Scoyoc, L. V. (2006) · American Journal of Public Health · doi:10.2105/ajph.2005.063263 · Cited by 145 · see citing works
Self-citationAnastos, K., Schneider, M. F., Gange, S. J., MINKOFF, H. L., Greenblatt, R. M., Feldman, J. G., Levine, A. M., Delapenha, R., & Cohen, M. H. (2005) · PubMed · Cited by 142 · see citing works
Carrico, A. W., & Antoni, M. H. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31817a5d30 · Cited by 139 · see citing works
Psychiatric co-morbidity in vulnerable populations receiving primary care for HIV/AIDS
Israelski, D. M., Prentiss, D., Lubega, S., Balmas, G., Garcia, P., Muhammad, M. A., Cummings, S. E., & Koopman, C. (2006) · AIDS Care · doi:10.1080/09540120600774230 · Cited by 136 · see citing works
Relationship of psychosocial factors to HIV disease progression1,2,3
Patterson, T. L., Shaw, W. S., Semple, S. J., Cherner, M., McCutchan, J. A., Atkinson, J. H., Grant, I., & Nannis, E. D. (1996) · Annals of Behavioral Medicine · doi:10.1007/bf02903937 · Cited by 132 · see citing works
Li, X., Margolick, J. B., Conover, C. S., Badri, S. M., Riddler, S. A., Witt, M. D., & Jacobson, L. P. (2005) · PubMed · Cited by 113 · see citing works
Effects of AIDS-Related Bereavement on HIV Progression Among New York City Gay Men
Kemeny, M. E., & Dean, L. (1995) · AIDS Education and Prevention · doi:10.1521/aeap.1995.7.supp.36 · Cited by 103 · see citing works
Use of Psychotropic Medications Among HIV-Infected Patients in the United States
Vitiello, B., Burnam, M. A., Bing, E. G., Beckman, R., & Shapiro, M. F. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.547 · Cited by 102 · see citing works
Immune System Changes After the Death of a Partner in HIV-Positive Gay Men
Kemeny, M. E., Weiner, H., Durán, R. E., Taylor, S. E., Visscher, B. R., & Fahey, J. L. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199511000-00007 · Cited by 95 · see citing works
Stressful life events and symptom onset in HIV infection
Kessler, R. C., Foster, C., Joseph, J. G., Ostrow, D., Wortman, C. B., Phair, J., & Chmiel, J. S. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.6.733 · Cited by 95 · see citing works
Psychosocial Influences on HIV-1 Disease Progression: Neural, Endocrine, and Virologic Mechanisms
Cole, S. W. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181773bbd · Cited by 92 · see citing works
Ickovics, J. R., Milan, S., BOLAND, R. J., Schoenbaum, E. E., Schuman, P. C., & Vlahov, D. (2006) · AIDS · doi:10.1097/01.aids.0000244204.95758.15 · Cited by 89 · see citing works
Behavioral Mediation of the Relationship Between Psychosocial Factors and HIV Disease Progression
Gore-Felton, C. E., & Koopman, C. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318177353e · Cited by 86 · see citing works
Goodkin, K., Feaster, D. J., Tuttle, R., Blaney, N. T., Kumar, M., Baum, M. K., Shapshak, P., & Fletcher, M. A. (1996) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.3.1.109-118.1996 · Cited by 84 · see citing works
Kalichman, S. C. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181773bce · Cited by 72 · see citing works
Are there alternatives to traditional polygraph procedures?
Bashore, T. R., & Rapp, P. E. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.113.1.3 · Cited by 57 · see citing works
Predictors of AIDS-Related Morbidity and Mortality in a Southern U.S. Cohort
Mugavero, M. J., Pence, B. W., Whetten, K., Leserman, J., Swartz, M. S., Stangl, D. K., & Thielman, N. M. (2007) · AIDS Patient Care and STDs · doi:10.1089/apc.2006.0167 · Cited by 56 · see citing works
Self-citationImmune correlates of stress and depression.
Evans, D. L., Leserman, J., Pedersen, C. A., Golden, R. N., Lewis, M. H., Folds, J., & Ozer, H. (1989) · PubMed · Cited by 54 · see citing works
Self-citationHowland, L. C., Gortmaker, S. L., MOFENSON, L. M., Spino, C., Gardner, J. D., Gorski, H., Fowler, M. G., & Oleske, J. M. (2000) · PEDIATRICS · doi:10.1542/peds.106.3.540 · Cited by 52 · see citing works
Psychological Distress and Progression to AIDS in a Cohort of Injection Drug Users
Golub, E. T., Astemborski, J. A., Hoover, D. R., Anthony, J. C., Vlahov, D., & Strathdee, S. A. (2003) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200304010-00013 · Cited by 46 · see citing works
Taylor, S. L., Burnam, M. A., Sherbourne, C. D., Andersen, R. M., & Cunningham, W. E. (2004) · The Journal of Behavioral Health Services & Research · doi:10.1007/bf02287378 · Cited by 35 · see citing works
Petitto, J. M., Leserman, J., Perkins, D. O., Stern, R. A., Silva, S. G., Silva, S. G., Zheng, B., Folds, J. D., Golden, R. N., & Evans, D. L. (2000) · Behavioral Medicine · doi:10.1080/08964280009595743 · Cited by 23 · see citing works
Self-citationTwenty Years into the HIV Epidemic, Do We CARE Enough To Manage It Well?
Holmes, W. C., & Conare, K. R. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-8_part_1-200110160-00012 · Cited by 3 · see citing works
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A Handbook for the Study of Mental Health Second Edition
Scheid, T. L., & Brown, T. N. (2009) · Cited by 1,320 · see citing works
HIV Stigma Mechanisms and Well-Being Among PLWH: A Test of the HIV Stigma Framework
Earnshaw, V. A., Smith, L. R., Chaudoir, S. R., Amico, K. R., & Copenhaver, M. M. (2013) · AIDS and Behavior · doi:10.1007/s10461-013-0437-9 · Cited by 805 · see citing works
Depression and HIV/AIDS Treatment Nonadherence: A Review and Meta-analysis
Gonzalez, J. S., Batchelder, A., Psaros, C., & Safren, S. (2011) · Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31822d490a · Cited by 782 · see citing works
Mental health and HIV/AIDS: the need for an integrated response
Remien, R. H., Stirratt, M. J., Nguyen, N., Robbins, R. N., Pala, A. N., & Mellins, C. A. (2019) · AIDS · doi:10.1097/qad.0000000000002227 · Cited by 727 · see citing works
Ten Surprising Facts About Stressful Life Events and Disease Risk
Cohen, S., Murphy, M. L. M., & Prather, A. A. (2019) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-102857 · Cited by 531 · see citing works
Rosenfield, S., & Mouzon, D. M. (2012) · Handbooks of sociology and social research · doi:10.1007/978-94-007-4276-5_14 · Cited by 553 · see citing works
Framing Mechanisms Linking HIV-Related Stigma, Adherence to Treatment, and Health Outcomes
Turan, B., Hatcher, A. M., Weiser, S. D., Johnson, M. O., Rice, W. S., & Turan, J. M. (2017) · American Journal of Public Health · doi:10.2105/ajph.2017.303744 · Cited by 492 · see citing works
Depression in HIV Infected Patients: a Review
Nanni, M. G., Caruso, R., Mitchell, A. J., Meggiolaro, E., & Grassi, L. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-014-0530-4 · Cited by 511 · see citing works
Whetten, K., Reif, S., Whetten, R., & Murphy-McMillan, L. K. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31817749dc · Cited by 352 · see citing works
HIV and depression: 2008 review and update
Rabkin, J. G. (2008) · Current HIV/AIDS Reports · doi:10.1007/s11904-008-0025-1 · Cited by 345 · see citing works
Depression and immunity: A role for T cells?
Miller, A. H. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.009 · Cited by 340 · see citing works
A review of psychological correlates of adjustment in patients with multiple sclerosis
Dennison, L., Moss-Morris, R., & Chalder, T. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2008.12.001 · Cited by 330 · see citing works
Quality of life: The ultimate outcome measure of interventions in major depressive disorder
IsHak, W. W., Greenberg, J. M., Balayan, K., Kapitanski, N., Jeffrey, J., Fathy, H., Fakhry, H., & Rapaport, M. H. (2011) · Harvard Review of Psychiatry · doi:10.3109/10673229.2011.614099 · Cited by 313 · see citing works
Life Stress and Health: A Review of Conceptual Issues and Recent Findings
Slavich, G. M. (2016) · Teaching of Psychology · doi:10.1177/0098628316662768 · Cited by 300 · see citing works
Link, B. G., & Phelan, J. C. (2012) · Handbooks of sociology and social research · doi:10.1007/978-94-007-4276-5_25 · Cited by 304 · see citing works
Williams, E. C., Hahn, J. A., Saitz, R., Bryant, K., Lira, M. C., & Samet, J. H. (2016) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13204 · Cited by 294 · see citing works
Slavich, G. M., & Shields, G. S. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000534 · Cited by 268 · see citing works
Do, A. N., Rosenberg, E. S., Sullivan, P. S., Beer, L., Strine, T. W., Schulden, J. D., Fagan, J. L., Freedman, M. S., & Skarbinski, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092842 · Cited by 274 · see citing works
Kretchy, I. A., Owusu-Daaku, F. T., & Danquah, S. A. (2014) · International Journal of Mental Health Systems · doi:10.1186/1752-4458-8-25 · Cited by 264 · see citing works
The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253 · see citing works
Maternal depressive symptoms and early childhood cognitive development: a meta-analysis
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Arseniou, S., Arvaniti, A., & Samakouri, M. A. (2013) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12097 · Cited by 231 · see citing works
Earnshaw, V. A., Lang, S. M., Lippitt, M., Jin, H., & Chaudoir, S. R. (2014) · AIDS and Behavior · doi:10.1007/s10461-014-0758-3 · Cited by 231 · see citing works
Safren, S. A., O’Cleirigh, C. M., Bullis, J. R., Otto, M. W., Stein, M. D., & Pollack, M. H. (2012) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0028208 · Cited by 221 · see citing works
Bhana, A., Rathod, S. D., Selohilwe, O., Kathree, T., & Petersen, I. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0503-0 · Cited by 197 · see citing works
Do Positive Psychosocial Factors Predict Disease Progression in HIV-1? A Review of the Evidence
Ironson, G., & Hayward, H. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318177216c · Cited by 174 · see citing works
Fisher, E. B., Fitzgibbon, M., Glasgow, R. E., Haire-Joshu, D. L., Hayman, L. L., Kaplan, R. M., Nanney, M. S., & Ockene, J. K. (2011) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2010.12.031 · Cited by 183 · see citing works
Alcohol and HIV Disease Progression: Weighing the Evidence
Hahn, J. A., & Samet, J. H. (2010) · Current HIV/AIDS Reports · doi:10.1007/s11904-010-0060-6 · Cited by 181 · see citing works
Gayner, B., Esplen, M. J., DeRoche, P., Wong, J., Bishop, S., Kavanagh, L., & Butler, K. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-011-9350-8 · Cited by 171 · see citing works
Mental Health in Women Living With HIV: The Unique and Unmet Needs
Waldron, E. M., Burnett‐Zeigler, I., Wee, V., Ng, Y. K. W., Koenig, L. J., Pederson, A. B., Tomaszewski, E. P., & Miller, E. S. (2021) · Journal of the International Association of Providers of AIDS Care (JIAPAC) · doi:10.1177/2325958220985665 · Cited by 174 · see citing works
Pence, B. W. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp006 · Cited by 158 · see citing works
Chishinga, N., Kinyanda, E., Weiss, H. A., Patel, V., Ayles, H., & Seedat, S. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-75 · Cited by 146 · see citing works
View of God as benevolent and forgiving or punishing and judgmental predicts HIV disease progression
Ironson, G., Stuetzle, R., Ironson, D., Balbin, E., Kremer, H., George, A., Schneiderman, N., & Fletcher, M. (2011) · Journal of behavioral medicine · doi:10.1007/s10865-011-9314-z · Cited by 112 · see citing works
Blashill, A. J., Perry, N., & Safren, S. A. (2011) · Current HIV/AIDS Reports · doi:10.1007/s11904-011-0089-1 · Cited by 140 · see citing works
Carrico, A. W., & Antoni, M. H. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31817a5d30 · Cited by 139 · see citing works
Carrico, A. W., Riley, E. D., Johnson, M. O., Charlebois, E. D., Neilands, T. B., Remien, R. H., Lightfoot, M. A., Steward, W. T., Weinhardt, L. S., Kelly, J. A., et al. (2010) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318201df63 · Cited by 137 · see citing works
The Depression Treatment Cascade in Primary Care: A Public Health Perspective
Pence, B. W., O’Donnell, J. K., & Gaynes, B. N. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0274-y · Cited by 133 · see citing works
Pain, Mood, and Substance Abuse in HIV
Merlin, J. S., Westfall, A. O., Raper, J. L., Zinski, A., Norton, W. E., Willig, J. H., Gross, R., Ritchie, C. S., Saag, M. S., & Mugavero, M. J. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3182662215 · Cited by 132 · see citing works
Kalichman, S. C., & Grebler, T. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181f01be3 · Cited by 129 · see citing works
The shifting landscape of health care: toward a model of health care empowerment.
Johnson, M. O. (2011) · American Journal of Public Health · doi:10.2105/ajph.2009.189829 · Cited by 134 · see citing works
Mugavero, M. J., Raper, J. L., Reif, S., Whetten, K., Leserman, J., Thielman, N. M., & Pence, B. W. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181bfe8d2 · Cited by 122 · see citing works
Self-citationCommon mental disorders in TB/HIV co-infected patients in Ethiopia
Deribew, A., Tesfaye, M., Hailmichael, Y., Apers, L., Abebe, G., Duchateau, L., & Colebunders, R. (2010) · BMC Infectious Diseases · doi:10.1186/1471-2334-10-201 · Cited by 121 · see citing works
A Review of Recent Literature on Trauma Among Individuals Living with HIV
LeGrand, S., Reif, S., Sullivan, K., Murray, K., Barlow, M. L., & Whetten, K. (2015) · Current HIV/AIDS Reports · doi:10.1007/s11904-015-0288-2 · Cited by 121 · see citing works
Chida, Y., & Vedhara, K. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.01.013 · Cited by 119 · see citing works
Is intimate partner violence associated with HIV infection among women in the United States?
Sareen, J., Pagura, J., & Grant, B. F. (2009) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2009.02.004 · Cited by 115 · see citing works
Abas, M., Nyamayaro, P., Bere, T., Saruchera, E., Mothobi, N. Z., Simms, V., Mangezi, W., Macpherson, K., Croome, N., Magidson, J., et al. (2017) · Aids and Behavior · doi:10.1007/s10461-016-1659-4 · Cited by 83 · see citing works
Wang, T., Fu, H., Kaminga, A. C., Li, Z., Guo, G., Chen, L., & Li, Q. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1741-8 · Cited by 110 · see citing works
Relationship Between Spiritual Coping and Survival in Patients with HIV
Ironson, G., Kremer, H., & Lucette, A. (2016) · Journal of general internal medicine · doi:10.1007/s11606-016-3668-4 · Cited by 17 · see citing works
Predictors of Late Presentation for HIV Diagnosis: A Literature Review and Suggested Way Forward
Mukolo, A., Villegas, R., Aliyu, M. H., & Wallston, K. A. (2012) · AIDS and Behavior · doi:10.1007/s10461-011-0097-6 · Cited by 108 · see citing works
The Influence of Depression on the Progression of HIV
Schuster, R. M., Bornovalova, M. A., & Hunt, E. D. (2011) · Behavior Modification · doi:10.1177/0145445511425231 · Cited by 108 · see citing works
Pence, B. W., Gaynes, B. N., Atashili, J., O’Donnell, J. K., Tayong, G., Kats, D., Whetten, R., Whetten, K., NJAMNSHI, A. K., & Ndumbe, P. M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.05.056 · Cited by 105 · see citing works
Palar, K., Kushel, M., Frongillo, E. A., Riley, E. D., Grede, N., Bangsberg, D. R., & Weiser, S. D. (2014) · AIDS and Behavior · doi:10.1007/s10461-014-0922-9 · Cited by 102 · see citing works
Breet, E., Kagee, A., & Seedat, S. (2014) · AIDS Care · doi:10.1080/09540121.2014.901486 · Cited by 101 · see citing works
Social support and the psychological wellbeing of people living with HIV/AIDS in Ghana
Asante, K. O. (2012) · African Journal of Psychiatry · doi:10.4314/ajpsy.v15i5.42 · Cited by 101 · see citing works
Kaaya, S., Blander, J., Antelman, G., Cyprian, F., Emmons, K. M., Matsumoto, K., Chopyak, E., Levine, M., & Fawzi, M. C. S. (2013) · AIDS Care · doi:10.1080/09540121.2013.763891 · Cited by 99 · see citing works
Passos, S. M. K., & Souza, L. D. D. M. (2015) · Cadernos de Saúde Pública · doi:10.1590/0102-311x00000514 · Cited by 98 · see citing works
Global Systematic Review of Common Mental Health Disorders in Adults Living with HIV
Hoare, J., Sevenoaks, T., Mtukushe, B., Williams, T., Heany, S. J., & Phillips, N. J. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-021-00583-w · Cited by 99 · see citing works
Suzuki, H., Savitz, J. B., Teague, T. K., Gandhapudi, S. K., Tan, C., Misaki, M., McKinney, B. A., Irwin, M. R., Drevets, W. C., & Bodurka, J. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.011 · Cited by 94 · see citing works
Mental Health Services in South Africa: Taking stock
Lund, C., Petersen, I., Kleintjes, S., & Bhana, A. (2012) · African Journal of Psychiatry · doi:10.4314/ajpsy.v15i6.48 · Cited by 94 · see citing works
Marshall, G. D. (2010) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2010.09.013 · Cited by 93 · see citing works
Serum kynurenic acid is reduced in affective psychosis
Wurfel, B., Drevets, W., Bliss, S., Mcmillin, J., Suzuki, H., Ford, B., Morris, H., Teague, T., Dantzer, R., & Savitz, J. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.88 · Cited by 92 · see citing works
Psychosocial Influences on HIV-1 Disease Progression: Neural, Endocrine, and Virologic Mechanisms
Cole, S. W. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181773bbd · Cited by 92 · see citing works
Rios, P. D. L., Okoli, C., Castellanos, E., Allan, B., Young, B., Brough, G., Muchenje, M., Eremin, A., Corbelli, G. M., McBritton, M., et al. (2020) · AIDS and Behavior · doi:10.1007/s10461-020-03055-1 · Cited by 91 · see citing works
Eller, L. S., Rivero‐Méndez, M., Voss, J. G., Chen, W.-T., Chaiphibalsarisdi, P., Iipinge, S. N., Johnson, M. O., Portillo, C. J., Corless, I. B., Sullivan, K. M., et al. (2013) · AIDS Care · doi:10.1080/09540121.2013.841842 · Cited by 91 · see citing works
Klimas, N. G., Koneru, A. O., & FLETCHER, M. A. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31817ae69f · Cited by 91 · see citing works
Midtbø, V., Shirima, V., Skovdal, M., & Daniel, M. (2012) · African Journal of AIDS Research · doi:10.2989/16085906.2012.734987 · Cited by 90 · see citing works
Effects of behavioral stress reduction Transcendental Meditation intervention in persons with HIV
Chhatre, S., Metzger, D. S., Frank, I., Boyer, J., Thompson, E., Nidich, S. I., Montaner, L. J., & Jayadevappa, R. (2013) · AIDS Care · doi:10.1080/09540121.2013.764396 · Cited by 86 · see citing works
Behavioral Mediation of the Relationship Between Psychosocial Factors and HIV Disease Progression
Gore-Felton, C. E., & Koopman, C. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318177353e · Cited by 86 · see citing works
Depression as an evolutionary strategy for defense against infection
Anders, S. L., Tanaka, M., & Kinney, D. K. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.12.002 · Cited by 84 · see citing works
Wu, J., Ci-yong, L., Xueqing, D., Wang, H., & Lingyao, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032312 · Cited by 85 · see citing works
Prevalence of depression and anxiety disorders in HIV-positive outpatients in rural Tanzania
Marwick, K. F. M., & Kaaya, S. (2010) · AIDS Care · doi:10.1080/09540120903253981 · Cited by 85 · see citing works
Depression in patients with HIV is under‐diagnosed: a cross‐sectional study in Denmark
Rodkjær, L. Ø., Laursen, T. L., Balle, N., & Sodemann, M. (2009) · HIV Medicine · doi:10.1111/j.1468-1293.2009.00741.x · Cited by 84 · see citing works
Rzeszutek, M., Oniszczenko, W., & Firląg‐Burkacka, E. (2017) · Journal of Behavioral Medicine · doi:10.1007/s10865-017-9861-z · Cited by 87 · see citing works
Emotional support and gender in people living with HIV: effects on psychological well-being
The Eurosupport Study Group, Gordillo, V. C., Fekete, E. M., Platteau, T., Antoni, M. H., Schneiderman, N., & Nöstlinger, C. (2009) · Journal of Behavioral Medicine · doi:10.1007/s10865-009-9222-7 · Cited by 78 · see citing works
HIV stigma and viral load among African-American women receiving treatment for HIV
Kemp, C. G., Lipira, L. E., Huh, D., Nevin, P. E., Turan, J. M., Simoni, J. M., Cohn, S. E., Bahk, M., Berzins, B., Andrasik, M. P., et al. (2019) · AIDS · doi:10.1097/qad.0000000000002212 · Cited by 79 · see citing works
Transgender women and HIV-related health disparities: falling off the HIV treatment cascade
Kalichman, S. C., Hernandez, D. B., Finneran, S. D., Price, D. M., & Driver, R. (2017) · Sexual Health · doi:10.1071/sh17015 · Cited by 78 · see citing works
Glynn, T. R., Safren, S. A., Carrico, A. W., Mendez, N. A., Duthely, L. M., Dale, S. K., Jones, D. L., Feaster, D. J., & Rodriguez, A. E. (2019) · AIDS and Behavior · doi:10.1007/s10461-019-02619-0 · Cited by 79 · see citing works
Chaudoir, S. R., Norton, W. E., Earnshaw, V. A., Moneyham, L. L., Mugavero, M. J., & Hiers, K. M. (2011) · AIDS and Behavior · doi:10.1007/s10461-011-0039-3 · Cited by 77 · see citing works
Mental Illness and the Criminal Justice System
Hiday, V. A., & Burns, P. J. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511984945.029 · Cited by 77 · see citing works
González-García, M., Ferrer, M. J., Borràs, X., Muñoz-Moreno, J. A., Miranda, C., Puig, J., Pérez‐Álvarez, N., Soler, J., Feliu‐Soler, A., Clotet, B., et al. (2013) · AIDS and Behavior · doi:10.1007/s10461-013-0612-z · Cited by 80 · see citing works
Effects of exercise on depression and anxiety in persons living with HIV: A meta-analysis
Heißel, A., Zech, P. A., Rapp, M. A., Schuch, F. B., Lawrence, J. B., Kangas, M., & Heinzel, S. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.109823 · Cited by 76 · see citing works
Seth, P., Kidder, D. P., Pals, S. L., Parent, J., Mbatia, R., Chesang, K., Mbilinyi, D., Koech, E., Nkingwa, M., Katuta, F., et al. (2013) · Prevention Science · doi:10.1007/s11121-013-0420-8 · Cited by 76 · see citing works
SeyedAlinaghi, S., Jam, S., Foroughi, M., Imani, A., Mohraz, M., Djavid, G. E., & Black, D. S. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31825abfaa · Cited by 76 · see citing works
Psychological Approaches to Mental Illness
Peterson, C. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511984945.008 · Cited by 76 · see citing works
Flickinger, T., DeBolt, C. L., Waldman, A. L., Reynolds, G., Cohn, W. F., Beach, M. C., Ingersoll, K. S., & Dillingham, R. (2016) · AIDS and Behavior · doi:10.1007/s10461-016-1587-3 · Cited by 76 · see citing works
Mental Health, Psychosocial Challenges and Resilience in Older Adults Living with HIV
Halkitis, P. N., Krause, K. D., & Vieira, D. L. (2016) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000448564 · Cited by 74 · see citing works
Blashill, A. J., Safren, S. A., Wilhelm, S., Jampel, J. D., Taylor, S. W., O’Cleirigh, C. M., & Mayer, K. H. (2017) · Health Psychology · doi:10.1037/hea0000505 · Cited by 72 · see citing works
Maman, S., Cathcart, R., Burkhardt, G., Omba, S., & Behets, F. (2009) · Social Science & Medicine · doi:10.1016/j.socscimed.2008.12.028 · Cited by 72 · see citing works
Seay, J. S., McIntosh, R., Fekete, E. M., Fletcher, M. A., Kumar, M., Schneiderman, N., & Antoni, M. H. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.022 · Cited by 70 · see citing works
Relf, M. V., Pan, W., Edmonds, A., Ramirez, C. B., Amarasekara, S., & Adimora, A. A. (2019) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002033 · Cited by 70 · see citing works
Pereira, M., & Canavarro, M. C. (2011) · AIDS and Behavior · doi:10.1007/s10461-011-9928-8 · Cited by 70 · see citing works
Childhood Trauma and Health Outcomes in HIV-Infected Patients
Pence, B. W., Mugavero, M. J., Carter, T., Leserman, J., Thielman, N. M., Raper, J. L., Proeschold‐Bell, R. J., Reif, S., & Whetten, K. (2011) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31824150bb · Cited by 69 · see citing works
Self-citationMarital Status and Mental Health
Williams, K., Frech, A., & Carlson, D. L. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511984945.020 · Cited by 68 · see citing works
A Conceptual Framework for Understanding Chronic Pain in Patients with HIV
Merlin, J. S., Zinski, A., Norton, W. E., Ritchie, C. S., Saag, M. S., Mugavero, M. J., Treisman, G. J., & Hooten, W. M. (2013) · Pain Practice · doi:10.1111/papr.12052 · Cited by 68 · see citing works
Raison, C. L., & Miller, A. H. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.194 · Cited by 68 · see citing works
Scott-Sheldon, L. A. J., Balletto, B. L., Donahue, M. L., Feulner, M. M., Cruess, D. G., Salmoirago-Blotcher, E., Wing, R. R., & Carey, M. P. (2019) · AIDS and Behavior · doi:10.1007/s10461-018-2236-9 · Cited by 68 · see citing works
Neuropsychiatric complications of aging with HIV
Watkins, C. C., & Treisman, G. J. (2012) · Journal of NeuroVirology · doi:10.1007/s13365-012-0108-z · Cited by 64 · see citing works
Kidia, K. K., Machando, D., Bere, T. C., Macpherson, K., Nyamayaro, P. C., Potter, L., Makadzange, T., Munjoma, R., Marufu, M., Araya, R., et al. (2015) · Tropical Medicine & International Health · doi:10.1111/tmi.12502 · Cited by 67 · see citing works
Matsumoto, S., Yamaoka, K., Takahashi, K., Tanuma, J., Mizushima, D., Duy, C., Nguyen, D. T., Nguyen, H. D. T., Nguyen, K. V., & Oka, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-15768-w · Cited by 66 · see citing works
Kurbi, H. A., Shumet, S., Nassir, Z., Agidew, M., & Angaw, D. A. (2019) · AIDS Research and Treatment · doi:10.1155/2019/4610458 · Cited by 66 · see citing works
- Authors
- Leserman, J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Leserman, Jane
- Venue
- Psychosomatic Medicine
- Published
- 2008-06
- Volume
- 70
- Issue
- 5
- Pages
- 539-545
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2018119542
- Cited by
- 662
- References
- 63
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 22 · 2023: 18 · 2022: 35 · 2021: 37 · 2020: 35 · 2019: 45 · 2018: 43 · 2017: 86 · 2016: 47 · 2015: 35 · 2014: 38 · 2013: 44 · 2012: 50
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Complementary and Integrative Health (R01AT002035)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- HIV disease progression, depression, stress, trauma, life events, CD4 count, viral load, clinical deterioration, mortality, psychoneuroimmunology, highly active antiretroviral therapy, psychosocial interventions
- MeSH terms
- Depressive Disorder, Health Services Needs and Demand, Humans, Life Change Events, Longitudinal Studies, Patient Care Team, Patient Compliance, Psychoneuroimmunology, Risk Factors, Stress, Psychological, HIV Infections, Comorbidity, Disease Progression, CD4 Lymphocyte Count, Viral Load, Antiretroviral Therapy, Highly Active
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