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Cited by 30Neurological disorders and treatmentsObsessive-Compulsive Spectrum DisordersTranscranial Magnetic Stimulation Studies

Deep brain stimulation for psychiatric diseases: what are the risks?

Saleh, Christian, Fontaine, Denys·2015·Current Psychiatry Reports
DOI 10.1007/s11920-015-0565-1
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Abstract

Despite the application of deep brain stimulation (DBS) as an efficient treatment modality for psychiatric disorders, such as obsessive-compulsive disorder (OCD), Gilles de la Tourette Syndrome (GTS), and treatment refractory major depression (TRD), few patients are operated or included in clinical trials, often for fear of the potential risks of an approach deemed too dangerous. To assess the surgical risks, we conducted an analysis of publications on DBS for psychiatric disorders. A PubMed search was conducted on reports on DBS for OCD, GTS, and TRD. Forty-nine articles were included. Only reports on complications related to DBS were selected and analyzed. Two hundred seventy-two patients with a mean follow-up of 22 months were included in our analysis. Surgical mortality was nil. The overall mortality was 1.1 %: two suicides were unrelated to DBS and one death was reported to be unlikely due to DBS. The majority of complications were transient and related to stimulation. Long-term morbidity occurred in 16.5 % of cases. Three patients had permanent neurological complications due to intracerebral hemorrhage (2.2 %). Complications reported in DBS for psychiatric diseases appear to be similar to those reported for DBS in movement disorders. But class I evidence is lacking. Our analysis was based mainly on small non-randomized studies. A significant number of patients (approximately 150 patients) who were treated with DBS for psychiatric diseases had to be excluded from our analysis as no data on complications was available. The exact prevalence of complications of DBS in psychiatric diseases could not be established. DBS for psychiatric diseases is promising, but remains an experimental technique in need of further evaluation. A close surveillance of patients undergoing DBS for psychiatric diseases is mandatory.

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  • Neurostimulation such as vagus nerve stimulation, deep brain stimulation, or electroconvulsive therapy carries a risk of infections and other potential side effects due to surgical implantation.

    “Neurostimulation, such as vagus nerve stimulation (VNS), deep brain stimulation (DBS), or electroconvulsive therapy (ECT), has been recommended and is effective for treatment-resistant depression; however, these interventions also possess a certain risk of developing infections and other potential side effects due to surgical implantation.[6–8]”

    From Transcutaneous auricular vagus nerve stimulation in treating major depressive disorder: A systematic review and meta-analysis (2018) · cites this paper as [8]

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Authors
Saleh, C., & Fontaine, D.
Affiliations
Centre Hospitalier Universitaire de Nice (FR)
Corresponding author
  • Saleh, Christian
  • Fontaine, Denys
ORCID
Venue
Current Psychiatry Reports
Publisher
Springer Science and Business Media LLC
Published
2015-03-21
Volume
17
Issue
5
Pages
33-33
ISSN
  • 1523-3812 (ISSN-L)
  • 1535-1645
DOI
10.1007/s11920-015-0565-1
OpenAlex
W2056640951
Cited by
30
References
104
Citations by year
2025: 4 · 2024: 2 · 2022: 3 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 6 · 2016: 3
FWCI
0.66
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Current Psychiatry Reports (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Boston Scientific Corporation
  • School of Medicine, Emory University
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords
deep brain stimulation, mental illness, obsessive-compulsive disorder, Tourette syndrome, surgical complications, intracerebral hemorrhage, long-term morbidity, suicide
MeSH terms
Major Depressive Disorder, Tourette Syndrome, Humans, Obsessive-Compulsive Disorder, Risk, Therapies, Investigational, Deep Brain Stimulation

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