Double-blind optimization of subcallosal cingulate deep brain stimulation for treatment-resistant depression: a pilot study
Open accessAbstract
BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is reported to be a safe and effective new treatment for treatment-resistant depression (TRD). However, the optimal electrical stimulation parameters are unknown and generally selected by trial and error. This pilot study investigated the relationship between stimulus parameters and clinical effects in SCC-DBS treatment for TRD. METHODS: Four patients with TRD underwent SCC-DBS surgery. In a double-blind stimulus optimization phase, frequency and pulse widths were randomly altered weekly, and corresponding changes in mood and depression were evaluated using a visual analogue scale (VAS) and the 17-item Hamilton Rating Scale for Depression (HAM-D-17). In the open-label postoptimization phase, depressive symptoms were evaluated biweekly for 6 months to determine long-term clinical outcomes. RESULTS: Longer pulse widths (270-450 μs) were associated with reductions in HAM-D-17 scores in 3 patients and maximal happy mood VAS responses in all 4 patients. Only 1 patient showed acute clinical or mood effects from changing the stimulation frequency. After 6 months of open-label therapy, 2 patients responded and 1 patient partially responded. LIMITATIONS: Limitations include small sample size, weekly changes in stimulus parameters, and fixed-order and carry-forward effects. CONCLUSION: Longer pulse width stimulation may have a role in stimulus optimization for SCC-DBS in TRD. Longer pulse durations produce larger apparent current spread, suggesting that we do not yet know the optimal target or stimulus parameters for this therapy. Investigations using different stimulus parameters are required before embarking on large-scale randomized sham-controlled trials.
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Studies of subcallosal cingulate cortex DBS for treatment-resistant depression generally use fixed frequency (130 Hz) and pulse-width (90 μs).
“While in general, studies of SCC DBS for TRD use fixed frequency (130 Hz) and pulse-width (90 μs), three studies were specifically designed to test effects of different stimulation parameters [32][33][34].”
From Deep brain stimulation for depression. (2022) · cites this paper as [33]
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Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Which elements are excited in electrical stimulation of mammalian central nervous system: A review
Ranck, J. B. (1975) · Brain Research · doi:10.1016/0006-8993(75)90364-9 · Cited by 2,024 · see citing works
Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
Fisher, R. S., Salanova, V., Witt, T. C., Worth, R. M., Henry, T. R., Gross, R. E., Oommen, K. J., Osorio, I., Nazzaro, J. M., Labar, D., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02536.x · Cited by 1,930 · see citing works
Diagnosis and definition of treatment-resistant depression
Fava, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00231-2 · Cited by 1,380 · see citing works
Responsive cortical stimulation for the treatment of medically intractable partial epilepsy
Morrell, M. J. (2011) · Neurology · doi:10.1212/wnl.0b013e3182302056 · Cited by 1,282 · see citing works
Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression
Lozano, A. M., Mayberg, H. S., Giacobbe, P., Hamani, C., Craddock, R. C., & Kennedy, S. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.034 · Cited by 1,024 · see citing works
(1997) · PubMed · Cited by 727 · see citing works
Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Unipolar and Bipolar Depression
Holtzheimer, P. E. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1456 · Cited by 608 · see citing works
Sackeim, H. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00271-8 · Cited by 568 · see citing works
Johansen-Berg, H., Gutman, D. A., Behrens, T. E. J., Matthews, P. M., Rushworth, M. F. S., Katz, E., Lozano, A. M., & Mayberg, H. S. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm167 · Cited by 561 · see citing works
The subcallosal cingulate gyrus in the context of major depression
Hamani, C., Mayberg, H., Stone, S., Laxton, A., Haber, S., & Lozano, A. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.034 · Cited by 508 · see citing works
Deep brain stimulation for treatment-resistant depression: follow-up after 3 to 6 years
Kennedy, S. H., Giacobbe, P., Rizvi, S. J., Placenza, F. M., Nishikawa, Y., Mayberg, H. S., & Lozano, A. M. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10081187 · Cited by 481 · see citing works
Selection of stimulus parameters for deep brain stimulation
Kuncel, A. M., & Grill, W. M. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.05.031 · Cited by 460 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression: Follow-Up After 3 to 6Years
Ballenger, J. C. (2012) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/j.ypsy.2011.08.041 · Cited by 365 · see citing works
Lozano, A. M., Giacobbe, P., Hamani, C., Rizvi, S. J., Kennedy, S. H., Kolivakis, T. T., Debonnel, G., Sadikot, A. F., Lam, R. W., Howard, A. K., et al. (2012) · Journal of Neurosurgery · doi:10.3171/2011.10.jns102122 · Cited by 356 · see citing works
Deep Brain Stimulation for Psychiatric Disorders
Holtzheimer, P. E., & Mayberg, H. S. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113638 · Cited by 332 · see citing works
Puigdemont, D., Pérez‐Egea, R., Portella, M. J., Molet, J., de Diego-Adeliño, J., Gironell, A., Raduà, J., Gómez‐Ansón, B., Rodríguez, R. R., Serra-Blasco, M., et al. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001088 · Cited by 235 · see citing works
The improved Clinical Global Impression Scale (iCGI): development and validation in depression
Kadouri, A., Corruble, E., & Falissard, B. (2007) · BMC Psychiatry · doi:10.1186/1471-244x-7-7 · Cited by 200 · see citing works
Does stimulation of the GPi control dyskinesia by activating inhibitory axons?
Wu, Y.-Y., Levy, R., Ashby, P., Tasker, R. R., & Dostrovsky, J. O. (2001) · Movement Disorders · doi:10.1002/mds.1046 · Cited by 181 · see citing works
Hamani, C., Mayberg, H., Snyder, B., Giacobbe, P., Kennedy, S., & Lozano, A. M. (2009) · Journal of neurosurgery · doi:10.3171/2008.10.jns08763 · Cited by 160 · see citing works
Brain stimulation for the treatment of epilepsy
Jobst, B. C., Darcey, T. M., Thadani, V. M., & Roberts, D. W. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02618.x · Cited by 127 · see citing works
Subthalamic Nucleus Stimulation
Moro, E., Poon, Y. W., Lozano, A. M., Saint‐Cyr, J. A., & Lang, A. E. (2006) · Archives of Neurology · doi:10.1001/archneur.63.9.1266 · Cited by 121 · see citing works
Nursing Time to Program and Assess Deep Brain Stimulators in Movement Disorder Patients
Hunka, K., Suchowersky, O., Wood, S. M., Derwent, L., & Kiss, Z. H. T. (2005) · Journal of Neuroscience Nursing · doi:10.1097/01376517-200508000-00006 · Cited by 88 · see citing works
Self-citationBrain stimulation for the treatment of epilepsy
Fridley, J., Thomas, J. G., Navarro, J. C., & Yoshor, D. (2012) · Neurosurgical FOCUS · doi:10.3171/2012.1.focus11334 · Cited by 72 · see citing works
Richter, E. O., Davis, K. D., Hamani, C., Hutchison, W. D., Dostrovsky, J. O., & Lozano, A. M. (2004) · Neurosurgery · doi:10.1227/01.neu.0000108644.42992.95 · Cited by 69 · see citing works
MacQUEEN, G. M., Parkin, C. K. E., MARRIOTT, M. J., Bégin, H., & Hasey, G. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0724 · Cited by 61 · see citing works
Chalouhi, N., Dumont, A. S., Tjoumakaris, S. I., Gonzalez, L. F., Bilyk, J. R., Randazzo, C. G., Hasan, D. M., Dalyai, R., Rosenwasser, R. H., & Jabbour, P. M. (2012) · Neurosurgical FOCUS · doi:10.3171/2012.1.focus123 · Cited by 40 · see citing works
L-tyrosine to alleviate the effects of stress?
Young, S. N. (2007) · PubMed Central · Cited by 36 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [10]First MB, Spitzer RL, Gibbon M, et al. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P) New York: Biometrics Research, New York State Psychiatric Institute; 2002. [Google Scholar]
- [29]Dougherty DD, Carpenter LL, Bhati MT, et al. A randomized sham-controlled trial of DBS of the VC/VS for treatment-resistant depression [abstract]. Society of Biological Psychiatry 67th annual scientific convention; 2012 May 3–5; Philadelphia, Pa. [Google Scholar]
Cited by
Sorted by citations
Holtzheimer, P. E., Husain, M. M., Lisanby, S. H., Taylor, S. F., Whitworth, L. A., McClintock, S., Slavin, K. V., Berman, J., McKhann, G. M., Patil, P. G., et al. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30371-1 · Cited by 577 · see citing works
Riva-Posse, P., Choi, K. S., Holtzheimer, P. E., McIntyre, C. C., Gross, R. E., Chaturvedi, A., Crowell, A. L., Garlow, S. J., Rajendra, J. K., & Mayberg, H. S. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.03.029 · Cited by 460 · see citing works
Riva-Posse, P., Choi, K. S., Holtzheimer, P. E., Crowell, A. L., Garlow, S. J., Rajendra, J. K., McIntyre, C. C., Gross, R. E., & Mayberg, H. S. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.59 · Cited by 441 · see citing works
Cingulate dynamics track depression recovery with deep brain stimulation
Alagapan, S., Choi, K. S., Heisig, S., Riva‐Posse, P., Crowell, A. L., Tiruvadi, V., Obatusin, M., Veerakumar, A., Waters, A. C., Gross, R. E., et al. (2023) · Nature · doi:10.1038/s41586-023-06541-3 · Cited by 277 · see citing works
Dandekar, M. P., Fenoy, A. J., Carvalho, A. F., Soares, J. C., & Quevedo, J. (2018) · Molecular Psychiatry · doi:10.1038/mp.2018.2 · Cited by 264 · see citing works
Crowell, A. L., Riva‐Posse, P., Holtzheimer, P. E., Garlow, S. J., Kelley, M. E., Gross, R. E., Denison, L., Quinn, S., & Mayberg, H. S. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.18121427 · Cited by 185 · see citing works
Deep brain stimulation for depression.
Figee, M., Riva-Posse, P., Choi, K. S., Bederson, L., Mayberg, H. S., & Kopell, B. H. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01270-3 · Cited by 175 · see citing works
A systematic review and meta-analysis of deep brain stimulation for depression
Kisely, S., Li, A., Warren, N., & Siskind, D. (2018) · Depression and Anxiety · doi:10.1002/da.22746 · Cited by 165 · see citing works
Deep brain stimulation targets for treating depression
Drobisz, D., & Damborská, A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.004 · Cited by 159 · see citing works
Grahn, P. J., Mallory, G. W., Khurram, O. U. H., Berry, B. M., Hachmann, J. T., Bieber, A. J., Bennet, K. E., Min, H.-K. P., Chang, S.-Y., Lee, K. H., et al. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00169 · Cited by 158 · see citing works
Choi, K. S., Riva‐Posse, P., Gross, R. E., & Mayberg, H. S. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.2564 · Cited by 133 · see citing works
Deep brain stimulation (DBS) at the interface of neurology and psychiatry
Williams, N., & Okun, M. S. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68341 · Cited by 125 · see citing works
Ramasubbu, R., Lang, S., & Kiss, Z. H. T. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00302 · Cited by 111 · see citing works
Self-citationDeep brain stimulation in the treatment of depression
Delaloye, S., & Holtzheimer, P. E. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.1/sdelaloye · Cited by 105 · see citing works
Crowell, A. L., Garlow, S. J., Riva-Posse, P., & Mayberg, H. S. (2015) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00041 · Cited by 105 · see citing works
A systematic review and meta-analysis of deep brain stimulation in treatment-resistant depression
Zhou, C., Zhang, H., Qin, Y., Tian, T., Xu, B., Chen, J., Zhou, X., Zeng, L., Fang, L., Qi, X., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.012 · Cited by 100 · see citing works
Raymaekers, S., Luyten, L., Bervoets, C., Gabriëls, L., & Nuttin, B. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.66 · Cited by 82 · see citing works
Ramasubbu, R., Clark, D. L., Golding, S., Dobson, K. S., Mackie, A., Haffenden, A., & Kiss, Z. H. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30415-8 · Cited by 80 · see citing works
Self-citationBari, A., Mikell, C. B., Abosch, A., Ben‐Haim, S., Buchanan, R. J., Burton, A. W., Carcieri, S., Cosgrove, G. R., D’Haese, P.-F., Daskalakis, Z. J., et al. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-317082 · Cited by 70 · see citing works
Self-citationCook (2014) · doi:10.1016/j.nec.2013.10.002 · Cited by 69 · see citing works
Hardenacke, K., Shubina, E., Bührle, C., Zapf, A. C., Lenartz, D., Klosterkötter, J., Visser-Vandewalle, V. E. R. M., & Kuhn, J. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00159 · Cited by 68 · see citing works
A Review of Brain Stimulation Treatments for Late-Life Depression
Blumberger, D. M., Hsu, J. H., & Daskalakis, Z. J. (2015) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-015-0059-0 · Cited by 64 · see citing works
Optimizing Deep Brain Stimulation Parameters in Obsessive–Compulsive Disorder
van Westen, M., Rietveld, E., Bergfeld, I. O., de Koning, P. P., Vullink, N., Ooms, P., Graat, I., Liebrand, L. C., van den Munckhof, P., Schuurman, R., et al. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13243 · Cited by 62 · see citing works
Eitan, R., Fontaine, D., Benoît, M., Giordana, C., Darmon, N., Israel, Z., Linesky, E., Arkadir, D., Ben-Naim, S., Iserlles, M., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.09.026 · Cited by 62 · see citing works
Hitti, F. L., Yang, A. I., Cristancho, M. A., & Baltuch, G. H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092796 · Cited by 51 · see citing works
Brown, E. C., Clark, D., Forkert, N. D., Molnar, C., Kiss, Z. H. T., & Ramasubbu, R. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0745-5 · Cited by 51 · see citing works
Self-citationElias, G. J. B., Germann, J., Boutet, A., Pancholi, A., Beyn, M. E., Bhatia, K. D., Neudorfer, C., Loh, A., Rizvi, S. J., Bhat, V., et al. (2021) · Brain · doi:10.1093/brain/awab284 · Cited by 49 · see citing works
3T MRI of rapid brain activity changes driven by subcallosal cingulate deep brain stimulation
Elias, G. J. B., Germann, J., Boutet, A., Loh, A., Li, B. C. W., Pancholi, A., Beyn, M. E., Naheed, A., Bennett, N., Pinto, J., et al. (2021) · Brain · doi:10.1093/brain/awab447 · Cited by 49 · see citing works
Deep brain stimulation in mental health: Review of evidence for clinical efficacy
Fitzgerald, P. B., & Segrave, R. A. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415598011 · Cited by 47 · see citing works
Smart, O., Choi, K. S., Riva-Posse, P., Tiruvadi, V., Rajendra, J., Waters, A. C., Crowell, A. L., Edwards, J., Gross, R. E., & Mayberg, H. S. (2018) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2018.00043 · Cited by 41 · see citing works
Being open minded about neuromodulation trials: Finding success in our “failures”
Fins, J. J., Kubu, C. S., Mayberg, H. S., Merkel, R., Nuttin, B., & Schlaepfer, T. E. (2016) · Brain stimulation · doi:10.1016/j.brs.2016.12.012 · Cited by 39 · see citing works
Clark, D. L., Johnson, K. A., Butson, C. R., Lebel, C., Gobbi, D., Ramasubbu, R., & Kiss, Z. H. T. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.03.006 · Cited by 36 · see citing works
Self-citationBrain–computer interfaces for neuropsychiatric disorders
Oganesian, L. L., & Shanechi, M. M. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00177-2 · Cited by 39 · see citing works
Sun, L., & Hinrichs, H. (2016) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2016.03.020 · Cited by 36 · see citing works
Sankar, T., Chakravarty, M. M., Jawa, N. A., Li, S. X., Giacobbe, P., Kennedy, S. H., Rizvi, S. J., Mayberg, H. S., Hamani, C., & Lozano, A. M. (2019) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.180207 · Cited by 36 · see citing works
Wu, H.-F., Chen, Y., Chu, M.-C., Hsu, Y.-T., Lu, T.-Y., Chen, I.-T., Chen, P. S., & Lin, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092840 · Cited by 31 · see citing works
Deep brain stimulation for psychiatric diseases: what are the risks?
Saleh, C., & Fontaine, D. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0565-1 · Cited by 30 · see citing works
Target selection for deep brain stimulation in treatment resistant schizophrenia.
Corripio, I., Roldán, A., Mckenna, P., Sarró, S., Alonso-Solís, A., Salgado, L., Álvarez, E., Molet, J., Pomarol-Clotet, E., & Portella, M. (2021) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110436 · Cited by 27 · see citing works
Khairuddin, S., Ngo, F. Y., Lim, W. L., Aquili, L., Khan, N. A., Fung, M.-L., Chan, Y., Temel, Y., & Lim, L. W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103260 · Cited by 26 · see citing works
Ashkan, K., Mirza, A. B., Tambirajoo, K., & Furlanetti, L. L. (2020) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2020.09.004 · Cited by 24 · see citing works
Surgical Approaches in Psychiatry: A Survey of the World Literature on Psychosurgery
Neumaier, F., Paterno, M., Alpdogan, S., Tevoufouet, E. E., Schneider, T., Hescheler, J., & Albanna, W. (2016) · World Neurosurgery · doi:10.1016/j.wneu.2016.10.008 · Cited by 24 · see citing works
State of the Art: Novel Applications for Deep Brain Stimulation
Roy, H., Green, A. L., & Aziz, T. Z. (2017) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12604 · Cited by 23 · see citing works
Thomson, C. J., Segrave, R. A., Fitzgerald, P. B., Richardson, K. E., Racine, É., & Carter, A. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.755276 · Cited by 22 · see citing works
Hitti, F. L., Widge, A. S., Riva‐Posse, P., Malone, D. A., Okun, M. S., Shanechi, M. M., Foote, K. D., Lisanby, S. H., Ankudowich, E., Chivukula, S., et al. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.05.011 · Cited by 21 · see citing works
Crowell, A. L., Riva‐Posse, P., Garlow, S. J., & Mayberg, H. S. (2014) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-014-0008-z · Cited by 21 · see citing works
Effectiveness and Adverse Effects of Deep Brain Stimulation: Umbrella Review of Meta-Analyses
Deschner, J., Papageorgiou, S. N., & Papageorgiou, P. (2016) · Journal of Neurological Surgery Part A Central European Neurosurgery · doi:10.1055/s-0036-1592158 · Cited by 19 · see citing works
Deep brain stimulation for treatment-resistant depression: a safe and effective option
Torre, D. L., Torre, A. D., Chirchiglia, D., Volpentesta, G., Guzzi, G., & Lavano, A. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1749049 · Cited by 18 · see citing works
Elias, G. J. B., Germann, J., Boutet, A., Beyn, M. E., Giacobbe, P., Song, H. N., Choi, K. S., Mayberg, H. S., Kennedy, S. H., & Lozano, A. M. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.08.014 · Cited by 20 · see citing works
Bukumirić, Z., Starčević, V., Stanisavljevic, D. M., Marinković, J., Milic, N. M., Djukić, A., Janjic, V. S., Čorac, A., Ilic, A., Kostic, M., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.10.054 · Cited by 17 · see citing works
Biomarkers for Deep Brain Stimulation in Animal Models of Depression
Yuen, J., Rusheen, A. E., Price, J. B., Barath, A. S., Shin, H., Kouzani, A. Z., Berk, M., Blaha, C. D., Lee, K. H., & Oh, Y. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13483 · Cited by 16 · see citing works
Beeker, T., Schlaepfer, T. E., & Coenen, V. A. (2017) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2017.00011 · Cited by 16 · see citing works
Yuan, Z., Yang, H., Wang, P., Hou, X., Xu, K., Zhou, Y., Dai, R., Gao, Y., Gao, X., Guo, Q., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.07.018 · Cited by 15 · see citing works
Brain-derived neurotrophic factor and subcallosal deep brain stimulation for refractory depression
Ramasubbu, R., Vecchiarelli, H. A., Hill, M. N., & Kiss, Z. H. T. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.952775 · Cited by 14 · see citing works
Self-citationAdverse Effects of Deep Brain Stimulation for Treatment-Resistant Depression: A Scoping Review
Lapa, J. D. D. S., Duarte, J. F. S., Campos, A. C. P., Davidson, B., Nestor, S. M., Rabin, J. S., Giacobbe, P., Lipsman, N., & Hamani, C. (2024) · Neurosurgery · doi:10.1227/neu.0000000000002910 · Cited by 14 · see citing works
Deep Brain Stimulation for Depression
Filkowski, M. M., & Sheth, S. A. (2019) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2018.12.007 · Cited by 13 · see citing works
Recruitment Challenges for Studies of Deep Brain Stimulation for Treatment-Resistant Depression
Ramasubbu, R., Golding, S., Williams, K., Mackie, A., MacQUEEN, G. M., & Kiss, Z. H. T. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s299913 · Cited by 13 · see citing works
Self-citationPatel, E., Ramaiah, P., Mamaril‐Davis, J., Bauer, I. L., Koujah, D., Seideman, T. A., Kelbert, J., Nosova, K., & Bina, R. W. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.251 · Cited by 13 · see citing works
Kabotyanski, K. E., Najera, R. A., Banks, G. P., Sharma, H., Provenza, N. R., Hayden, B. Y., Mathew, S. J., & Sheth, S. A. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02951-7 · Cited by 12 · see citing works
Zhang, X., Wang, X., Dong, D., Sun, X., Zhong, X., Xiong, G., Cheng, C., Lei, H., Chai, Y., Yu, M., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.09.003 · Cited by 11 · see citing works
Arsenault, D., Drouin‐Ouellet, J., Saint‐Pierre, M., Petrou, P., Dubois, M., Križ, J., Barker, R. A., Cicchetti, A., & Cicchetti, F. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.287243 · Cited by 11 · see citing works
Prefrontal network engagement by deep brain stimulation in limbic hubs
Allawala, A. B., Bijanki, K. R., Oswalt, D. N., Mathura, R. K., Adkinson, J. A., Pirtle, V., Shofty, B., Robinson, M. E., Harrison, M. T., Mathew, S. J., et al. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1291315 · Cited by 8 · see citing works
The Targets of Deep Brain Stimulation in the Treatment of Treatment‐Resistant Depression: A Review
Dong, J., Dai, M., Guo, Z., Xu, T., Li, F., & Li, J. (2025) · Brain and Behavior · doi:10.1002/brb3.70505 · Cited by 8 · see citing works
Neuromodulation Therapies in the Elderly Depressed Patient
Manepalli, J. N., & Sapkota, N. (2014) · Current Geriatrics Reports · doi:10.1007/s13670-014-0098-1 · Cited by 6 · see citing works
Deep Brain Stimulation for Depression
Bergfeld, I. O., & Figee, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-36346-8_18 · Cited by 7 · see citing works
Deep Brain Stimulation (DBS) in Treatment-Resistant Depression (TRD): Hope and Concern
Asir, B., Boscutti, A., Fenoy, A. J., & Quevedo, J. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-981-97-4402-2_9 · Cited by 6 · see citing works
Graph Theory and Modeling of Network Topology in Clinical Neurosurgery
Mithani, K., Suresh, H., & Ibrahim, G. M. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-64892-2_7 · Cited by 6 · see citing works
Schläpfer, T. E., Meyer‐Lindenberg, A., Synofzik, M., Visser-Vandewalle, V. E. R. M., Voges, J., & Coenen, V. A. (2021) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2021.0017 · Cited by 5 · see citing works
Livingston, R., Anandan, S., & Moukaddam, N. J. (2016) · Psychiatric Annals · doi:10.3928/00485713-20160219-01 · Cited by 5 · see citing works
(2014) · Cited by 4 · see citing works
Deep brain stimulation - depression and obsessive-compulsive disorder
Bernardo, W. M., Cukiert, A., & Botelho, R. V. (2018) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.64.11.963 · Cited by 4 · see citing works
Subgenual Cingulate Deep Brain Stimulation for Treatment-Resistant Depression
Bezchlibnyk, Y. B., Cheng, J. J., Bijanki, K. R., Mayberg, H. S., & Gross, R. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805353-9.00091-7 · Cited by 4 · see citing works
What do we know about astrocytes and the antidepressant effects of DBS?
Campos, A. C. P., Pagano, R. L., Lipsman, N., & Hamani, C. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114501 · Cited by 4 · see citing works
Sadeghzadeh, S., Swaminathan, A., Bhanot, P., Steeman, S., Xu, A., Shah, V., Purger, D., & Buch, V. P. (2024) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.04.007 · Cited by 5 · see citing works
Unadkat, P., Quevedo, J., Soares, J. C., & Fenoy, A. J. (2024) · Discover Mental Health · doi:10.1007/s44192-024-00062-9 · Cited by 3 · see citing works
Khan, A., Ahmed, R., Kotapati, V. P., Dar, S. K., Qamar, I., Jafri, A., Ibrahim, M., Kumar, P., & Begum, G. (2018) · International Journal of Medicine and Public Health · doi:10.5530/ijmedph.2018.3.26 · Cited by 3 · see citing works
Conroy, S. K., & Holtzheimer, P. E. (2019) · Personalized Medicine in Psychiatry · doi:10.1016/j.pmip.2019.10.002 · Cited by 3 · see citing works
Electrical deep neuromodulation in psychiatry
Polosan, M., & Figee, M. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.06.007 · Cited by 2 · see citing works
The Clinical and Ethical Practice of Neuromodulation – Deep Brain Stimulation and Beyond
Christen, M., & Müller, S. (2018) · Frontiers research topics · doi:10.3389/978-2-88945-373-3 · Cited by 2 · see citing works
Treatment-Resistant Depression: Deep Brain Stimulation
Riva‐Posse, P., & Janjua, A. U. (2020) · Springer eBooks · doi:10.1007/978-3-030-34906-6_28 · Cited by 2 · see citing works
McInerney, S. J., Giacobbe, P., Cyriac, A., & Kennedy, S. H. (2015) · Wiley eBooks · doi:10.1002/9781118801086.ch14 · Cited by 2 · see citing works
Can Deep Brain Stimulation Be a Promising Treatment for Treatment-Resistant Depression?
Nazanin, A., & Ijeuma, N. (2023) · International Journal of Depression and Anxiety · doi:10.23937/2643-4059/1710036 · Cited by 1 · see citing works
Comparative Side‐Effects of Neurosurgical Treatment of Treatment‐Resistant Depression
Keat, A. L. E., Li, K. T. J., Teo, C. H., & Soga, T. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70090 · Cited by 1 · see citing works
Liene, P., Amoussou, J. R., von Gunten, A., & Elowe, J. (2025) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2025.100682 · Cited by 2 · see citing works
Rijn, E. M. D.-V., Mensinger, M. E., Dougherty, D. D., & Widge, A. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-99742-3.00015-1 · Cited by 2 · see citing works
Deep Brain Stimulation for Depression: An Update
Ryder, J. G., & Holtzheimer, P. E. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0073-6 · Cited by 1 · see citing works
Functional Restoration for Neurological Trauma: Current Therapies and Future Directions
Leiphart, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-40208-6_28 · Cited by 1 · see citing works
Network Modulation in Neuropsychiatric Disorders Using the Virtual Brain
Protzner, A. B., An, S., & Jirsa, V. (2021) · Springer eBooks · doi:10.1007/978-3-030-59797-9_8 · Cited by 1 · see citing works
Ognjanovic, K. (2015) · Scholarship@Western (Western University) · Cited by 1 · see citing works
Xu, J. (2022) · International Journal of Frontiers in Medicine · doi:10.25236/ijfm.2022.041107 · Cited by 1 · see citing works
Ramasubbu, R. (2016) · Evidence-Based Mental Health · doi:10.1136/eb-2015-102110
Self-citationThe Effectiveness of Deep Brain Stimulation in the Treatment of Bipolar Disorder
Bhatti, A. B. (2016) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v4i11.111
Neuromodulation for Psychiatric Disorders
Hescham, S., Tönge, M., Jahanshahi, A., & Temel, Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800454-8.00014-8
A Review of Brain Stimulation Treatments for Late-Life
Hsu, J. H., & Daskalakis, Z. J. (2015)
Julião, Í. E. G. S., Santana, D. F., & da Silva, L. J. (2019) · Arquivos Brasileiros de Neurocirurgia Brazilian Neurosurgery · doi:10.1055/s-0039-1692158
Development of brain stimulation
Crowell, A. L., Riva‐Posse, P., & Mayberg, H. S. (2020) · doi:10.1093/med/9780198713005.003.0019
Pulsbreite spielt keine Rolle für die Wirksamkeit der THS bei therapieresistenter Depression
Weyerhäuser, J., & Kayser, S. (2020) · InFo Neurologie + Psychiatrie · doi:10.1007/s15005-020-1492-1
Estado del arte: nuevas aplicaciones para la estimulación cerebral profunda.
Roy, H., Green, A. L., & Aziz, T. Z. (2018) · NeuroTarget · doi:10.47924/neurotarget2018128
Deep brain stimulation for depression
Kitay, B. M., & Riva‐Posse, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18496-3.00019-7
Villamil, F., Mandolesi, J., Baudo, M. C., Paolinelli, P. S., Vidal, M. F., & Costanzo, E. Y. (2024) · NeuroTarget · doi:10.47924/neurotarget2024463
Deep brain stimulation for treatment-resistant depression
Riva‐Posse, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824067-0.00022-0
- Authors
- Ramasubbu, R., Anderson, S., Haffenden, A., Chavda, S., & Kiss, Z. H. T.
- Affiliations
- Alberta Health Services (CA)
- Venue
- Journal of Psychiatry and Neuroscience
- Publisher
- Canadian Science Publishing
- Published
- 2013-09
- Volume
- 38
- Issue
- 5
- Pages
- 325-332
- ISSN
- 1180-4882 (ISSN-L)
- 1488-2434
- PMC
- PMC3756116
- OpenAlex
- W1964261330
- Cited by
- 101
- References
- 30
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 12 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 11 · 2019: 6 · 2018: 12 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 7 · 2013: 3
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatry and Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- subcallosal cingulate, deep brain stimulation, treatment-resistant depression, stimulation parameter optimization, pulse duration, stimulation frequency, current spread, long-term clinical outcomes
- MeSH terms
- Double-Blind Method, Female, Gyrus Cinguli, Humans, Male, Middle Aged, Pilot Projects, Deep Brain Stimulation, Depressive Disorder, Treatment-Resistant
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