Cited by 875Mental Health Treatment and AccessPsychiatric care and mental health servicesHealth Policy Implementation Science

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Challenges and Opportunities in Global Mental Health: a Research-to-Practice Perspective

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Wainberg, Milton L., Scorza, Pamela, Shultz, James M., Helpman, Liat, Mootz, Jennifer J., Johnson, Karen A., Neria, Yuval, Bradford, Jean-Marie E., Oquendo, Maria A., Arbuckle, Melissa R.·2017·Current Psychiatry Reports

DOI 10.1007/s11920-017-0780-zPMC PMC5553319

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Abstract

Purpose of review Globally, the majority of those who need mental health care worldwide lack access to high-quality mental health services. Stigma, human resource shortages, fragmented service delivery models, and lack of research capacity for implementation and policy change contribute to the current mental health treatment gap. In this review, we describe how health systems in low- and middle-income countries (LMICs) are addressing the mental health gap and further identify challenges and priority areas for future research.Recent findings Common mental disorders are responsible for the largest proportion of the global burden of disease; yet, there is sound evidence that these disorders, as well as severe mental disorders, can be successfully treated using evidence-based interventions delivered by trained lay health workers in low-resource community or primary care settings. Stigma is a barrier to service uptake. Prevention, though necessary to address the mental health gap, has not solidified as a research or programmatic focus. Research-to-practice implementation studies are required to inform policies and scale-up services. Four priority areas are identified for focused attention to diminish the mental health treatment gap and to improve access to high-quality mental health services globally: diminishing pervasive stigma, building mental health system treatment and research capacity, implementing prevention programs to decrease the incidence of mental disorders, and establishing sustainable scale up of public health systems to improve access to mental health treatment using evidence-based interventions.

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Additional file 4 of Testing pathways to scale: study protocol for a three-arm randomized controlled trial of a centralized and a decentralized (“Train the Trainers”) dissemination of a mental health program for Kenyan adolescents
Ochuku, B., Osborn, T. L., Nerima, D., van der Markt, A., Rusch, T. W., Omune, H., Akello, S., Ndetei, D. M., & Venturo‐Conerly, K. E. (2023) · Figshare · doi:10.6084/m9.figshare.23938567
Additional file 4 of Trajectory of suicide among Indian children and adolescents: a pooled analysis of national data from 1995 to 2021
Jena, S., Swain, P. K., Senapati, R. E., & Acharya, S. K. (2024) · Figshare · doi:10.6084/m9.figshare.27140571
Additional file 1 of Improving integrated depression and non-communicable disease care in Malawi through engaged leadership and supportive implementation climate
Sansbury, G. M., Pence, B. W., Zimba, C. C., Yanguela, J., Landrum, K. R., Matewere, M., Mbota, M., Malava, J., Tikhiwa, H. A., Morrison, A. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24819461
Additional file 2 of Study protocol for a stepped-wedge implementation study investigating the intersectoral collaboration of implementering the TREAT INTERACT intervention for primary school teachers and the mhGAP for health care workers for child mental health promotion in Uganda
Skar, A.-M. S., Engebretsen, I. M. S., Braathu, N., Aber, H., Bækkelund, H., Kühl, M.-J., Kabatooro, M. M., Nalugya, J. S., Skokauskas, N., Skylstad, V., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26231310
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Ae-Ngibise, K. A., Sakyi, L., Adwan-Kamara, L., Lund, C., & Weobong, B. (2022) · Research Square · doi:10.21203/rs.3.rs-2135817/v1
Additional file 1 of Trajectory of suicide among Indian children and adolescents: a pooled analysis of national data from 1995 to 2021
Jena, S., Swain, P. K., Senapati, R. E., & Acharya, S. K. (2024) · Figshare · doi:10.6084/m9.figshare.27140562
Additional file 3 of Study protocol for a stepped-wedge implementation study investigating the intersectoral collaboration of implementering the TREAT INTERACT intervention for primary school teachers and the mhGAP for health care workers for child mental health promotion in Uganda
Skar, A.-M. S., Engebretsen, I. M. S., Braathu, N., Aber, H., Bækkelund, H., Kühl, M.-J., Kabatooro, M. M., Nalugya, J. S., Skokauskas, N., Skylstad, V., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26747231
Additional file 3 of Trajectory of suicide among Indian children and adolescents: a pooled analysis of national data from 1995 to 2021
Jena, S., Swain, P. K., Senapati, R. E., & Acharya, S. K. (2024) · Figshare · doi:10.6084/m9.figshare.27140568
Additional file 3 of Testing pathways to scale: study protocol for a three-arm randomized controlled trial of a centralized and a decentralized (“Train the Trainers”) dissemination of a mental health program for Kenyan adolescents
Ochuku, B., Osborn, T. L., Nerima, D., van der Markt, A., Rusch, T., Omune, H., Akello, S., Ndetei, D. M., & Venturo‐Conerly, K. E. (2023) · Figshare · doi:10.6084/m9.figshare.23938564
Additional file 1 of Study protocol for a stepped-wedge implementation study investigating the intersectoral collaboration of implementering the TREAT INTERACT intervention for primary school teachers and the mhGAP for health care workers for child mental health promotion in Uganda
Skar, A.-M. S., Engebretsen, I. M. S., Braathu, N., Aber, H., Bækkelund, H., Kühl, M.-J., Kabatooro, M. M., Nalugya, J. S., Skokauskas, N., Skylstad, V., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26231139
Additional file 1 of Detection and disclosure of workplace mental health challenges: an exploratory study from India
Poddar, A., & Chhajer, R. (2024) · Figshare · doi:10.6084/m9.figshare.26749031
Additional file 1 of Testing pathways to scale: study protocol for a three-arm randomized controlled trial of a centralized and a decentralized (“Train the Trainers”) dissemination of a mental health program for Kenyan adolescents
Ochuku, B., Osborn, T. L., Nerima, D., van der Markt, A., Rusch, T., Omune, H., Akello, S., Ndetei, D. M., & Venturo‐Conerly, K. E. (2023) · Figshare · doi:10.6084/m9.figshare.23938558
Additional file 2 of Explaining adults’ mental health help-seeking through the lens of the theory of planned behavior: a scoping review
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Additional file 2 of Trajectory of suicide among Indian children and adolescents: a pooled analysis of national data from 1995 to 2021
Jena, S., Swain, P. K., Senapati, R. E., & Acharya, S. K. (2024) · Figshare · doi:10.6084/m9.figshare.27140565
Additional file 2 of Testing pathways to scale: study protocol for a three-arm randomized controlled trial of a centralized and a decentralized (“Train the Trainers”) dissemination of a mental health program for Kenyan adolescents
Ochuku, B., Osborn, T. L., Nerima, D., van der Markt, A., Rusch, T. W., Omune, H., Akello, S., Ndetei, D. M., & Venturo‐Conerly, K. E. (2023) · Figshare · doi:10.6084/m9.figshare.23938561
Additional file 1 of The epidemiology of common mental disorders in Libya: a systematic review
Abdulshafea, M., Rhouma, A. H., Gire, N., AlMadhoob, A., Arshad, U., & Husain, N. (2021) · Figshare · doi:10.6084/m9.figshare.17124698
Additional file 2 of Developing and evaluating an interprofessional shared decision-making care model for patients with perinatal depression in maternal care in urban China: a study protocol
Xiang, D., Xia, X., & Liang, D. (2024) · Figshare · doi:10.6084/m9.figshare.24494511
Additional file 1 of Developing and evaluating an interprofessional shared decision-making care model for patients with perinatal depression in maternal care in urban China: a study protocol
Xiang, D., Xia, X., & Liang, D. (2023) · Figshare · doi:10.6084/m9.figshare.24494163
Additional file 1 of Screening and referral is not enough: a qualitative exploration of barriers to access and uptake of mental health services in patients with cardiovascular diseases
Collopy, C. M., Cosh, S. M., & Tully, P. J. (2021) · Figshare · doi:10.6084/m9.figshare.13550001
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“28 Given the powerful psychological effects of these compounds and their potential to cure diseases like depression, anxiety, and post-traumatic stress disorder (PTSD), it makes sense that current psychedelic research has prioritized neuropsychiatric effects.”
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Zhu, J., Xie, J., Gan, G., Lu, Z., Zhang, H., Wang, J., Dong, X., Zheng, Q., Li, L., Zhang, Y., et al. (2025) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2025.152661
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Maran, P. L., Gabirondo, P., Vlaic, A., Alonzo-Castillo, T., Rojo, T., Zaldua, C., Vendrell-Serres, J., Ramos‐Quiroga, J. A., Braquehais, M. D., & Rodríguez‐Urrutia, A. (2025) · doi:10.2196/preprints.90491
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Delsoz, M., Raja, H., Hussain, Z. S., Zadeh, V. M., Elahi, M., Wesberry, J. M., Jerkins, B. M., Wright, C. L., Kanner, E. M., & Yousefi, S. (2026) · Journal of Ophthalmic and Vision Research · doi:10.18502/jovr.v20.17535
“[30] Disparities in access to quality mental healthcare may result in underdiagnosis or inadequate treatment for individuals with glaucoma, potentially contributing to higher rates of mental health disorders.”
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Lawrence, H., Stirman, S. W., Dorison, S. H., Yun, T., & Jones, M. (2026) · doi:10.2196/preprints.91157
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Bohnert, A. S. B., Fritsche, L., & Sen, S. (2026) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2026.01.004
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Bailey, D., Ikhile, D., Modipane, M., Nalinya, S., Jidong, D. E., Madhombiro, M., Makgahlela, M., Mangezi, W. O., Monera-Penduka, T. G., Musoke, D., et al. (2026) · The Journal of Mental Health Training Education and Practice · doi:10.1108/jmhtep-08-2023-0071
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Zhao, W., Tang, W., Chen, S., Yao, J., Hu, J., Zhou, Q., Tao, J., Gao, R., Zhang, J., Wu, Y., et al. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-07807-6
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Kaur, B., & Chen, D. (2025) · International Conference on Cyber-Physical Social Intelligence (ICCSI) · doi:10.1109/cpsi66656.2025.11343977
“…many individuals experiencing mental health difficulties often remain undiagnosed or untreated due to barriers such as social stigma, lack of access to mental health services, poor quality of service, discrimination, treatment gaps due to limited resources and underreporting of symptoms [2].”
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Davoodi, A., VLACHOS, I. K., Bares, M., Brunovský, M., & Paluš, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.26.701781
“Major Depressive Disorder (MDD) is a widespread and serious mental health condition affecting an estimated 300 million people worldwide (1–3).”
Beyond Reactive Empathy: Efficient RL for Proactive, Emotion-Adaptive, and LLM-based Mental Health Chatbot DesignPreprint
Chen, W., Wang, Y., & Zhou, T. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6128326

Authors: Wainberg, M. L., Scorza, P., Shultz, J. M., Helpman, L., Mootz, J. J., Johnson, K. A., Neria, Y., Bradford, J.-M. E., Oquendo, M. A., & Arbuckle, M. R.
Affiliations: Columbia University Irving Medical Center (US)
University of Miami (US)
Corresponding author: Wainberg, Milton L.
ORCID: Wainberg, Milton L.
Scorza, Pamela
Shultz, James M.
Helpman, Liat
Mootz, Jennifer J.
Johnson, Karen A.
Neria, Yuval
Arbuckle, Melissa R.
Venue: Current Psychiatry Reports
Publisher: Springer Science and Business Media LLC
Published: 2017-04-19
Volume: 19
Issue: 5
Pages: 28-28
ISSN: 1523-3812 (ISSN-L)
1535-1645
DOI: 10.1007/s11920-017-0780-z
PMC: PMC5553319
OpenAlex: W2606586703
Cited by: 875
References: 105
Citations by year: 2026: 117 · 2025: 179 · 2024: 148 · 2023: 138 · 2022: 111 · 2021: 71 · 2020: 73 · 2019: 24 · 2018: 11 · 2017: 1
FWCI: 4.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (unspecified)
Locations: Current Psychiatry Reports (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (T32MH096724)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
Keywords: global mental health, mental health treatment gap, access to mental health care, mental health stigma, common mental disorders, severe mental illness, lay health workers, community mental health services, primary care, mental health prevention, implementation research, research capacity building, low- and middle-income countries, mental health policy
MeSH terms: Mental Disorders, Health Personnel, Humans, Mental Health, Mental Health Services, Public Health, Global Health

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Challenges and Opportunities in Global Mental Health: a Research-to-Practice Perspective

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