Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease

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Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

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Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

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Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

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Mitochondrial fusion protects against neurodegeneration in the cerebellum

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Synaptic Mitochondria Are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions

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Activity-driven local ATP synthesis is required for synaptic function

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Tau is essential to β-amyloid-induced neurotoxicity

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Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

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Caspase activation precedes and leads to tangles

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Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

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The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

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Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice

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Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

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Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients

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Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

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Tau truncation during neurofibrillary tangle evolution in Alzheimer’s disease

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Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage

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Mitochondria at the Synapse

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Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer’s disease

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The role of tau kinases in Alzheimer's disease.

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Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons

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Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

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Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo

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Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s Disease

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Accumulation of Aspartic Acid 421 - and Glutamic Acid 391 -Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

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Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion

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Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

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Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

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Amyloid-β Annular Protofibrils Evade Fibrillar Fate in Alzheimer Disease Brain

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Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

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Glycogen Synthase Kinase 3β Induces Caspase-cleaved Tau Aggregation in Situ

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Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity

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Site-specific Phosphorylation and Caspase Cleavage Differentially Impact Tau-Microtubule Interactions and Tau Aggregation

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OPA1 loss of function affects in vitro neuronal maturation

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Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity

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The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

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Mitochondria Modulate Ca2+-Dependent Glutamate Release from Rat Cortical Astrocytes

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Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons

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Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

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Amyloid Beta Peptide-Induced Cerebral Neuronal Loss Is Mediated By Caspase-3 In Vivo

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Mitochondrial Free Ca2+ Levels and Their Effects on Energy Metabolism in Drosophila Motor Nerve Terminals

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Caspase-3-Dependent Proteolytic Cleavage of Tau Causes Neurofibrillary Tangles and Results in Cognitive Impairment During Normal Aging

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Co-expression of truncated and full-length tau induces severe neurotoxicity

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Mechanisms of tau and Aβ-induced excitotoxicity

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Truncated tau at D421 is associated with neurodegeneration and tangle formation in the brain of Alzheimer transgenic models

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Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death

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Tau facilitates Aβ-induced loss of mitochondrial membrane potential independent of cytosolic calcium fluxes in mouse cortical neurons

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Caspase-Mediated Truncation of Tau Potentiates Aggregation

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GRK5 dysfunction accelerates tau hyperphosphorylation in APP (swe) mice through impaired cholinergic activity

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Synergy between amyloid-β and tau in Alzheimer’s disease

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Roles of tau protein in health and disease

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Synaptic degeneration in Alzheimer disease

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Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies

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Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

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The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases

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The Association of Tau With Mitochondrial Dysfunction in Alzheimer’s Disease

Cheng, Y., & Bai, F. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00163 · Cited by 239 · see citing works

Updates in Alzheimer's disease: from basic research to diagnosis and therapies

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Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders

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Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration

Maria Jose Perez, J., Jara, C., & Quintanilla, R. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00441 · Cited by 153 · see citing works

Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease

Villavicencio-Tejo, F., & Quintanilla, R. A. (2021) · Antioxidants · doi:10.3390/antiox10071069 · Cited by 135 · see citing works

Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca2+ handling

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Insights into Disease-Associated Tau Impact on Mitochondria

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Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease

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Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus

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The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders

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Mitochondrial dysfunction in Alzheimer's disease: Guiding the path to targeted therapies

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Impact of Tau on Neurovascular Pathology in Alzheimer's Disease

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Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin

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Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2

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Activities of mitochondrial respiratory chain complexes in platelets of patients with Alzheimer's disease and depressive disorder

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Tau-targeting therapy in Alzheimer’s disease: Critical advances and future opportunities

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The Role of Mitochondrial Impairment in Alzheimer´s Disease Neurodegeneration: The Tau Connection

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Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells

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Molecular Targets in Alzheimer’s Disease

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Cellular and molecular influencers of neuroinflammation in Alzheimer's disease: Recent concepts & roles

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An update on the association between traumatic brain injury and Alzheimer’s disease: Focus on Tau pathology and synaptic dysfunction

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Targeting tau only extracellularly is likely to be less efficacious than targeting it both intra- and extracellularly

Congdon, E. E., Jiang, Y., & Sigurdsson, E. M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.12.002 · Cited by 37 · see citing works

All the Tau We Cannot See

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The role of mitochondrial dysfunction in the pathogenesis of Alzheimer’s disease and future strategies for targeted therapy

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Activation of the Nrf2 Pathway Prevents Mitochondrial Dysfunction Induced by Caspase-3 Cleaved Tau: Implications for Alzheimer’s Disease

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Tau truncation in the pathogenesis of Alzheimer’s disease: a narrative review

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Tau Deletion Prevents Cognitive Impairment and Mitochondrial Dysfunction Age Associated by a Mechanism Dependent on Cyclophilin-D

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Tau clearance reverses touch neuron dysfunction in both young and aged C. elegans

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Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies

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Application of the Movable Type Free Energy Method to the Caspase-Inhibitor Binding Affinity Study

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PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders

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Generation and Characterization of the First Murine Model of Alzheimer’s Disease with Mutated AβPP Inserted in a BALB/c Background (C.B6/J-APP swe )

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Back in Person: Frontiers in Medicinal Chemistry 2023

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Targeting Mitochondrial Dynamics as a Restorative Approach in the Treatment of Alzheimer’s Disease

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Unraveling the Role of Mitochondria in Alzheimer’s Disease

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Tau Clearance Reverses Neuronal Dysfunction in Both Young and Aged C. elegansPreprint

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Mitochondria in the Cerebral and Cerebellar Cortex in Alzheimer’s Disease, Target for a Therapeutic Approach

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Long-read sequencing-based analyses of the adult Drosophila brain transcriptome in physiological and pathological settings

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The truncated Tau fragment 315–441 produced by Caspase-2 translocates to the nucleus and alters the proteome of neuroblastoma cells

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Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons

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Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells

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Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

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Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore

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Pathological Impact of Tau Proteolytical Process on Neuronal and Mitochondrial Function: a Crucial Role in Alzheimer’s Disease

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