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Adaptation to Early Knee Osteoarthritis: The Role of Risk, Resilience, and Disease Severity on Pain and Physical Functioning
Open accessAbstract
BACKGROUND: Radiographic joint changes are used to diagnose osteoarthritis; however, they alone do not adequately predict who experiences symptoms. PURPOSE: To examine psychological risk and resilience factors in combination with an objective indicator of disease severity (knee X-rays) to determine what factors best account for pain and physical functioning in an early knee osteoarthritis (KOA) population. METHODS: Structural equation modeling was used to analyze data from 275 men and women with early KOA. RESULTS: Structural equation modeling yielded a fair to good fit of the data, suggesting that both risk and resilience were important in predicting pain and physical functioning over and above disease severity in the expected directions. Resilience's effect on pain was mediated through self-efficacy, suggesting that higher self-efficacy was linked to lower pain and better physical functioning. CONCLUSIONS: Results provide an integrative model of adjustment to early KOA and may be important to the prevention of disability in this population.
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“Higher levels of catastrophizing are related to enhanced fMRI responses to calibrated noxious stimuli in areas such as anterior insular cortex among both fibromyalgia patients 396, and pain-free adults 397.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [396]
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“Other neuroimaging work has highlighted maladaptive activity or connectivity in the amygdala 396, 398, 399.”
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Self-citation
Metadata
- Authors
- Wright, L. J., Zautra, A. J., & Going, S.
- Affiliations
- University of California San Diego (US)
- Arizona State University (US)
- University of Arizona (US)
- Corresponding author
- Wright, Lisa Johnson
- ORCID
- Going, Scott
- Venue
- Annals of Behavioral Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-08
- Volume
- 36
- Issue
- 1
- Pages
- 70-80
- ISSN
- 0742-5554 (ISSN-L)
- 0883-6612
- 1532-4796
- PMC
- PMC2613296
- OpenAlex
- W2169351650
- Cited by
- 141
- References
- 65
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 12 · 2016: 15 · 2015: 5 · 2014: 14 · 2013: 12 · 2012: 7
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR047595)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Keywords
- knee osteoarthritis, early osteoarthritis, psychological adjustment, resilience, psychological risk factors, self-efficacy, pain, physical function, disease severity, knee radiographs, disability prevention
- MeSH terms
- Adaptation, Psychological, Adult, Affect, Depressive Disorder, Factor Analysis, Statistical, Female, Humans, Knee Joint, Male, Middle Aged, Models, Psychological, Radiography, Self-Assessment, Severity of Illness Index, Chi-Square Distribution, Cost of Illness, Pain Threshold, Risk Assessment, Osteoarthritis, Knee, Self Efficacy
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