2015 Guidelines for establishing genetically modified rat models for cardiovascular research
Open accessAbstract
The rat has long been a key physiological model for cardiovascular research, most of the inbred strains having been previously selected for susceptibility or resistance to various cardiovascular diseases (CVD). These CVD rat models offer a physiologically relevant background on which candidates of human CVD can be tested in a more clinically translatable experimental setting. However, a diverse toolbox for genetically modifying the rat genome to test molecular mechanisms has only recently become available. Here, we provide a high-level description of several strategies for developing genetically modified rat models of CVD.
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With advancements in rat genetic modification technologies, it is now possible to create rat models of senescent cell clearance.
“With advancements in genetic modification technologies in the rat [47–51], it is now possible to create rat models of senescent cell clearance.”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [49]
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Self-citation
- Authors
- Flister, M. J., Prokop, J. W., Lazar, J., Shimoyama, M., Dwinell, M., & Geurts, A.
- Affiliations
- Medical College of Wisconsin (US)
- Corresponding author
- Flister, Michael J.
- Venue
- Journal of Cardiovascular Translational Research
- Published
- 2015-04-29
- Volume
- 8
- Issue
- 4
- Pages
- 269-277
- ISSN
- 1937-5387 (ISSN-L)
- 1937-5395
- PMC
- PMC4475456
- OpenAlex
- W2023760353
- Cited by
- 24
- References
- 81
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 4 · 2019: 7 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Cardiovascular Translational Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1dp2od008396-01)
- National Heart, Lung, and Blood Institute (L30 HL125010, R01HL064541)
- National Cancer Institute (R01CA193343)
- National Institute of Diabetes and Digestive and Kidney Diseases (L30 DK096592)
- National Institute of Environmental Health Sciences (K01ES025435)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- cardiovascular disease models, cardiovascular disease susceptibility, transgenic rats
- MeSH terms
- Animals, Cardiovascular Diseases, Disease Models, Animal, Gene Expression Regulation, Genetic Markers, Genetic Techniques, Humans, Phenotype, Species Specificity, Genetic Predisposition to Disease, Biomedical Research, Rats, Rats, Transgenic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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