Nitric oxide deficiency is a primary driver of hypertension
Abstract
Hypertension remains a global health crisis. High blood pressure is the number one modifiable risk factor in the onset and progression of cardiovascular disease. Despite many different classes of drug therapies approved for hypertension, the use of polypharmacy and recommendations on lifestyle modification, many patients still suffer from uncontrolled or unmanaged hypertension. Nitric oxide is a naturally produced vasodilator that controls and regulates vascular tone and therefore controls and regulates blood pressure. Research over the past 40 years reveals that loss of nitric oxide production, termed endothelial dysfunction, is the earliest event in the development of hypertension. Strategies aimed at preventing the loss of nitric oxide production and/or therapeutic strategies designed to restore nitric oxide production will likely have a positive effect on patients' health and lead to better management of blood pressure. This review article will focus on the loss of nitric oxide production as the primary contributor to hypertension and also discuss safe and clinically proven strategies to restore nitric oxide production and recapitulate nitric oxide based signaling in humans.
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Nitric oxide produced by eNOS induces vasodilation, and its deficiency under high angiotensin II levels leads to increased constriction of blood vessels.
“Another crucial mechanism involves nitric oxide (NO) production by endothelial nitric oxide synthase (eNOS); NO induces vasodilation, and its deficiency under high angiotensin II levels leads to increased constriction of blood vessels [48].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [48]
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- Authors
- Bryan, N. S.
- Corresponding author
- Bryan, Nathan S.
- ORCID
- Bryan, Nathan S.
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 206
- Pages
- 115325
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W4308453693
- Cited by
- 77
- References
- 115
- Citations by year
- 2026: 23 · 2025: 27 · 2024: 21 · 2023: 6
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- hypertension, nitric oxide, endothelial dysfunction, nitric oxide deficiency, nitric oxide signaling, vasodilation, vascular tone, cardiovascular disease, blood pressure regulation
- MeSH terms
- Blood Pressure, Cardiovascular Diseases, Endothelium, Vascular, Humans, Hypertension, Nitric Oxide, Vasodilator Agents
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