Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells

Shoji, Kaori; Tsubaki, Masanobu; Yamazoe, Yuzuru; Satou, Takao; Itoh, Tatsuki; Kidera, Yasuhiro; Tanimori, Yoshihiro; Yanae, Masashi; Matsuda, Hideaki; Taga, Atsushi; Nakamura, Haruyuki; Nishida, Shozo

doi:10.1007/s12272-011-0316-8

Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells

Mangiferin, 1,3,6,7-tetrahydroxyxanthone-C2-β-D: -glucoside (C-glucosylxanthone), is a xanthone derivative that is widely distributed in higher plants. Recently, mangiferin was found to exhibit potential antitumor effects. However, the molecular mechanisms of this effect have not been elucidated.…