Mangiferin induces apoptosis by regulating Bcl-2 and Bax expression in the CNE2 nasopharyngeal carcinoma cell line
Open accessAbstract
To investigate the anti-proliferative mechanism of mangiferin in a human nasopharyngeal carcinoma cell line, CNE2 cells were incubated with different concentrations of mangiferin (12.5, 25, 50, 100, 150 and 200 μM) or with PBS as a control for 72 hours. Analyses were made of the cell cycle and apoptosis with measurement of mRNA and protein levels of two apoptosis-related genes, Bcl-2 and Bax. Flow cytometry assays showed mangiferin could inhibit CNE2 cell proliferation via G2/M arrest and induction of early apoptosis. Real time PCR and Western blotting showed the mRNA and protein level of Bcl-2 to be down-regulated, while those of Bax were up-regulated, when CNE2 cells were treated with mangiferin. This investigation indicated anti-proliferation effects of mangiferin through induction of cell apoptosis regulated by Bcl-2 and Bax expression.
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MGF induces apoptosis in nasopharyngeal carcinoma cells by modulating the mitochondrial pathway, decreasing antiapoptotic Bcl-2 and increasing proapoptotic Bax expression.
“MGF induces apoptosis in nasopharyngeal carcinoma cells by modulating the mitochondrial pathway, decreasing antiapoptotic Bcl-2 and increasing proapoptotic Bax expression (61).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [61]
The Abstract and Discussion report apoptosis in mangiferin-treated CNE2 nasopharyngeal carcinoma cells, with decreased Bcl-2 and increased Bax expression. The Discussion links Bcl-2-family proteins to the mitochondrial pathway, but presents their involvement in these cells as a suggestion; it does not establish that mangiferin modulates that pathway. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThrough regulation of Bcl-2 and Bax expression, mangiferin potently inhibits tumor cell proliferation and induces apoptosis in nasopharyngeal carcinoma cells.
“Pan et al (60) demonstrated that through regulation of Bcl-2, apoptosis regulator (Bcl-2) and Bcl-2 associated X, apoptosis regulator (Bax) expression, mangiferin potently inhibits tumor cell proliferation and induces apoptosis in nasopharyngeal carcinoma cells.”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [60]
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- Authors
- Pan, L.-L., Wang, A.-Y., Huang, Y.-Q., Luo, Y., & Ling, M.
- Affiliations
- Guangxi Medical University (CN)
- ORCID
- Luo, Yu
- Venue
- Asian Pacific Journal of Cancer Prevention
- Published
- 2014-09-15
- Volume
- 15
- Issue
- 17
- Pages
- 7065-7068
- ISSN
- 1513-7368 (ISSN-L)
- OpenAlex
- W2149813065
- Cited by
- 66
- References
- 19
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 11 · 2017: 5 · 2016: 5 · 2015: 4
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Asian Pacific Journal of Cancer Prevention (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Keywords
- mangiferin, nasopharyngeal carcinoma, CNE2 cells, apoptosis, Bcl-2, Bax, G2/M cell cycle arrest, antiproliferative activity, flavonoids
- MeSH terms
- Nasopharyngeal Carcinoma, Carcinoma, Humans, Nasopharyngeal Neoplasms, RNA, Messenger, Gene Expression Regulation, Neoplastic, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Genes, bcl-2, Reverse Transcriptase Polymerase Chain Reaction, Xanthones, Cell Line, Tumor, Cell Proliferation, bcl-2-Associated X Protein, Cell Cycle Checkpoints
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