Cited by 166Obesity, Physical Activity, DietPharmacology and Obesity TreatmentObesity and Health Practices

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The Association Between Rate of Initial Weight Loss and Long-Term Success in Obesity Treatment: Does Slow and Steady Win the Race?

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Nackers, Lisa M., Ross, Kathryn M., Perri, Michael G.·2010·International Journal of Behavioral Medicine

DOI 10.1007/s12529-010-9092-yPMC PMC3780395

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Abstract

Background Controversy exists regarding the optimal rate of weight loss for long-term weight management success.Purpose This study examined whether gradual initial weight loss was associated with greater long-term weight reduction than rapid initial loss.Methods Groups were drawn from participants in the TOURS trial, which included a sample of middle-aged (mean = 59.3 years) obese women (mean BMI = 36.8) who received a 6-month lifestyle intervention followed by a 1-year extended care program. Participants were encouraged to reduce caloric intake to achieve weight losses of 0.45 kg/week. Groups were categorized as "FAST" (> or =0.68 kg/week, n = 69), "MODERATE" (> or =0.23 and <0.68 kg/week, n = 104), and "SLOW" (<0.23 kg/week, n = 89) based on rate of weight loss during first month of treatment.Results The FAST, MODERATE, and SLOW groups differed significantly in mean weight changes at 6 months (-13.5, -8.9, and -5.1 kg, respectively, ps < 0.001), and the FAST and SLOW groups differed significantly at 18 months (-10.9, -7.1, and -3.7 kg, respectively, ps < 0.001). No significant group differences were found in weight regain between 6 and 18 months (2.6, 1.8, and 1.3 kg, respectively, ps < 0.9). The FAST and MODERATE groups were 5.1 and 2.7 times more likely to achieve 10% weight losses at 18 months than the SLOW group.Conclusion Collectively, findings indicate both short- and long-term advantages to fast initial weight loss. Fast weight losers obtained greater weight reduction and long-term maintenance, and were not more susceptible to weight regain than gradual weight losers.

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Authors: Nackers, L. M., Ross, K. M., & Perri, M. G.
Affiliations: University of Florida Health (US)
Corresponding author: Nackers, Lisa M.
ORCID: Ross, Kathryn M.
Perri, Michael G.
Venue: International Journal of Behavioral Medicine
Publisher: Springer Science and Business Media LLC
Published: 2010-05-05
Volume: 17
Issue: 3
Pages: 161-167
ISSN: 1070-5503 (ISSN-L)
1532-7558
DOI: 10.1007/s12529-010-9092-y
PMC: PMC3780395
OpenAlex: W2158253734
Cited by: 166
References: 34
Citations by year: 2026: 7 · 2025: 8 · 2024: 7 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 18 · 2019: 16 · 2018: 14 · 2017: 11 · 2016: 12 · 2015: 10 · 2014: 14 · 2013: 7 · 2012: 6
FWCI: 6.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: International Journal of Behavioral Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P30AG028740)
National Heart, Lung, and Blood Institute (R18HL073326)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity and Health Practices
Keywords: obesity treatment, rapid weight loss, long-term weight maintenance, weight regain, lifestyle intervention, caloric restriction, middle-aged women
MeSH terms: Aged, Energy Intake, Diet, Reducing, Female, Humans, Middle Aged, Motor Activity, Obesity, Patient Compliance, Time Factors, Weight Loss, Body Mass Index, Risk Reduction Behavior

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The Association Between Rate of Initial Weight Loss and Long-Term Success in Obesity Treatment: Does Slow and Steady Win the Race?

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