Weight change in the first 2 months of a lifestyle intervention predicts weight changes 8 years later: Early Weight Loss
Open accessAbstract
OBJECTIVE: Examine the relationship between 1- and 2-month weight loss (WL) and 8-year WL among participants enrolled in a lifestyle intervention. METHODS: 2,290 Look AHEAD participants (BMI: 35.65 ± 5.93 kg/m(2) ) with type 2 diabetes received an intensive behavioral WL intervention. RESULTS: 1- and 2-month WL were associated with yearly WL through Year 8 (P's < 0.0001). At Month 1, participants losing 2-4% and >4% had 1.62 (95% CI: 1.32, 1.98) and 2.79 (95% CI: 2.21, 3.52) times higher odds of achieving ≥5% WL at Year 4 and 1.28 (95% CI: 1.05,1.58) and 1.77 (95% CI: 1.40, 2.24) times higher odds of achieving ≥5% WL at Year 8, compared to those losing <2% initially. At Month 2, 3-6% WL resulted in greater odds of achieving ≥5% WL at Year 4 (OR = 1.85; CI: 1.48, 2.32), and >6% WL resulted in the greatest odds of achieving ≥5% WL at Year 4 (OR = 3.85; CI: 3.05, 4.88) and Year 8 (OR = 2.28; CI: 1.81, 2.89), compared to those losing <3%. Differences in adherence between WL categories were observed as early as Month 2. CONCLUSIONS: 1- and 2-month WL was associated with 8-year WL. Future studies should examine whether alternative treatment strategies can be employed to improve treatment outcomes among those with low initial WL.
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More rapid early weight loss with more intensive programmes is associated with better longer-term weight outcomes.
“More rapid early weight loss with more intensive programmes is associated with better longer-term weight outcomes [69], but severe caloric restriction without attention to nutrient content can have unwanted effects.”
Consistent evidence is accruing that long-term weight loss maintenance is better after more rapid early weight loss.
“Consistent evidence is also accruing that long-term weight loss maintenance is better after more rapid early weight loss [69].”
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Defining and identifying predictors of rapid response to pediatric obesity treatment
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Weight management program for first responders: Feasibility study and lessons learned
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- Authors
- Unick, J. L., Neiberg, R. H., Hogan, P. E., Cheskin, L. J., Dutton, G. R., Jeffery, R., Nelson, J. A., Pi-Sunyer, X., West, D. S., Wing, R. R., & the Look AHEAD Research Group
- Affiliations
- Brown University (US)
- Wake Forest University Health Sciences (US)
- Johns Hopkins University (US)
- University of Alabama at Birmingham (US)
- University of Minnesota (US)
- Southwest American Indian Center; Phoenix Arizona USA
- Columbia University Irving Medical Center (US)
- University of South Carolina (US)
- Corresponding author
- Unick, Jessica L.
- ORCID
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2015-06-25
- Volume
- 23
- Issue
- 7
- Pages
- 1353-1356
- ISSN
- 1930-7381 (ISSN-L)
- PMC
- PMC4481874
- OpenAlex
- W1530088824
- Cited by
- 161
- References
- 11
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 11 · 2023: 10 · 2022: 10 · 2021: 17 · 2020: 23 · 2019: 20 · 2018: 24 · 2017: 17 · 2016: 12 · 2015: 3
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR001120, UL1TR001082, UL1TR000170, 5p30dk046204-15)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-57171, DK 57136, DK57149, DK 57002, DK57182, DK56990, (DK 046204, DK57008, DK57177, DK 57078, DK57219, U01DK057149, DK-57178, U01DK057151, U01DK057135, U01DK057131, U01DK056990, DK-57135, U01DK057136, DK-56992, DK57154, U01DK057178, U01DK057182, U01DK057078, U01DK057154, U01DK057008, U01DK057171, DK57131, U01DK057002, K01DK100498, U01DK057219, U01DK056992, U01DK057177, P30DK026687, P30DK017047, P30DK048520, P30DK079626, DK 57151, P30-DK046204, P30-DK 48520)
- National Center for Research Resources (M01-RR-0021140, M01RR-00051, M01RR002719, M01RR000056, M01RR01346, M01RR000051, M01RR001066, M01RR001346, M0-1-RR-02719, M01-RR01066)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- weight loss, lifestyle intervention, type 2 diabetes, Look AHEAD trial, early weight loss, long-term weight loss, behavioral weight management
- MeSH terms
- Aged, Behavior Therapy, Body Weight, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Life Style, Male, Middle Aged, Obesity, Weight Loss, Treatment Outcome
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