The major volatile compound 2-phenylethanol from the biocontrol yeast, Pichia anomala, inhibits growth and expression of aflatoxin biosynthetic genes of Aspergillus flavus

Hua, Sui Sheng T.; Beck, John J.; Sarreal, Siov Bouy L.; Gee, Wai

doi:10.1007/s12550-014-0189-z

Cited by 181Mycotoxins in Agriculture and FoodMicrobial Natural Products and BiosynthesisPlant Pathogens and Fungal Diseases

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

The major volatile compound 2-phenylethanol from the biocontrol yeast, Pichia anomala, inhibits growth and expression of aflatoxin biosynthetic genes of Aspergillus flavus

Hua, Sui Sheng T., Beck, John J., Sarreal, Siov Bouy L., Gee, Wai·2014·Mycotoxin Research

DOI 10.1007/s12550-014-0189-z

Open this paper in CoChat — free account

Abstract

Aspergillus flavus is a ubiquitous saprophyte that is able to produce the most potent natural carcinogenic compound known as aflatoxin B1 (AFB1). This toxin frequently contaminates crops including corn, cotton, peanuts, and tree nuts causing substantial economic loss worldwide. Consequently, more than 100 countries have strict regulations limiting AFB1 in foodstuffs and feedstuffs. Plants and microbes are able to produce volatile compounds that act as a defense mechanism against other organisms. Pichia anomala strain WRL-076 is a biocontrol yeast currently being tested to reduce AF contamination of tree nuts in California. We used the SPME-GC/MS analysis and identified the major volatile compound produced by this strain to be 2-phenylethanol (2-PE). It inhibited spore germination and AF production of A. flavus. Inhibition of AF formation by 2-PE was correlated with significant down regulation of clustering AF biosynthesis genes as evidenced by several to greater than 10,000-fold decrease in gene expression. In a time-course analysis we found that 2-PE also altered the expression patterns of chromatin modifying genes, MYST1, MYST2, MYST3, gcn5, hdaA and rpdA. The biocontrol capacity of P. anomala can be attributed to the production of 2-PE, which affects spore germination, growth, toxin production, and gene expression in A. flavus.

Integrity signals

Registry

Crossref · 10.1007/s12550-014-0189-z

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

2-phenylethanol was identified as the key component of the P. anomala volatilome preventing spore germination, mycelial growth and toxin production by Aspergillus flavus.
“2-phenylethanol was identified as the key component of the P. anomala volatilome preventing spore germination, mycelial growth and toxin production by Aspergillus flavus (Hua et al. 2014).”
From Biocontrol yeasts: mechanisms and applications (2019) · cites this paper as Hua et al. 2014

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Clustered Pathway Genes in Aflatoxin Biosynthesis
Yu, J., Chang, P., Ehrlich, K. C., Cary, J. W., Bhatnagar, D., Cleveland, T. E., Payne, G. A., Linz, J. E., Woloshuk, C. P., & Bennett, J. W. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.3.1253-1262.2004 · Cited by 806
Regulations relating to mycotoxins in food
van Egmond, H. P., Schothorst, R. C., & Jonker, M. A. (2007) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-007-1317-9 · Cited by 738
Aspergillus flavus
Amaike, S., & Keller, N. P. (2011) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-072910-095221 · Cited by 686
Epidemiology Of Aflatoxin Formation By Aspergillus Flavus
Diener, U. L., Cole, R. J., Sanders, T. H., Payne, G. A., Lee, L. S., & Klich, M. A. (1987) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.25.1.249 · Cited by 556
Case–Control Study of an Acute Aflatoxicosis Outbreak, Kenya, 2004
Azziz‐Baumgartner, E., Lindblade, K. A., Gieseker, K. E., Rogers, H. S., Kieszak, S. M., Njapau, H., Schleicher, R. L., McCoy, L. F., Misore, A. O., DeCock, K. M., et al. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8384 · Cited by 480
Secondary metabolism in fungi: does chromosomal location matter?
Palmer, J. M., & Keller, N. P. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.04.008 · Cited by 222
Aflatoxin Biosynthesis: Current Frontiers
Roze, L. V., Hong, S.-Y., & Linz, J. E. (2012) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-083012-123702 · Cited by 216
Mycotoxins in botanicals and dried fruits: A review
Trucksess, M. W., & Scott, P. M. (2008) · Food Additives & Contaminants Part A · doi:10.1080/02652030701567459 · Cited by 204
Mycotoxins in edible tree nuts
Molyneux, R. J., Mahoney, N. E., Jong Heon, K. I. M., & Campbell, B. C. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2007.07.028 · Cited by 145
Aflatoxin biosynthesis gene clusters and flanking regions
Ehrlich, K., Yu, J., & Cotty, P. J. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02637.x · Cited by 141
Aflatoxin, Hepatitis and Worldwide Liver Cancer Risks
Henry, S. H., Bosch, F. X., & Bowers, J. C. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0629-4_24 · Cited by 129
Colonization of wounded peanut seeds by soil fungi: selectivity for species from Aspergillus section Flavi
Horn, B. W. (2005) · Mycologia · doi:10.1080/15572536.2006.11832854 · Cited by 111
The initiation and pattern of spread of histone H4 acetylation parallel the order of transcriptional activation of genes in the aflatoxin cluster
Roze, L. V., Arthur, A. E., Hong, S., Chanda, A., & Linz, J. E. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05952.x · Cited by 109
Effects of volatile aldehydes from Aspergillus-resistant varieties of corn on Aspergillus parasiticus growth and aflatoxin biosynthesis
Wright, M. S., Greene-McDowelle, D. M., Zeringue, H. J., Bhatnagar, D., & Cleveland, T. E. (2000) · Toxicon · doi:10.1016/s0041-0101(99)00221-4 · Cited by 94
The Aflatoxin Biosynthesis Cluster Gene, aflX , Encodes an Oxidoreductase Involved in Conversion of Versicolorin A to Demethylsterigmatocystin
Cary, J. W., Ehrlich, K. C., Bland, J. M., & Montalbano, B. G. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.2.1096-1101.2006 · Cited by 78
Interactions of Saprophytic Yeasts with a nor Mutant of Aspergillus flavus
Hua, S.-S. T., Baker, J. L., & Flores-Espiritu, M. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.6.2738-2740.1999 · Cited by 75
Self-citation
Effect of Soybean Volatile Compounds on Aspergillus flavus Growth and Aflatoxin Production
Cleveland, T. E., Carter‐Wientjes, C. H., Lucca, A. J. D., & Boué, S. M. (2009) · Journal of Food Science · doi:10.1111/j.1750-3841.2009.01078.x · Cited by 55
Willow volatiles influence growth, development, and secondary metabolism in Aspergillus parasiticus
Roze, L. V., Koptina, A., Laivenieks, M., Beaudry, R. M., Jones, A. D., Kanarsky, A. V., & Linz, J. E. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3339-7 · Cited by 38
Fluorescent Viability Stains to Probe the Metabolic Status of Aflatoxigenic Fungus in Dual Culture of Aspergillus flavus and Pichia anomala
Hua, S. S. T., Brandl, M. T., Hernlem, B. J., Eng, J. G., & Sarreal, S. B. L. (2010) · Mycopathologia · doi:10.1007/s11046-010-9352-z · Cited by 21
Self-citation
Progress in Prevention of Aflatoxin Contamination in Food by Preharvest Application of a Yeast Strain,Pichia AnomalaWRL‐076
Hua, S. S. T. (2006) · Wiley eBooks · doi:10.1002/9783527611904.ch57 · Cited by 7
Self-citation

Flagged first, then by citations

Research works printed but not linked: 1

Hua SST, Parfitt DE, Holtz BA (2006) Evaluation of a biopesticide, Pichia anomala WRL-076 to control Aspergillus flavus in a commercial orchard. Proceedings of the Fifth California Conference of Biological Control, Riverside, 25–27 July, pp 152–155

Sorted by citations

Biocontrol yeasts: mechanisms and applications
Freimoser, F. M., Rueda-Mejia, M. P., Tilocca, B., & Migheli, Q. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2728-4 · Cited by 462
Physiology, ecology and industrial applications of aroma formation in yeast
Dzialo, M. C., Park, R., Steensels, J., Lievens, B., & Verstrepen, K. J. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux031 · Cited by 458
Biocontrol ability and action mechanism of food-isolated yeast strains against Botrytis cinerea causing post-harvest bunch rot of table grape
Parafati, L., Vitale, A., Restuccia, C., & Cirvilleri, G. (2015) · Food Microbiology · doi:10.1016/j.fm.2014.11.013 · Cited by 391
Antifungal Microbial Agents for Food Biopreservation—A Review
Leyva Salas, M., Mounier, J., Valence, F., Coton, M., Thierry, A., & Coton, E. (2017) · Microorganisms · doi:10.3390/microorganisms5030037 · Cited by 349
Updating techniques on controlling mycotoxins - A review
Luo, Y., Liu, X., & Li, J. (2018) · Food Control · doi:10.1016/j.foodcont.2018.01.016 · Cited by 283
Nectar‐inhabiting microorganisms influence nectar volatile composition and attractiveness to a generalist pollinator
Rering, C. C., Beck, J. J., Hall, G. W., McCartney, M. M., & Vannette, R. L. (2017) · New Phytologist · doi:10.1111/nph.14809 · Cited by 247
Self-citation
The Floral Microbiome: Plant, Pollinator, and Microbial Perspectives
Vannette, R. L. (2020) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-011720-013401 · Cited by 223
Scent of a Killer: Microbial Volatilome and Its Role in the Biological Control of Plant Pathogens
Tilocca, B., Cao, A., & Migheli, Q. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00041 · Cited by 216
Volatile organic compounds from Wickerhamomyces anomalus, Metschnikowia pulcherrima and Saccharomyces cerevisiae inhibit growth of decay causing fungi and control postharvest diseases of strawberries
Oro, L., Feliziani, E., Ciani, M., Romanazzi, G., & Comitini, F. (2018) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2017.10.027 · Cited by 179
Postharvest biocontrol ability of killer yeasts against Monilinia fructigena and Monilinia fructicola on stone fruit
Grzegorczyk, M., Żarowska, B., Restuccia, C., & Cirvilleri, G. (2016) · Food Microbiology · doi:10.1016/j.fm.2016.09.005 · Cited by 145
ROS Stress and Cell Membrane Disruption are the Main Antifungal Mechanisms of 2-Phenylethanol against Botrytis cinerea
Zou, X., Wei, Y., Jiang, S., Xu, F., Wang, H., Zhan, P., & Shao, X. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06187 · Cited by 144
Bioprotective Role of Yeasts
Muccilli, S., & Restuccia, C. (2015) · Microorganisms · doi:10.3390/microorganisms3040588 · Cited by 141
Mechanisms of action for 2-phenylethanol isolated from Kloeckera apiculata in control of Penicillium molds of citrus fruits
Liu, P., Cheng, Y., Yang, M., Liu, Y., Chen, K., Long, C.-A., & Deng, X. (2014) · BMC Microbiology · doi:10.1186/s12866-014-0242-2 · Cited by 135
Adverse Effects, Transformation and Channeling of Aflatoxins Into Food Raw Materials in Livestock
Peles, F., Sípos, P., Győri, Z., Pfliegler, W. P., Giacometti, F., Serraino, A., Pagliuca, G., Gazzotti, T., & Pócsi, I. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02861 · Cited by 135
Effect of yeast volatile organic compounds on ochratoxin A-producing Aspergillus carbonarius and A. ochraceus
Farbo, M. G., Urgeghe, P. P., Fiori, S., Marcello, A., Oggiano, S., Balmas, V., Hassan, Z. U., Jaoua, S., & Migheli, Q. (2018) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2018.06.023 · Cited by 128
Mycotoxins – prevention and decontamination by yeasts
Pfliegler, W. P., Pusztahelyi, T., & Pócsi, I. (2015) · Journal of Basic Microbiology · doi:10.1002/jobm.201400833 · Cited by 124
The Aspergilli and Their Mycotoxins: Metabolic Interactions With Plants and the Soil Biota
Pfliegler, W. P., Pócsi, I., Győri, Z., & Pusztahelyi, T. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02921 · Cited by 122
Biological Control and Mitigation of Aflatoxin Contamination in Commodities
Peles, F., Sípos, P., Kovács, S., Győri, Z., Pócsi, I., & Pusztahelyi, T. (2021) · Toxins · doi:10.3390/toxins13020104 · Cited by 119
Interactions among filamentous fungi Aspergillus niger, Fusarium verticillioides and Clonostachys rosea: fungal biomass, diversity of secreted metabolites and fumonisin production
Chatterjee, S., Kuang, Y., Splivallo, R., Chatterjee, P., & Karlovský, P. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0698-3 · Cited by 119
The Biology of Pichia membranifaciens Killer Toxins
Belda, I., Ruiz, J., Alonso, A., Marquina, D., & Santos, A. (2017) · Toxins · doi:10.3390/toxins9040112 · Cited by 111
Potential of fumigation of orange fruits with volatile organic compounds produced by Saccharomyces cerevisiae to control citrus black spot disease at postharvest
Toffano, L., Fialho, M. B., & Pascholati, S. F. (2017) · Biological Control · doi:10.1016/j.biocontrol.2017.02.009 · Cited by 110
Biological control as an alternative to synthetic fungicides for the management of grey and blue mould diseases of table grapes: a review
Zhang, H., Godana, E. A., Sui, Y., Yang, Q., Zhang, X., & Zhao, L. (2020) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1794793 · Cited by 109
Mining the Volatilomes of Plant-Associated Microbiota for New Biocontrol Solutions
Bailly, A., & Weisskopf, L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01638 · Cited by 105
Yeasts from Different Habitats and Their Potential as Biocontrol Agents
Pretscher, J., Fischkal, T., Branscheidt, S., Jäger, L., Kahl, S., Schlander, M., Thines, E., & Claus, H. (2018) · Fermentation · doi:10.3390/fermentation4020031 · Cited by 104
Inhibitory Effect of Cinnamaldehyde, Citral, and Eugenol on Aflatoxin Biosynthetic Gene Expression and Aflatoxin B 1 Biosynthesis in Aspergillus flavus
Liang, D., Xing, F., Selvaraj, J. N., Liu, X., Wang, L., Hua, H., Zhou, L., Zhao, Y., Wang, Y., & Liu, Y. (2015) · Journal of Food Science · doi:10.1111/1750-3841.13144 · Cited by 104
Chemical signaling and insect attraction is a conserved trait in yeasts
Becher, P. G., Hagman, A., Verschut, V., Chakraborty, A., Rozpędowska, E., Lebreton, S., Bengtsson, M., Flick, G., Witzgall, P., & Piškur, J. (2018) · Ecology and Evolution · doi:10.1002/ece3.3905 · Cited by 107
Volatile Organic Compounds: A Review of Their Current Applications as Pest Biocontrol and Disease Management
Razo‐Belman, R., & Ozuna, C. (2023) · Horticulturae · doi:10.3390/horticulturae9040441 · Cited by 98
Performance evaluation of volatile organic compounds by antagonistic yeasts immobilized on hydrogel spheres against gray, green and blue postharvest decays
Parafati, L., Vitale, A., Restuccia, C., & Cirvilleri, G. (2017) · Food Microbiology · doi:10.1016/j.fm.2016.11.021 · Cited by 95
Control of Aflatoxigenic Molds by Antagonistic Microorganisms: Inhibitory Behaviors, Bioactive Compounds, Related Mechanisms, and Influencing Factors
Ren, X., Zhang, Q., Zhang, W., Mao, J., & Li, P. (2020) · Toxins · doi:10.3390/toxins12010024 · Cited by 95
Biocontrol ability and action mechanisms of Aureobasidium pullulans GE17 and Meyerozyma guilliermondii KL3 against Penicillium digitatum DSM2750 and Penicillium expansum DSM62841 causing postharvest diseases
Ağırman, B., & Erten, H. (2020) · Yeast · doi:10.1002/yea.3501 · Cited by 93
The power of the smallest: The inhibitory activity of microbial volatile organic compounds against phytopathogens
Almeida, O. A. C., de Araujo, N. O., Dias, B. H. S., Freitas, C. S. A., Coerini, L. F., Ryu, C., & Oliveira, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.951130 · Cited by 99
Volatile Organic Compound-Mediated Antifungal Activity of Pichia spp. and Its Effect on the Metabolic Profiles of Fermentation Communities
Zhang, H., Du, H., & Xu, Y. (2021) · Applied and Environmental Microbiology · doi:10.1128/aem.02992-20 · Cited by 92
Aureobasidium pullulans volatilome identified by a novel, quantitative approach employing SPME-GC-MS, suppressed Botrytis cinerea and Alternaria alternata in vitro
Don, S. Y., Schmidtke, L. M., Gambetta, J. M., & Steel, C. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-61471-8 · Cited by 90
Antifungal activity of volatile emitted from Enterobacter asburiae Vt-7 against Aspergillus flavus and aflatoxins in peanuts during storage
Gong, A., Dong, F.-Y., Hu, M., Kong, X., Wei, F.-F., Gong, S., Zhang, Y., Zhang, J., Wu, A., & Liao, Y. (2019) · Food Control · doi:10.1016/j.foodcont.2019.106718 · Cited by 84
High Efficacy of the Volatile Organic Compounds of Streptomyces yanglinensis 3-10 in Suppression of Aspergillus Contamination on Peanut Kernels
Lyu, A., Yang, L., Wu, M., Zhang, J., & Li, G. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00142 · Cited by 84
Aflatoxin B1 inhibition in Aspergillus flavus by Aspergillus niger through down-regulating expression of major biosynthetic genes and AFB1 degradation by atoxigenic A. flavus
Xing, F., Wang, L., Liu, X., Selvaraj, J. N., Wang, Y., Zhao, Y., & Liu, Y. (2017) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2017.05.013 · Cited by 82
Sweet Scents: Nectar Specialist Yeasts Enhance Nectar Attraction of a Generalist Aphid Parasitoid Without Affecting Survival
Sobhy, I. S., Baets, D., Goelen, T., Herrera‐Malaver, B., Bosmans, L., den Ende, W. V., Verstrepen, K. J., WÄCKERS, F. L., Jacquemyn, H., & Lievens, B. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.01009 · Cited by 81
Biocontrol Activity of Volatile-ProducingBacillus megateriumandPseudomonas protegensAgainstAspergillusandPenicilliumspp. Predominant in Stored Rice Grains: Study II
Mannaa, M., & Kim, K. D. (2018) · Mycobiology · doi:10.1080/12298093.2018.1454015 · Cited by 80
Microbial Volatile Organic Compounds: Insights into Plant Defense
Montejano-Ramírez, V., Ávila-Oviedo, J. L., Campos-Mendoza, F. J., & Valencia‐Cantero, E. (2024) · Plants · doi:10.3390/plants13152013 · Cited by 75
Biocontrol Ability and Action Mechanism of Starmerella bacillaris (Synonym Candida zemplinina) Isolated from Wine Musts against Gray Mold Disease Agent Botrytis cinerea on Grape and Their Effects on Alcoholic Fermentation
Lemos, W. J., Bovo, B., Nadai, C., Crosato, G., Carlot, M., Favaron, F., Giacomini, A., & Corich, V. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01249 · Cited by 74
Biological control of aflatoxin-producing Aspergillus flavus by volatile organic compound-producing antagonistic yeasts
Jaibangyang, S., Nasanit, R., & Limtong, S. (2020) · BioControl · doi:10.1007/s10526-020-09996-9 · Cited by 73
Comparative metabolic expressions of fermented soybeans according to different microbial starters
Park, M. K., & Kim, Y. S. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.125461 · Cited by 68
Research advance in gas detection of volatile organic compounds released in rice quality deterioration process
Liu, K., Zhang, C., Xu, J., & Liu, Q. (2021) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12846 · Cited by 68
Control of postharvest blue and gray mold in kiwifruit by Wickerhamomyces anomalus and its mechanism of antifungal activity
Zhao, Q., Shi, Y., Xu, C., Jiang, Z., Liu, J., Sui, Y., & Zhang, H. (2023) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2023.112345 · Cited by 68
Biocontrol activity of volatile organic compounds from Streptomyces alboflavus TD-1 against Aspergillus flavus growth and aflatoxin production
Yang, M., Lu, L., Pang, J., Hu, Y., Guo, Q. M., Li, Z., Wu, S., Liu, H., & Wang, C. (2019) · The Journal of Microbiology · doi:10.1007/s12275-019-8517-9 · Cited by 68
Suppression of Aflatoxin Biosynthesis in Aspergillus flavus by 2-Phenylethanol Is Associated with Stimulated Growth and Decreased Degradation of Branched-Chain Amino Acids
Chang, P., Hua, S.-S. T., Sarreal, S. B. L., & Li, R. W. (2015) · Toxins · doi:10.3390/toxins7103887 · Cited by 66
Self-citation
Screening antagonistic yeasts against citrus green mold and the possible biocontrol mechanisms of Pichia galeiformis ( BAF03 )
Chen, O., Yi, L., Deng, L., Ruan, C., & Zeng, K. (2020) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10407 · Cited by 63
Advanced mycotoxin control and decontamination techniques in view of an increased aflatoxin risk in Europe due to climate change
Loi, M., Logrieco, A. F., Pusztahelyi, T., Leiter, É., Hornok, L., & Pócsi, I. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1085891 · Cited by 63
Inhibitory effect of Pichia membranaefaciens and Kloeckera apiculata against Monilinia fructicola and their biocontrol ability of brown rot in postharvest plum
Zhang, J., Xie, J., Zhou, Y., Deng, L., Yao, S., & Zeng, K. (2017) · Biological Control · doi:10.1016/j.biocontrol.2017.07.013 · Cited by 63
Mycotoxins: Impact on Health and Strategies for Prevention and Detoxification in the Food Chain
Peivasteh-Roudsari, L., Pirhadi, M., Shahbazi, R., Eghbaljoo–Gharehgheshlaghi, H., Sepahi, M., Alizadeh, A. M., Tajdar‐oranj, B., & Jazaeri, S. (2021) · Food Reviews International · doi:10.1080/87559129.2020.1858858 · Cited by 61
Evaluation of antagonistic activity and mechanisms of endophytic yeasts against pathogenic fungi causing economic crop diseases
Khunnamwong, P., Lertwattanasakul, N., Jindamorakot, S., Suwannarach, N., Matsui, K., & Limtong, S. (2019) · Folia Microbiologica · doi:10.1007/s12223-019-00764-6 · Cited by 59
Perfume Guns: Potential of Yeast Volatile Organic Compounds in the Biological Control of Mycotoxin-Producing Fungi
Oufensou, S., Hassan, Z. U., Balmas, V., Jaoua, S., & Migheli, Q. (2023) · Toxins · doi:10.3390/toxins15010045 · Cited by 54
Exploring yeast‐based microbial interactions: The next frontier in postharvest biocontrol
Ağırman, B., Çarşanba, E., Settanni, L., & Erten, H. (2023) · Yeast · doi:10.1002/yea.3895 · Cited by 54
Effect of Cinnamaldehyde on Morphological Alterations of Aspergillus ochraceus and Expression of Key Genes Involved in Ochratoxin A Biosynthesis
Wang, L., Jin, J., Liu, X., Wang, Y., Liu, Y., Zhao, Y., & Xing, F. (2018) · Toxins · doi:10.3390/toxins10090340 · Cited by 53
The action mechanism and biocontrol potentiality of novel isolates of Saccharomyces cerevisiae against the aflatoxigenic Aspergillus flavus
Abdel-Kareem, M. M., Rasmey, A.-H. M., & Zohri, A.-N. A. (2018) · Letters in Applied Microbiology · doi:10.1111/lam.13105 · Cited by 53
Mechanisms of action of the yeast Debaryomyces nepalensis for control of the pathogen Colletotrichum gloeosporioides in mango fruit
Zhou, Y., Li, W., Zeng, J., & Shao, Y. (2018) · Biological Control · doi:10.1016/j.biocontrol.2018.05.014 · Cited by 52
Volatile organic compounds and rapid proliferation of Candida pseudolambica W16 are modes of action against gray mold in peach fruit
Zou, X., Wei, Y., Jiang, S., Cao, Z., Xu, F., Wang, H., Zhan, P., & Shao, X. (2021) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2021.111751 · Cited by 52
Characteristics of microbial community and aroma compounds in traditional fermentation of Pixian broad bean paste as compared to industrial fermentation
Li, X., Zhao, C., Zheng, C., Liu, J., Vu, V. H., Wang, X., & Sun, Q. (2017) · International Journal of Food Properties · doi:10.1080/10942912.2017.1373358 · Cited by 50
Large-Scale Comparative Analysis of Eugenol-Induced/Repressed Genes Expression in Aspergillus flavus Using RNA-seq
Lv, C., Wang, P., Ma, L., Zheng, M., Liu, Y., & Xing, F. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01116 · Cited by 49
Inhibitory Effect of Volatiles Emitted From Alcaligenes faecalis N1-4 on Aspergillus flavus and Aflatoxins in Storage
Gong, A., Wu, N., Kong, X., Zhang, Y., Hu, M., Gong, S., Dong, F.-Y., Wang, J., Zhao, Z., & Liao, Y. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01419 · Cited by 47
Biocontrol and Probiotic Function of Non-Saccharomyces Yeasts: New Insights in Agri-Food Industry
Comitini, F., Canonico, L., Agarbati, A., & Ciani, M. (2023) · Microorganisms · doi:10.3390/microorganisms11061450 · Cited by 48
Biocontrol of Rice Seedling Rot Disease Caused by Curvularia lunata and Helminthosporium oryzae by Epiphytic Yeasts from Plant Leaves
Limtong, S., Into, P., & Attarat, P. (2020) · Microorganisms · doi:10.3390/microorganisms8050647 · Cited by 45
Eight-carbon volatiles: prominent fungal and plant interaction compounds
Pennerman, K. K., Yin, G., & Bennett, J. W. (2021) · Journal of Experimental Botany · doi:10.1093/jxb/erab438 · Cited by 44
Biocontrol Activity of Volatile-ProducingBacillus megateriumandPseudomonas protegensagainstAspergillus flavusand Aflatoxin Production on Stored Rice Grains
Mannaa, M., Oh, J. Y., & Kim, K. D. (2017) · Mycobiology · doi:10.5941/myco.2017.45.3.213 · Cited by 44
Current Strategies in Controlling Aspergillus flavus and Aflatoxins in Grains during Storage: A Review
Gong, A., Song, M., & Zhang, J. (2024) · Sustainability · doi:10.3390/su16083171 · Cited by 43
Challenges facing the biological control strategy for eliminating aflatoxin contamination
Ehrlich, K., Moore, G. G., Mellon, J. E., & Bhatnagar, D. (2014) · World Mycotoxin Journal · doi:10.3920/wmj2014.1696 · Cited by 43
Biocontrol ability of killer yeasts (Saccharomyces cerevisiae) isolated from wine against Colletotrichum gloeosporioides on grape
Liu, Z., Du, S. H., Ren, Y., & Liu, Y. (2017) · Journal of Basic Microbiology · doi:10.1002/jobm.201700264 · Cited by 42
Isolation of a Novel Kluyveromyces marxianus Strain QKM-4 and Evidence of Its Volatilome Production and Binding Potentialities in the Biocontrol of Toxigenic Fungi and Their Mycotoxins
Alasmar, R. M., Hassan, Z. U., Zeidan, R., Al-Thani, R. F., Al-Shamary, N., Alnaimi, H., Migheli, Q., & Jaoua, S. (2020) · ACS Omega · doi:10.1021/acsomega.0c02124 · Cited by 41
Antifungal activity of the volatile organic compounds produced by Ceratocystis fimbriata strains WSJK-1 and Mby
Gao, Y., Ren, H., He, S., Duan, S., Xing, S., Li, X., & Huang, Q. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1034939 · Cited by 40
Wickerhamomyces anomalus: A promising yeast for controlling mold growth and diverse biotechnological applications
Godana, E. A., Edo, G. S., Yang, Q., Zhang, X., Zhao, L., Wang, K., Ngea, G. L. N., & Zhang, H. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104649 · Cited by 40
Investigation of Pseudomonas fluorescens strain 3JW1 on preventing and reducing aflatoxin contaminations in peanuts
Yang, X., Zhang, Q., Chen, Z.-Y., Liu, H., & Li, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178810 · Cited by 39
Occurrence of Mycotoxins and Toxigenic Fungi in Cereals and Application of Yeast Volatiles for Their Biological Control
Alkuwari, A., Hassan, Z. U., Zeidan, R., Al-Thani, R. F., & Jaoua, S. (2022) · Toxins · doi:10.3390/toxins14060404 · Cited by 39
Application of Low-Fermenting Yeast Lachancea thermotolerans for the Control of Toxigenic Fungi Aspergillus parasiticus, Penicillium verrucosum and Fusarium graminearum and Their Mycotoxins
Zeidan, R., Hassan, Z. U., Al-Thani, R. F., Balmas, V., & Jaoua, S. (2018) · Toxins · doi:10.3390/toxins10060242 · Cited by 36
Biocontrol features of Clavispora lusitaniae against Penicillium digitatum on lemons
Pérez, M. F., Díaz, M. A., Pereyra, M. M., Córdoba, J. M., Isas, A. S., Sepúlveda, M., Ramallo, J. C., & Dib, J. R. (2019) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2019.05.012 · Cited by 36
Use of yeasts from different environments for the control of Penicillium expansum on table grapes at storage temperature
Assaf, L. A. R., Pedrozo, L. P., Nally, M. C., Pesce, V. M., Toro, M. E., de Figueroa, L. I. C., & Vázquez, F. (2020) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2020.108520 · Cited by 36
Yeast Associated with Rice Phylloplane and Their Contribution to Control of Rice Sheath Blight Disease
Into, P., Khunnamwong, P., Jindamoragot, S., Am-In, S., Intanoo, W., & Limtong, S. (2020) · Microorganisms · doi:10.3390/microorganisms8030362 · Cited by 36
A carnivorous mushroom paralyzes and kills nematodes via a volatile ketone
Lee, C.-H., Lee, Y.-Y., Chang, Y., Pon, W.-L., Lee, S., Wali, N., Nakazawa, T., Honda, Y., Shie, J., & Hsueh, Y. (2023) · Science Advances · doi:10.1126/sciadv.ade4809 · Cited by 36
The Use of Candida pyralidae and Pichia kluyveri to Control Spoilage Microorganisms of Raw Fruits Used for Beverage Production
Mewa-Ngongang, M., du Plessis, H. W., Ntwampe, S. K. O., Chidi, B. S., Hutchinson, U. F., Mekuto, L., & Jolly, N. P. (2019) · Foods · doi:10.3390/foods8100454 · Cited by 36
Biocontrol potential of wine yeasts against four grape phytopathogenic fungi disclosed by time-course monitoring of inhibitory activities
Esteves, M., Lage, P., Sousa, J., Centeno, F., Teixeira, M. D. F., Tenreiro, R. P., & Mendes‐Ferreira, A. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1146065 · Cited by 34
Biological Control of Aspergillus flavus by the Yeast Aureobasidium pullulans In Vitro and on Tomato Fruit
Podgórska-Kryszczuk, I. (2023) · Plants · doi:10.3390/plants12020236 · Cited by 35
Antifungal Activity of Volatile Components from Ceratocystis fimbriata and Its Potential Biocontrol Mechanism on Alternaria alternata in Postharvest Cherry Tomato Fruit
Xing, S., Gao, Y., Li, X., Ren, H., Gao, Y., Yang, H., Liu, Y., He, S., & Huang, Q. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.02713-22 · Cited by 34
Quorum sensing: cell-to-cell communication in Saccharomyces cerevisiae
Li, L., Pan, Y., Zhang, S., Yang, T., Li, Z., Wang, B., Sun, H., Zhang, M., & Li, X. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1250151 · Cited by 34
Phenotypic characterization of cell-to-cell interactions between two yeast species during alcoholic fermentation
Luyt, N. A., Beaufort, S., Divol, B., Setati, M. E., Taillandier, P., & Bauer, F. F. (2021) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-021-03154-8 · Cited by 33
Mycotoxins in maize: mitigation actions, with a chain management approach
Palumbo, R., Gonçalves, A. P., Gkrillas, A., Logrieco, A. F., Dorne, J. L. C. M., Dall’Asta, C., Venâncio, A., & Battilani, P. (2020) · Phytopathologia Mediterranea · doi:10.36253/phyto-11142 · Cited by 32
Biocontrol potential of native yeast strains against Aspergillus flavus and aflatoxin production in pistachio
Moradi, M., Rohani, M., Fani, S. R., Mosavian, M. T. H., Probst, C., & Khodaygan, P. (2020) · Food Additives & Contaminants Part A · doi:10.1080/19440049.2020.1811901 · Cited by 31
Fusarium verticillioides and Aspergillus flavus Co-Occurrence Influences Plant and Fungal Transcriptional Profiles in Maize Kernels and In Vitro
Lanubile, A., Giorni, P., Bertuzzi, T., Marocco, A., & Battilani, P. (2021) · Toxins · doi:10.3390/toxins13100680 · Cited by 31
Yeast-based solutions in controlling plant pathogens
Ali, A., Ölmez, F., Zeshan, M. A., Mubeen, M., Iftikhar, Y., Sajid, A., Abid, M. A., Kumar, A., Divvela, P. K., & Solanki, M. K. (2024) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2024.103199 · Cited by 30
Mycotoxin Contamination Status of Cereals in China and Potential Microbial Decontamination Methods
Zhang, J., Tang, X., Cai, Y., & Zhou, W.-W. (2023) · Metabolites · doi:10.3390/metabo13040551 · Cited by 29
Volatile Organic Compounds of Scheffersomyces spartinae W9 Have Antifungal Effect against Botrytis cinerea on Strawberry Fruit
Zou, X., Wei, Y., Zhu, J., Sun, J., & Shao, X. (2023) · Foods · doi:10.3390/foods12193619 · Cited by 29
Sequential production of secondary metabolites by one operon affects interspecies interactions in Enterobacter sp. CGMCC 5087
Liu, L., Chen, G., Liu, J., Bao, W., Li, X., Yang, K., Shi, S., Zhao, B., Wang, Q., Cao, X., et al. (2023) · The Innovation Life · doi:10.59717/j.xinn-life.2023.100023 · Cited by 28
In vitro assessment of antifungal activities of antagonistic fungi towards pathogenic Ganoderma boninense under metal stress
Ting, A. S. Y., & Jioe, E. (2016) · Biological Control · doi:10.1016/j.biocontrol.2016.02.002 · Cited by 27
Volatile organic compounds of Clavispora lusitaniae AgL21 restrain citrus postharvest pathogens
Pereyra, M. M., Garmendia, G., Rossini, C., Meinhardt, F., Vero, S., & Dib, J. R. (2022) · Biological Control · doi:10.1016/j.biocontrol.2022.105025 · Cited by 27
Application of Bioactive Coatings with Killer Yeasts to Control Post-Harvest Apple Decay Caused by Botrytis cinerea and Penicillium italicum
Błaszczyk, U., Wyrzykowska, S., & Gąstoł, M. (2022) · Foods · doi:10.3390/foods11131868 · Cited by 26
Transcriptional Regulation of Aflatoxin Biosynthesis and Conidiation in Aspergillus flavus by Wickerhamomyces anomalus WRL-076 for Reduction of Aflatoxin Contamination
Hua, S.-S. T., Sarreal, S. B. L., Chang, P., & Yu, J. (2019) · Toxins · doi:10.3390/toxins11020081 · Cited by 26
Self-citation
The quorum‐sensing molecule 2‐phenylethanol impaired conidial germination, hyphal membrane integrity and growth of Penicillium expansum and Penicillium nordicum
Huang, C. S., Qian, Y., Viana, T., Siegumfeldt, H., Arneborg, N., Larsen, N., & Jespersen, L. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14621 · Cited by 26
Effects of temperature and relative humidity on Aflatoxin B1 reduction in corn grains and antagonistic activities against Aflatoxin-producing Aspergillus flavus by a volatile organic compound-producing yeast, Kwoniella heveanensis DMKU-CE82
Jaibangyang, S., Nasanit, R., & Limtong, S. (2021) · BioControl · doi:10.1007/s10526-021-10082-x · Cited by 24
Adaptive responses of Kluyveromyces marxianus CCT 7735 to 2-phenylethanol stress: Alterations in membrane fatty-acid composition, ergosterol content, exopolysaccharide production and reduction in reactive oxygen species
Balbino, T. R., da Silveira, F. A., Ventorim, R. Z., do Nascimento, A. G., de Oliveira, L. L., & da Silveira, W. B. (2021) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2021.103561 · Cited by 22
Bioactive Compounds from and against Yeasts in the One Health Context: A Comprehensive Review
Tadioto, V., Giehl, A., Cadamuro, R. D., Guterres, I. Z., dos Santos, Â. A., Bressan, S. K., Werlang, L., Stambuk, B. U., Fongaro, G., Silva, I. T., et al. (2023) · Fermentation · doi:10.3390/fermentation9040363 · Cited by 22
Fungal Genes and Metabolites Associated with the Biocontrol of Soil-borne Plant Pathogenic Fungi
Daguerre, Y., Edel‐Hermann, V., & Steinberg, C. (2016) · Springer eBooks · doi:10.1007/978-3-319-19456-1_27-1 · Cited by 22
Rhamnolipids inhibit aflatoxins production in Aspergillus flavus by causing structural damages in the fungal hyphae and down-regulating the expression of their biosynthetic genes
Rodrigues, A. I., Gudiña, E. J., Abrunhosa, L., Malheiro, A. R., Fernandes, R., Teixeira, J. A., & Rodrigues, L. R. (2021) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2021.109207 · Cited by 22

Suppression of Aflatoxin Biosynthesis in Aspergillus flavus by 2-Phenylethanol Is Associated with Stimulated Growth and Decreased Degradation of Branched-Chain Amino Acids
Chang, P., Hua, S.-S. T., Sarreal, S. B. L., & Li, R. W. (2015) · Toxins · doi:10.3390/toxins7103887 · Cited by 66
Self-citation
Transcriptional Regulation of Aflatoxin Biosynthesis and Conidiation in Aspergillus flavus by Wickerhamomyces anomalus WRL-076 for Reduction of Aflatoxin Contamination
Hua, S.-S. T., Sarreal, S. B. L., Chang, P., & Yu, J. (2019) · Toxins · doi:10.3390/toxins11020081 · Cited by 26
Self-citation
Volatiles of antagonistic soil yeasts inhibit growth and aflatoxin production of Aspergillus flavus
Natarajan, S., Balachandar, D., Senthil, N., Velazhahan, R., & Paranidharan, V. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127150 · Cited by 33
The potential role of fungal volatile organic compounds in Aspergillus flavus biocontrol efficacy
Moore, G. G., Lebar, M. D., Carter‐Wientjes, C. H., & Gilbert, M. K. (2021) · Biological Control · doi:10.1016/j.biocontrol.2021.104686 · Cited by 37
Inhibitory effect of volatiles produced by Bacillus safensis TR ‐47 on Aspergillus flavus and aflatoxins in the peanuts during storage
Gong, A., Hong, R., Wang, G., Liu, J., Li, S., Yang, P., Zhang, Y., Yang, G., Chen, Z., Wu, A., et al. (2025) · Pest Management Science · doi:10.1002/ps.70331 · Cited by 7

Authors: Hua, S. S. T., Beck, J. J., Sarreal, S. B. L., & Gee, W.
Affiliations: Agricultural Research Service (US)
Corresponding author: Hua, Sui Sheng T.
ORCID: Beck, John J.
Venue: Mycotoxin Research
Publisher: Springer Science and Business Media LLC
Published: 2014-02-07
Volume: 30
Issue: 2
Pages: 71-78
ISSN: 0178-7888 (ISSN-L)
1867-1632
DOI: 10.1007/s12550-014-0189-z
OpenAlex: W2113340002
Cited by: 181
References: 21
Citations by year: 2026: 10 · 2025: 12 · 2024: 15 · 2023: 25 · 2022: 23 · 2021: 17 · 2020: 21 · 2019: 11 · 2018: 11 · 2017: 19 · 2016: 8 · 2015: 5 · 2014: 4
FWCI: 14.01
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Mycotoxin Research (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Agriculture
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogens and Fungal Diseases
Keywords: 2-phenylethanol, Wickerhamomyces anomalus, Aspergillus flavus, aflatoxin biosynthesis, aflatoxin B1, biocontrol yeast, volatile compounds, spore germination inhibition, gene expression regulation, chromatin modifiers, GCN5, mycotoxin reduction
MeSH terms: Aflatoxins, Antifungal Agents, Aspergillus flavus, Phenylethyl Alcohol, Pichia, Gene Expression Regulation, Fungal, Gene Expression Profiling, Biosynthetic Pathways, Volatile Organic Compounds

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The major volatile compound 2-phenylethanol from the biocontrol yeast, Pichia anomala, inhibits growth and expression of aflatoxin biosynthetic genes of Aspergillus flavus

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks