CoChat
Sign Up
Cited by 128Mycotoxins in Agriculture and FoodPolyamine Metabolism and ApplicationsPlant Pathogens and Fungal Diseases

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Effect of yeast volatile organic compounds on ochratoxin A-producing Aspergillus carbonarius and A. ochraceus

Open access
Farbo, Maria Grazia, Urgeghe, Pietro Paolo, Fiori, Stefano, Marcello, Angela, Oggiano, Stefania, Balmas, Virgilio, Hassan, Zahoor Ul, Jaoua, Samir, Migheli, Quirico·2018·International Journal of Food Microbiology
DOI 10.1016/j.ijfoodmicro.2018.06.023
Open this paper in CoChat — free accountOpen PDF

Abstract

Many foods and beverages in temperate and tropical regions are prone to contamination by ochratoxin A (OTA), one of the most harmful mycotoxins for human and animal health. Aspergillus ochraceus and Aspergillus carbonarius are considered among the main responsible for OTA contamination. We have previously demonstrated that four low or non- fermenting yeasts are able to control the growth and sporulation of OTA-producing Aspergilli both in vitro and on detached grape berries: the biocontrol effect was partly due to the release of volatile organic compounds (VOCs). Aiming to further characterise the effect of VOCs produced by biocontrol yeast strains, we observed that, beside vegetative growth and sporulation, the volatile compounds significantly reduced the production of OTA by two A. carbonarius and A. ochraceus isolates. Exposure to yeast VOCs also affected gene expression in both species, as confirmed by downregulation of polyketide synthase, non-ribosomal peptide synthase, monooxygenase, and the regulatory genes laeA and veA. The main compound of yeast VOCs was 2-phenylethanol, as detected by Headspace-Solid Phase Microextraction-Gas Chromatography-Tandem Mass Spectrometry (HS-SPME-GC-MS) analysis. Yeast VOCs represent a promising tool for the containment of growth and development of mycotoxigenic fungi, and a valuable aid to guarantee food safety and quality.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.ijfoodmicro.2018.06.023

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • More than twenty different VOCs were identified in the volatilomes of selected biocontrol strains of Cyberlindnera jadinii, Candida friedrichii, C. intermedia, and Lachancea thermotolerans.

    “More than twenty different VOCs were identified in the volatilomes of selected biocontrol strains of Cyberlindnera jadinii, Candida friedrichii, C. intermedia, and Lachancea thermotolerans”

    From Biocontrol yeasts: mechanisms and applications (2019) · cites this paper as Farbo et al. 2018

  • 2-phenylethanol was the most abundant and responsible for the inhibition of both mycelial growth and ochratoxin A production by Aspergillus carbonarius and A. ochraceus.

    “2-phenylethanol was the most abundant and responsible for the inhibition of both mycelial growth and ochratoxin A production by Aspergillus carbonarius and A. ochraceus (Farbo et al. 2018; Fiori et al. 2014; Tilocca et al. 2019).”

    From Biocontrol yeasts: mechanisms and applications (2019) · cites this paper as Farbo et al. 2018

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 63

  1. Abarca, 2003, Aspergillus carbonarius as the main source of ochratoxin A contamination in dried vine fruits from the Spanish market, J. Food Prot., 66, 504, 10.4315/0362-028X-66.3.504 · DOI
  2. Abbas, 2009, Analysis of the effect of nutritional factors on OTA and OTB biosynthesis and polyketide synthase gene expression in Aspergillus ochraceus, Int. J. Food Microbiol., 135, 22, 10.1016/j.ijfoodmicro.2009.07.014 · DOI
  3. Arrarte, 2017, Volatile organic compounds produced by Antarctic strains of Candida sake play a role in the control of postharvest pathogens of apples, Biol. Control, 109, 14, 10.1016/j.biocontrol.2017.03.002 · DOI · Paper page
  4. Bacha, 2009, Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A, Fungal Genet. Biol., 46, 77, 10.1016/j.fgb.2008.09.015 · DOI
  5. Bayram, 2008, VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism, Science, 320, 1504, 10.1126/science.1155888 · DOI
  6. Bleve, 2006, Isolation of epiphytic yeasts with potential for biocontrol of Aspergillus carbonarius and A. niger on grape, Int. J. Food Microbiol., 108, 204, 10.1016/j.ijfoodmicro.2005.12.004 · DOI
  7. Bok, 2004, LaeA, a regulator of secondary metabolism in Aspergillus spp, Eukaryot. Cell, 3, 527, 10.1128/EC.3.2.527-535.2004 · DOI · Paper page
  8. Bragulat, 2001, An easy screening method for fungi producing ochratoxin A in pure culture, Int. J. Food Microbiol., 71, 139, 10.1016/S0168-1605(01)00581-5 · DOI
  9. Buzzini, 2005, Production of volatile organic sulfur compounds (VOCs) by basidiomycetous yeasts, FEMS Yeast Res., 5, 379, 10.1016/j.femsyr.2004.10.011 · DOI
  10. Cabañes, 2013, Characterization of nonochratoxigenic strains of Aspergillus carbonarius from grapes, Food Microbiol., 36, 135, 10.1016/j.fm.2013.05.004 · DOI
  11. Castegnaro, 1998, Sex- and strain-specific induction of renal tumors by ochratoxin A in rats correlated with DNA adduction, Int. J. Cancer, 77, 70, 10.1002/(SICI)1097-0215(19980703)77:1<70::AID-IJC12>3.0.CO;2-D · DOI
  12. Chang, 2015, Suppression of aflatoxin biosynthesis in Aspergillus flavus by 2-phenylethanol is associated with stimulated growth and decreased degradation of branched-chain amino acids, Toxins, 7, 3887, 10.3390/toxins7103887 · DOI
  13. Crespo-Sempere, 2013, Vea and LaeA transcriptional factors regulate ochratoxin A biosynthesis in Aspergillus carbonarius, Int. J. Food Microbiol., 166, 479, 10.1016/j.ijfoodmicro.2013.07.027 · DOI
  14. De Curtis, 2012, Environmental factors affect the activity of biocontrol agents against ochratoxigenic Aspergillus carbonarius on wine grape, Int. J. Food Microbiol., 159, 17, 10.1016/j.ijfoodmicro.2012.07.023 · DOI
  15. Di Francesco, 2015, Production of volatile organic compounds by Aureobasidium pullulans as a potential mechanism of action against postharvest fruit pathogens, Biol. Control, 81, 8, 10.1016/j.biocontrol.2014.10.004 · DOI · Paper page
  16. Droby, 2009, Twenty years of postharvest biocontrol research: is it time for a new paradigm?, Postharvest Biol. Technol., 52, 137, 10.1016/j.postharvbio.2008.11.009 · DOI · Paper page
  17. Duarte, 2010, A review on ochratoxin A occurrence and effects of processing of cereal and cereal derived food products, Food Microbiol., 27, 187, 10.1016/j.fm.2009.11.016 · DOI
  18. Farbo, 2016, Adsorption of ochratoxin A from grape juice by yeast cells immobilised in calcium alginate beads, Int. J. Food Microbiol., 217, 29, 10.1016/j.ijfoodmicro.2015.10.012 · DOI
  19. Fialho, 2010, Volatile organic compounds produced by Saccharomyces cerevisiae inhibit the in vitro development of Guignardia citricarpa, the causal agent of citrus black spot, World J. Microbiol. Biotechnol., 26, 925, 10.1007/s11274-009-0255-4 · DOI · Paper page
  20. Fiori, 2014, Biocontrol activity of four non- and low-fermenting yeast strains against Aspergillus carbonarius and their ability to remove ochratoxin A from grape juice, Int. J. Food Microbiol., 189, 45, 10.1016/j.ijfoodmicro.2014.07.020 · DOI · Paper page
  21. Gallo, 2009, Characterisation of a pks gene which is expressed during ochratoxin A production by Aspergillus carbonarius, Int. J. Food Microbiol., 129, 8, 10.1016/j.ijfoodmicro.2008.10.022 · DOI
  22. Gallo, 2012, New insight into the ochratoxin A biosynthetic pathway through deletion of a nonribosomal peptide synthetase gene in Aspergillus carbonarius, Appl. Environ. Microbiol., 78, 8208, 10.1128/AEM.02508-12 · DOI
  23. Gallo, 2014, Identification and characterization of the polyketide synthase involved in ochratoxin A biosynthesis in Aspergillus carbonarius, Int. J. Food Microbiol., 179, 10, 10.1016/j.ijfoodmicro.2014.03.013 · DOI
  24. Geisen, 2006, A gene cluster of the ochratoxin a biosynthetic genes in Penicillium, Mycotoxin Res., 22, 134, 10.1007/BF02956777 · DOI
  25. Gil-Serna, 2018, Description of an orthologous cluster of ochratoxin A biosynthetic genes in Aspergillus and Penicillium species. A comparative analysis, Int. J. Food Microbiol., 268, 35, 10.1016/j.ijfoodmicro.2017.12.028 · DOI
  26. Huang, 2011, Control of postharvest Botrytis fruit rot of strawberry by volatile organic compounds of Candida intermedia, Phytopathology, 101, 859, 10.1094/PHYTO-09-10-0255 · DOI · Paper page
  27. Huff, 1979, Mycotoxins - their biosynthesis in fungi: ochratoxins-metabolites of combined pathways, J. Food Prot., 42, 815, 10.4315/0362-028X-42.10.815 · DOI
  28. Huffman, 2010, Recent advancements in the biosynthetic mechanisms for polyketide-derived mycotoxins, Biopolymers, 93, 764, 10.1002/bip.21483 · DOI
  29. Janisiewicz, 2010, Yeasts associated with nectarines and their potential for biological control of brown rot, Yeast, 27, 389, 10.1002/yea.1763 · DOI
  30. Kanchiswamy, 2015, Chemical diversity of microbial volatiles and their potential for plant growth and productivity, Front. Plant Sci., 6, 151, 10.3389/fpls.2015.00151 · DOI
  31. Karolewiez, 2005, Cloning a part of the ochratoxin A biosynthetic gene cluster of Penicillium nordicum and characterization of the ochratoxin polyketide synthase gene, Syst. Appl. Microbiol., 28, 588, 10.1016/j.syapm.2005.03.008 · DOI
  32. Kogkaki, 2015, Effect of interaction between Aspergillus carbonarius and non-ochratoxigenic grape-associated fungal isolates on growth and ochratoxin A production at different water activities and temperatures, Food Microbiol., 46, 521, 10.1016/j.fm.2014.09.014 · DOI
  33. Krogh, 1978, Casual associations of mycotoxic nephropathy, Acta Pathol. Microbiol. Immunol. Scand. A, 269, 1
  34. Linde, 2016, The global regulator LaeA controls production of citric acid and endoglucanases in Aspergillus carbonarius, J. Ind. Microbiol. Biotechnol., 43, 1139, 10.1007/s10295-016-1781-3 · DOI
  35. Liu, 2013, Review: utilization of antagonistic yeasts to manage postharvest fungal diseases of fruit, Int. J. Food Microbiol., 167, 153, 10.1016/j.ijfoodmicro.2013.09.004 · DOI · Paper page
  36. Liu, 2014, Mechanisms of action for 2-phenylethanol isolated from Kloeckera apiculata in control of Penicillium molds of citrus fruits, BMC Microbiol., 14, 242, 10.1186/s12866-014-0242-2 · DOI
  37. Maffei, 2011, Plant volatiles: production, function and pharmacology, Nat. Prod. Rep., 28, 1359, 10.1039/c1np00021g · DOI
  38. Malandrakis, 2013, Effect of phenylpyrrole-resistance on fitness parameters and ochratoxin production in Aspergillus carbonarius, Int. J. Food Microbiol., 165, 287, 10.1016/j.ijfoodmicro.2013.05.019 · DOI
  39. Masoud, 2006, The effects of yeasts involved in the fermentation of Coffea arabica in East Africa on growth and ochratoxin A (OTA) production by Aspergillus ochraceus, Int. J. Food Microbiol., 106, 229, 10.1016/j.ijfoodmicro.2005.06.015 · DOI
  40. Morath, 2012, Fungal volatile organic compounds: a review with emphasis on their biotechnological potential, Fungal Biol. Rev., 26, 73, 10.1016/j.fbr.2012.07.001 · DOI
  41. Niessen, 2005, Advances in the molecular diagnosis of ochratoxin A–producing fungi, Food Addit. Contam., 22, 324, 10.1080/02652030500058452 · DOI
  42. O'Callaghan, 2003, A polyketide synthase gene required for ochratoxin A biosynthesis in Aspergillus ochraceus, Microbiology, 149, 3485, 10.1099/mic.0.26619-0 · DOI
  43. O'Callaghan, 2006, Ochratoxin A biosynthetic genes in Aspergillus ochraceus are dfferentially regulated by pH and nutritional stimuli, Fungal Genet. Biol., 43, 213, 10.1016/j.fgb.2005.11.005 · DOI
  44. O'Callaghan, 2013, Functional characterization of the polyketide synthase gene required for ochratoxin A biosynthesis in Penicillium verrucosum, Int. J. Food Microbiol., 161, 172, 10.1016/j.ijfoodmicro.2012.12.014 · DOI
  45. Parafati, 2015, Biocontrol ability and action mechanism of food-isolated yeast strains against Botrytis cinerea causing post-harvest bunch rot of table grape, Food Microbiol., 47, 85, 10.1016/j.fm.2014.11.013 · DOI · Paper page
  46. Parafati, 2017, Performance evaluation of volatile organic compounds by antagonistic yeasts immobilized oh hydrogel spheres against gray, green and blue postharvest decays, Food Microbiol., 63, 191, 10.1016/j.fm.2016.11.021 · DOI · Paper page
  47. Passoth, 2006, Biotechnology, physiology and genetics of the yeast Pichia anomala, FEMS Yeast Res., 6, 3, 10.1111/j.1567-1364.2005.00004.x · DOI
  48. Ponsone, 2011, Biocontrol as a strategy to reduce the impact of ochratoxin A and Aspergillus section Nigri in grapes, Int. J. Food Microbiol., 151, 70, 10.1016/j.ijfoodmicro.2011.08.005 · DOI
  49. Romano, 2015, Proton transfer reaction-mass spectrometry: online and rapid determination of volatile organic compounds of microbial origin, Appl. Microbiol. Biotechnol., 99, 3787, 10.1007/s00253-015-6528-y · DOI
  50. Rosenkranz, 1965, Phenethyl alcohol. I. Effect on macromolecular synthesis of Escherichia coli, J. Bacteriol., 89, 1354, 10.1128/jb.89.5.1354-1369.1965 · DOI
  51. Schmidt-Heydt, 2013, Fungicides effectively used for growth inhibition of several fungi could induce mycotoxin biosynthesis in toxigenic species, Int. J. Food Microbiol., 166, 407, 10.1016/j.ijfoodmicro.2013.07.019 · DOI
  52. Strobel, 2001, Volatile antimicrobials from Muscodor albus, a novel endophytic fungus, Microbiology, 147, 2943, 10.1099/00221287-147-11-2943 · DOI
  53. Suwannarach, 2010, Muscodor cinnamon, a new endophytic species from Cinnamomum bejolghota, Mycotaxon, 114, 15, 10.5248/114.15 · DOI
  54. Van den Dool, 1963, A generalization of the retention index system including linear temperature programmed gas-liquid partition chromatography, J. Chromatogr. A, 11, 463, 10.1016/S0021-9673(01)80947-X · DOI
  55. Van der Merwe, 1965, Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh, Nature, 205, 1112, 10.1038/2051112a0 · DOI
  56. Wang, 2015, Functional characterization of new polyketide synthase genes involved in ochratoxin A biosynthesis in Aspergillus ochraceus fc-1, Toxins, 7, 2723, 10.3390/toxins7082723 · DOI
  57. Werner, 2016, Belowground communication: impacts of volatile organic compounds (VOCs) from soil fungi on other soil-inhabiting organisms, Appl. Microbiol. Biotechnol., 100, 8651, 10.1007/s00253-016-7792-1 · DOI
  58. Worapong, 2001, Muscodor albus anam. gen. et sp. nov., an endophyte from Cinnamomum zeylanicum, Mycotaxon, 79, 67
  59. Wriessnegger, 2013, Yeast metabolic engineering-targeting sterol metabolism and terpenoid formation, Prog. Lipid Res., 52, 277, 10.1016/j.plipres.2013.03.001 · DOI
  60. Yan, 2011, Isolation and identification of a putative scent-related gene RhMYB1 from rose, Mol. Biol. Rep., 38, 4475, 10.1007/s11033-010-0577-1 · DOI
  61. Zeilinger, 2016, Secondary metabolism in Trichoderma - chemistry meets genomics, Fungal Biol. Rev., 30, 74, 10.1016/j.fbr.2016.05.001 · DOI
  62. Zhang, 2016, Control of ochratoxin A-producing fungi in grape berry by microbial antagonists: a review, Trends Food Sci. Technol., 51, 88, 10.1016/j.tifs.2016.03.012 · DOI
  63. Zhu, 2015, Inhibition of the growth and ochratoxin A production by Aspergillus carbonarius and Aspergillus ochraceus in vitro and in vivo through antagonistic yeasts, Food Control, 50, 125, 10.1016/j.foodcont.2014.08.042 · DOI

Cited by

Sorted by citations

Metadata

Authors
Farbo, M. G., Urgeghe, P. P., Fiori, S., Marcello, A., Oggiano, S., Balmas, V., Hassan, Z. U., Jaoua, S., & Migheli, Q.
Affiliations
  • University of Sassari (IT)
  • Qatar University (QA)
Corresponding author
Migheli, Quirico
ORCID
Venue
International Journal of Food Microbiology
Publisher
Elsevier BV
Published
2018-11
Volume
284
Pages
1-10
ISSN
0168-1605 (ISSN-L)
DOI
10.1016/j.ijfoodmicro.2018.06.023
OpenAlex
W2811189719
Cited by
128
References
4
Citations by year
2026: 7 · 2025: 21 · 2024: 19 · 2023: 27 · 2022: 18 · 2021: 14 · 2020: 13 · 2019: 8 · 2018: 1
FWCI
7.97
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Food Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • UnissResearch (Università degli Studi di Sassari) (submittedVersion, cc-by-nc-nd)
  • Qatar University QSpace (Qatar University) (submittedVersion)
Funders
  • Qatar National Research Fund
  • Qatar Foundation
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogens and Fungal Diseases
Keywords
ochratoxin A, Aspergillus carbonarius, Aspergillus ochraceus, biological control, 2-phenylethanol, mycotoxin production, gene expression, polyketide synthase, nonribosomal peptide synthetase, LaeA, VeA, grape berries, food safety
MeSH terms
Aspergillus, Fruit, Humans, Mixed Function Oxygenases, Mycotoxins, Ochratoxins, Peptide Synthases, Phenylethyl Alcohol, Spores, Fungal, Gene Expression Regulation, Fungal, Vitis, Polyketide Synthases, Volatile Organic Compounds, Microbial Interactions, Biological Control Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review