The Short- and Long-term Causal Relationships Between Self-compassion, Trait Mindfulness, Caregiver Stress, and Depressive Symptoms in Family Caregivers of Patients with Lung Cancer
Open accessAbstract
Objectives Using a prospective longitudinal design, this paper examines a serial mediation model of the associations between self-compassion, trait mindfulness, caregiver stress, and depressive symptoms among the family caregivers of patients with lung cancer. Methods A four-wave design was used, with initial assessment (T1) and three follow-ups, at the 2 nd month (T2), the 5 th month (T3), and the 8 th month (T4). A total of 123 family caregivers completed the baseline measurements, including caregiver stress, self-compassion, trait mindfulness, and depressive symptoms. Data were analyzed by serial mediation models to determine the causal ordering of these variables. Results Nearly one-quarter of the family caregivers suffered from clinically significant depressive symptoms and the severity of their depression remained unchanged throughout the 8-month follow-up period. Both cross-sectional and longitudinal path analyses revealed that the relationship between self-compassion and depressive symptoms was mediated sequentially by trait mindfulness and caregiver stress. The subscale analysis indicated that the association of higher compassionate action with fewer depressive symptoms was through chain-mediating effects of higher mindful awareness and lower caregiver stress. Conclusions Family caregivers who have higher levels of self-compassion tend to have more mindfulness; greater mindfulness leads to lower levels of perceived caregiving stress which, in turn, links to fewer symptoms of depression. Both self-compassion and mindfulness could be regarded as protective factors for caregivers to reduce caregiving stress and depression.
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Cites
Using Self-Report Assessment Methods to Explore Facets of Mindfulness
Baer, R. A., Smith, G. T., Hopkins, J., Krietemeyer, J., & Toney, L. (2006) · Assessment · doi:10.1177/1073191105283504 · Cited by 7,511 · cited 5× · see citing works
“The FFMQ showed acceptable internal consistency reliability in the current sample: α = 0.73 to 0.85.”
MethodInfluentialComparison of Beck Depression Inventories -IA and -II in psychiatric outpatients
Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965 · cited 1× · see citing works
“Depressive Symptoms Family caregivers’ depressive symptoms were assessed using the 21-item Beck Depression Inventory-II (BDI-II) to measure the presence and severity of depressive symptoms (Beck et al., 1996).”
MethodSelf-Compassion: An Alternative Conceptualization of a Healthy Attitude Toward Oneself
NEFF, K. (2003) · Self and Identity · doi:10.1080/15298860309032 · Cited by 5,440 · cited 2× · see citing works
“Neff (2003) and Gilbert et al.”
BackgroundShapiro, S. L., Carlson, L. E., Astin, J. A., & Freedman, B. (2006) · Journal of Clinical Psychology · doi:10.1002/jclp.20237 · Cited by 4,002 · cited 2× · see citing works
“Mindfulness decreases the unrealistic appraisal of stressful events because it leads individuals to shift attention from a ruminative to a present-centered focus, encouraging acceptance towards the experience of a present moment rather than avoidance of that experience (Shapiro et al., 2006).”
BackgroundSelf-Compassion: Conceptualizations, Correlates, & Interventions
Barnard, L. K., & Curry, J. F. (2011) · Review of General Psychology · doi:10.1037/a0025754 · Cited by 835 · cited 1× · see citing works
“People who practice self-compassion have a lower probability of being self-critical and a higher probability of engaging in self-care and positive change, aiding them in being mindful and responding constructively to difficult experiences (Barnard & Curry, 2011; Jay Miller et al., 2019).”
BackgroundHow Does Mindfulness Training Affect Health? A Mindfulness Stress Buffering Account
Creswell, J. D., & Lindsay, E. K. (2014) · Current Directions in Psychological Science · doi:10.1177/0963721414547415 · Cited by 543 · cited 1× · see citing works
“Being mindful enables people to be more aware and accepting of their experiences of the present moment, leading to reductions in stress levels and other negative outcomes (Colgan et al., 2019; Creswell & Lindsay, 2014).”
BackgroundThe development of compassionate engagement and action scales for self and others
Gilbert, P., Catarino, F., Duarte, C., Matos, M., Kolts, R., Stubbs, J., Ceresatto, L., Duarte, J., Pinto-Gouveia, J., & Basran, J. (2017) · Journal of Compassionate Health Care · doi:10.1186/s40639-017-0033-3 · Cited by 527 · cited 2× · see citing works
“Self‑Compassion The 13-item self-compassion scale measured persons’ abilities to have compassion toward themselves (Gilbert et al., 2017).”
BackgroundMethodInwood, E., & Ferrari, M. (2018) · Applied Psychology: Health and Well-Being · doi:10.1111/aphw.12127 · Cited by 483 · cited 1× · see citing works
“…both clinical and nonclinical settings have consistently identified self-compassion to be negatively associated with depressive symptoms and maladaptive emotion regulation strategies, and particularly those of rumination and avoidance (Bakker et al., 2019; Inwood & Ferrari, 2018; Zhu et al., 2019).”
BackgroundAlsubaie, M., Abbott, R., Dunn, B., Dickens, C., Keil, T. F., Henley, W., & Kuyken, W. (2017) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.04.008 · Cited by 383 · see citing works
Mindfulness and Self-Compassion: Exploring Pathways to Adolescent Emotional Well-Being
Bluth, K., & Blanton, P. W. (2014) · Journal of Child and Family Studies · doi:10.1007/s10826-013-9830-2 · Cited by 270 · see citing works
Family caregiver burden, skills preparedness, and quality of life in non-small cell lung cancer
Grant, M., Sun, V., Fujinami, R., Sidhu, R., Otis-Green, S., Juarez, G., Klein, L., & Ferrell, B. (2013) · Oncology Nursing Forum · doi:10.1188/13.onf.337-346 · Cited by 212 · cited 1× · see citing works
“It has been found that caregiving burdens generally either remain unchanged or increase over a 6-month period (Grant et al., 2013; Milbury et al., 2013).”
BackgroundPsychological and neural mechanisms of trait mindfulness in reducing depression vulnerability
Paul, N. A., Stanton, S. J., Greeson, J. M., Smoski, M. J., & Wang, L. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss070 · Cited by 193 · see citing works
Milbury, K., Badr, H., Fossella, F., Pisters, K., & Carmack, C. (2013) · Supportive Care in Cancer · doi:10.1007/s00520-013-1795-6 · Cited by 178 · cited 1× · see citing works
“It has been found that caregiving burdens generally either remain unchanged or increase over a 6-month period (Grant et al., 2013; Milbury et al., 2013).”
BackgroundMindful emotion regulation: Exploring the neurocognitive mechanisms behind mindfulness
Grecucci, A., Pappaianni, E., Siugzdaite, R., Theuninck, A., & Job, R. (2015) · BioMed Research International · doi:10.1155/2015/670724 · Cited by 177 · cited 1× · see citing works
“Mindfulness, thus, creates for the individual opportunities for reflection, which enable more adaptive and flexible ways of responding to difficult situations (Grecucci et al., 2015; Shapiro et al., 2006).”
BackgroundNipp, R. D., El-Jawahri, A. R., Fishbein, J. N., Gallagher, E. R., Stagl, J. M., Park, E. R., Jackson, V. A., Pirl, W. F., Greer, J. A., & Temel, J. S. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw205 · Cited by 174 · cited 1× · see citing works
“Lung cancer patients’ heavy symptom burdens and low survival rates lead their family members to be in a high-risk group for suffering from depressive symptoms and psychological distress (Nipp et al., 2016; Tan et al., 2018).”
BackgroundFinlay‐jones, A. L. (2017) · Clinical Psychologist · doi:10.1111/cp.12131 · Cited by 159 · cited 1× · see citing works
“There is also a probability that self-compassion is associated with a decrease in the use of negative coping strategies, such as rumination, self-criticism, emotional suppression, and avoidance (Finlay-Jones, 2017).”
BackgroundKrieger, T., Berger, T., & Holtforth, M. G. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.032 · Cited by 150 · cited 1× · see citing works
“Cross-lagged panel analyses show that self-compassion predicted depressive symptoms and the occurrence of a major depressive episode over time (Krieger et al., 2016).”
BackgroundTan, J.-Y., Molassiotis, A., Lloyd-Williams, M., & Yorke, J. (2018) · European Journal of Cancer Care · doi:10.1111/ecc.12691 · Cited by 127 · cited 1× · see citing works
“Lung cancer patients’ heavy symptom burdens and low survival rates lead their family members to be in a high-risk group for suffering from depressive symptoms and psychological distress (Nipp et al., 2016; Tan et al., 2018).”
BackgroundSiminoff, L. A., Genderson, M. W., & Baker, S. (2010) · Psycho-Oncology · doi:10.1002/pon.1696 · Cited by 114 · cited 1× · see citing works
“Studies have found that 22–60% of family caregivers of lung cancer patients suffer from clinical depression (Nightingale et al., 2019; Siminoff et al., 2010).”
BackgroundLynch, S. H., Shuster, G., & Lobo, M. L. (2017) · Aging & Mental Health · doi:10.1080/13607863.2017.1364344 · Cited by 105 · cited 1× · see citing works
“While undertaking long-term caregiving burdens, family caregivers commonly experience physical and emotional exhaustion, which is referred to as compassion fatigue (Lynch et al., 2018).”
BackgroundSubič-Wrana, C., Beutel, M. E., Brähler, E., Stöbel‐Richter, Y., Knebel, A., Lane, R. D., & Wiltink, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091846 · Cited by 96 · see citing works
Jaffray, L., Bridgman, H., Stephens, M., & Skinner, T. (2016) · Palliative Medicine · doi:10.1177/0269216315600331 · Cited by 88 · see citing works
Banerjee, M., Cavanagh, K., & Strauss, C. (2017) · Mindfulness · doi:10.1007/s12671-017-0740-z · Cited by 80 · see citing works
Day, J. R., & Anderson, R. A. (2011) · Nursing Research and Practice · doi:10.1155/2011/408024 · Cited by 76 · cited 1× · see citing works
“Their depressive symptoms and psychological distress influence their capacity to provide compassionate care to their loved ones (Day & Anderson, 2011).”
BackgroundBanerjee, M., Cavanagh, K., & Strauss, C. (2018) · Mindfulness · doi:10.1007/s12671-017-0837-4 · Cited by 75 · cited 2× · see citing works
“A later disengagement in mindfulness intervention was predicted for individuals with baseline levels of worry and rumination (Banerjee et al., 2018).”
BackgroundMosher, C. E., Jaynes, H., Hanna, N., & Ostroff, J. (2012) · Supportive Care in Cancer · doi:10.1007/s00520-012-1532-6 · Cited by 72 · see citing works
Zhu, L., Yao, J., Jun, W., Wu, L., Gao, Y., Xie, J., Liu, A., Ranchor, A. V., & Schroevers, M. J. (2019) · Psycho-Oncology · doi:10.1002/pon.5174 · Cited by 63 · cited 1× · see citing works
“Recent studies in both clinical and nonclinical settings have consistently identified self-compassion to be negatively associated with depressive symptoms and maladaptive emotion regulation strategies, and particularly those of rumination and avoidance (Bakker et al., 2019; Inwood & Ferrari, 2018; Zhu et al., 2019).”
BackgroundEmotion Regulation as a Mediator of Self-Compassion and Depressive Symptoms in Recurrent Depression
Bakker, A. M., Cox, D. W., Hubley, A. M., & Owens, R. L. (2019) · Mindfulness · doi:10.1007/s12671-018-1072-3 · Cited by 61 · cited 1× · see citing works
“Recent studies in both clinical and nonclinical settings have consistently identified self-compassion to be negatively associated with depressive symptoms and maladaptive emotion regulation strategies, and particularly those of rumination and avoidance (Bakker et al., 2019; Inwood & Ferrari, 2018; Zhu et al., 2019).”
BackgroundMindfulness and Self-compassion as Unique and Common Predictors of Affect in the General Population
López, A., Sanderman, R., & Schroevers, M. J. (2016) · Mindfulness · doi:10.1007/s12671-016-0568-y · Cited by 53 · cited 1× · see citing works
“The cross-sectional study showed that higher levels of both self-compassion and mindfulness were associated with lower levels of depression (Lopez et al., 2016).”
BackgroundSelf-Compassion as a Predictor of Self-Care: A Study of Social Work Clinicians
Miller, J. “., Lee, J., Niu, C., Grise-Owens, E., & Bode, M. (2019) · Clinical Social Work Journal · doi:10.1007/s10615-019-00710-6 · Cited by 52 · see citing works
Rowe, A. C., Shepstone, L. L., Carnelley, K. B., Cavanagh, K., & Millings, A. (2016) · Mindfulness · doi:10.1007/s12671-016-0499-7 · Cited by 44 · cited 2× · see citing works
“However, a cross-sectional study utilizing mediation analysis indicates that self-compassion increases the individual’s motivation to engage in mindfulness training (Rowe et al., 2016).”
BackgroundPsychometric Evaluation of Kingston Caregiver Stress Scale
Sadak, T., Korpak, A., Wright, J., Lee, M.-K., Noel, M., Buckwalter, K., & Borson, S. (2017) · Clinical Gerontologist · doi:10.1080/07317115.2017.1313349 · Cited by 42 · see citing works
de Sá, A. R., Liebel, G., de Andrade, A. G., Andrade, L. H., Gorenstein, C., & Wang, Y. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00050 · Cited by 37 · cited 1× · see citing works
“39% (n = 30) of family caregivers scored above the BDI-II cut-off point of 13, for clinically significant depressive symptoms (Junior et al., 2019).”
BackgroundColgan, D. D., Klee, D., Memmott, T., Proulx, J. A., & Oken, B. (2018) · Stress and Health · doi:10.1002/smi.2845 · Cited by 29 · cited 1× · see citing works
“Being mindful enables people to be more aware and accepting of their experiences of the present moment, leading to reductions in stress levels and other negative outcomes (Colgan et al., 2019; Creswell & Lindsay, 2014).”
BackgroundCaregiver Burden and Depression Among Chinese Family Caregivers: the Role of Self-compassion
Xu, S., Zhang, H., & Wang, J. (2020) · Mindfulness · doi:10.1007/s12671-020-01378-7 · Cited by 26 · see citing works
Nightingale, C., Steffen, L., Tooze, J., Petty, W., Danhauer, S., Badr, H., & Weaver, K. E. (2019) · Global Advances in Health and Medicine · doi:10.1177/2164956119865160 · Cited by 21 · cited 1× · see citing works
“Studies have found that 22–60% of family caregivers of lung cancer patients suffer from clinical depression (Nightingale et al., 2019; Siminoff et al., 2010).”
BackgroundPires, F. B. C., Lacerda, S. S., Balardin, J. B., Portes, B., Tobo, P. R., Barrichello, C., Amaro, E., & Kozasa, E. H. (2018) · BMC Women s Health · doi:10.1186/s12905-018-0685-y · Cited by 21 · cited 1× · see citing works
“Moreover, as supported by previous findings (Pires et al., 2018), people with higher self-compassion scores report greater mindfulness and sensitivity to emotional stimuli.”
Result
Flagged first, then by citations
4 of the 41 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Geng HM Chuang DM Yang F Yang Y Liu WM Liu LH Tian HM Prevalence and determinants of depression in caregivers of cancer patients: A systematic review and meta-analysis Medicine (Baltimore) 2018 97 39 e11863 10.1097/MD.0000000000011863 30278483 PMC6181540 · DOI · Paper page
- Hayes, A. F. (2017). Introduction to mediation, moderation, and conditional process analysis. (2nd ed.). Guilford Press.
Cited by
Sorted by citations
Wang, J., Drossaert, C. H. C., Knevel, M., Chen, L., Bohlmeijer, E. T., & Schroevers, M. J. (2025) · Stress and Health · doi:10.1002/smi.70090 · Cited by 15 · see citing works
“The Compassionate Engagement and Action Scale (CEAS; Gilbert et al. 2017) was employed by two studies (Hsieh et al. 2021; Murfield et al. 2020).”
Coping with family function changes: A qualitative study of couples facing advanced lung cancer
Pan, X., Yang, Y., Chen, X., Huang, W., Ye, J., Huang, Y., & Li, Y. M. (2024) · Asia-Pacific Journal of Oncology Nursing · doi:10.1016/j.apjon.2024.100504 · Cited by 15 · see citing works
“This fi nding is consistent with the results of other studies conducted from a dichotomous perspective; 17 – 19 which showed that the advanced stage of LC had a signi fi cant impact on the lifestyle, interactions, and family structure of the patients.”
ResultPan, Y.-Q., Chen, R.-Y., & Yang, D. (2023) · Nursing Open · doi:10.1002/nop2.1609 · Cited by 11 · see citing works
“…of depression, nursing strategies such as skill training programs in self- compassion, positive appraisal and active coping should be developed for adult children to normalise their perceptions of filial duties and enhance their preparedness (Chan et al., 2018; Hsieh et al., 2021; Xu et al., 2020).”
BackgroundZhao, X., Zhang, Y., Qin, R., Li, G., He, X., Shen, X., & Li, P. (2023) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2023.102491 · Cited by 12 · see citing works
Hua, Z. (2026) · Families in Society The Journal of Contemporary Social Services · doi:10.1177/10443894261435229 · Cited by 2 · see citing works
Kalav, S., Çullu, M., & Özkaraca, Z. (2026) · BMC Nursing · doi:10.1186/s12912-026-04584-1 · Cited by 2 · see citing works
“Prior research supports the link between caregiver mindfulness and favorable care outcomes, including higher self-compassion, lower burden, and lower burnout [26, 59, 60, 67, 70].”
Noursina, S., & Kiani, Q. (2023) · Nursing and Midwifery Journal · doi:10.61186/unmf.21.7.558 · Cited by 2 · see citing works
Noei, F. R., Atashi, V., & Ashouri, E. (2023) · The Journal of Mental Health Training Education and Practice · doi:10.1108/jmhtep-08-2022-0068 · Cited by 3 · see citing works
Wang, S., Lei, J., Li, M., Wu, Y., Guan, Q., & Zhang, R. (2025) · Mindfulness · doi:10.1007/s12671-025-02605-9 · Cited by 1 · see citing works
“The meta-analysis revealed that non-significant overall effects on caregivers' anxiety and depression, which is inconsistent with the study by Hsieh et al. (2021).”
Duran, S., & Aydoğdu, A. (2024) · Health Education Research · doi:10.1093/her/cyae031 · Cited by 1 · see citing works
Associations Between Guilt and Self‐Compassion Among Iranian Family Caregivers of Cancer Patients
Salarmohamadi, A., Torkaman, M., Pourkhajoei, S., & Asadi, N. (2026) · Health & Social Care in the Community · doi:10.1155/hsc/8177627
Williams, M. P., Simon, D. M., Seward, M., Tatar, R., Huberty, J., Vranceanu, A., & Plys, E. (2026) · JMIR Aging · doi:10.2196/83618
“This trajectory in mindfulness and stress ratings reflects several previous findings, where an initial effect of mindfulness skills on the primary outcome is observed, followed by a period of attenuation [45-48].”
- Authors
- Hsieh, C.-C., Lin, Z.-Z., Ho, C.-C., Yu, C.-J., Chen, H.-J., Chen, Y.-W., & Hsiao, F.-H.
- Affiliations
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- National Taiwan Normal University (TW)
- Corresponding author
- Hsiao, Fei-Hsiu
- ORCID
- Venue
- Mindfulness
- Published
- 2021-05-05
- Volume
- 12
- Issue
- 7
- Pages
- 1812-1821
- ISSN
- 1868-8527 (ISSN-L)
- 1868-8535
- PMC
- PMC8096886
- OpenAlex
- W3158007794
- Cited by
- 19
- References
- 41
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 6 · 2021: 1
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mindfulness (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Health Professions › Pharmacy › Nursing care and research
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- self-compassion, trait mindfulness, caregiver stress, depressive symptoms, family caregivers, lung cancer, serial mediation, compassionate action, mindful awareness, protective factors
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