Cited by 108Autophagy in Disease and TherapyMuscle Physiology and DisordersExercise and Physiological Responses

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Autophagic response to exercise training in skeletal muscle with age

Kim, Yong An, Kim, Young Sang, Oh, Seung Lyul, Kim, Hee-Jae, Song, Wook·2013·Journal of Physiology and Biochemistry

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Abstract

Autophagy, a highly conserved quality control mechanism, is essential for the maintenance of cellular homeostasis and for the orchestration of an efficient cellular response to stress. During aging, the efficiency of autophagic degradation declines, and intracellular waste products accumulate. Therefore, in this study, we tested the hypothesis that skeletal muscle from old mice would have decreased autophagosome formation when compared to the muscle from young mice. We also examined whether autophagic regulatory events differ between muscle fiber types and in response to exercise in aged male mice. The extensor digitorum longus (EDL) and gastrocnemius muscles were studied in young and old ICR mice. Exercise was performed by allowing the mice to run on a treadmill with a 5° incline at 16.4 m/min for 40 min/day, 5 days/week for 8 weeks after a 1-week adaptation period. Our results indicated that the levels of microtubule-associated protein 1b light chain 3, a marker of autophagosome formation, were lower in both the EDL and the gastrocnemius muscle of old mice compared to those young mice. To identify the factors related to the changes observed, the expression of autophagy regulatory proteins was examined in the EDL and gastrocnemius muscles. Beclin-1, autophagy-related gene 7 (ATG7), and lysosome-associated membrane protein were found to be lower in the EDL and gastrocnemius muscles of old mice compared to those in the young mice, then Beclin-1, ATG7, and muscle-specific RING finger protein-1 upregulated after regular exercise. Moreover, the muscle weight/body weight was significantly increased only in the gastrocnemius muscle of the old trained mice. These data suggest that autophagy regulatory events are attenuated in old skeletal muscle. However, this effect is upregulated when animals are subjected to exercise training.

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Authors: Kim, Y. A., Kim, Y. S., Oh, S. L., Kim, H.-J., & Song, W.
Affiliations: Chungnam National University (KR)
Seoul National University (KR)
Corresponding author: Song, Wook
ORCID: Kim, Yong An
Kim, Young Sang
Kim, Hee-Jae
Song, Wook
Venue: Journal of Physiology and Biochemistry
Publisher: Springer Science and Business Media LLC
Published: 2013-03-08
Volume: 69
Issue: 4
Pages: 697-705
ISSN: 1138-7548 (ISSN-L)
1877-8755
DOI: 10.1007/s13105-013-0246-7
OpenAlex: W2041198637
Cited by: 108
References: 36
Citations by year: 2026: 4 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 14 · 2020: 6 · 2019: 12 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 17 · 2014: 9 · 2013: 3
FWCI: 9.23
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Physiology and Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: autophagy, exercise training, skeletal muscle aging, autophagosome formation, LC3B, Beclin-1, ATG7, LAMP1, muscle fiber type, extensor digitorum longus, gastrocnemius, treadmill running, muscle mass
MeSH terms: Tripartite Motif Proteins, Beclin-1, Autophagy-Related Protein 7, Aging, Animals, Autophagy, Body Weight, Male, Mice, Inbred ICR, Microtubule-Associated Proteins, Muscle Proteins, Organ Size, Physical Conditioning, Animal, Biomarkers, Gene Expression, Muscle, Skeletal, Ubiquitin-Protein Ligases, Apoptosis Regulatory Proteins, Mice

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Autophagic response to exercise training in skeletal muscle with age

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