The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
Bioactive peptides of animal origin: a review
Open accessAbstract
Bioactive peptides are specific protein fragments which, above and beyond their nutritional capabilities, have a positive impact on the body's function or condition which may ultimately influence health. Although, inactive within the sequence of the parent proteins, these peptides can be released during proteolysis or fermentation and play an important role in human health by affecting the digestive, endocrine, cardiovascular, immune and nervous systems. Several peptides that are released in vitro or in vivo from animal proteins have been attributed to different health effects, including antimicrobial properties, blood pressure-lowering (ACE inhibitory) effects, cholesterol-lowering ability, antithrombotic and antioxidant activities, opioid activities, enhancement of mineral absorption and/or bioavailability, cytomodulatory and immunomodulatory effects, antiobesity, and anti-genotoxic activity. Several functional foods based on the bioactivities of these peptides with scientifically evidenced health claims are already on the market or under development by food companies. Consumer's increasing interest in these products has given an impetus to the food industry and scientific sector who are continuously exploring the possibilities for the development of new functional products based on these peptides. In this review, we describe above stated properties of bioactive peptides of animal origin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similar to dietary supplements, functional foods attempt to improve health by incorporating bioactive compounds that may alter lipid, vascular, and other metabolic pathways, microbiome composition and function, and digestive and inflammatory systems.114-121”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [119]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ondetti, M. A., Rubin, B., & Cushman, D. W. (1977) · Science · doi:10.1126/science.191908 · Cited by 1,868
Bioactive peptides: Production and functionality
Korhonen, H. J. T., & Pihlanto, A. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2005.10.012 · Cited by 1,822
Scientific Concepts of Functional Foods in Europe Consensus Document
(1999) · British Journal Of Nutrition · doi:10.1017/s0007114599000471 · Cited by 1,134
Kitts, D., & Weiler, K. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033454883 · Cited by 910
Sánchez, A., & Vázquez, A. (2017) · Food Quality and Safety · doi:10.1093/fqs/fyx006 · Cited by 868
Purification and Characterization of Angiotensin I-Converting Enzyme Inhibitors from Sour Milk
Nakamura, Y., Yamamoto, N., Sakai, K., Ōkubo, A., Yamazaki, S., & Takano, T. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76689-9 · Cited by 838
Food-derived Bioactive Peptides - Opportunities for Designing Future Foods
Korhonen, H. T., & Pihlanto, A. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033454892 · Cited by 790
Milk-derived bioactive peptides: From science to applications
Korhonen, H. J. T. (2009) · Journal of Functional Foods · doi:10.1016/j.jff.2009.01.007 · Cited by 729
Hypotensive Peptides from Milk Proteins
Fitzgerald, R. J., Murray, B. A., & Walsh, D. J. (2004) · Journal of Nutrition · doi:10.1093/jn/134.4.980s · Cited by 725
Bioactive milk peptides: a prospectus.
Clare, D. A., & Swaisgood, H. E. (2000) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(00)74983-6 · Cited by 718
Research works printed but not linked: 8
- Becker GL (1993) Preserving food and health: antioxidants make functional, nutritious preservatives. Food Process (Chicago) 12:54–56
- Khora SS (2013) Marine fish-derived bioactive peptides and proteins for human therapeutics. Int J Pharm Pharm Sci 5:31–37
- Meister W, Birch-Hirschfeld E, Koban M, Schilken U, Kunze G, Blasig R (1994) β-casomorphins and related peptides. In: Brantl V, Teschemacher H (eds) Recent developments. VCH, Veinheim, pp 66–72
- Nurminen ML, Sipola M, Kaarto H, Pihlanto-Leppala A, Piilola K, Korpela R, Tossavainen O, Korhonen H, Vapaatalo H (2000) Alphalactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats. Life Sci 66:1535–1543 · DOI
- Nyberg F, Sanderson K, Glamsta EL (1997) The hemorphins: a new class of opioid peptides derived from the blood protein hemoglobin. Biopolymers 43:147–156 · DOI
- Saïd B, Dominique B (2011) Mineral-binding peptides from food. In: Hettiarachchy NS, Sato K, Marshall MR, Kannan A (eds) Bioactive food proteins and peptides. Applications in human health. CRC Press, Boca Raton, pp 117–130
- Won-Kyo J, Pyo-Jam P, Hee-Guk B, Sung-Hoon M, Se-Kwon K (2005) Preparation of Hoki (Johnius belengeri), bone oligophosphopeptide with a high affinity to calcium by carnivorous intestine crude proteinase. Food Chem 91:333–340 · DOI
- Zhao Q, Girreau I, Sannier F, Piot JM (1997) Opioid peptides derived from hemoglobin: hemorphins. Biopolymers 43:75–98 · DOI
Cited by
Sorted by citations
Items 301–309 of 309
Functional foods and their potential impact on women’s health in Chile
Mansilla, M. L., Cabezas, B. H., Villegas, P. B., Romero, L. Q., Torres‐Farfan, C., & Salazar‐Petres, E. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1778228
Dong, X., Wang, Z., Xu, B., & Feng, J. (2026) · Food Research International · doi:10.1016/j.foodres.2026.119343
Vihan, V., Singh, V. P., Umaraw, P., Verma, A. K., & Singh, C. (2026) · Food and Humanity · doi:10.1016/j.foohum.2026.101341
Muthuvel, I., Priyadharshini, D., Ponnaiah, S. K., Kavitha, P. S., & Selvaraj, K. V. (2026) · Springer eBooks · doi:10.1007/978-3-032-29927-7_7
Shazad, A., Tlais, A. Z. A., Hernández‐Ledesma, B., Gómez‐Cortés, P., Trossolo, E., Filannino, P., Gobbetti, M., & Cagno, R. D. (2026) · Future Foods · doi:10.1016/j.fufo.2026.101177
( N -Hydroxy)amide-Mediated Rapid Head-to-Tail Cyclization of Unprotected Peptides in Water
Zhang, Y., Wang, W., Yang, H., & Fu, H. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c11517
Zhang, J., Zhou, W., Wei, L., Liu, X., Chen, L., Mao, J., & Yu, J. (2026) · Foods · doi:10.3390/foods15213775
Metadata
- Authors
- Bhat, Z. F., Kumar, S., & Bhat, H. F.
- Affiliations
- Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu (IN)
- Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir (IN)
- Corresponding author
- Bhat, Z. F.
- Venue
- Journal of Food Science and Technology
- Published
- 2015-01-21
- Volume
- 52
- Issue
- 9
- Pages
- 5377-5392
- ISSN
- 0022-1155 (ISSN-L)
- 0975-8402
- PMC
- PMC4554628
- OpenAlex
- W2088757255
- Cited by
- 308
- References
- 177
- Citations by year
- 2026: 17 · 2025: 32 · 2024: 32 · 2023: 32 · 2022: 46 · 2021: 41 · 2020: 32 · 2019: 23 · 2018: 22 · 2017: 20 · 2016: 10 · 2015: 1
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Food Science and Technology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- bioactive peptides, animal protein, proteolysis, fermentation, angiotensin-converting enzyme inhibition, blood pressure reduction, cholesterol lowering, antioxidant activity, antimicrobial peptides, opioid activity, mineral bioavailability, immunomodulation, anti-obesity, functional foods, health claims
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
