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4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1

Yang, Huirong, Wang, Jia, Liu, Mengjie, Chen, Xizi, Huang, Min, Tan, Dan, Dong, Meng-Qiu, Wong, Catherine C. L., Wang, Jiawei, Xu, Yanhui, Wang, Hong-Wei·2016·Protein & Cell
DOI 10.1007/s13238-016-0346-6PMC PMC5205667
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Research works printed but not linked: 29

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  2. Baretic D, Berndt A, Ohashi Y, Johnson CM, Williams RL (2016) Tor forms a dimer through an N-terminal helical solenoid with a complex topology. Nat Commun 7:11016 · DOI
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  12. Holz MK, Blenis J (2005) Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 280:26089–26093 · DOI
  13. Holz MK, Ballif BA, Gygi SP, Blenis J (2005) mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123:569–580 · DOI · Paper page
  14. Inoki K, Corradetti MN, Guan KL (2005) Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37:19–24 · DOI
  15. Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163–175 · DOI
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  22. Stretton C, Hoffmann TM, Munson MJ, Prescott A, Taylor PM, Ganley IG, Hundal HS (2015) GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling. Biochem J 470:207–221 · DOI
  23. Tee AR, Blenis J (2005) mTOR, translational control and human disease. Semin Cell Dev Biol 16:29–37 · DOI
  24. Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J (2003) Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 13:1259–1268 · DOI · Paper page
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  28. Yip CK, Murata K, Walz T, Sabatini DM, Kang SA (2010) Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell 38:768–774 · DOI · Paper page
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Metadata

Authors
Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M.-Q., Wong, C. C. L., Wang, J., Xu, Y., & Wang, H.-W.
Venue
Protein & Cell
Publisher
Oxford University Press (OUP)
Published
2016-12
Volume
7
Issue
12
Pages
878-887
ISSN
  • 1674-800X
  • 1674-8018
DOI
10.1007/s13238-016-0346-6
PMC
PMC5205667
Cited by
96
References
8
Language
en
Licence
creativecommons.org/licenses/by/4.0 (unspecified)

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