MASH Suite: A User-Friendly and Versatile Software Interface for High-Resolution Mass Spectrometry Data Interpretation and Visualization
Open accessAbstract
The rapid advancements in mass spectrometry (MS) instrumentation, particularly in Fourier transform (FT) MS, have made the acquisition of high-resolution and high-accuracy mass measurements routine. However, the software tools for the interpretation of high-resolution MS data are underdeveloped. Although several algorithms for the automatic processing of high-resolution MS data are available, there is still an urgent need for a user-friendly interface with functions that allow users to visualize and validate the computational output. Therefore, we have developed MASH Suite, a user-friendly and versatile software interface for processing high-resolution MS data. MASH Suite contains a wide range of features that allow users to easily navigate through data analysis, visualize complex high-resolution MS data, and manually validate automatically processed results. Furthermore, it provides easy, fast, and reliable interpretation of top-down, middle-down, and bottom-up MS data. MASH Suite is convenient, easily operated, and freely available. It can greatly facilitate the comprehensive interpretation and validation of high-resolution MS data with high accuracy and reliability.
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MASH Suite and MASH Suite Pro are earlier generations of proteomics software.
“Advancing on our previous generations of proteomics software, MASH Suite10 and MASH Suite Pro,11 MASH Explorer has many new features including (1) development of a universal platform for streamlined data processing from various vendor formats to standardize the data analysis; (2) integration of multiple deconvolution and database search algorithms for significantly enhanced protein identification;”
From MASH Explorer: A Universal Software Environment for Top-Down Proteomics (2020) · cites this paper as [10]
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- Authors
- Guner, H., Close, P. L., Cai, W., Zhang, H., Peng, Y., Gregorich, Z. R., & Ge, Y.
- Affiliations
- Human Proteomics Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA
- University of Wisconsin–Madison (US)
- Corresponding author
- Ge, Ying
- Venue
- Journal of the American Society for Mass Spectrometry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-01-03
- Volume
- 25
- Issue
- 3
- Pages
- 464-470
- ISSN
- 1044-0305 (ISSN-L)
- PMC
- PMC3940544
- OpenAlex
- W1984607596
- Cited by
- 73
- References
- 15
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 6
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of the American Society for Mass Spectrometry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Heart, Lung, and Blood Institute (R01HL109810, R01HL096971)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- high-resolution mass spectrometry, mass spectral interpretation, data visualization, software interface, top-down mass spectrometry, middle-down mass spectrometry, bottom-up mass spectrometry, automated data processing, Fourier transform mass spectrometry
- MeSH terms
- Proteins, Software, User-Computer Interface, Proteomics, Tandem Mass Spectrometry
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