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Cited by 30Wound Healing and TreatmentsMesenchymal stem cell researchExtracellular vesicles in disease

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Advances in mesenchymal stem/stromal cell-based therapy and their extracellular vesicles for skin wound healing

Saadh, Mohamed J., Ramírez-Coronel, Andrés Alexis, Saini, Ravinder Singh, Arias-Gonzáles, José Luis, Amin, Ali H., Gavilán, Juan Carlos Orosco, Sârbu, Ioan·2023·Human Cell
DOI 10.1007/s13577-023-00904-8
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Abstract

Wound healing is a dynamic and complicated process containing overlapping phases. Presently, definitive therapy is not available, and the investigation into optimal wound care is influenced by the efficacy and cost-effectiveness of developing therapies. Accumulating evidence demonstrated the potential role of mesenchymal stem/stromal cell (MSC) therapy in several tissue injuries and diseases due to their high proliferation and differentiation abilities along with an easy collection procedure, low tumorigenesis, and immuno-privileged status. MSCs have also accelerated wound repair in all phases through their advantageous properties, such as accelerating wound closure, improving re-epithelialization, elevating angiogenesis, suppressing inflammation, and modulating extracellular matrix (ECM) remodeling. In addition, the beneficial therapeutic impacts of MSCs are largely associated with their paracrine functions, including extracellular vesicles (EVs). Exosomes and microvesicles are the two main subgroups of EVs. These vesicles are heterogeneous bilayer membrane structures that contain several proteins, lipids, and nucleic acids. EVs have emerged as a promising alternative to stem cell-based therapies because of their lower immunogenicity, tumorigenicity, and ease of management. MSCs from various sources have been widely investigated in skin wound healing and regeneration. Considering these features, in this review, we highlighted recent studies that the investigated therapeutic potential of various MSCs and MSC-EVs in skin damages and wounds.

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Metadata

Authors
Saadh, M. J., Ramírez-Coronel, A. A., Saini, R. S., Arias-Gonzáles, J. L., Amin, A. H., Gavilán, J. C. O., & Sârbu, I.
Affiliations
  • Applied Science Private University (JO)
  • King Khalid University (SA)
  • Mansoura University (EG)
  • Private University of the North (PE)
  • Grigore T. Popa University of Medicine and Pharmacy (RO)
Corresponding author
Sârbu, Ioan
ORCID
Venue
Human Cell
Publisher
Springer Science and Business Media LLC
Published
2023-04-17
Volume
36
Issue
4
Pages
1253-1264
ISSN
  • 0914-7470 (ISSN-L)
  • 1749-0774
DOI
10.1007/s13577-023-00904-8
OpenAlex
W4366082882
Cited by
30
References
8
Citations by year
2026: 4 · 2025: 11 · 2024: 9 · 2023: 6
FWCI
1.02
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Human Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
mesenchymal stem cells, extracellular vesicles, skin wound healing, exosomes, microvesicles, paracrine signaling, re-epithelialization, angiogenesis, inflammation modulation, extracellular matrix remodeling, skin regeneration, immunogenicity
MeSH terms
Extracellular Vesicles, Wound Healing, Mesenchymal Stem Cell Transplantation, Exosomes, Mesenchymal Stem Cells

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